Comparing Dsui_1418 FitnessBrowser__PS:Dsui_1418 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
55% identity, 99% coverage: 3:253/253 of query aligns to 2:250/252 of 7ac8A
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
55% identity, 99% coverage: 3:253/253 of query aligns to 2:250/253 of Q9X0C6
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
54% identity, 99% coverage: 3:253/253 of query aligns to 2:250/253 of 1gpwC
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
52% identity, 100% coverage: 2:253/253 of query aligns to 1:250/250 of 7qc8A
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
54% identity, 99% coverage: 3:253/253 of query aligns to 3:253/253 of 1h5yB
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
53% identity, 99% coverage: 3:253/253 of query aligns to 1:243/243 of 4ewnD
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
49% identity, 99% coverage: 4:253/253 of query aligns to 1:248/251 of 5d2tA
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
52% identity, 99% coverage: 3:253/253 of query aligns to 2:241/244 of 3zr4E
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
48% identity, 99% coverage: 3:253/253 of query aligns to 1:249/250 of 6dnjA
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
51% identity, 99% coverage: 3:253/253 of query aligns to 2:236/237 of 2wjzE
3iivB Evolutionary optimization of computationally designed enzymes: kemp eliminases of the ke07 series (see paper)
48% identity, 100% coverage: 2:253/253 of query aligns to 1:249/262 of 3iivB
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
41% identity, 99% coverage: 3:253/253 of query aligns to 2:257/258 of P60664
1ox4B Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
35% identity, 100% coverage: 1:253/253 of query aligns to 237:537/538 of 1ox4B
P33734 Imidazole glycerol phosphate synthase hisHF; IGP synthase; IGPS; ImGP synthase; EC 4.3.2.10; EC 3.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
34% identity, 100% coverage: 1:253/253 of query aligns to 234:549/552 of P33734
1ox5A Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
35% identity, 100% coverage: 1:253/253 of query aligns to 237:531/532 of 1ox5A
3tdmA Computationally designed tim-barrel protein, halfflr (see paper)
50% identity, 40% coverage: 124:224/253 of query aligns to 1:99/120 of 3tdmA
Sites not aligning to the query:
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
30% identity, 92% coverage: 7:240/253 of query aligns to 2:238/246 of 5abtA
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
30% identity, 92% coverage: 7:240/253 of query aligns to 2:235/241 of 5ab3A
4tx9A Crystal structure of hisap from streptomyces sviceus with degraded profar (see paper)
29% identity, 81% coverage: 7:212/253 of query aligns to 11:210/246 of 4tx9A
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
28% identity, 94% coverage: 6:242/253 of query aligns to 5:237/240 of 5dn1A
>Dsui_1418 FitnessBrowser__PS:Dsui_1418
MALAKRIIPCLDVTAGRVVKGTNFVELRDAGDPVEIARRYDEQGADEVTFLDITASSDQR
DIILHIIEACASQVFIPLTVGGGVRKVEDVRRLLNAGADKVSMNTAAVQNPDLVSDASAK
VGSQCIVVAIDAKQTAPGQWCVFTHGGRNNTGIDVVTWAKDVATRGAGEILLTSMDRDGT
KNGFDLALTRAVSDAVAIPVIASGGVGNLQHLADGVTQGGADAVLAASIFHFGEYTVRQA
KEYMRDRGIEVRL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory