SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_0627 FitnessBrowser__PS:Dsui_0627 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 93% coverage: 7:254/267 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

E

R

A

T

S

E

D

N

V

I

A

V

K

K

H

Y

F
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F

G

G

G

E

V
x
F

K

K

A

A

L

L

R

D

G

G

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S

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C

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K

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G

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T

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L

L

I

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I

G

G

P

P

N

N

G
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G

A
x
S

G
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G

K
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K

T
x
S

T
|
T

F

L

F

I

N

N

C

V

L

I

T

T

G

G

L

F

Y

L

V

K

P

A

N

D

G

E

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G

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R

I

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Y

F

F

A

E

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N

A

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T

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A

E

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P

H

A

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E

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L

A

Y

A

H

R

Y

G

G

I

I

A

V

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R

T

T

F

F

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Q

N

T

I

P

R

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L

P

F

L

A

K

H

E

M

M

T

T

A

V

L

L

E

E

N

N

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L

M

L

V

I

G

G

R

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H

I

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A

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S

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L

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Y

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K

P

W

G

I

T

P

R

K

A

E

E

E

A

M

A

V

I

-

Q

-

R

E

R

K

A

A

E

F

E

K

L

I

L

L

H

E

Y

F

V

L

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K

I

L

A

S

D

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L

A

Y

H

D

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A

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D

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M

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R

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E

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A

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P

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K

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E
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E

P

P

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I

A

A

G

G

M

V

N

A

A

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S

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T

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D

L

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T

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L

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E

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K

A

D

K

G

G

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F

L

L

L

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E

E

H

H

D

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K

D

L

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C

I

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H

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L

A

Y

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V

L

M

D

F

Y

N

G

G

E

Q

K

I

I

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C

A

-

E

-

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G

-

E

E

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N

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L

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K

-

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L

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G

G

binding adenosine-5'-diphosphate: F14 (= F17), F17 (≠ V20), G40 (= G43), S41 (≠ A44), G42 (= G45), K43 (= K46), S44 (≠ T47), T45 (= T48)
binding magnesium ion: S44 (≠ T47), E176 (= E181)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 93% coverage: 7:254/267 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

L

I

L

L

E

R

A

T

S

E

D

N

V

I

A

V

K

K

H

Y

F
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F

G

G

G

E

V
x
F

K

K

A

A

L

L

R

D

G

G

V

V

S

S

L

I

T

S

I

V

R

N

E

K

G

G

E

D

I

V

Y

T

G

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

F

L

F

I

N

N

C

V

L

I

T

T

G

G

L

F

Y

L

V

K

P

A

N

D

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E

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G

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R

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V

Y

F

F

A

E

G

N

A

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E

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L

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T

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L

A

Y

A

H

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Y

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G

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I

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R

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T

F

F

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Q

N

T

I

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R

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L

P

F

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A

K

H

E

M

M

T

T

A

V

L

L

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E

N

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G

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A

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A

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K

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D

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L

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D

L

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G

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C

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Y

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V

L

M

D

F

Y

N

G

G

E

Q

K

I

I

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C

A

-

E

-

G

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R

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G

-

E

E

E

D

E

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A

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V

L

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K

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D

D

P

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E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (= F17), F17 (≠ V20), N39 (= N42), G40 (= G43), G42 (= G45), K43 (= K46), S44 (≠ T47), T45 (= T48)

3c4jA Abc protein artp in complex with atp-gamma-s
32% identity, 87% coverage: 7:239/267 of query aligns to 3:222/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

E

D

A

V

S

H

D

Q

V

L

A

K

K

K

H

S

F
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F

G

G

G

S

V

L

K

E

A
x
V

L

L

R

K

G

G

V

I

S

N

L

V

T

H

I

I

R

R

E

E

G

G

E

E

I

V

Y

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

F

F

F

L

N

R

C

C

L

L

T

N

G

L

L

L

Y

E

V

D

P

F

N

D

G

E

G

G

R

E

I

I

V

I

F

I

A

D

G

G

A

I

E

N

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L

D

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S

K

A

D

P

T

H

N

K

L

V

N

A

K

A

V

R

R

G

E

-

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

A

P

H

H

M

M

T

T

A

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L

L

E

N

N

N

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M

T

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L

G

A

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P

H

M

Q

K

R

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T

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R

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G

-

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F

-

G

-

A

-

I

V

F

R

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P

P

G

R

T

E

R

K

A

A

E

E

E

A

A

K

A

A

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M

Q

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R

-

A

-

E

-

E

E

L

L

H

D

Y

K

V

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G

G

I

L

A

K

D

D

R

K

A

A

H

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D

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L

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A

P

K

D

H

S

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L

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S

Y

G

G

G

D

Q

Q

A

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Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

A

L

L

F

D

D

E

E

P

P

A

T

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G

A

M

L

N

D

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S

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E

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G

G

E

E

L

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L

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S

L

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K

G

Q

I

L

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N

D

E

G

G

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M

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T

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M

L

V

I

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E

T

H

H

D

E

V

M

K

G

L

F

V

A

M

R

G

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

L

M

D

D

Y

G

G

G

E

Y

K

I

I

I

C

E

E

E

D

G

V

K

P

P

binding phosphothiophosphoric acid-adenylate ester: F13 (= F17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (≠ A44), G41 (= G45), K42 (= K46), S43 (≠ T47), T44 (= T48)

3c41J Abc protein artp in complex with amp-pnp/mg2+
32% identity, 87% coverage: 7:239/267 of query aligns to 3:222/242 of 3c41J

query
sites
3c41J

L

M

L

I

E

D

A

V

S

H

D

Q

V

L

A

K

K

K

H

S

F
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F

G

G

G

S

V

L

K

E

A
x
V

L

L

R

K

G

G

V

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S

N

L

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T

H

I

I

R

R

E

E

G

G

E

E

I

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Y

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

F

F

F

L

N

R

C

C

L

L

T

N

G

L

L

L

Y

E

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D

P

F

N

D

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E

G

G

R

E

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I

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I

F

I

A

D

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G

A

I

E

N

L

L

D

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T

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S

K

A

D

P

T

H

N

K

L

V

N

A

K

A

V

R

R

G

E

-

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

A

P

H

H

M

M

T

T

A

V

L

L

E

N

N

N

V

I

M

T

V

L

G

A

R

P

H

M

Q

K

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

V

F

R

R

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W

P

P

G

R

T

E

R

K

A

A

E

E

E

A

A

K

A

A

I

M

Q

-

R

-

A

-

E

-

E

E

L

L

H

D

Y

K

V

V

G

G

I

L

A

K

D

D

R

K

A

A

H

H

D

A

L

Y

A

P

K

D

H

S

L

L

S

S

Y

G

G

G

D

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

A

L

L

F

D
|
D

E

E

P

P

A

T

A

S

G

A

M

L

N

D

A

P

S

E

E

M

T

V

G

G

E

E

L

V

R

L

T

S

L

V

I

M

E

K

G

Q

I

L

R

A

K

N

D

E

G

G

I

M

T

T

V

M

L

V

I

V

E

T

H

H

D

E

V

M

K

G

L

F

V

A

M

R

G

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

L

M

D

D

Y

G

G

G

E

Y

K

I

I

I

C

E

E

E

D

G

V

K

P

P

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), G41 (= G45), K42 (= K46), S43 (≠ T47), T44 (= T48)
binding magnesium ion: S43 (≠ T47), D163 (= D180)

2olkA Abc protein artp in complex with adp-beta-s
32% identity, 87% coverage: 7:239/267 of query aligns to 3:222/242 of 2olkA

query
sites
2olkA

L

M

L

I

E

D

A

V

S

H

D

Q

V

L

A

K

K

K

H

S

F
|
F

G

G

G

S

V

L

K

E

A
x
V

L

L

R

K

G

G

V

I

S

N

L

V

T

H

I

I

R

R

E

E

G

G

E

E

I

V

Y

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

F

F

F

L

N

R

C

C

L

L

T

N

G

L

L

L

Y

E

V

D

P

F

N

D

G

E

G

G

R

E

I

I

V

I

F

I

A

D

G

G

A

I

E

N

L

L

D

K

T

A

S

K

A

D

P

T

H

N

K

L

V

N

A

K

A

V

R

R

G

E

-

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

A

P

H

H

M

M

T

T

A

V

L

L

E

N

N

N

V

I

M

T

V

L

G

A

R

P

H

M

Q

K

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

V

F

R

R

K

T

W

P

P

G

R

T

E

R

K

A

A

E

E

E

A

A

K

A

A

I

M

Q

-

R

-

A

-

E

-

E

E

L

L

H

D

Y

K

V

V

G

G

I

L

A

K

D

D

R

K

A

A

H

H

D

A

L

Y

A

P

K

D

H

S

L

L

S

S

Y

G

G

G

D

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

A

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

M

L

N

D

A

P

S

E

E

M

T

V

G

G

E

E

L

V

R

L

T

S

L

V

I

M

E

K

G

Q

I

L

R

A

K

N

D

E

G

G

I

M

T

T

V

M

L

V

I

V

E

T

H

H

D

E

V

M

K

G

L

F

V

A

M

R

G

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

L

M

D

D

Y

G

G

G

E

Y

K

I

I

I

C

E

E

E

D

G

V

K

P

P

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (≠ A44), G41 (= G45), K42 (= K46), S43 (≠ T47), T44 (= T48)

2oljA Abc protein artp in complex with adp/mg2+
32% identity, 87% coverage: 7:239/267 of query aligns to 3:222/242 of 2oljA

query
sites
2oljA

L

M

L

I

E

D

A

V

S

H

D

Q

V

L

A

K

K

K

H

S

F
|
F

G

G

G

S

V

L

K

E

A
x
V

L

L

R

K

G

G

V

I

S

N

L

V

T

H

I

I

R

R

E

E

G

G

E

E

I

V

Y

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

F

F

F

L

N

R

C

C

L

L

T

N

G

L

L

L

Y

E

V

D

P

F

N

D

G

E

G

G

R

E

I

I

V

I

F

I

A

D

G

G

A

I

E

N

L

L

D

K

T

A

S

K

A

D

P

T

H

N

K

L

V

N

A

K

A

V

R

R

G

E

-

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

A

P

H

H

M

M

T

T

A

V

L

L

E

N

N

N

V

I

M

T

V

L

G

A

R

P

H

M

Q

K

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

V

F

R

R

K

T

W

P

P

G

R

T

E

R

K

A

A

E

E

E

A

A

K

A

A

I

M

Q

-

R

-

A

-

E

-

E

E

L

L

H

D

Y

K

V

V

G

G

I

L

A

K

D

D

R

K

A

A

H

H

D

A

L

Y

A

P

K

D

H

S

L

L

S

S

Y

G

G

G

D

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

A

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

M

L

N

D

A

P

S

E

E

M

T

V

G

G

E

E

L

V

R

L

T

S

L

V

I

M

E

K

G

Q

I

L

R

A

K

N

D

E

G

G

I

M

T

T

V

M

L

V

I

V

E

T

H

H

D

E

V

M

K

G

L

F

V

A

M

R

G

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

L

M

D

D

Y

G

G

G

E

Y

K

I

I

I

C

E

E

E

D

G

V

K

P

P

binding adenosine-5'-diphosphate: F13 (= F17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (≠ A44), G41 (= G45), K42 (= K46), S43 (≠ T47), T44 (= T48)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
33% identity, 93% coverage: 8:256/267 of query aligns to 3:237/238 of 6s8nB

query
sites
6s8nB

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F

Y

G

K

G

G

V

R

K

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

L

I

F

F

A
x
R

H

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L
x
M

A
x
G

K
x
Q

H

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H

H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

G

G

A

E

E

D

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ A95), M133 (≠ L152), G134 (≠ A153), Q135 (≠ K154)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
33% identity, 93% coverage: 8:256/267 of query aligns to 3:237/238 of 6s8gA

query
sites
6s8gA

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V
x
R

K

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

L

I

F

F

A

R

H

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K

Q

H
x
S

L

L

S
|
S

Y

G

G

G

D
x
E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H

H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

G

G

A

E

E

D

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F17), R15 (≠ V20), N37 (= N42), G40 (= G45), K41 (= K46), T42 (= T47), T43 (= T48), Q84 (= Q89), S136 (≠ H155), S138 (= S157), E141 (≠ D160)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
34% identity, 93% coverage: 8:254/267 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V

R

K

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

L

I

F

F

A

R

H

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K

Q

H
x
S

L

L

S
|
S

Y
x
G

G
|
G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E
|
E

P

P

A

F

A

A

G
|
G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H
|
H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (≠ F17), N37 (= N42), G38 (= G43), G40 (= G45), K41 (= K46), T42 (= T47), T43 (= T48), Q84 (= Q89), S136 (≠ H155), S138 (= S157), G139 (≠ Y158), G140 (= G159), E162 (= E181), G166 (= G185), H194 (= H213)

6mbnA Lptb e163q in complex with atp (see paper)
33% identity, 93% coverage: 8:256/267 of query aligns to 4:238/241 of 6mbnA

query
sites
6mbnA

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V
x
R

K

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

L

I

F

F

A

R

H

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K

Q

H

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

Q

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H
|
H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

G

G

A

E

E

D

binding adenosine-5'-triphosphate: Y13 (≠ F17), R16 (≠ V20), V18 (≠ A22), N38 (= N42), G39 (= G43), G41 (= G45), K42 (= K46), T43 (= T47), T44 (= T48), H195 (= H213)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
33% identity, 92% coverage: 8:253/267 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V
x
R

K

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P
x
L

H
|
H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F
x
P

Q
|
Q

N

E

I
x
A

R
x
S

L

I

F
|
F

A
x
R

H
x
R

M
x
L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I
x
V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K
x
Q

H

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R
|
R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H

H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F17), R15 (≠ V20), V17 (≠ A22), N37 (= N42), G38 (= G43), G40 (= G45), K41 (= K46), T42 (= T47), T43 (= T48)
binding magnesium ion: T42 (= T47), Q84 (= Q89)
binding novobiocin: L71 (≠ P76), H72 (= H77), P83 (≠ F88), A86 (≠ I91), S87 (≠ R92), F89 (= F94), R90 (≠ A95), R91 (≠ H96), L92 (≠ M97), V101 (≠ I119), Q135 (≠ K154), R149 (= R168)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
33% identity, 92% coverage: 8:253/267 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V
x
R

K

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

L

I

F

F

A

R

H

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K

Q

H

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H

H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F17), R15 (≠ V20), V17 (≠ A22), G38 (= G43), G40 (= G45), K41 (= K46), T42 (= T47), T43 (= T48)
binding magnesium ion: T42 (= T47), Q84 (= Q89)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
33% identity, 92% coverage: 8:252/267 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

E

T

A

A

S

K

D

N

V

L

A

A

K

K

H

A

F
x
Y

G

K

G

G

V
x
R

K

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

T

T

I

V

R

N

E

S

G

G

E

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

F

T

F

F

N

Y

C

M

L

V

T

V

G

G

L

I

Y

V

V

P

P

R

N

D

G

A

G

G

R

N

I

I

V

I

F

I

A

D

G

D

A

D

E

D

L

I

D

S

T

L

S

L

A

P

P

L

H

H

K

A

V

R

A

A

A

R

R

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

L

I

F
|
F

A
x
R

H
x
R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

M

M

V

-

G

-

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

A

I

V

F

L

R

Q

T

I

P

-

G

-

T

-

R

R

A

D

E

D

E

L

A

S

A

A

I

E

Q

Q

R

R

-

E

-

D

R

R

A

A

E

N

E

E

L

L

L

M

H

E

Y

E

V

F

G

H

I

I

A

E

D

H

R

L

A

R

H

D

D

S

L

M

A

G

K

Q

H

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

A

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

M

V

N

D

A

P

S

I

E

S

T

V

G

I

E

D

L

I

R

K

T

R

L

I

I

I

E

E

G

H

I

L

R

R

K

D

D

S

G

G

I

L

T

G

V

V

L

L

L

I

I

T

E

D

H

H

D

N

V

V

K

R

L

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

V

A

A

Y

V

I

L

V

D

S

Y

Q

G

G

E

H

K

L

I

I

C

A

E

H

D

G

V

T

P

P

A

T

V

E

V

I

Q

L

K

Q

D

D

P

E

R

H

V

V

I

K

T

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F17), R15 (≠ V20), V17 (≠ A22), G38 (= G43), G40 (= G45), K41 (= K46), T42 (= T47), T43 (= T48)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F94), R90 (≠ A95), R91 (≠ H96)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
31% identity, 91% coverage: 7:248/267 of query aligns to 4:234/501 of P04983

query
sites
P04983

L

L

E

Q

A

L

S

K

D

G

V

I

A

D

K

K

H

A

F

F

G

P

G

G

V

V

K

K

A

A

L

L

R

S

G

G

V

A

S

A

L

L

T

N

I

V

R

Y

E

P

G

G

E

R

I

V

Y

M

G

A

L

L

I

V

G

G

P

E

N

N

G

G

A

A

G

G

K
|
K

T

S

T

T

F

M

N

K

C

V

L

L

T

T

G

G

L

I

Y

Y

V

T

P

R

N

D

G

A

G

G

R

T

I

L

V

L

F

W

A

L

G

G

A

K

E

E

L

T

D

T

T

F

S

T

A

G

P

P

H

K

K

S

V

S

A

Q

A

E

R

A

G

G

I

I

A

G

R

I

T

I

F

H

Q

Q

N

E

I

L

R

N

L

L

F

I

A

P

H

Q

M

L

T

T

A

I

L

A

E

E

N

N

V

I

M

F

V

L

G

G

R

R

H

E

Q

F

R

V

T

N

R

R

A

-

G

-

V

-

F

F

G

G

A

K

I

I

F

-

R

-

T

-

P

-

G

-

T

-

R

-

A

-

E

D

E

W

A

K

A

T

I

M

Q

Y

R

A

R

E

A

A

E

D

E

K

L

L

H

A

Y

K

V

L

G

N

I

L

A

R

D

F

R

K

A

S

H

D

D

K

L

L

A

V

K

G

H

D

L

L

S

S

Y

I

G

G

D

D

Q

Q

R

Q

R

M

L

V

E

E

I

I

A

A

R

K

A

V

L

L

A

S

T

F

E

E

P

S

K

K

L

V

L

I

A

I

L

M

D

D

E

E

P

P

A

T

A

D

G

A

M

L

N

T

A

D

S

T

E

E

T

T

G

E

E

S

L

L

R

F

T

R

L

V

I

I

E

R

G

E

I

L

R

K

K

S

D

Q

G

G

I

R

T

G

V

I

L

V

L

Y

I

I

E

S

H

H

D

R

V

M

K

K

L

E

V

I

M

F

G

E

L

I

C

C

D

D

R

D

V

V

A

T

V

V

L

F

D

R

Y

D

G

G

E

Q

K

F

I

I

C

A

E

E

D

R

V

E

P

V

A

A

V

S

V

L

Q

T

K

E

D

D

P

S

R

L

V

I

K43 (= K46) mutation to R: Loss of transport.

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
33% identity, 90% coverage: 7:247/267 of query aligns to 1:233/343 of P30750

query
sites
P30750

L

M

L

I

E

K

A

L

S

S

D

N

V

I

A

T

K

K

H

V

F

F

G

H

-

Q

-

G

-

T

-

R

G

T

V

I

K

Q

A

A

L

L

R

N

G

N

V

V

S

S

L

L

T

H

I

V

R

P

E

A

G

G

E

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

F

L

F

I

N

R

C

C

L

V

T

N

G

L

L

L

Y

E

V

R

P

P

N

T

G

E

G

G

R

S

I

V

V

L

F

V

A

D

G

G

A

Q

E

E

L

L

D

T

T

T

S

L

A

S

P

E

H

S

K

E

V

L

-

T

-

K

A

A

A

R

R

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

L

L

F

L

A

S

H

S

M

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

-

F

L

R

E

T

L

P

D

G

N

T

T

R

P

A

K

E

D

E

E

A

-

I

V

Q

K

R

R

A

V

E

T

E

E

L

L

H

S

Y

L

V

V

G

G

I

L

A

G

D

D

R

K

A

H

H

D

D

S

L

Y

A

P

K

S

H

N

L

L

S

S

Y

G

G

G

D

Q

Q

K

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

A

L

L

C

D

D

E
|
E

P

A

A

T

A

S

G

A

M

L

N

D

A

P

S

A

E

T

T

T

G

R

E

S

L

I

R

L

T

E

L

L

I

L

E

K

G

D

I

I

-

N

R

R

K

R

D

L

G

G

I

L

T

T

V

I

L

L

I

I

E

T

H

H

D

E

V

M

K

D

L

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

V

V

A

A

V

V

L

I

D

S

Y

N

G

G

E

E

K

L

I

I

C

E

E

Q

D

D

V

T

P

V

A

S

V

E

V

V

Q

F

K

S

D

H

P

P

R

K

40:46 (vs. 42:48, 71% identical) binding ATP
E166 (= E181) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
32% identity, 90% coverage: 7:247/267 of query aligns to 2:228/241 of 4u00A

query
sites
4u00A

L

I

E

R

A

I

S

R

D

N

V

L

A

H

K

K

H

W

F
|
F

G

G

G

P

V

L

K

H

A
x
V

L

L

R

K

G

G

V

I

S

H

L

L

T

E

I

V

R

A

E

P

G

G

E

E

I

K

Y

L

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

F

L

F

I

N

R

C

T

L

I

T

N

G

R

L

L

Y

E

V

D

P

F

N

Q

G

E

G

G

R

E

I

V

V

V

F

V

A

D

G

G

A

L

E

S

L

V

D

K

T

D

S

D

A

R

P

A

H

L

K

R

V

E

A

I

A

R

R

R

G

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

Q

I

F

R

N

L

L

F

F

A

P

H

H

M

M

T

T

A

V

L

L

E

E

N

N

V

V

M

T

V

L

G

A

R

-

H

P

Q

M

R

R

T

V

R

R

A

-

G

-

V

-

F

-

G

-

A

-

I

-

F

-

R

R

T

W

P

P

G

R

T

E

R

K

A

A

E

E

E

K

A

K

A

A

I

L

Q

-

R

-

A

-

E

-

E

E

L

L

H

E

Y

R

V

V

G

G

I

I

A

L

D

D

R

Q

A

A

H

R

D

K

L

Y

A

P

K

A

H

Q

L

L

S

S

Y

G

G

G

D

Q

Q

Q

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

A

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

M

L

N

D

A

P

S

E

E

M

T

V

G

G

E

E

L

V

R

L

T

D

L

V

I

M

E

R

G

D

I

L

R

A

K

Q

D

G

G

G

I

M

T

T

V

M

L

V

I

V

E

T

H

H

D

E

V

M

K

G

L

F

V

A

M

R

G

E

L

V

C

A

D

D

R

R

V

V

A

V

V

F

L

M

D

D

Y

G

G

G

E

Q

K

I

I

V

C

E

E

E

D

G

V

R

P

P

A

E

V

E

V

I

Q

F

K

T

D

R

P

P

R

K

binding adenosine-5'-diphosphate: F12 (= F17), V17 (≠ A22), S37 (≠ N42), G38 (= G43), S39 (≠ A44), G40 (= G45), K41 (= K46), S42 (≠ T47), T43 (= T48)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
33% identity, 90% coverage: 7:247/267 of query aligns to 2:234/344 of 6cvlD

query
sites
6cvlD

L

M

L

I

E

K

A

L

S

S

D

N

V

I

A

T

K

K

H

V

F
|
F

G

H

-
x
Q

-

G

-

T

-

R

G

T

V
x
I

K

Q

A

A

L

L

R

N

G

N

V

V

S

S

L

L

T

H

I

V

R

P

E

A

G

G

E

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

F

L

F

I

N

R

C

C

L

V

T

N

G

L

L

L

Y

E

V

R

P

P

N

T

G

E

G

G

R

S

I

V

V

L

F

V

A

D

G

G

A

Q

E

E

L

L

D

T

T

T

S

L

A

S

P

E

H

S

K

E

V

L

-

T

-

K

A

A

A

R

R

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

L

L

F

L

A

S

H

S

M

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

-

F

L

R

E

T

L

P

D

G

N

T

T

R

P

A

K

E

D

E

E

A

-

I

V

Q

K

R

R

A

V

E

T

E

E

L

L

H

S

Y

L

V

V

G

G

I

L

A

G

D

D

R

K

A

H

H

D

D

S

L

Y

A

P

K

S

H
x
N

L

L

S
|
S

Y

G

G

G

D
x
Q

Q

K

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

A

L

L

C

D

D

E

Q

P

A

A

T

A

S

G

A

M

L

N

D

A

P

S

A

E

T

T

T

G

R

E

S

L

I

R

L

T

E

L

L

I

L

E

K

G

D

I

I

-

N

R

R

K

R

D

L

G

G

I

L

T

T

V

I

L

L

I

I

E

T

H
|
H

D

E

V

M

K

D

L

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

V

V

A

A

V

V

L

I

D

S

Y

N

G

G

E

E

K

L

I

I

C

E

E

Q

D

D

V

T

P

V

A

S

V

E

V

V

Q

F

K

S

D

H

P

P

R

K

binding phosphothiophosphoric acid-adenylate ester: F12 (= F17), Q14 (vs. gap), I19 (≠ V20), S41 (≠ N42), G42 (= G43), A43 (= A44), G44 (= G45), K45 (= K46), S46 (≠ T47), T47 (= T48), N141 (≠ H155), S143 (= S157), Q146 (≠ D160), H200 (= H213)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
33% identity, 90% coverage: 7:247/267 of query aligns to 2:234/344 of 3tuzC

query
sites
3tuzC

L

M

L

I

E

K

A

L

S

S

D

N

V

I

A

T

K

K

H

V

F
|
F

G

H

-
x
Q

-

G

-

T

-

R

G

T

V

I

K

Q

A

A

L

L

R

N

G

N

V

V

S

S

L

L

T

H

I

V

R

P

E

A

G

G

E

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N

S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

F

L

F

I

N

R

C

C

L

V

T

N

G

L

L

L

Y

E

V

R

P

P

N

T

G

E

G

G

R

S

I

V

V

L

F

V

A

D

G

G

A

Q

E

E

L

L

D

T

T

T

S

L

A

S

P

E

H

S

K

E

V

L

-

T

-

K

A

A

A

R

R

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

L

L

F

L

A

S

H

S

M

R

T

T

A

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

R

-

H

-

Q

-

R

-

T

-

R

-

A

-

G

-

V

-

F

-

G

-

A

-

I

-

F

L

R

E

T

L

P

D

G

N

T

T

R

P

A

K

E

D

E

E

A

-

I

V

Q

K

R

R

A

V

E

T

E

E

L

L

H

S

Y

L

V

V

G

G

I

L

A

G

D

D

R

K

A

H

H

D

D

S

L

Y

A

P

K

S

H

N

L

L

S

S

Y

G

G

G

D

Q

Q

K

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

A

L

L

C

D

D

E

Q

P

A

A

T

A

S

G

A

M

L

N

D

A

P

S

A

E

T

T

T

G

R

E

S

L

I

R

L

T

E

L

L

I

L

E

K

G

D

I

I

-

N

R

R

K

R

D

L

G

G

I

L

T

T

V

I

L

L

I

I

E

T

H

H

D

E

V

M

K

D

L

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

V

V

A

A

V

V

L

I

D

S

Y

N

G

G

E

E

K

L

I

I

C

E

E

Q

D

D

V

T

P

V

A

S

V

E

V

V

Q

F

K

S

D

H

P

P

R

K

binding adenosine-5'-diphosphate: F12 (= F17), Q14 (vs. gap), G42 (= G43), G44 (= G45), K45 (= K46), S46 (≠ T47), T47 (= T48)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
33% identity, 90% coverage: 7:247/267 of query aligns to 2:234/344 of 3tuiC

query
sites
3tuiC

L

M

L

I

E

K

A

L

S

S

D

N

V

I

A

T

K

K

H

V

F
|
F

G

H

-

Q

-

G

-

T

-

R

G

T

V

I

K

Q

A

A

L

L

R

N

G

N

V

V

S

S

L

L

T

H

I

V

R

P

E

A

G

G

E

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S