SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_0609 FitnessBrowser__PS:Dsui_0609 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0DPQ8 Aromatic O-demethylase, reductase subunit; NADH--hemoprotein reductase; EC 1.6.2.- from Amycolatopsis sp. (strain ATCC 39116 / 75iv2) (see paper)
38% identity, 95% coverage: 1:320/337 of query aligns to 1:318/334 of P0DPQ8

query
sites
P0DPQ8

M

M

S

T

F

F

S

A

V

V

T

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I

V

E

-

P

-

G

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G

H

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A

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T

I

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E

A

A

A

F

L

L

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R

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G

G

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W

M

M

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P

Y

N

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C
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C

R

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C

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C

K

K

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C

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G

G

E

E

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D

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E

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L

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A

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A

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G

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A

D

D

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-

L

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-

E

E

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V

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S

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A

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A

-

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R

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x
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x
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x
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T

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-

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N

D

G

G

M

L

K

A

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A

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D

I

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E

L

A

N

T

G

G

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P

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-

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T

G

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S

-

D

-

E

-

P

E

D

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P

A

A

A

Y

T

-

D

-

G

-

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-

N

-

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-

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C35 (= C37) binding
C40 (= C42) binding
C43 (= C45) binding
C75 (= C77) binding
RQYS 145:148 (≠ RSFS 148:151) binding
HVR 162:164 (≠ HIR 165:167) binding
VAT 170:172 (≠ LFT 173:175) binding
T215 (= T214) binding

Sites not aligning to the query:

330 binding
334 binding

5ogxA Crystal structure of amycolatopsis cytochrome p450 reductase gcob. (see paper)
38% identity, 95% coverage: 2:320/337 of query aligns to 1:317/333 of 5ogxA

query
sites
5ogxA

S

T

F

F

S

A

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V

T

S

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V

E

-

P

-

G

G

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H

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x
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G
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C

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K

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N

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R

binding flavin-adenine dinucleotide: Y132 (= Y137), R144 (= R148), Q145 (≠ S149), Y146 (≠ F150), S147 (= S151), H161 (= H165), V162 (≠ I166), V165 (= V169), G168 (= G172), V169 (≠ L173), A170 (≠ F174), T171 (= T175), T214 (= T214)
binding fe2/s2 (inorganic) cluster: C34 (= C37), N35 (≠ R38), G37 (= G40), C39 (= C42), G40 (= G43), C42 (= C45), C74 (= C77)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 329, 331, 333

4wqmA Structure of the toluene 4-monooxygenase nadh oxidoreductase t4mof, k270s k271s variant (see paper)
30% identity, 93% coverage: 2:315/337 of query aligns to 1:307/326 of 4wqmA

query
sites
4wqmA

S

S

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G

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C
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x
N

D
x
S

G
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G

A

G

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C

G
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G

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C

K

K

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E

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M

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S

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M

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F

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Y

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M

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W

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K

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H

N

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A

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A

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N

D

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S

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S

G

Y

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T

T

G

G

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Y

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H

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E

A

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I

M

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D

Y

F

M

P

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G

L

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G

G

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A

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F

Y

Y

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C

C

G

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K

binding flavin-adenine dinucleotide: C36 (= C37), S38 (≠ D39), W57 (≠ K58), Y135 (= Y137), R146 (= R148), A147 (≠ S149), Y148 (≠ F150), S149 (= S151), I162 (≠ H165), V163 (≠ I166), G169 (= G172), K170 (≠ L173), V171 (≠ F174), S172 (≠ T175), S209 (≠ T214)
binding fe2/s2 (inorganic) cluster: Y34 (= Y35), C36 (= C37), N37 (≠ R38), G39 (= G40), C41 (= C42), G42 (= G43), C44 (= C45), C76 (= C77)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 325

Q03304 Toluene-4-monooxygenase system, ferredoxin--NAD(+) reductase component; T4MO; Ferredoxin--NAD(+) reductase; Toluene-4-monooxygenase systme, electron transfer component; EC 1.18.1.3 from Pseudomonas mendocina (see paper)
29% identity, 93% coverage: 3:315/337 of query aligns to 2:307/326 of Q03304

query
sites
Q03304

F

F

S

N

V

I

T

Q

I

S

E

D

P

D

G

L

Q

L

H

H

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F

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A

A

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N

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A

A

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Y

Y

G

E

C
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R

N

D

S

G

G

A

G

C
|
C

G

G

A

A

C
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C

K

K

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I

K

E

V

L

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L

C

E

G

G

E

E

V

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C

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K

A

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D

L

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L

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E

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I

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K

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A

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D

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A

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H

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K

T

P

Q

M

S

I

V

L

F

L

I

A

A

G

G

T

S

G

G

F

I

A

A

P

P

I

M

K

V

A

S

I

M

V

V

E

N

H

T

A

L

L

I

Y

A

T

Q

Q

G

S

Y

K

E

R

K

P

P

M

I

V

T

I

V

Y

F

W

Y

G

G

N

S

R

R

N

L

K

E

A

A

G

E

L

L

Y

E

M

A

D

A

E

E

L

T

P

L

A

F

R

G

W

W

A

-

E

-

H

K

S

E

H

N

I

L

T

K

Y

L

V

I

P

N

V

V

L

S

S

S

E

S

P

V

A

V

A

G

T

N

D

S

G

E

W

K

N

K

G

Y

R

P

T

T

G

G

L

Y

V

V

H

H

E

E

A

I

V

I

M

P

Q

E

D

Y

F

M

P

E

D

G

L

L

S

L

G

G

H

A

Q

E

V

F

Y

Y

V

L

C

C

G

G

A

P

P

P

V

Q

M

M

V

I

E

N

A

S

A

V

K

Q

R

K

C36 (= C37) binding
C41 (= C42) binding
C44 (= C45) binding
C76 (= C77) binding
RAYS 146:149 (≠ RSFS 148:151) binding
IVK 162:164 (≠ HIR 165:167) binding
KVS 170:172 (≠ LFT 173:175) binding

7c3bC Ferredoxin reductase in carbazole 1,9a-dioxygenase (fad apo form) (see paper)
28% identity, 98% coverage: 3:333/337 of query aligns to 7:333/334 of 7c3bC

query
sites
7c3bC

F

Y

S

Q

V

L

T

K

I

I

E

E

P

-

G

G

Q

Q

H

A

H

P

F

G

A

T

A

C

E

G

S

S

D

D

E

K

T

S

I

L

L

L

E

V

A

S

A

A

L

L

R

A

Q

N

G

G

L

I

T

G

M

L

P

P

Y
|
Y

G

E

C
|
C

R
x
A

D

S

G
|
G

A

G

C
|
C

G
|
G

A

V

C
|
C

K

K

G

F

K

E

V

L

L

L

C

E

G

G

E

T

V

V

D

Q

H

S

G

M

K

W

S

P

Q

D

P

A

H

P

A

G

L

L

S

S

E

S

A

R

D

D

K

R

A

E

A

K

G

G

L

N

T

R

-

H

L

L

F

A

C
|
C

C

Q

A

C

K

I

A

A

K

L

T

S

D

D

L

L

T

R

L

I

E

K

C

V

R

A

-

V

E

Q

V

D

R

K

S

Y

A

I

S

P

D

A

I

I

P

P

V

I

K

S

T

K

L

M

P

E

S

A

R

E

I

V

E

V

K

A

M

V

E

R

K

A

V

L

A

T

A

H

D

D

V

L

M

L

V

S

L

V

H

K

L

L

R

R

-

T

-

D

L

V

P

P

A

A

T

-

E

-

R

-

F

-

Q

N

F

F

L

L

T

P

G

G

Q

Q

Y

F

V

C

D

L

I

I

L

E

L

A

K

E

D

Q

-

L

-

P

G

G

K

V

R

V

R

R

S

A

F

Y

S

S

L

M

A

A

N

N

A

S

P

M

H

N

D

P

D

D

A

G

F

F

L

W

Q

E

L

F

H

Y

I

I

R

K

L

R

V

V

P

P

G

T

G

G

L

R

F

F

T

S

E

P

H

W

V

L

F

F

N

E

G

N

M

R

K

K

E

V

R

G

D

A

I

R

L

L

R

F

L

L

N

T

G

G

P

P

H

M

G

G

S

T

F

S

F

F

L

F

R

R

E

P

D

G

S

T

D

G

K

R

P

K

M

S

I

L

L

C

L

I

A

G

G

G

T

A

G

G

F

L

A

S

P

-

I

Y

K

A

A

A

I

A

V

I

E

A

H

R

A

A

L

S

Y

I

T

R

Q

E

S

T

K

D

R

K

P

P

M

V

V

K

I

L

Y

F

W

Y

G

G

N

S

R

R

N

T

K

P

A

R

G

D

L

A

Y

-

M

-

D

-

E

-

L

-

P

-

A

V

R

R

W

W

A

I

-

D

-

I

-

D

A

I

E

D

H

E

S

D

H

K

I

L

T

E

Y

V

V

V

P

Q

V

A

L

V

S

T

E

E

P

-

A

-

A

D

T

T

D

D

G

S

-

L

W

W

N

Q

G

G

R

P

T

I

G

G

L

F

V

I

H

H

E

Q

-

V

-

D

-

A

A

A

V

L

M

L

Q

E

D

T

F

L

P

P

D

E

L

-

S

-

G

-

H

Y

Q

E

V

I

Y

Y

V

L

C

A

G

G

A

P

P

P

V

P

M

M

V

V

E

D

A

A

A

T

K

V

R

R

D

M

F

L

T

L

G

G

R

K

C

-

G

G

L

V

P

P

E

R

A

D

E

Q

F

I

F

H

A

F

D

D

S

A

F

F

binding fe2/s2 (inorganic) cluster: Y38 (= Y35), C40 (= C37), A41 (≠ R38), G43 (= G40), C45 (= C42), G46 (= G43), C48 (= C45), C81 (= C77)

1krhA X-ray structure of benzoate dioxygenase reductase (see paper)
26% identity, 93% coverage: 20:334/337 of query aligns to 23:335/337 of 1krhA

query
sites
1krhA

E

E

T

T

I

L

L

S

E

D

A

A

L

Y

R

R

Q

Q

G

Q

L

I

T

N

M

I

P

P

Y
x
M

G
x
D

C
|
C

R
|
R

D

E

G
|
G

A

E

C
|
C

G
|
G

A

T

C
|
C

K

R

G

A

K

F

V

C

L

E

C

S

G

G

E

N

V

Y

D

D

H

M

G

P

K

E

S

D

Q

N

-

Y

-

I

P

E

H

D

A

A

L

L

S

T

E

P

A

E

D

E

K

A

A

Q

G

G

L

Y

T

V

L

L

F

A

C
|
C

C

Q

A

C

K

R

A

P

K

T

T

S

D

D

L

A

T

V

L

F

E

Q

C

I

R

Q

E

A

V

S

R

S

S

E

A

V

S

C

D

K

I

T

P

K

V

I

K

H

T

H

L

F

P

E

S

G

R

T

I

L

E

A

K

R

M

V

E

E

K

N

V

L

A

S

A

D

D

S

V

T

M

I

V

T

L

F

H

D

L

I

R

Q

L

L

P

D

A

D

T

G

E

Q

-

P

R

D

F

I

Q

H

F

F

L

L

T

A

G

G

Q

Q

Y
|
Y

V

V

D

N

I

V

L

T

L

L

K

P

-

G

D

T

G

T

K

E

R

T

R
|
R

S
|
S

F
x
Y

S
|
S

L

F

A

S

N

S

A

Q

P

P

H

-

D

G

D

N

A

R

F

L

L

T

Q

G

L

F

H
x
V

I
x
V

R

R

L

N

V

V

P

P

G

Q

G
|
G

L
x
K

F
x
M

T
x
S

E

E

H

Y

V

L

F

S

N

V

G

Q

M

A

K

K

E

A

R

G

D

D

I

K

L

M

R

S

L

F

N

T

G

G

P

P

H

F

G

G

S

S

F

F

F

Y

L

L

R

R

E

-

D

D

S

V

D

K

K

R

P

P

M

V

I

L

L

M

L

L

A

A

G

G

T
|
T

G

G

F

I

A

A

P

P

I

F

K

L

A

S

I

M

V

L

E

Q

H

V

A

L

L

E

Y

Q

T

K

Q

G

S

S

K

E

R

H

P

P

M

V

V

R

I

L

Y

V

W

F

G

G

N

V

R

T

N

Q

K

D

A

C

G

D

L

L

Y

V

M

A

D

L

E

E

L

-

P

-

A

-

R

Q

W

L

A

D

A

A

E

L

H

Q

S

Q

H

K

I

L

T

P

Y

W

V

F

P

E

V

Y

L

R

S

T

E

V

P

V

A

A

A

H

T

A

D

E

G

S

W

Q

N

H

G

E

R

R

T

K

G

G

L

Y

V

V

H

T

E

G

A

H

V

I

M

E

Q

Y

D

D

F

W

P

L

D

N

L

G

S

G

G

E

H

V

Q

D

V

V

Y

Y

V

L

C
|
C

G

G

A

P

P

V

V

P

M

M

V

V

E

E

A

A

A

V

K

-

R

R

D

S

F

W

T

L

G

D

R

T

C

Q

G

G

L

I

P

Q

E

P

A

A

E

N

F

F

F

L

A

F

D
x
E

S

K

F
|
F

T
x
S

active site: C306 (= C304)
binding flavin-adenine dinucleotide: Y143 (= Y137), R155 (= R148), S156 (= S149), Y157 (≠ F150), S158 (= S151), V171 (≠ H165), V172 (≠ I166), G178 (= G172), K179 (≠ L173), M180 (≠ F174), S181 (≠ T175), T219 (= T214), E332 (≠ D331), F334 (= F333), S335 (≠ T334)
binding fe2/s2 (inorganic) cluster: M38 (≠ Y35), D39 (≠ G36), C40 (= C37), R41 (= R38), G43 (= G40), C45 (= C42), G46 (= G43), C48 (= C45), C82 (= C77)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 336, 337

7c3aA Ferredoxin reductase in carbazole 1,9a-dioxygenase (see paper)
26% identity, 98% coverage: 3:333/337 of query aligns to 6:320/321 of 7c3aA

query
sites
7c3aA

F

Y

S

Q

V

L

T

K

I

I

E

E

P

-

G

G

Q

Q

H

A

H

P

F

G

A

T

A

C

E

G

S

S

D

D

E

K

T

S

I

L

L

L

E

V

A

S

A

A

L

L

R

A

Q

N

G

G

L

I

T

G

M

L

P

P

Y
|
Y

G

E

C
|
C

R
x
A

D
x
S

G
|
G

A

G

C
|
C

G
|
G

A

V

C
|
C

K

K

G

F

K

E

V

L

L

L

C

E

G

G

E

T

V

V

D

Q

H

S

G

M

K
x
W

S

P

Q

D

P

A

H

P

A

G

L

L

S

S

E

S

A

R

D

D

K

R

A

E

A

K

G

G

L

N

T

R

-

H

L

L

F

A

C
|
C

C

Q

A

C

K

I

A

A

K

L

T

S

D

D

L

L

T

R

L

I

E

K

C

V

R

A

-

V

E

Q

V

D

R

K

S

Y

A

I

S

P

D

A

I

I

P

P

V

I

K

S

T

K

L

M

P

E

S

A

R

E

I

V

E

V

K

A

M

V

E

R

K

A

V

L

A

T

A

H

D

D

V

L

M

L

V

S

L

V

H

K

L

L

R

R

-

T

-

D

L

V

P

P

A

A

T

-

E

-

R

-

F

-

Q

N

F

F

L

L

T

P

G

G

Q

Q

Y

F

V

C

D

L

I

I

L

E

L

A

K

E

D

Q

-

L

-

P

G

G

K

V

R

V

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

S

P

M

H

N

D

P

D

D

A

G

F

F

L

W

Q

E

L

F

H
x
Y

I
|
I

R

K

L

R

V

V

P

P

G

T

G
|
G

L
x
R

F
|
F

T
x
S

E

P

H

W

V

L

F

F

N

E

G

N

M

R

K

K

E

V

R

G

D

A

I

R

L

L

R

F

L

L

N

T

G

G

P

P

H

M

G

G

S

T

F

S

F

F

L

F

R

R

E

P

D

G

S

T

D

G

K

R

P

K

M

S

I

L

L

C

L

I

A

G

G

G

T
x
A

G

G

F

L

A

S

P

-

I

Y

K

A

A

A

I

A

V

I

E

A

H

R

A

A

L

S

Y

I

T

R

Q

E

S

T

K

D

R

K

P

P

M

V

V

K

I

L

Y

F

W

Y

G

G

N

S

R

R

N

T

K

P

A

R

G

D

L

-

Y

-

M

-

D

-

E

-

L

-

P

A

A

V

R

R

W

W

A

I

A

D

E

I

H

D

S

I

H

D

I

E

T

D

Y

K

V

L

P

E

V

V

L

V

S

Q

E

A

P

V

A

T

A

F

T

I

D

H

G

-

W

-

N

-

G

-

R

-

T

-

G

Q

L

V

V

V

H

D

E

A

A

A

V

L

M

L

Q

E

D

T

F

L

P

P

D

E

L

-

S

-

G

-

H

Y

Q

E

V

I

Y

Y

V

L

C

A

G

G

A

P

P

P

V

P

M

M

V

V

E

D

A

A

A

T

K

V

R

R

D

M

F

L

T

L

G

G

R

K

C

-

G

G

L

V

P

P

E

R

A

D

E

Q

F

I

F

H

A

F

D

D

S

A

F
|
F

binding flavin-adenine dinucleotide: C39 (= C37), S41 (≠ D39), W60 (≠ K58), R152 (= R148), A153 (≠ S149), Y154 (≠ F150), S155 (= S151), Y169 (≠ H165), I170 (= I166), G176 (= G172), R177 (≠ L173), F178 (= F174), S179 (≠ T175), A218 (≠ T214), F320 (= F333)
binding fe2/s2 (inorganic) cluster: Y37 (= Y35), C39 (= C37), A40 (≠ R38), G42 (= G40), C44 (= C42), G45 (= G43), C47 (= C45), C80 (= C77)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 321

8a1uF Sodium pumping nadh-quinone oxidoreductase with substrates nadh and q2 (see paper)
25% identity, 85% coverage: 47:333/337 of query aligns to 87:405/405 of 8a1uF

query
sites
8a1uF

G

G

K

D

V

I

L

L

C

P

G

T

E

E

V

L

D

D

H

H

G

-

K

-

S

-

Q

-

P

-

H

-

A

-

L

I

S

S

E

K

A

G

D

E

K

A

A

R

A

E

G

G

L

E

T

R

L

L

F

A

C
|
C

C

Q

A

V

K

A

A

V

K

K

T

A

D

D

L

M

T

D

L

L

E

E

C

L

R

P

E

E

V

-

R

-

S

-

A

-

S

E

D

I

I

F

P

G

V

V

K

K

T

K

L

W

P

E

S

C

R

T

I

V

E

I

K

S

M

N

E

D

K

N

V

K

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

K

L

L

R

A

L

I

P

P

A

D

T

G

E

E

R

S

F

V

Q

P

F

F

L

R

T

A

G

G

Q

G

Y
|
Y

V

I

D

Q

I

I

-

E

-

A

-

P

-

A

-

H

-

V

-

K

-

Y

-

A

-

D

-

F

-

D

-

V

-

P

-

E

-

K

-

Y

-

R

-

G

-

D

-

W

-

D

-

K

-

F

-

N

L

L

L

F

K

R

D

Y

G

E

K

S

R

K

-

V

-

D

-

E

-

P

-

I

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

F

A

G

F

I

L

I

Q

M

L

L

H

N

I

V

R
|
R

L

I

V
x
A

P

T

G

P

-
x
P

-

P

-

N

-

P

-

N

-
x
V

-
x
P

-

P

G
|
G

L
x
Q

F
x
M

T

S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

A

R

G

D

D

I

K

L

C

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

G
|
G

T
x
A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

K

S

S

K

K

R

R

P

K

M

M

V

S

I

Y

Y

W

W

Y

G
|
G

N

A

R
|
R

N

S

K

K

A

R

G

E

L

M

Y

F

M

Y

D

V

E

E

L

D

P

F

A

D

R

G

W

L

A

A

E

E

H

N

S

D

H

N

I

F

T

V

Y

W

V

H

P

C

V

A

L

L

S
|
S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

Y

T

T

G

G

L
x
F

V

I

H

H

E

N

A

V

V

L

M

Y

Q

E

D

N

F

Y

P

-

D

-

L

L

S

K

G

D

H

H

Q

E

V

A

-

P

-

E

-

D

-

C

-

E

-

Y

Y

Y

V

M

C
|
C

G
|
G

A
x
P

P

P

V

-

M
|
M

V
x
M

E

N

A

A

K

V

R

I

D

N

F

M

T

L

G

K

R

N

C

L

G

G

L

V

P

E

E

E

A

E

E

N

F

I

F

L

A

L

D
|
D

S

D

F
|
F

binding flavin-adenine dinucleotide: Y166 (= Y137), R209 (= R148), A210 (≠ S149), Y211 (≠ F150), S212 (= S151), A230 (≠ V169), P233 (vs. gap), V239 (vs. gap), P240 (vs. gap), G242 (= G172), Q243 (≠ L173), M244 (≠ F174), A282 (≠ T214), F405 (= F333)
binding fe2/s2 (inorganic) cluster: C110 (= C77)
binding 1,4-dihydronicotinamide adenine dinucleotide: S212 (= S151), R228 (= R167), G281 (= G213), A282 (≠ T214), G309 (= G240), R311 (= R242), S339 (= S270), F353 (≠ L284), C377 (= C304), G378 (= G305), P379 (≠ A306), M381 (= M309), M382 (≠ V310), D403 (= D331)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 69, 71, 73, 75, 76, 78

8a1yF Sodium pumping nadh-quinone oxidoreductase with inhibitor hqno (see paper)
25% identity, 85% coverage: 47:333/337 of query aligns to 88:406/408 of 8a1yF

query
sites
8a1yF

G

G

K

D

V

I

L

L

C

P

G

T

E

E

V

L

D

D

H

H

G

-

K

-

S

-

Q

-

P

-

H

-

A

-

L

I

S

S

E

K

A

G

D

E

K

A

A

R

A

E

G

G

L

E

T

R

L

L

F

A

C
|
C

C

Q

A

V

K

A

A

V

K

K

T

A

D

D

L

M

T

D

L

L

E

E

C

L

R

P

E

E

V

-

R

-

S

-

A

-

S

E

D

I

I

F

P

G

V

V

K

K

T

K

L

W

P

E

S

C

R

T

I

V

E

I

K

S

M

N

E

D

K

N

V

K

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

K

L

L

R

A

L

I

P

P

A

D

T

G

E

E

R

S

F

V

Q

P

F

F

L

R

T

A

G

G

Q

G

Y

Y

V

I

D

Q

I

I

-

E

-

A

-

P

-

A

-

H

-

V

-

K

-

Y

-

A

-

D

-

F

-

D

-

V

-

P

-

E

-

K

-

Y

-

R

-

G

-

D

-

W

-

D

-

K

-

F

-

N

L

L

L

F

K

R

D

Y

G

E

K

S

R

K

-

V

-

D

-

E

-

P

-

I

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

F

A

G

F

I

L

I

Q

M

L

L

H

N

I
x
V

R
|
R

L

I

V
x
A

P

T

G

P

-

P

-

N

-

P

-

N

-
x
V

-
x
P

-

P

G
|
G

L
x
Q

F
x
M

T

S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

A

R

G

D

D

I

K

L

C

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

K

S

S

K

K

R

R

P

K

M

M

V

S

I

Y

Y

W

W

Y

G

G

N

A

R

R

N

S

K

K

A

R

G

E

L

M

Y

F

M

Y

D

V

E

E

L

D

P

F

A

D

R

G

W

L

A

A

E

E

H

N

S

D

H

N

I

F

T

V

Y

W

V

H

P

C

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

Y

T

T

G

G

L

F

V

I

H

H

E

N

A

V

V

L

M

Y

Q

E

D

N

F

Y

P

-

D

-

L

L

S

K

G

D

H

H

Q

E

V

A

-

P

-

E

-

D

-

C

-

E

-

Y

Y

Y

V

M

C

C

G

G

A

P

P

P

V

-

M

M

V

M

E

N

A

A

K

V

R

I

D

N

F

M

T

L

G

K

R

N

C

L

G

G

L

V

P

E

E

E

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F

F

binding flavin-adenine dinucleotide: R210 (= R148), A211 (≠ S149), Y212 (≠ F150), S213 (= S151), V228 (≠ I166), R229 (= R167), A231 (≠ V169), V240 (vs. gap), P241 (vs. gap), G243 (= G172), Q244 (≠ L173), M245 (≠ F174)
binding fe2/s2 (inorganic) cluster: C111 (= C77)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 70, 74, 76, 77, 79

A5F5Y4 Na(+)-translocating NADH-quinone reductase subunit F; Na(+)-NQR subunit F; Na(+)-translocating NQR subunit F; NQR complex subunit F; NQR-1 subunit F; EC 7.2.1.1 from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) (see paper)
25% identity, 85% coverage: 47:333/337 of query aligns to 88:406/408 of A5F5Y4

query
sites
A5F5Y4

G

G

K

D

V

I

L

L

C

P

G

T

E

E

V

L

D

D

H

H

G

-

K

-

S

-

Q

-

P

-

H

-

A

-

L

I

S

S

E

K

A

G

D

E

K

A

A

R

A

E

G

G

L

E

T

R

L

L

F

A

C
|
C

C

Q

A

V

K

A

A

V

K

K

T

A

D

D

L

M

T

D

L

L

E

E

C

L

R

P

E

E

V

-

R

-

S

-

A

-

S

E

D

I

I

F

P

G

V

V

K

K

T

K

L

W

P

E

S

C

R

T

I

V

E

I

K

S

M

N

E

D

K

N

V

K

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

K

L

L

R

A

L

I

P

P

A

D

T

G

E

E

R

S

F

V

Q

P

F

F

L

R

T

A

G

G

Q

G

Y

Y

V

I

D

Q

I

I

-

E

-

A

-

P

-

A

-

H

-

V

-

K

-

Y

-

A

-

D

-

F

-

D

-

V

-

P

-

E

-

K

-

Y

-

R

-

G

-

D

-

W

-

D

-

K

-

F

-

N

L

L

L

F

K

R

D

Y

G

E

K

S

R

K

-

V

-

D

-

E

-

P

-

I

R
|
R

S

A

F
x
Y

S

S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

F

A

G

F

I

L

I

Q

M

L

L

H

N

I

V

R

R

L

I

V

A

P

T

G

P

-

P

-

N

-

P

-

N

-

V

-

P

G

G

L

Q

F

M

T
x
S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

A

R

G

D

D

I

K

L

C

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

K

S

S

K

K

R

R

P

K

M

M

V

S

I

Y

Y

W

W

Y

G

G

N

A

R

R

N

S

K

K

A

R

G

E

L

M

Y

F

M

Y

D

V

E

E

L

D

P

F

A

D

R

G

W

L

A

A

E

E

H

N

S

D

H

N

I

F

T

V

Y

W

V

H

P

C

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

Y

T

T

G

G

L

F

V

I

H

H

E

N

A

V

V

L

M

Y

Q

E

D

N

F

Y

P

-

D

-

L

L

S

K

G

D

H

H

Q

E

V

A

-

P

-

E

-

D

-

C

-

E

-

Y

Y

Y

V

M

C

C

G

G

A

P

P

P

V

-

M

M

V

M

E

N

A

A

K

V

R

I

D

N

F

M

T

L

G

K

R

N

C

L

G

G

L

V

P

E

E

E

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F

F

C111 (= C77) binding ; mutation to A: Loss of the 2Fe-2S center, but does not affect flavin content. Exhibits very low NADH:quinone oxidoreductase activity.
R210 (= R148) mutation to L: Decreases flavin content, but does not affect the 2Fe-2S center. Exhibits very low NADH:quinone oxidoreductase activity.
Y212 (≠ F150) mutation to L: Decreases flavin content, but does not affect the 2Fe-2S center. Exhibits very low NADH:quinone oxidoreductase activity.
S246 (≠ T175) mutation to A: Decreases flavin content, but does not affect the 2Fe-2S center. Exhibits very low NADH:quinone oxidoreductase activity.

Sites not aligning to the query:

70 binding ; C→A: Loss of the 2Fe-2S center, but does not affect flavin content. Exhibits very low NADH:quinone oxidoreductase activity.
76 binding ; C→A: Loss of the 2Fe-2S center, but does not affect flavin content. Exhibits very low NADH:quinone oxidoreductase activity.
79 binding ; C→A: Loss of the 2Fe-2S center, but does not affect flavin content. Exhibits very low NADH:quinone oxidoreductase activity.

7c3bB Ferredoxin reductase in carbazole 1,9a-dioxygenase (fad apo form) (see paper)
26% identity, 98% coverage: 3:333/337 of query aligns to 6:305/306 of 7c3bB

query
sites
7c3bB

F

Y

S

Q

V

L

T

K

I

I

E

E

P

-

G

G

Q

Q

H

A

H

P

F

G

A

T

A

C

E

G

S

S

D

D

E

K

T

S

I

L

L

L

E

V

A

S

A

A

L

L

R

A

Q

N

G

G

L

I

T

G

M

L

P

P

Y
|
Y

G

E

C
|
C

R
x
A

D

S

G
|
G

A

G

C
|
C

G
|
G

A

V

C
|
C

K

K

G

F

K

E

V

L

L

L

C

E

G

G

E

T

V

V

D

Q

H

S

G

M

K

W

S

P

Q

D

P

A

H

P

A

G

L

L

S

S

E

S

A

R

D

D

K

R

A

E

A

K

G

G

L

N

T

R

-

H

L

L

F

A

C
|
C

C

Q

A

C

K

I

A

A

K

L

T

S

D

D

L

L

T

R

L

I

E

K

C

V

R

A

-

V

E

Q

V

D

R

K

S

Y

A

I

S

P

D

A

I

I

P

P

V

I

K

S

T

K

L

M

P

E

S

A

R

E

I

V

E

V

K

A

M

V

E

R

K

A

V

L

A

T

A

H

D

D

V

L

M

L

V

S

L

V

H

K

L

L

R

R

-

T

-

D

L

V

P

P

A

A

T

-

E

-

R

-

F

-

Q

N

F

F

L

L

T

P

G

G

Q

Q

Y

F

V

C

D

L

I

I

L

E

L

A

K

E

D

Q

-

L

-

P

G

G

K

V

R

V

R

R

S

A

F

Y

S

S

L

M

A

A

N

N

A

S

P

M

H

N

D

P

D

D

A

G

F

F

L

W

Q

E

L

F

H

Y

I

I

R

K

L

R

V

V

P

P

G

-

L

-

F

F

T

S

E

P

H

W

V

L

F

F

N

E

G

N

M

R

K

K

E

V

R

G

D

A

I

R

L

L

R

F

L

L

N

T

G

G

P

P

H

M

G

G

S

T

F

S

F

F

L

F

R

R

E

P

D

G

S

T

D

G

K

R

P

K

M

S

I

L

L

C

L

I

A

G

G

G

T

A

G

G

F

-

A

-

P

-

I

L

K

S

A

Y

I

A

V

A

E

A

H

I

A

A

L

R

Y

A

T

S

Q

I

S

R

K

E

R

T

P

D

M

V

V

K

I

L

Y

F

W

Y

G

G

N

S

R

R

N

T

K

P

A

W

G

-

L

I

Y

D

M

I

D

D

E

E

L

V

P

-

A

V

R

Q

W

A

A

V

A

T

E

E

H

F

S

I

H

H

I

-

T

-

Y

-

V

-

P

-

V

-

L

-

S

-

E

-

P

-

A

-

T

-

D

-

G

-

W

-

N

-

G

-

R

-

T

-

G

Q

L

V

V

V

H

D

E

A

A

A

V

L

M

L

Q

E

D

T

F

L

P

P

D

E

L

-

S

-

G

-

H

Y

Q

E

V

I

Y

Y

V

L

C

A

G

G

A

P

P

P

V

P

M

M

V

V

E

D

A

A

A

T

K

V

R

R

D

M

F

L

T

L

G

G

R

K

C

-

G

G

L

V

P

P

E

R

A

D

E

Q

F

I

F

H

A

F

D

D

S

A

F

F

binding fe2/s2 (inorganic) cluster: Y37 (= Y35), C39 (= C37), A40 (≠ R38), G42 (= G40), C44 (= C42), G45 (= G43), C47 (= C45), C80 (= C77)

7qu0A X-ray structure of fad domain of nqrf of klebsiella pneumoniae (see paper)
25% identity, 70% coverage: 99:333/337 of query aligns to 2:279/279 of 7qu0A

query
sites
7qu0A

P

P

V

V

K

K

T

K

L

W

P

E

S

C

R

E

I

V

E

I

K

S

M

N

E

D

K

N

V

K

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

K

L

L

R

R

L

I

P

P

A

E

T

G

E

E

R

V

F

V

Q

P

F

F

L

R

T

A

G

G

Q

G

Y
|
Y

V

I

D

Q

I

I

L

E

-

C

-

P

-

H

-

K

-

V

-

A

-

Y

-

A

-

D

-

F

-

D

-

V

-

P

-

D

-

E

-

Y

-

R

-

S

-

D

-

W

-

D

-

K

-

F

-

N

-

L

-

F

-

R

-

Y

-

V

-

S

-

E

L

V

K

K

D

E

G

P

K

T

R

L

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

K

A

G

F

I

L

I

Q

M

L

L

H

N

I

V

R

R

L

I

V
x
A

P
x
T

G
x
P

-
x
P

-

P

-

K

-

I

-

P

-

D

-
x
A

-
x
P

G
|
G

L
x
I

F
x
M

T
x
S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

P

R

G

D

D

I

K

L

V

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

E

D

-

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

H

S

S

K

T

R

R

P

K

M

I

V

S

I

F

Y

W

W

Y

G

G

N

A

R

R

N

S

K

L

A

R

G

E

L

M

Y

F

M

Y

D

D

E

E

L

E

P

F

A

E

R

Q

W

L

A

A

A

R

E

D

H

N

S

P

H

N

I

F

T

T

Y

F

V

H

P

V

V

A

L

L

S
|
S

E

D

P

P

A

L

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

H

T

T

G

G

L
x
F

V

I

H

H

-

N

-

V

-

L

-

Y

E

E

A

N

V

Y

M

L

Q

R

D

D

F

H

P

P

D

A

L

P

S

E

G

D

H

C

Q

E

V

F

Y

Y

V

M

C

C

G

G

A

P

P

P

V

V

M
|
M

V

-

E

N

A

A

K

V

R

I

D

K

F

M

T

L

G

K

R

D

C

L

G

G

L

V

P

E

E

D

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F
|
F

binding ~{N}-[2,6-bis(fluoranyl)phenyl]ethanamide: S213 (= S270), F227 (≠ L284), M256 (= M309)
binding flavin-adenine dinucleotide: Y40 (= Y137), R83 (= R148), A84 (≠ S149), Y85 (≠ F150), S86 (= S151), A104 (≠ V169), T105 (≠ P170), P106 (≠ G171), P107 (vs. gap), A113 (vs. gap), P114 (vs. gap), P115 (vs. gap), G116 (= G172), I117 (≠ L173), M118 (≠ F174), S119 (≠ T175), F279 (= F333)

7qtyA X-ray structure of fad domain of nqrf of klebsiella pneumoniae (see paper)
25% identity, 70% coverage: 99:333/337 of query aligns to 2:279/279 of 7qtyA

query
sites
7qtyA

P

P

V

V

K

K

T

K

L

W

P

E

S

C

R

E

I

V

E

I

K

S

M

N

E

D

K

N

V

K

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

K

L

L

R

R

L

I

P

P

A

E

T

G

E

E

R

V

F

V

Q

P

F

F

L

R

T

A

G

G

Q

G

Y
|
Y

V

I

D

Q

I

I

L

E

-

C

-

P

-

H

-

K

-

V

-

A

-

Y

-

A

-

D

-

F

-

D

-

V

-

P

-

D

-

E

-

Y

-

R

-

S

-

D

-

W

-

D

-

K

-

F

-

N

-

L

-

F

-

R

-

Y

-

V

-

S

-

E

L

V

K

K

D

E

G

P

K

T

R

L

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

K

A

G

F

I

L

I

Q

M

L

L

H
x
N

I

V

R

R

L

I

V
x
A

P
x
T

G

P

-
x
P

-

P

-

K

-

I

-

P

-

D

-
x
A

-
x
P

-

P

G
|
G

L
x
I

F
x
M

T
x
S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

P

R

G

D

D

I

K

L

V

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

E

D

-

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

H

S

S

K

T

R

R

P

K

M

I

V

S

I

F

Y

W

W

Y

G

G

N
x
A

R
|
R

N

S

K

L

A

R

G

E

L

M

Y

F

M

Y

D

D

E

E

L

E

P

F

A

E

R

Q

W

L

A

A

A

R

E

D

H

N

S

P

H

N

I

F

T

T

Y

F

V

H

P

V

V

A

L

L

S
|
S

E

D

P

P

A

L

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

H

T

T

G

G

L
x
F

V

I

H
|
H

-

N

-

V

-

L

-

Y

E

E

A

N

V

Y

M

L

Q

R

D

D

F

H

P

P

D

A

L

P

S

E

G

D

H

C

Q

E

V

F

Y

Y

V

M

C

C

G

G

A

P

P

P

V
|
V

M
|
M

V

-

E

N

A

A

K

V

R

I

D

K

F

M

T

L

G

K

R

D

C

L

G

G

L

V

P

E

E

D

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F
|
F

binding 1-(furan-2-ylmethyl)-3-(2-methylphenyl)thiourea: A184 (≠ N241), R185 (= R242), S213 (= S270), F227 (≠ L284), H229 (= H286), V255 (= V308), M256 (= M309)
binding flavin-adenine dinucleotide: Y40 (= Y137), R83 (= R148), A84 (≠ S149), Y85 (≠ F150), S86 (= S151), N100 (≠ H165), A104 (≠ V169), T105 (≠ P170), P107 (vs. gap), A113 (vs. gap), P114 (vs. gap), G116 (= G172), I117 (≠ L173), M118 (≠ F174), S119 (≠ T175), F279 (= F333)

7qu3A X-ray structure of fad domain of nqrf of pseudomonas aeruginosa (see paper)
26% identity, 70% coverage: 99:333/337 of query aligns to 2:278/279 of 7qu3A

query
sites
7qu3A

P

P

V

V

K

K

T

K

L

W

P

E

S

C

R

T

I

V

E

E

K

S

M

N

E

P

K

N

V

V

A

A

A

T

D

F

V

I

M

K

V

E

L

L

H

T

L

L

R

R

L

L

P

P

A

D

T

G

E

E

R

S

F

V

Q

D

F

F

L

R

T

A

G

G

Q

G

Y
|
Y

V

V

-

Q

-

L

-

E

-

C

-

P

-

H

-

V

-

E

-

Y

-

K

D

D

I

F

L

D

L

I

K

Q

D

P

G

E

K

Y

R

R

-

G

-

D

-

W

-

D

-

K

-

F

-

N

-

M

-

W

-

R

-

Y

-

V

-

S

-

K

-

V

-

D

-

E

-

T

-

V

-

I

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

Q

A

G

F

V

L

V

Q

K

L

F

H
x
N

I

I

R
|
R

L

I

-
x
A

-
x
S

-

P

-

G

-

S

-

D

V
x
L

P
|
P

G

P

G
|
G

L
x
Q

F
x
M

T
x
S

E

S

H

W

V

V

F

F

N

N

G

-

M

L

K

K

E

P

R

G

D

D

I

K

L

V

R

T

L

V

N

Y

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

E

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

G
|
G

T
x
A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

R

Y

R

T

L

Q

K

S

S

K

N

R

R

P

K

M

I

V

S

I

F

Y

W

W

Y

G
|
G

N

A

R

R

N

S

K

L

A

R

G

E

L

A

Y

F

M

Y

D

T

E

E

L

E

P

Y

A

D

R

Q

W

L

A

Q

A

A

E

E

H

N

S

P

H

N

I

F

T

Q

Y

W

V

H

P

L

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

L

T

T

G

G

L
x
F

V
x
I

H

H

-

N

-

V

-

L

-

F

E

E

A

N

V

Y

M

L

Q

K

D

D

F

H

P

P

D

A

L

P

S

E

G

D

H

C

Q

E

V

F

Y

Y

V

M

C

C

G

G

A
x
P

P

P

V

M

M
|
M

V

N

E

A

A

A

A

V

K

I

R

K

D

M

F

L

T

T

G

D

R

-

C

L

G

G

L

V

P

E

E

R

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F
|
F

binding flavin-adenine dinucleotide: Y40 (= Y137), R83 (= R148), A84 (≠ S149), Y85 (≠ F150), S86 (= S151), N100 (≠ H165), A104 (vs. gap), S105 (vs. gap), L112 (≠ V169), P113 (= P170), G115 (= G172), Q116 (≠ L173), M117 (≠ F174), S118 (≠ T175), A155 (≠ T214), F278 (= F333)
binding 4-(benzimidazol-1-ylmethyl)benzenecarbonitrile: R102 (= R167), G154 (= G213), G182 (= G240), F226 (≠ L284), I227 (≠ V285), P252 (≠ A306), M255 (= M309)

7qu5A X-ray structure of fad domain of nqrf of pseudomonas aeruginosa (see paper)
26% identity, 70% coverage: 99:333/337 of query aligns to 2:278/280 of 7qu5A

query
sites
7qu5A

P

P

V

V

K

K

T

K

L

W

P

E

S

C

R

T

I

V

E

E

K

S

M

N

E

P

K

N

V

V

A

A

A

T

D
x
F

V

I

M

K

V

E

L

L

H

T

L

L

R

R

L

L

P

P

A

D

T

G

E

E

R

S

F

V

Q

D

F

F

L

R

T

A

G

G

Q

G

Y
|
Y

V

V

-

Q

-

L

-

E

-

C

-

P

-

H

-

V

-

E

-

Y

-

K

D

D

I

F

L

D

L

I

K

Q

D

P

G

E

K

Y

R

R

-

G

-

D

-

W

-

D

-

K

-
x
F

-

N

-
x
M

-

W

-

R

-

Y

-

V

-

S

-

K

-

V

-

D

-

E

-

T

-

V

-

I

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

Q

A

G

F

V

L

V

Q

K

L

F

H
x
N

I

I

R

R

L

I

-
x
A

-
x
S

-

P

-
x
P

-

G

-

S

-

D

V
x
L

P
|
P

G

P

G
|
G

L
x
Q

F
x
M

T
x
S

E

S

H

W

V

V

F

F

N

N

G

-

M

L

K

K

E

P

R

G

D

D

I

K

L

V

R

T

L

V

N

Y

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

E

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T
x
A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

R

Y

R

T

L

Q

K

S

S

K

N

R

R

P

K

M

I

V

S

I

F

Y

W

W

Y

G

G

N

A

R

R

N

S

K

L

A

R

G

E

L

A

Y

F

M

Y

D

T

E

E

L

E

P

Y

A
x
D

R

Q

W

L

A

Q

A

A

E

E

H

N

S

P

H

N

I

F

T

Q

Y
x
W

V
x
H

P
x
L

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

L

T

T

G

G

L

F

V

I

H

H

-

N

-

V

-

L

-

F

E

E

A

N

V

Y

M

L

Q

K

D

D

F

H

P

P

D

A

L

P

S

E

G

D

H

C

Q

E

V

F

Y

Y

V

M

C

C

G

G

A

P

P

P

V

M

M

M

V

N

E

A

A

A

A

V

K

I

R

K

D

M

F

L

T

T

G

D

R

-

C

L

G

G

L

V

P

E

E

R

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F
|
F

binding flavin-adenine dinucleotide: Y40 (= Y137), R83 (= R148), A84 (≠ S149), Y85 (≠ F150), S86 (= S151), N100 (≠ H165), A104 (vs. gap), L112 (≠ V169), P113 (= P170), G115 (= G172), Q116 (≠ L173), M117 (≠ F174), S118 (≠ T175), A155 (≠ T214), F278 (= F333)
binding gamma-Valerolactone: F19 (≠ D116), F68 (vs. gap), M70 (vs. gap), S105 (vs. gap), P108 (vs. gap), D196 (≠ A254), W207 (≠ Y265), H208 (≠ V266), L209 (≠ P267)

4u9uA Crystal structure of nqrf fad-binding domain from vibrio cholerae (see paper)
28% identity, 55% coverage: 148:333/337 of query aligns to 81:277/279 of 4u9uA

query
sites
4u9uA

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

E

D

E

D

F

A

G

F

I

L

I

Q

M

L

L

H
x
N

I

V

R

R

L

I

V
x
A

P
x
T

G
x
P

-

P

-

N

-

P

-

N

-
x
V

-
x
P

-

P

G
|
G

L
x
Q

F
x
M

T
x
S

E

S

H

Y

V

I

F

W

N

S

G

-

M

L

K

K

E

A

R

G

D

D

I

K

L

C

R

T

L

I

N

S

G

G

P

P

H

F

G

G

S

E

F

F

L

A

R

K

E

-

D

D

S

T

D

D

K

A

P

E

M

M

I

V

L

F

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

M

K

R

A

S

-

H

I

I

V

F

E

D

H

Q

A

L

L

K

Y

R

T

L

Q

K

S

S

K

K

R

R

P

K

M

M

V

S

I

Y

Y

W

W

Y

G

G

N

A

R

R

N

S

K

K

A
x
R

G

E

L
x
M

Y

F

M

Y

D

V

E

E

L

D

P

F

A

D

R

G

W

L

A
|
A

A

A

E

E

H
x
N

S
x
D

H

N

I
x
F

T

V

Y

W

V

H

P

C

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

Y

T

T

G

G

L

F

V

I

H

H

E

N

A

V

V

L

M

Y

Q

E

D

N

F

Y

P

-

D

-

L

L

S

K

G

D

H

H

Q

E

V

A

-

P

-

E

-

D

-

C

-

E

-

Y

Y

Y

V

M

C

C

G

G

A

P

P

P

V

-

M

M

V

M

E

N

A

A

K

V

R

I

D

N

F

M

T

L

G

K

R

N

C

L

G

G

L

V

P

E

E

E

A

E

E

N

F

I

F

L

A

L

D

D

S

D

F
|
F

binding flavin-adenine dinucleotide: R81 (= R148), A82 (≠ S149), Y83 (≠ F150), S84 (= S151), N98 (≠ H165), A102 (≠ V169), T103 (≠ P170), P104 (≠ G171), V111 (vs. gap), P112 (vs. gap), G114 (= G172), Q115 (≠ L173), M116 (≠ F174), S117 (≠ T175), F277 (= F333)
binding magnesium ion: R186 (≠ A245), M188 (≠ L247)
binding sodium ion: A198 (= A257), N201 (≠ H260), D202 (≠ S261), F204 (≠ I263)

Sites not aligning to the query:

1tvcA Fad and nadh binding domain of methane monooxygenase reductase from methylococcus capsulatus (bath) (see paper)
29% identity, 60% coverage: 131:333/337 of query aligns to 43:244/250 of 1tvcA

query
sites
1tvcA

Q

K

F

F

L

E

T

P

G

G

Q

Q

Y
x
F

V

M

D

D

I

L

L

T

L

I

K

P

D

G

G

T

K

D

-

V

R

S

R
|
R

S
|
S

F
x
Y

S
|
S

L

P

A

A

N

N

A

L

P

P

H

N

D

P

D

E

A

G

F

R

L

L

Q

E

L

F

H
x
L

I
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I

R
|
R

L

V

V
x
L

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P

G

E

G

G

L

R

F
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F

T

S

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D

H

Y

V

L

F

R

N

N

G

D

M

A

K

R

E

V

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G

D

Q

I

V

L

L

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L

V

N

K

G

G

P

P

H

L

G

G

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V

F

F

F

G

L

L

R

K

E

E

D

R

S

G

D

M

K

A

P

P

M

R

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Y

L

F

L

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A

A

G

G

T

T

G
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G

F

L

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A

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P

I

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K

V

A

S

I

M

V

V

E

R

H

Q

A

M

L

Q

Y

E

T

W

Q

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S

A

K

P

R

N

P

E

M

T

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R

I

I

Y

Y

W

F

G

G

-

V

N
|
N

R

T

N

E

K

P

A
x
E

G

L

L

F

Y

Y

M

I

D

D

E

E

L

L

P

K

A

S

R

-

W

L

A

E

A

R

E

S

H

M

S

R

H

N

I

L

T

T

Y

V

V

K

P

A

V

C

L

V

S

W

E

H

P

P

A
x
S

A
x
G

T

D

D

-

G

-

W

W

N

E

G

G

R

E

T

Q

G

G

L

S

V

P

H

I

E

D

A

A

V

L

M

R

Q

E

D

D

F

L

P

E

D

S

L

S

S

D

G

A

H

N

-

P

Q

D

V

I

Y

Y

V
x
L

C

C

G

G

A

P

P

P

V

G

M

M

V

I

E

D

A

A

K

C

R

E

D

L

F

V

T

R

G

S

R

R

C

-

G

G

L

I

P

P

E

G

A

E

E

Q

F

V

F

F

A

F

D
x
E

S

K

F
|
F

active site: Y63 (≠ F150), S64 (= S151), L215 (≠ V303)
binding dihydroflavine-adenine dinucleotide: F49 (≠ Y137), R61 (= R148), S62 (= S149), Y63 (≠ F150), S64 (= S151), L78 (≠ H165), I79 (= I166), R80 (= R167), L82 (≠ V169), F87 (= F174), G128 (= G215), N155 (= N241), E159 (≠ A245), S186 (≠ A273), G187 (≠ A274), E242 (≠ D331), F244 (= F333)

Sites not aligning to the query:

binding dihydroflavine-adenine dinucleotide: 24, 245

2r6hC Crystal structure of the domain comprising the NAD binding and the fad binding regions of the nadh:ubiquinone oxidoreductase, na translocating, f subunit from porphyromonas gingivalis
26% identity, 55% coverage: 148:333/337 of query aligns to 86:288/289 of 2r6hC

query
sites
2r6hC

R
|
R

S
x
A

F
x
Y

S
|
S

L

M

A

A

N

N

A

Y

P

P

H

A

D

E

D

G

A

N

F

I

L

I

Q

T

L

L

H
x
N

I

V

R

R

L

I

-
x
A

-
x
T

-

P

-

F

-

D

-

R

-

A

-

N

-

K

-

W

-

K

-

A

-

G

V
x
I

P
x
K

G
x
P

G
|
G

L
x
I

F
x
S

T
x
S

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S

H

Y

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I

F

F

N

S

G

-

M

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K

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R

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M

L

M

N

S

G

G

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P

H

Y

G

G

S

D

F

F

F

H

L

I

R

-

E

Q

D

D

S

T

D

D

K

A

P

E

M

M

I

L

L

Y

L

I

A

G

G

G

T

A

G

G

F

M

A

A

P

P

I

L

K

R

A

A

I

Q

V

I

E

L

H

H

A

L

L

F

Y

R

T

T

Q

L

S

K

K

T

R

G

P

R

M

K

V

V

I

S

Y

Y

W

W

-

Y

G

G

N

A

R

R

N

S

K

K

A

N

G

E

L

I

Y

F

M

Y

D

E

E

E

L

D

P

F

A

R

R

E

W

I

A

E

A

R

E

E

H

F

S

P

H

N

I

F

T

K

Y

F

V

H

P

I

V

A

L

L

S

S

E

D

P

P

A

Q

A

P

T

E

D

D

G

N

W

W

N

T

G

G

R

Y

T

V

G

G

L

F

V

I

H

H

E

Q

A

V

V

I

M

Y

Q

D

D

N

F

Y

P

-

D

-

L

L

S

K

G

D

H

H

-

D

-

A

-

P

-

E

-

D

-

I

Q

E

V

Y

Y

Y

V

M

C
|
C

G

G

A

P

P

G

V

P

M

M

V

A

E

N

A

A

A

V

K

K

R

-

D

G

F

M

T

L

G

E

R

N

C

L

G

G

L

V

P

P

E

R

A

N

E

M

F

L

F

F

A

F

D

D

S

D

F
|
F

active site: C260 (= C304)
binding flavin-adenine dinucleotide: R86 (= R148), A87 (≠ S149), Y88 (≠ F150), S89 (= S151), N103 (≠ H165), A107 (vs. gap), T108 (vs. gap), I122 (≠ V169), K123 (≠ P170), P124 (≠ G171), G125 (= G172), I126 (≠ L173), S127 (≠ F174), S128 (≠ T175), F288 (= F333)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 43

6xtfD Crystal structure a thioredoxin reductase from gloeobacter violaceus bound to its electron donor (see paper)
41% identity, 23% coverage: 10:88/337 of query aligns to 12:88/96 of 6xtfD

query
sites
6xtfD

G

G

Q

K

H

K

H

E

F

I

A

D

A

C

E

P

S

S

D

D

E

E

T

Y

I

I

L

L

E

D

A

A

L

E

R

R

Q

Q

G

G

L

L

T

D

M

L

P

P

Y

F

G
x
S

C
|
C

R
|
R

D

A

G
|
G

A

A

C
|
C

G

S

A

T

C
|
C

K

A

G

G

K

K

V

M

L

V

C

S

G

G

E

T

V

I

D

D

H

Q

G

G

K

D

S

Q

Q

S

P

-

H

-

A

F

L

L

S

D

E

D

A

D

D

Q

K

I

A

A

G

G

L

Y

T

V

L

L

F

T

C
|
C

C

V

A

A

K

Y

A

P

K

T

T

S

D

N

L

C

T

S

L

I

E

E

binding flavin-adenine dinucleotide: S38 (≠ G36), C39 (= C37)
binding fe2/s2 (inorganic) cluster: C39 (= C37), R40 (= R38), G42 (= G40), C44 (= C42), C47 (= C45), C77 (= C77)

2eixA The structure of physarum polycephalum cytochrome b5 reductase (see paper)
25% identity, 55% coverage: 144:329/337 of query aligns to 55:242/243 of 2eixA

query
sites
2eixA

D

D

G

G

K

K

R

E

-

I

-

Y

R
|
R

S
x
P

F
x
Y

S
x
T

L

P

A

V

N

S

A

S

P

D

H

D

D

E

D

K

A

G

F

Y

L

F

Q

D

L

L

H
x
I

I

I

R

K

L

V

V
x
Y

P

E

G
x
K

G
|
G

L

Q

F
x
M

T
x
S

E

Q

H

Y

V

I

F

-

N

D

G

H

M

L

K

N

E

P

R

G

D

D

I

F

L

L

R

Q

L

V

N

R

G

G

P

P

H

K

G

G

S

Q

F

F

F

D

L

Y

R

K

E

P

D

N

S

M

D

V

K

K

P

E

M

M

I

G

L

M

L

I

A

A

G

G

T
|
T

G

G

F

I

A
x
T

P

P

I

M

K

L

A

Q

I

V

V

A

E

R

H

A

A

I

L

I

Y

K

T

N

Q

P

S

K

K

E

R

K

P

T

M

I

V

I

-

N

I

L

Y

I

W

F

G

A

N

N

R

V

N

N

K

E

A

D

G

D

L

I

Y

L

M

L

D

R

E

T

L

E

P

L

A

D

R

D

W

M

A

A

A

K

E

K

H

Y

S

S

H

N

I

F

T

K

Y

V

V

Y

P

Y

V

V

L

L

S

N

E

N

P

P

A

P

A

A

T

-

D

-

G

G

W

W

N

T

G

G

R

G

T

V

G

G

L
x
F

V

V

H

S

-

A

E

D

A

M

V

I

M

K

Q

Q

D

H

F

F

-

S

P

P

D

P

L

S

S

S

G

D

H

I

Q

K

V

V

Y

M

V

M

C
|
C

G

G

A

P

P

P

V
x
M

M

M

V

N

E

K

A
|
A

A

M

K

Q

R

G

D

H

F

L

T

E

G

T

R

L

C

G

G

Y

L

T

P

P

E

E

A

Q

E

W

F

F

F

I

active site: Y63 (≠ F150), T64 (≠ S151), C217 (= C304)
binding flavin-adenine dinucleotide: R61 (= R148), P62 (≠ S149), Y63 (≠ F150), T64 (≠ S151), I78 (≠ H165), Y82 (≠ V169), K84 (≠ G171), G85 (= G172), M87 (≠ F174), S88 (≠ T175), T126 (= T214), T129 (≠ A217), F195 (≠ L284), M221 (≠ V308), A225 (= A312)

Sites not aligning to the query:

active site: 47

Query Sequence

>Dsui_0609 FitnessBrowser__PS:Dsui_0609
MSFSVTIEPGQHHFAAESDETILEAALRQGLTMPYGCRDGACGACKGKVLCGEVDHGKSQ
PHALSEADKAAGLTLFCCAKAKTDLTLECREVRSASDIPVKTLPSRIEKMEKVAADVMVL
HLRLPATERFQFLTGQYVDILLKDGKRRSFSLANAPHDDAFLQLHIRLVPGGLFTEHVFN
GMKERDILRLNGPHGSFFLREDSDKPMILLAGGTGFAPIKAIVEHALYTQSKRPMVIYWG
NRNKAGLYMDELPARWAAEHSHITYVPVLSEPAATDGWNGRTGLVHEAVMQDFPDLSGHQ
VYVCGAPVMVEAAKRDFTGRCGLPEAEFFADSFTFSS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory