SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_1023 FitnessBrowser__PS:Dsui_1023 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
51% identity, 95% coverage: 1:215/226 of query aligns to 1:215/222 of P0A9R7

query
sites
P0A9R7

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K41 (= K41) mutation to R: Does not bind ATP.
C49 (≠ A49) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
51% identity, 95% coverage: 1:215/226 of query aligns to 1:215/219 of 8w6iD

query
sites
8w6iD

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binding phosphothiophosphoric acid-adenylate ester: Y11 (= Y11), S37 (= S37), G38 (= G38), A39 (= A39), G40 (= G40), K41 (= K41), S42 (≠ T42), T43 (= T43), Q86 (= Q86), K130 (≠ R130), Q137 (≠ A137), S139 (= S139), G140 (= G140), G141 (= G141), E142 (= E142), H195 (= H195)

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
51% identity, 95% coverage: 1:215/226 of query aligns to 1:215/218 of 8hd0A

query
sites
8hd0A

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binding adenosine-5'-triphosphate: Y11 (= Y11), R15 (≠ Y15), A17 (= A17), G40 (= G40), K41 (= K41), S42 (≠ T42), T43 (= T43), S139 (= S139), G141 (= G141)

8tzjA Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
52% identity, 90% coverage: 1:203/226 of query aligns to 2:210/220 of 8tzjA

query
sites
8tzjA

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binding adenosine-5'-diphosphate: Y12 (= Y11), R16 (≠ Y15), A18 (= A17), G39 (= G38), G41 (= G40), K42 (= K41), S43 (≠ T42)

8i6rB Cryo-em structure of pseudomonas aeruginosa ftse(e163q)x/envc complex with atp in peptidisc (see paper)
48% identity, 97% coverage: 1:220/226 of query aligns to 1:220/222 of 8i6rB

query
sites
8i6rB

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binding adenosine-5'-triphosphate: Y11 (= Y11), H15 (≠ Y15), S37 (= S37), A39 (= A39), G40 (= G40), K41 (= K41), S42 (≠ T42), T43 (= T43), D137 (≠ A137), S139 (= S139), T140 (≠ G140), G141 (= G141), Q142 (≠ E142)
binding magnesium ion: K41 (= K41), S42 (≠ T42)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
43% identity, 95% coverage: 1:215/226 of query aligns to 3:217/230 of 6z4wA

query
sites
6z4wA

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I

V

V

I

G

G

L

E

S

N

P

R

K

R

E

N

A

I

G

K

K

R

R

R

A

V

R

M

A

E

A

V

L

L

D

D

K

L

V

V

G

G

L

L

L

K

E

H

R

K

E

V

K

R

A

S

N

F

P

P

I

N

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

I

A

A

I

I

A

A

R

R

A

A

V

I

V

V

N

N

R

N

P

P

A

K

I

V

L

L

L

I

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

P

D

D

S

N

A

S

G

W

E

E

V

I

M

M

E

N

L

L

F

L

K

E

A

R

F

I

H

N

Q

L

V

Q

G

G

V

T

T

T

V

I

I

L

L

M

A

A

T

T

H

H

D

N

T

S

Q

Q

W

I

V

V

R

N

H

T

L

L

N

R

P

H

R

R

V

V

L

I

W

A

V

I

E

E

H

N

G

G

Q

R

V

V

binding adenosine-5'-diphosphate: Y13 (= Y11), T17 (≠ Y15), A19 (= A17), G40 (= G38), G42 (= G40), K43 (= K41), S44 (≠ T42), T45 (= T43)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
43% identity, 95% coverage: 1:215/226 of query aligns to 3:217/229 of 6z67B

query
sites
6z67B

M

I

I

I

S

E

F

M

S

R

A

D

V

V

H

V

K

K

R

K

Y
|
Y

P

D

T

N

G
|
G

Y

T

E

T

A
|
A

L

L

R

R

G

G

V

V

S

S

F

V

D

S

I

V

E

Q

A

P

G

G

E

E

L

F

V

A

F

Y

I

I

T

V

G

G

H

P

S
|
S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

F

C

I

K

R

L

S

A

L

A

Y

A

R

I

E

E

V

R

K

P

I

T

D

S

K

G

G

S

S

V

L

V

S

V

V

N

A

G

G

Q

F

N

N

L

L

A

V

A

K

L

I

R

K

K

K

S

K

A

D

I

V

P

P

Y

L

V

L

R

R

R

R

N

S

F

V

G

G

L

V

V

V

F

F

Q

Q

D

D

Q

Y

K

K

L

L

L

L

F

P

D

K

R

K

T

T

V

V

L

Y

D

E

N

N

V

I

L

A

L

Y

P

A

L

M

A

E

I

V

V

I

G

G

L

E

S

N

P

R

K

R

E

N

A

I

G

K

K

R

R

R

A

V

R

M

A

E

A

V

L

L

D

D

K

L

V

V

G

G

L

L

L

K

E

H

R

K

E

V

K

R

A

S

N

F

P

P

I

N

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

I

A

A

I

I

A

A

R

R

A

A

V

I

V

V

N

N

R

N

P

P

A

K

I

V

L

L

L

I

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

P

D

D

S

N

A

S

G

W

E

E

V

I

M

M

E

N

L

L

F

L

K

E

A

R

F

I

H

N

Q

L

V

Q

G

G

V

T

T

T

V

I

I

L

L

M

A

A

T

T

H

H

D

N

T

S

Q

Q

W

I

V

V

R

N

H

T

L

L

N

R

P

H

R

R

V

V

L

I

W

A

V

I

E

E

H

N

G

G

Q

R

V

V

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y11), G16 (= G14), A19 (= A17), S39 (= S37), G40 (= G38), G42 (= G40), K43 (= K41), S44 (≠ T42), T45 (= T43)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc (see paper)
42% identity, 95% coverage: 1:215/226 of query aligns to 2:217/225 of 8iddA

query
sites
8iddA

M

M

I

I

S

T

F

L

S

D

A

H

V

V

H

T

K

K

R

Q

Y
|
Y

P

K

T

S

G

S

Y

A

E

R

-

P

A

A

L

L

R

D

G

D

V

I

S

N

F

V

D

K

I

I

E

D

A

K

G

G

E

E

L

F

V

V

F

F

I

L

T

I

G

G

H

P

S
|
S

G

G

A

S

G
|
G

K
|
K

T
x
S

T

T

L

F

C

M

K

R

L

L

A

L

A

L

A

A

I

A

E

E

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

R

V

V

N

S

G

K

Q

F

N

H

L

V

A

N

A

K

L

L

R

R

K

G

S

R

A

H

I

V

P

P

Y

K

V

L

R

R

R

Q

N

V

F

I

G

G

L

C

V

V

F

F

Q

Q

D

D

Q

F

K

R

L

L

L

L

F

Q

D

Q

R

K

T

T

V

V

L

Y

D

D

N

N

V

V

L

A

L

F

P

A

L

L

A

E

I

V

V

I

G

G

L

K

S

R

P

T

K

D

E

A

A

I

G

N

K

R

R

V

A

V

R

P

A

E

A

V

L

L

D

E

K

T

V

V

G

G

L

L

L

S

E

G

R

K

E

A

K

N

A

R

N

L

P

P

I

D

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

F

V

V

N

N

R

R

P

P

A

L

I

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

P

D

E

S

T

A

S

G

R

E

D

V

I

M

M

E

D

L

L

F

L

K

E

A

R

F

I

H

N

Q

R

V

T

G

G

V

T

T

T

V

V

I

L

L

M

A

A

T

T

H

H

D

D

T

H

Q

H

W

I

V

V

R

D

H

S

L

M

N

R

P

Q

R

R

V

V

L

V

W

E

V

L

E

S

H

L

G

G

Q

R

V

L

binding adenosine-5'-triphosphate: Y12 (= Y11), S39 (= S37), G42 (= G40), K43 (= K41), S44 (≠ T42)

8igqA Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
42% identity, 95% coverage: 1:215/226 of query aligns to 2:217/227 of 8igqA

query
sites
8igqA

M

M

I

I

S

T

F

L

S

D

A

H

V

V

H

T

K

K

R

Q

Y
|
Y

P

K

T

S

G

S

Y

A

E

R

-

P

A

A

L

L

R

D

G

D

V

I

S

N

F

V

D

K

I

I

E

D

A

K

G

G

E

E

L

F

V

V

F

F

I

L

T

I

G

G

H

P

S

S

G
|
G

A
x
S

G

G

K
|
K

T
x
S

T

T

L

F

C

M

K

R

L

L

A

L

A

L

A

A

I

A

E

E

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

R

V

V

N

S

G

K

Q

F

N

H

L

V

A

N

A

K

L

L

R

R

K

G

S

R

A

H

I

V

P

P

Y

K

V

L

R

R

R

Q

N

V

F

I

G

G

L

C

V

V

F

F

Q

Q

D

D

Q

F

K

R

L

L

L

L

F

Q

D

Q

R

K

T

T

V

V

L

Y

D

D

N

N

V

V

L

A

L

F

P

A

L

L

A

E

I

V

V

I

G

G

L

K

S

R

P

T

K

D

E

A

A

I

G

N

K

R

R

V

A

V

R

P

A

E

A

V

L

L

D

E

K

T

V

V

G

G

L

L

L

S

E

G

R

K

E

A

K

N

A

R

N

L

P

P

I

D

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

F

V

V

N

N

R

R

P

P

A

L

I

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

P

D

E

S

T

A

S

G

R

E

D

V

I

M

M

E

D

L

L

F

L

K

E

A

R

F

I

H

N

Q

R

V

T

G

G

V

T

T

T

V

V

I

L

L

M

A

A

T

T

H

H

D

D

T

H

Q

H

W

I

V

V

R

D

H

S

L

M

N

R

P

Q

R

R

V

V

L

V

W

E

V

L

E

S

H

L

G

G

Q

R

V

L

binding adenosine-5'-diphosphate: Y12 (= Y11), G40 (= G38), S41 (≠ A39), K43 (= K41), S44 (≠ T42)

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
42% identity, 95% coverage: 1:215/226 of query aligns to 1:216/229 of A5U7B7

query
sites
A5U7B7

M

M

I

I

S

T

F

L

S

D

A

H

V

V

H

T

K

K

R

Q

Y

Y

P

K

T

S

G

S

Y

A

E

R

-

P

A

A

L

L

R

D

G

D

V

I

S

N

F

V

D

K

I

I

E

D

A

K

G

G

E

E

L

F

V

V

F

F

I

L

T

I

G

G

H

P

S

S

G

G

A

S

G

G

K
|
K

T

S

T

T

L

F

C

M

K

R

L

L

A

L

A

L

A

A

I

A

E

E

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

R

V

V

N

S

G

K

Q

F

N

H

L

V

A

N

A

K

L

L

R

R

K

G

S

R

A

H

I

V

P

P

Y

K

V

L

R

R

R

Q

N

V

F

I

G

G

L
x
C

V

V

F

F

Q

Q

D

D

Q

F

K

R

L

L

L

L

F

Q

D

Q

R

K

T

T

V

V

L

Y

D

D

N

N

V

V

L

A

L

F

P

A

L

L

A

E

I

V

V

I

G

G

L

K

S

R

P

T

K

D

E

A

A

I

G

N

K

R

R

V

A

V

R

P

A

E

A

V

L

L

D

E

K

T

V

V

G

G

L

L

L

S

E

G

R

K

E

A

K

N

A

R

N

L

P

P

I

D

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

F

V

V

N

N

R

R

P

P

A

L

I

V

L

L

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

P

D

E

S

T

A

S

G

R

E

D

V

I

M

M

E

D

L

L

F

L

K

E

A

R

F

I

H

N

Q

R

V

T

G

G

V

T

T

T

V

V

I

L

L

M

A

A

T

T

H

H

D

D

T

H

Q

H

W

I

V

V

R

D

H

S

L

M

N

R

P

Q

R

R

V

V

L

V

W

E

V

L

E

S

H

L

G

G

Q

R

V

L

K42 (= K41) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ L83) mutation to A: Does not affect ATPase activity.

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
38% identity, 99% coverage: 1:223/226 of query aligns to 4:227/650 of 5ws4A

query
sites
5ws4A

M

L

I

L

S

E

F

V

S

S

A

N

V

L

H

V

K

R

R

E

Y

F

P

P

T

A

G

G

-

E

-

S

-

T

Y

I

E

Q

A

I

L

L

R

K

G

G

V

I

S

D

F

L

D

T

I

I

E

Y

A

E

G

G

E

E

L

L

V

V

F

A

I

I

T

V

G

G

H

Q

S
|
S

G
|
G

A

S

G

G

K

K

T
x
S

T

T

L

L

C

M

K

N

L

I

A

L

A

G

A

C

I

L

E

D

R

R

P

P

T

T

S

S

G

G

S

S

V

Y

V

K

V

V

N

N

G

G

Q

Q

N

E

L

T

A

G

A

K

L

L

R

E

K

P

S

D

A

Q

I

L

P

A

Y

Q

V

L

R

R

R

R

N

E

-

Y

F

F

G

G

L

F

V

I

F

F

Q

Q

D

R

Q

Y

K

H

L

L

L

L

F

G

D

D

R

L

T

S

V

A

L

E

D

G

N

N

V

V

L

E

L

V

P

P

L

A

A

V

I

Y

V

A

G

G

L

V

S

T

P

P

K

A

E

D

A

R

G

K

K

Q

R

R

A

A

R

T

A

A

A

L

L

L

D

T

K

E

V

L

G

G

L

L

L

G

E

T

R

K

E

T

K

Q

A

N

N

R

P

P

I

S

A

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

L

V

A

S

I

I

A

A

R

R

A

A

V

L

V

M

N

N

R

G

P

G

A

D

I

V

L

I

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

T

S

D

H

S

S

A

G

G

V

E

E

V

V

M

M

E

R

L

I

F

L

K

R

A

E

F

L

H

N

Q

A

V

A

G

G

V

H

T

T

V

I

I

I

L

L

A

V

T

T

H

H

D

D

T

M

Q

Q

W

V

V

A

R

K

H

N

L

A

N

T

P

-

R

R

V

I

L

I

W

E

V

I

E

S

H

D

G

G

Q

E

V

I

R

I

A

S

P

-

G

-

E

D

R

R

P

P

E

N

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S37), G44 (= G38), S48 (≠ T42)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
41% identity, 96% coverage: 1:218/226 of query aligns to 4:225/648 of P75831

query
sites
P75831

M

L

I

L

S

E

F

L

S

K

A

D

V

I

H

R

K

R

R

S

Y

Y

P

P

T

A

G

G

-

D

-

E

-

Q

Y

V

E

E

A

V

L

L

R

K

G

G

V

I

S

S

F

L

D

D

I

I

E

Y

A

A

G

G

E

E

L

M

V

V

F

A

I

I

T

V

G

G

H

A

S

S

G

G

A

S

G

G

K
|
K

T

S

T

T

L

L

C

M

K

N

L

I

A

L

A

G

A

C

I

L

E

D

R

K

P

A

T

T

S

S

G

G

S

T

V

Y

V

R

V

V

N

A

G

G

Q

Q

N

D

L

V

A

A

A

T

L

L

R

D

K

A

S

D

A

A

I

L

P

A

Y

Q

V

L

R

R

R

R

-

E

N

H

F

F

G

G

L

F

V

I

F

F

Q

Q

D

R

Q

Y

K

H

L

L

L

L

F

S

D

H

R

L

T

T

V

A

L

E

D

Q

N

N

V

V

L

E

L

V

P

P

L

A

A

V

I

Y

V

A

G

G

L

L

S

E

P

R

K

K

E

Q

A

R

G

L

K

L

R

R

A

A

R

Q

A

E

A

L

L

L

D

Q

K

R

V

L

G

G

L

L

L

E

E

D

R

R

E

T

K

E

A

Y

N

Y

P

P

I

A

A

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

R

R

L

V

A

S

I

I

A

A

R

R

A

A

V

L

V

M

N

N

R

G

P

G

A

Q

I

V

L

I

L

L

A

A

D
|
D

E

E

P

P

T

T

A

G

N

A

L

L

D

D

T

S

D

H

S

S

A

G

G

E

E

E

V

V

M

M

E

A

L

I

F

L

K

H

A

Q

F

L

H

R

Q

D

V

R

G

G

V

H

T

T

V

V

I

I

L

I

A

V

T

T

H

H

D

D

T

P

Q

Q

W

-

V

V

R

A

H

A

L

Q

N

A

P

E

R

R

V

V

L

I

W

E

V

I

E

R

H

D

G

G

Q

E

-

I

V

V

R

R

A

N

P

P

K47 (= K41) mutation to L: Lack of activity.
D169 (= D162) mutation to N: Lack of activity.

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
38% identity, 92% coverage: 9:215/226 of query aligns to 10:216/223 of 2pclA

query
sites
2pclA

K

K

R

K

Y

V

P

I

T

R

G

G

Y

Y

E

E

A

I

L

L

R

K

G

G

V

I

S

S

F

L

D

S

I

V

E

K

A

K

G

G

E

E

L

F

V

V

F

S

I

I

T

I

G

G

H

A

S

S

G

G

A

S

G

G

K

K

T

S

T

T

L

L

C

L

K

Y

L

I

A

L

A

G

A

L

I

L

E

D

R

A

P

P

T

T

S

E

G

G

S

K

V

V

V

F

V

L

N

E

G

G

Q

K

N

E

L

V

A

D

A

Y

L

T

R

N

K

E

S

K

A

E

I

L

P

S

Y

L

V

L

R

R

-

N

R

R

N

K

F

L

G

G

L

F

V

V

F

F

Q

Q

D

F

Q

H

K

Y

L

L

L

I

F

P

D

E

R

L

T

T

V

A

L

L

D

E

N

N

V

V

L

I

L

V

P

P

L

M

A

L

I

K

V

M

G

G

L

K

S

P

P

K

K

K

E

E

A

A

G

K

K

E

R

R

A

G

R

E

A

Y

A

L

L

L

D

S

K

E

V

L

G

G

L

L

L

G

E

D

R

K

E

L

K

S

A

R

N

K

P

P

I

Y

A

E

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

A

N

N

R

E

P

P

A

I

I

L

L

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

A

G

N

N

L

L

D

D

T

S

D

A

S

N

A

T

G

K

E

R

V

V

M

M

E

D

L

I

F

F

K

L

A

K

F

I

H

N

Q

E

V

G

G

G

V

T

T

S

V

I

I

V

L

M

A

V

T
|
T

H

H

D

E

T

R

Q

E

W

L

V

A

R

-

H

E

L

L

N

T

P

H

R

R

V

T

L

L

W

E

V

M

E

K

H

D

G

G

Q

K

V

V

binding magnesium ion: E165 (= E163), P166 (= P164), T167 (= T165), T196 (= T194)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
38% identity, 95% coverage: 1:215/226 of query aligns to 1:219/343 of P30750

query
sites
P30750

M

M

I

I

S

K

F

L

S

S

A

N

V

I

H

T

K

K

R

V

Y

F

P

H

T

Q

G

G

-

T

-

R

-

T

Y

I

E

Q

A

A

L

L

R

N

G

N

V

V

S

S

F

L

D

H

I

V

E

P

A

A

G

G

E

Q

L

I

V

Y

F

G

I

V

T

I

G

G

H

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

C

I

K

R

L

C

A

V

A

N

A

L

I

L

E

E

R

R

P

P

T

T

S

E

G

G

S

S

V

V

V

L

V

V

N

D

G

G

Q

Q

N

E

L

L

A

T

A

T

L

L

R

S

K

E

S

S

A

E

I

L

P

T

Y

K

V

A

R

R

R

R

N

Q

F

I

G

G

L

M

V

I

F

F

Q

Q

D

H

Q

F

K

N

L

L

L

L

F

S

D

S

R

R

T

T

V

V

L

F

D

G

N

N

V

V

L

A

L

L

P

P

L

L

A

E

I

L

V

D

G

N

L

T

S

P

P

K

K

D

E

E

A

V

G

K

K

R

R

R

A

V

R

T

A

E

A

L

L

L

D

S

K

L

V

V

G

G

L

L

L

G

E

D

R

K

E

H

K

D

A

S

N

Y

P

P

I

S

A

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

A

N

S

R

N

P

P

A

K

I

V

L

L

L

L

A

C

D

D

E
|
E

P

A

T

T

A

S

N

A

L

L

D

D

T

P

D

A

S

T

A

T

G

R

E

S

V

I

M

L

E

E

L

L

F

L

K

K

A

D

F

I

H

N

-

R

Q

R

V

L

G

G

V

L

T

T

V

I

I

L

L

L

A

I

T

T

H

H

D

E

T

M

Q

D

W

V

V

V

R

K

H

R

L

I

N

C

P

D

R

C

V

V

L

A

W

V

V

I

E

S

H

N

G

G

Q

E

V

L

40:46 (vs. 37:43, 86% identical) binding
E166 (= E163) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
38% identity, 95% coverage: 1:215/226 of query aligns to 2:220/344 of 6cvlD

query
sites
6cvlD

M

M

I

I

S

K

F

L

S

S

A

N

V

I

H

T

K

K

R

V

Y
x
F

P

H

T
x
Q

G

G

-

T

-

R

-

T

Y
x
I

E

Q

A

A

L

L

R

N

G

N

V

V

S

S

F

L

D

H

I

V

E

P

A

A

G

G

E

Q

L

I

V

Y

F

G

I

V

T

I

G

G

H

A

S
|
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

C

I

K

R

L

C

A

V

A

N

A

L

I

L

E

E

R

R

P

P

T

T

S

E

G

G

S

S

V

V

V

L

V

V

N

D

G

G

Q

Q

N

E

L

L

A

T

A

T

L

L

R

S

K

E

S

S

A

E

I

L

P

T

Y

K

V

A

R

R

R

R

N

Q

F

I

G

G

L

M

V

I

F

F

Q

Q

D

H

Q

F

K

N

L

L

L

L

F

S

D

S

R

R

T

T

V

V

L

F

D

G

N

N

V

V

L

A

L

L

P

P

L

L

A

E

I

L

V

D

G

N

L

T

S

P

P

K

K

D

E

E

A

V

G

K

K

R

R

R

A

V

R

T

A

E

A

L

L

L

D

S

K

L

V

V

G

G

L

L

L

G

E

D

R

K

E

H

K

D

A

S

N

Y

P

P

I

S

A
x
N

L

L

S
|
S

G

G

G

G

E
x
Q

Q

K

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

A

N

S

R

N

P

P

A

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

A

S

N

A

L

L

D

D

T

P

D

A

S

T

A

T

G

R

E

S

V

I

M

L

E

E

L

L

F

L

K

K

A

D

F

I

H

N

-

R

Q

R

V

L

G

G

V

L

T

T

V

I

I

L

L

L

A

I

T

T

H
|
H

D

E

T

M

Q

D

W

V

V

V

R

K

H

R

L

I

N

C

P

D

R

C

V

V

L

A

W

V

V

I

E

S

H

N

G

G

Q

E

V

L

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y11), Q14 (≠ T13), I19 (≠ Y15), S41 (= S37), G42 (= G38), A43 (= A39), G44 (= G40), K45 (= K41), S46 (≠ T42), T47 (= T43), N141 (≠ A137), S143 (= S139), Q146 (≠ E142), H200 (= H195)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
38% identity, 95% coverage: 1:215/226 of query aligns to 2:220/344 of 3tuzC

query
sites
3tuzC

M

M

I

I

S

K

F

L

S

S

A

N

V

I

H

T

K

K

R

V

Y
x
F

P

H

T
x
Q

G

G

-

T

-

R

-

T

Y

I

E

Q

A

A

L

L

R

N

G

N

V

V

S

S

F

L

D

H

I

V

E

P

A

A

G

G

E

Q

L

I

V

Y

F

G

I

V

T

I

G

G

H

A

S

S

G
|
G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

C

I

K

R

L

C

A

V

A

N

A

L

I

L

E

E

R

R

P

P

T

T

S

E

G

G

S

S

V

V

V

L

V

V

N

D

G

G

Q

Q

N

E

L

L

A

T

A

T

L

L

R

S

K

E

S

S

A

E

I

L

P

T

Y

K

V

A

R

R

R

R

N

Q

F

I

G

G

L

M

V

I

F

F

Q

Q

D

H

Q

F

K

N

L

L

L

L

F

S

D

S

R

R

T

T

V

V

L

F

D

G

N

N

V

V

L

A

L

L

P

P

L

L

A

E

I

L

V

D

G

N

L

T

S

P

P

K

K

D

E

E

A

V

G

K

K

R

R

R

A

V

R

T

A

E

A

L

L

L

D

S

K

L

V

V

G

G

L

L

L

G

E

D

R

K

E

H

K

D

A

S

N

Y

P

P

I

S

A

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

A

N

S

R

N

P

P

A

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

A

S

N

A

L

L

D

D

T

P

D

A

S

T

A

T

G

R

E

S

V

I

M

L

E

E

L

L

F

L

K

K

A

D

F

I

H

N

-

R

Q

R

V

L

G

G

V

L

T

T

V

I

I

L

L

L

A

I

T

T

H

H

D

E

T

M

Q

D

W

V

V

V

R

K

H

R

L

I

N

C

P

D

R

C

V

V

L

A

W

V

V

I

E

S

H

N

G

G

Q

E

V

L

binding adenosine-5'-diphosphate: F12 (≠ Y11), Q14 (≠ T13), G42 (= G38), G44 (= G40), K45 (= K41), S46 (≠ T42), T47 (= T43)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
38% identity, 95% coverage: 1:215/226 of query aligns to 2:220/344 of 3tuiC

query
sites
3tuiC

M

M

I

I

S

K

F

L

S

S

A

N

V

I

H

T

K

K

R

V

Y
x
F

P

H

T

Q

G

G

-

T

-

R

-

T

Y

I

E

Q

A

A

L

L

R

N

G

N

V

V

S

S

F

L

D

H

I

V

E

P

A

A

G

G

E

Q

L

I

V

Y

F

G

I

V

T

I

G

G

H

A

S

S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

C

I

K

R

L

C

A

V

A

N

A

L

I

L

E

E

R

R

P

P

T

T

S

E

G

G

S

S

V

V

V

L

V

V

N

D

G

G

Q

Q

N

E

L

L

A

T

A

T

L

L

R

S

K

E

S

S

A

E

I

L

P

T

Y

K

V

A

R

R

R

R

N

Q

F

I

G

G

L

M

V

I

F

F

Q

Q

D

H

Q

F

K

N

L

L

L

L

F

S

D

S

R

R

T

T

V

V

L

F

D

G

N

N

V

V

L

A

L

L

P

P

L

L

A

E

I

L

V

D

G

N

L

T

S

P

P

K

K

D

E

E

A

V

G

K

K

R

R

R

A

V

R

T

A

E

A

L

L

L

D

S

K

L

V

V

G

G

L

L

L

G

E

D

R

K

E

H

K

D

A

S

N

Y

P

P

I

S

A

N

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

A

N

S

R

N

P

P

A

K

I

V

L

L

L

L

A

C

D

D

E

Q

P

A

T

T

A

S

N

A

L

L

D

D

T

P

D

A

S

T

A

T

G

R

E

S

V

I

M

L

E

E

L

L

F

L

K

K

A

D

F

I

H

N

-

R

Q

R

V

L

G

G

V

L

T

T

V

I

I

L

L

L

A

I

T

T

H

H

D

E

T

M

Q

D

W

V

V

V

R

K

H

R

L

I

N

C

P

D

R

C

V

V

L

A

W

V

V

I

E

S

H

N

G

G

Q

E

V

L

binding adenosine-5'-diphosphate: F12 (≠ Y11), G42 (= G38), A43 (= A39), G44 (= G40), K45 (= K41), S46 (≠ T42), T47 (= T43)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
41% identity, 92% coverage: 9:217/226 of query aligns to 13:225/233 of P75957

query
sites
P75957

K

K

R

R

Y

Y

P

Q

T

E

G

G

-

S

-

V

-

Q

Y

T

E

D

A

V

L

L

R

H

G

N

V

V

S

S

F

F

D

S

I

V

E

G

A

E

G

G

E

E

L

M

V

M

F

A

I

I

T

V

G
|
G

H

S

S

S

G

G

A

S

G

G

K

K

T

S

T

T

L

L

C

L

K

H

L

L

A

L

A

G

A

G

I

L

E

D

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

I

V

F

N

N

G

G

Q

Q

N

P

L

M

A

S

A

K

L

L

R

S

K

S

S

A

A

A

I

K

P

A

Y

E

V

L

R

R

-

N

R

Q

N

K

F

L

G

G

L

F

V

I

F

Y

Q

Q

D

F

Q

H

K

H

L

L

L

L

F

P

D

D

R

F

T

T

V

A

L

L

D

E

N

N

V

V

L

A

L

M

P

P

L

L

A

L

I

I

V

G

G

K

L

K

S

K

P

P

K

A

E

E

A

I

G

N

K

S

R

R

A

A

R

L

A

E

A

M

L

L

D

K

K

A

V

V

G

G

L

L

L

D

E

H

R

R

E

A

K

N

A

H

N

R

P

P

I

S

A

E

L

L

S

S

G

G

G

G

E

E

Q

R

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

V

N

N

R

N

P

P

A

R

I

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

A

D

R

S

N

A

A

G

D

E

S

V

I

M

F

E

Q

L

L

F

L

K

G

A

E

F

L

H

N

Q

R

V

L

-

Q

G

G

V

T

T

A

V

F

I

L

L

V

A

V

T

T

H

H

D

D

T

L

Q

Q

W

L

V

A

R

K

H

R

L

M

N

S

P

-

R

R

V

Q

L

L

W

E

V

M

E

R

H

D

G

G

Q

R

V

L

R

T

A

A

G42 (= G35) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
41% identity, 92% coverage: 9:217/226 of query aligns to 10:222/226 of 7mdyC

query
sites
7mdyC

K

K

R

R

Y
|
Y

P

Q

T

E

G

G

-

S

-

V

-

Q

Y

T

E

D

A

V

L

L

R

H

G

N

V

V

S

S

F

F

D

S

I

V

E

G

A

E

G

G

E

E

L

M

V

M

F

A

I

I

T

V

G

G

H

S

S

S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

C

L

K

H

L

L

A

L

A

G

A

G

I

L

E

D

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

I

V

F

N

N

G

G

Q

Q

N

P

L

M

A

S

A

K

L

L

R

S

K

S

S

A

A

A

I

K

P

A

Y

E

V

L

R

R

-

N

R

Q

N

K

F

L

G

G

L

F

V

I

F

Y

Q
|
Q

D

F

Q

H

K

H

L

L

L

L

F

P

D

D

R

F

T

T

V

A

L

L

D

E

N

N

V

V

L

A

L

M

P

P

L

L

A

L

I

I

V

G

G

K

L

K

S

K

P

P

K

A

E

E

A

I

G

N

K

S

R

R

A

A

R

L

A

E

A

M

L

L

D

K

K

A

V

V

G

G

L

L

L

D

E

H

R

R

E

A

K

N

A
x
H

N

R

P

P

I

S

A
x
E

L

L

S
|
S

G
|
G

G
|
G

E

E

Q

R

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

V

N

N

R

N

P

P

A

R

I

L

L

V

L

L

A

A

D

D

E
|
E

P

P

T

T

A

G

N
|
N

L

L

D

D

T

A

D

R

S

N

A

A

G

D

E

S

V

I

M

F

E

Q

L

L

F

L

K

G

A

E

F

L

H

N

Q

R

V

L

-

Q

G

G

V

T

T

A

V

F

I

L

L

V

A

V

T

T

H
|
H

D

D

T

L

Q

Q

W

L

V

A

R

K

H

R

L

M

N

S

P

-

R

R

V

Q

L

L

W

E

V

M

E

R

H

D

G

G

Q

R

V

L

R

T

A

A

binding adp orthovanadate: Y12 (= Y11), G42 (= G38), S43 (≠ A39), G44 (= G40), K45 (= K41), S46 (≠ T42), T47 (= T43), Q91 (= Q86), H138 (≠ A133), E142 (≠ A137), S144 (= S139), G145 (= G140), G146 (= G141), E168 (= E163), N172 (= N167), H201 (= H195)
binding magnesium ion: S46 (≠ T42), Q91 (= Q86)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
41% identity, 92% coverage: 9:217/226 of query aligns to 10:222/222 of 7arlD

query
sites
7arlD

K

K

R

R

Y

Y

P

Q

T

E

G

G

-

S

-

V

-

Q

Y

T

E

D

A

V

L

L

R

H

G

N

V

V

S

S

F

F

D

S

I

V

E

G

A

E

G

G

E

E

L

M

V

M

F

A

I

I

T

V

G

G

H

S

S

S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T

T

L

L

C

L

K

H

L

L

A

L

A

G

A

G

I

L

E

D

R

T

P

P

T

T

S

S

G

G

S

D

V

V

V

I

V

F

N

N

G

G

Q

Q

N

P

L

M

A

S

A

K

L

L

R

S

K

S

S

A

A

A

I

K

P

A

Y

E

V

L

R

R

-

N

R

Q

N

K

F

L

G

G

L

F

V

I

F

Y

Q

Q

D

F

Q

H

K

H

L

L

L

L

F

P

D

D

R

F

T

T

V

A

L

L

D

E

N

N

V

V

L

A

L

M

P

P

L

L

A

L

I

I

V

G

G

K

L

K

S

K

P

P

K

A

E

E

A

I

G

N

K

S

R

R

A

A

R

L

A

E

A

M

L

L

D

K

K

A

V

V

G

G

L

L

L

D

E

H

R

R

E

A

K

N

A

H

N

R

P

P

I

S

A

E

L

L

S

S

G

G

G

G

E

E

Q

R

Q

Q

R

R

L

V

A

A

I

I

A

A

R

R

A

A

V

L

V

V

N

N

R

N

P

P

A

R

I

L

L

V

L

L

A

A

D

D

E

E

P

P

T

T

A

G

N

N

L

L

D

D

T

A

D

R

S

N

A

A

G

D

E

S

V

I

M

F

E

Q

L

L

F

L

K

G

A

E

F

L

H

N

Q

R

V

L

-

Q

G

G

V

T

T

A

V

F

I

L

L

V

A

V

T

T

H

H

D

D

T

L

Q

Q

W

L

V

A

R

K

H

R

L

M

N

S

P

-

R

R

V

Q

L

L

W

E

V

M

E

R

H

D

G

G

Q

R

V

L

R

T

A

A

binding adenosine-5'-diphosphate: G42 (= G38), G44 (= G40), K45 (= K41), S46 (≠ T42)

Query Sequence

>Dsui_1023 FitnessBrowser__PS:Dsui_1023
MISFSAVHKRYPTGYEALRGVSFDIEAGELVFITGHSGAGKTTLCKLAAAIERPTSGSVV
VNGQNLAALRKSAIPYVRRNFGLVFQDQKLLFDRTVLDNVLLPLAIVGLSPKEAGKRARA
ALDKVGLLEREKANPIALSGGEQQRLAIARAVVNRPAILLADEPTANLDTDSAGEVMELF
KAFHQVGVTVILATHDTQWVRHLNPRVLWVEHGQVRAPGERPEGQA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory