Comparing Dsui_0602 FitnessBrowser__PS:Dsui_0602 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2ag8A NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
45% identity, 99% coverage: 1:266/270 of query aligns to 1:261/263 of 2ag8A
3triA Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
40% identity, 97% coverage: 3:265/270 of query aligns to 5:269/272 of 3triA
5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline (see paper)
38% identity, 96% coverage: 5:263/270 of query aligns to 13:271/272 of 5bshA
5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+ (see paper)
38% identity, 96% coverage: 5:263/270 of query aligns to 13:271/272 of 5bsgA
5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+ (see paper)
38% identity, 96% coverage: 5:263/270 of query aligns to 13:271/272 of 5bsfA
5bseA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
38% identity, 96% coverage: 5:263/270 of query aligns to 13:271/272 of 5bseA
2rcyA Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
32% identity, 98% coverage: 1:264/270 of query aligns to 5:261/262 of 2rcyA
6xp0A Structure of human pycr1 complexed with n-formyl l-proline (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 3:267/272 of 6xp0A
8td1A Structure of pycr1 complexed with 3-(6-oxa-9-azaspiro(4.5)decane-9- carbonyl)benzoic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/280 of 8td1A
8td0A Structure of pycr1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2, 1-b][1,3]thiazole-3-carboxylic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/280 of 8td0A
8tczA Structure of pycr1 complexed with 2-(pyridin-2-yl)cyclopropane-1- carboxylic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/280 of 8tczA
8tcxA Structure of pycr1 complexed with 2,4-dioxo-1,2,3,4- tetrahydroquinazoline-6-carboxylic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/280 of 8tcxA
2izzA Crystal structure of human pyrroline-5-carboxylate reductase
34% identity, 97% coverage: 1:263/270 of query aligns to 2:269/272 of 2izzA
8tcwA Structure of pycr1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl) benzoic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/282 of 8tcwA
6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 4:271/276 of 6xp3A
8tcuA Structure of pycr1 complexed with 2-chloro-5-(2-oxoimidazolidin-1-yl) benzoic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/279 of 8tcuA
P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 4 papers)
34% identity, 97% coverage: 1:263/270 of query aligns to 1:268/319 of P32322
Sites not aligning to the query:
8tcyA Structure of pycr1 complexed with 7-fluoro-2-oxo-1,2,3,4- tetrahydroquinoline-6-carboxylic acid (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 8:275/281 of 8tcyA
2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 3:270/277 of 2graA
2gr9A Crystal structure of p5cr complexed with nadh (see paper)
34% identity, 97% coverage: 1:263/270 of query aligns to 3:270/277 of 2gr9A
>Dsui_0602 FitnessBrowser__PS:Dsui_0602
MKITFLGGGNMANALIGGLVNKGFAAGDIAVVELNADNRSKLEAAYGVRTFAGAEAAAWD
CDVIVLAVKPQSMKEAIAPIGPHLKDQLVVSIAAGLNLASLSRWLGGHRRLVRTMPNTPA
LIGAGVTGLYALPEVDAAGRAAAQRVLEAVGSAVWFADESQMDAVTAVSGSGPAYVFLFI
EALQQAGKDLGFDDEQARRLAIETVLGAAQLAAQSPDPASVLRERVTSKGGTTAAALAVM
ETAGVKAGIIAGVKAAEARGVELGQQLGAD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory