SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_1462 Dsui_1462 ABC-type antimicrobial peptide transport system, ATPase component to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
47% identity, 85% coverage: 40:265/267 of query aligns to 1:230/232 of 1f3oA

query
sites
1f3oA

L

M

I

I

V

K

L

L

D

K

N

N

L

V

S

T

K

K

S

T

Y
|
Y

R

K

R

M

G

G

Q

E

V

I

P

Y

V

A

L

L

E

K

R

N

I

V

S

N

F

L

N

N

I

I

A

K

A

E

G

G

E

E

F

F

L

V

A

S

L

I

M

M

G

G

P

P

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

N

N

L

I

I

I

A

G

G

C

I

L

D

D

R

K

P

P

D

T

S

E

G

G

T

E

L

V

S

Y

V

I

A

D

G

N

Q

I

D

K

I

T

A

N

A

D

L

L

E

D

A

D

E

E

L

L

A

T

A

K

W

I

R

R

A

R

E

D

N

K

V

I

G

G

F

F

I

V

F

F

Q

Q

F

Q

Y

F

N

N

L

L

M

I

P

P

V

L

L

L

T

T

A

A

L

L

E

E

N

N

V

V

E

E

L

L

P

P

L

L

L

I

L

F

K

K

N

Y

L

R

G

G

K

A

-

M

-

S

-

G

A

E

E

E

R

R

E

K

R

R

A

A

E

L

L

E

A

C

L

L

S

K

M

M

V

A

G

E

L

L

A

E

D

E

R

R

M

F

-

A

D

N

H

H

T

K

P

P

N

N

E

Q

L

L

S

S

G

G

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

D

N

P

P

T

P

L

I

I

I

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

K

S

T

A

G

G

E

D

K

I

I

L

M

H

Q

L

L

Q

K

R

K

L

L

N

N

D

E

E

E

L

D

G

G

K

K

T

T

I

V

V

V

M

V

V

V

T

T

H

H

D

D

Q

I

R

N

A

V

A

A

E

R

S

F

A

G

H

E

A

R

I

I

M

I

H

Y

L

L

E

K

K

D

G

G

E

E

L

V

S

E

A

R

R

E

Q

E

E

K

I

L

R

R

binding adenosine-5'-diphosphate: Y11 (= Y50), G41 (= G80), G43 (= G82), K44 (= K83), S45 (= S84), T46 (= T85)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
47% identity, 85% coverage: 40:265/267 of query aligns to 1:230/230 of 1l2tA

query
sites
1l2tA

L

M

I

I

V

K

L

L

D

K

N

N

L

V

S

T

K

K

S

T

Y
|
Y

R

K

R

M

G

G

Q

E

V

I

P

Y

V

A

L

L

E

K

R

N

I

V

S

N

F

L

N

N

I

I

A

K

A

E

G

G

E

E

F

F

L

V

A

S

L

I

M

M

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

N

N

L

I

I

I

A

G

G

C

I

L

D

D

R

K

P

P

D

T

S

E

G

G

T

E

L

V

S

Y

V

I

A

D

G

N

Q

I

D

K

I

T

A

N

A

D

L

L

E

D

A

D

E

E

L

L

A

T

A

K

W

I

R

R

A

R

E

D

N

K

V

I

G

G

F

F

I

V

F

F

Q

Q

F

Q

Y

F

N

N

L

L

M

I

P

P

V

L

L

L

T

T

A

A

L

L

E

E

N

N

V

V

E

E

L

L

P

P

L

L

L

I

L

F

K

K

N

Y

L

R

G

G

K

A

-

M

-

S

-

G

A

E

E

E

R

R

E

K

R

R

A

A

E

L

L

E

A

C

L

L

S

K

M

M

V

A

G

E

L

L

A

E

D

E

R

R

M
x
F

-

A

D

N

H

H

T

K

P

P

N

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

D

N

P

P

T

P

L

I

I

I

V

L

A

A

D

D

E

Q

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

K

S

T

A

G

G

E

D

K

I

I

L

M

H

Q

L

L

Q

K

R

K

L

L

N

N

D

E

E

E

L

D

G

G

K

K

T

T

I

V

V

V

M

V

V

V

T

T

H
|
H

D

D

Q

I

R

N

A

V

A

A

E

R

S

F

A

G

H

E

A

R

I

I

M

I

H

Y

L

L

E

K

K

D

G

G

E

E

L

V

S

E

A

R

R

E

Q

E

E

K

I

L

R

R

binding adenosine-5'-triphosphate: Y11 (= Y50), S40 (= S79), G41 (= G80), S42 (= S81), G43 (= G82), K44 (= K83), S45 (= S84), T46 (= T85), F138 (≠ M174), Q145 (≠ E180), S147 (= S182), G149 (= G184), Q150 (= Q185), H204 (= H239)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
49% identity, 83% coverage: 40:260/267 of query aligns to 3:222/226 of 5xu1B

query
sites
5xu1B

L

L

I

I

V

S

L

L

D

K

N

N

L

I

S

F

K

R

S

S

Y

Y

R

R

R

N

G

G

Q

D

Q

Q

V

E

V

L

P

Q

V

V

L

L

E

K

R

N

I

I

S

N

F

L

N

E

I

V

A

N

A

E

G

G

E

E

F

F

L

V

A

A

L

I

M

M

G

G

P

P

S

S

G

G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

L

M

N

N

L

T

I

I

A

G

G

M

I

L

D

D

R

T

P

P

D

T

S

S

G

G

T

E

L

Y

S

Y

V

L

A

E

G

G

Q

Q

D

E

I

V

A

A

A

G

L

L

E

G

E

E

A

K

E

Q

L

L

A

A

A

K

W

V

R

R

A

N

E

Q

N

Q

V

I

G

G

F

F

I

V

F

F

Q

Q

F

Q

Y

F

N

F

L

L

M

L

P

S

V

K

L

L

T

N

A

A

L

L

E

Q

N

N

V

V

E

E

L

L

P

P

L

L

L

I

L

Y

K

A

N

G

L

V

G

S

K

S

A

S

E

K

R

R

E

K

R

L

A

A

E

E

L

E

A

Y

L

L

S

D

M

K

V

V

G

E

L

L

A

T

D

E

R

R

M

S

D

H

H

H

T

L

P

P

N

S

E

E

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

D

N

P

P

T

S

L

I

I

I

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

T

E

K

S

T

A

G

G

N

D

Q

I

I

L

M

H

Q

L

L

Q

V

R

D

L

L

N

N

D

K

E

E

L

-

G

G

K

K

T

T

I

I

V

I

M

M

V

V

T

T

H

H

D

E

Q

P

R

E

A

I

A

A

E

A

S

Y

A

A

H

K

A

R

I

Q

M

I

H

V

L

I

E

R

K

D

G

G

E

V

L

I

S

S

A

S

binding magnesium ion: G45 (= G82), K46 (= K83), S47 (= S84)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 82% coverage: 39:258/267 of query aligns to 3:221/648 of P75831

query
sites
P75831

P

P

L

L

I

L

V

E

L

L

D

K

N

D

L

I

S

R

K

R

S

S

Y

Y

R

P

R

A

G

G

Q

D

Q

E

V

Q

V

V

P

E

V

V

L

L

E

K

R

G

I

I

S

S

F

L

N

D

I

I

A

Y

A

A

G

G

E

E

F

M

L

V

A

A

L

I

M

V

G

G

P

A

S

S

G

G

S

S

G

G

K
|
K

S

S

T

T

L

L

L

M

N

N

L

I

I

L

A

G

G

C

I

L

D

D

R

K

P

A

D

T

S

S

G

G

T

T

L

Y

S

R

V

V

A

A

G

G

Q

Q

D

D

I

V

A

A

A

T

L

L

E

D

E

A

A

D

E

A

L

L

A

A

A

Q

W

L

R

R

A

R

E

E

N

H

V

F

G

G

F

F

I

I

F

F

Q

Q

F

R

Y

Y

N

H

L

L

M

L

P

S

V

H

L

L

T

T

A

A

L

E

E

Q

N

N

V

V

E

E

L

V

P

P

L

A

L

V

L

Y

K

A

N

G

L

L

G

E

K

R

A

K

E

Q

R

R

R

L

E

L

R

R

A

A

E

Q

L

E

A

L

L

L

S

Q

M

R

V

L

G

G

L

L

A

E

D

D

R

R

M

T

D

E

H

Y

T

Y

P

P

N

A

E

Q

L

L

S

S

G

G

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

D

G

P

G

T

Q

L

V

I

I

V

L

A

A

D
|
D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

H

S

S

A

G

G

E

D

E

I

V

L

M

H

A

L

I

L

L

Q

H

R

Q

L

L

N

R

D

D

E

R

L

-

G

G

K

H

T

T

I

V

V

I

M

I

V

V

T

T

H

H

D

D

Q

P

R

Q

A

V

A

A

E

A

S

Q

A

A

H

E

A

R

I

V

M

I

H

E

L

I

E

R

K

D

G

G

E

E

L

I

K47 (= K83) mutation to L: Lack of activity.
D169 (= D205) mutation to N: Lack of activity.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
46% identity, 83% coverage: 40:260/267 of query aligns to 2:222/222 of 7arlD

query
sites
7arlD

L

L

I

L

V

Q

L

C

D

D

N

N

L

L

S

C

K

K

S

R

Y

Y

R

Q

R

E

G

G

Q

S

Q

V

V

Q

V

T

P

D

V

V

L

L

E

H

R

N

I

V

S

S

F

F

N

S

I

V

A

G

A

E

G

G

E

E

F

M

L

M

A

A

L

I

M

V

G

G

P

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T

T

L

L

N

H

L

L

I

L

A

G

G

G

I

L

D

D

R

T

P

P

D

T

S

S

G

G

T

D

L

V

S

I

V

F

A

N

G

G

Q

Q

D

P

I

M

A

S

A

K

L

L

E

S

A

A

E

A

L

K

A

A

A

E

W

L

R

R

A

N

E

Q

N

K

V

L

G

G

F

F

I

I

F

Y

Q

Q

F

F

Y

H

N

H

L

L

M

L

P

P

V

D

L

F

T

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

K

G

N

K

L

K

G

K

K

P

A

A

E

E

R

I

R

N

E

S

R

R

A

A

E

L

L

E

A

M

L

L

S

K

M

A

V

V

G

G

L

L

A

D

D

H

R

R

M

A

D

N

H

H

T

R

P

P

N

S

E

E

L

L

S

S

G

G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

D

N

P

P

T

R

L

L

I

V

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

N

L

L

D

D

R

A

E

R

S

N

A

A

G

D

D

S

I

I

L

F

H

Q

L

L

Q

G

R

E

L

L

N

N

D

R

E

L

L

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H

H

D

D

Q

L

R

Q

A

L

A

A

E

K

S

R

A

M

H

S

A

R

I

Q

M

L

H

E

L

M

E

R

K

D

G

G

E

R

L

L

S

T

A

A

binding adenosine-5'-diphosphate: G42 (= G80), G44 (= G82), K45 (= K83), S46 (= S84)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
46% identity, 83% coverage: 40:260/267 of query aligns to 5:225/233 of P75957

query
sites
P75957

L

L

I

L

V

Q

L

C

D

D

N

N

L

L

S

C

K

K

S

R

Y

Y

R

Q

R

E

G

G

Q

S

Q

V

V

Q

V

T

P

D

V

V

L

L

E

H

R

N

I

V

S

S

F

F

N

S

I

V

A

G

A

E

G

G

E

E

F

M

L

M

A

A

L

I

M

V

G
|
G

P

S

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

N

H

L

L

I

L

A

G

G

G

I

L

D

D

R

T

P

P

D

T

S

S

G

G

T

D

L

V

S

I

V

F

A

N

G

G

Q

Q

D

P

I

M

A

S

A

K

L

L

E

S

A

A

E

A

L

K

A

A

A

E

W

L

R

R

A

N

E

Q

N

K

V

L

G

G

F

F

I

I

F

Y

Q

Q

F

F

Y

H

N

H

L

L

M

L

P

P

V

D

L

F

T

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

K

G

N

K

L

K

G

K

K

P

A

A

E

E

R

I

R

N

E

S

R

R

A

A

E

L

L

E

A

M

L

L

S

K

M

A

V

V

G

G

L

L

A

D

D

H

R

R

M

A

D

N

H

H

T

R

P

P

N

S

E

E

L

L

S

S

G

G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

D

N

P

P

T

R

L

L

I

V

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

N

L

L

D

D

R

A

E

R

S

N

A

A

G

D

D

S

I

I

L

F

H

Q

L

L

Q

G

R

E

L

L

N

N

D

R

E

L

L

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H

H

D

D

Q

L

R

Q

A

L

A

A

E

K

S

R

A

M

H

S

A

R

I

Q

M

L

H

E

L

M

E

R

K

D

G

G

E

R

L

L

S

T

A

A

G42 (= G77) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
46% identity, 83% coverage: 40:260/267 of query aligns to 2:222/226 of 7mdyC

query
sites
7mdyC

L

L

I

L

V

Q

L

C

D

D

N

N

L

L

S

C

K

K

S

R

Y
|
Y

R

Q

R

E

G

G

Q

S

Q

V

V

Q

V

T

P

D

V

V

L

L

E

H

R

N

I

V

S

S

F

F

N

S

I

V

A

G

A

E

G

G

E

E

F

M

L

M

A

A

L

I

M

V

G

G

P

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

N

H

L

L

I

L

A

G

G

G

I

L

D

D

R

T

P

P

D

T

S

S

G

G

T

D

L

V

S

I

V

F

A

N

G

G

Q

Q

D

P

I

M

A

S

A

K

L

L

E

S

A

A

E

A

L

K

A

A

A

E

W

L

R

R

A

N

E

Q

N

K

V

L

G

G

F

F

I

I

F

Y

Q
|
Q

F

F

Y

H

N

H

L

L

M

L

P

P

V

D

L

F

T

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

K

G

N

K

L

K

G

K

K

P

A

A

E

E

R

I

R

N

E

S

R

R

A

A

E

L

L

E

A

M

L

L

S

K

M

A

V

V

G

G

L

L

A

D

D

H

R

R

M

A

D

N

H
|
H

T

R

P

P

N

S

E
|
E

L

L

S
|
S

G
|
G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

D

N

P

P

T

R

L

L

I

V

V

L

A

A

D

D

E
|
E

P

P

T

T

G

G

D
x
N

L

L

D

D

R

A

E

R

S

N

A

A

G

D

D

S

I

I

L

F

H

Q

L

L

Q

G

R

E

L

L

N

N

D

R

E

L

L

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H
|
H

D

D

Q

L

R

Q

A

L

A

A

E

K

S

R

A

M

H

S

A

R

I

Q

M

L

H

E

L

M

E

R

K

D

G

G

E

R

L

L

S

T

A

A

binding adp orthovanadate: Y12 (= Y50), G42 (= G80), S43 (= S81), G44 (= G82), K45 (= K83), S46 (= S84), T47 (= T85), Q91 (= Q129), H138 (= H176), E142 (= E180), S144 (= S182), G145 (= G183), G146 (= G184), E168 (= E206), N172 (≠ D210), H201 (= H239)
binding magnesium ion: S46 (= S84), Q91 (= Q129)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
46% identity, 83% coverage: 40:260/267 of query aligns to 4:224/229 of 7v8iD

query
sites
7v8iD

L

L

I

L

V

Q

L

C

D

D

N

N

L

L

S

C

K

K

S

R

Y

Y

R

Q

R

E

G

G

Q

S

Q

V

V

Q

V

T

P

D

V
|
V

L

L

E

H

R

N

I

V

S

S

F

F

N

S

I

V

A

G

A

E

G

G

E

E

F

M

L

M

A

A

L

I

M

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

N

H

L

L

I

L

A

G

G

G

I

L

D

D

R

T

P

P

D

T

S

S

G

G

T

D

L

V

S

I

V

F

A

N

G

G

Q

Q

D

P

I

M

A

S

A

K

L

L

E

S

A

A

E

A

L

K

A

A

A

E

W

L

R

R

A

N

E

Q

N

K

V

L

G

G

F

F

I

I

F

Y

Q
|
Q

F

F

Y

H

N

H

L

L

M

L

P

P

V

D

L

F

T

T

A

A

L

L

E

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

K

G

N

K

L

K

G

K

K

P

A

A

E

E

R

I

R

N

E

S

R

R

A

A

E

L

L

E

A

M

L

L

S

K

M

A

V

V

G

G

L

L

A

D

D

H

R
|
R

M

A

D

N

H
|
H

T

R

P

P

N

S

E
|
E

L

L

S
|
S

G

G

G
|
G

Q
x
E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

V

T

N

D

N

P

P

T

R

L

L

I

V

V

L

A

A

D

D

E

Q

P

P

T

T

G

G

D

N

L

L

D

D

R

A

E

R

S

N

A

A

G

D

D

S

I

I

L

F

H

Q

L

L

Q

G

R

E

L

L

N

N

D

R

E

L

L

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H
|
H

D

D

Q

L

R

Q

A

L

A

A

E

K

S

R

A

M

H

S

A

R

I

Q

M

L

H

E

L

M

E

R

K

D

G

G

E

R

L

L

S

T

A

A

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V59), S43 (= S79), G44 (= G80), G46 (= G82), K47 (= K83), S48 (= S84), T49 (= T85), Q93 (= Q129), R137 (= R173), H140 (= H176), E144 (= E180), S146 (= S182), G148 (= G184), E149 (≠ Q185), H203 (= H239)
binding magnesium ion: S48 (= S84), Q93 (= Q129)

8g4cB Bceabs atpgs high res tm (see paper)
43% identity, 82% coverage: 44:261/267 of query aligns to 7:224/248 of 8g4cB

query
sites
8g4cB

D

N

N

K

L

I

S

R

K

K

S

S

Y
|
Y

R

G

R

N

G

K

Q

L

Q

N

V

K

V

Q

P

E

V

V

L

L

E

K

R

G

I

I

S

D

F

I

N

H

I

I

A

E

A

K

G

G

E

E

F

F

L

V

A

S

L

I

M

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

L

L

N

N

L

V

I

L

A

S

G

S

I

I

D

D

R

Q

P

V

D

S

S

H

G

G

T

T

L

I

S

H

V

I

A

N

G

G

Q

N

D

D

I

M

A

T

A

A

L

M

E

K

E

E

A

K

E

Q

L

L

A

A

A

E

W

F

R

R

A

K

E

Q

N

H

V

L

G

G

F

F

I

I

F

F

Q

Q

F

D

Y

Y

N

N

L

L

M

L

P

D

V

T

L

L

T

T

A

V

L

K

E

E

N

N

V

I

E

L

L

L

P

P

L

L

L

S

L

I

K

T

N

K

L

L

G

S

K

K

A

K

E

E

R

A

R

N

E

R

R

K

A

F

E

E

L

E

A

V

L

A

S

K

M

E

V

L

G

G

L

I

A

Y

D

E

R

L

M

R

D

D

H

K

T

Y

P

P

N

N

E

E

L

I

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

I

I

T

H

D

D

P

P

T

S

L

I

I

I

V

F

A

A

D
|
D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

K

S

S

A

A

G

S

D

D

I

L

L

L

H

N

L

K

L

L

Q

S

R

Q

L

L

N

N

D

Q

E

K

L

R

G

N

K

A

T

T

I

I

V

I

M

M

V

V

T

T

H

H

D

D

Q

P

R

V

A

A

E

S

S

Y

A

C

H

G

A

R

I

V

M

I

H

F

L

I

E

K

K

D

G

G

E

Q

L

M

S

Y

A

T

R

Q

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y50), S42 (= S79), S44 (= S81), T47 (≠ S84), D168 (= D205)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
43% identity, 85% coverage: 40:265/267 of query aligns to 3:227/615 of 5lilA

query
sites
5lilA

L

I

I

I

V

E

L

I

D

K

N

Q

L

L

S

N

K

R

S

Y

Y
x
F

R

G

R

E

G

G

Q

E

Q

N

V

R

V

V

P

H

V
|
V

L

L

E

K

R

D

I

I

S

S

F

L

N

S

I

I

A

E

A

R

G

G

E

D

F

F

L

V

A

A

L

I

M

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

L

I

I

I

A

G

G

C

I

L

D

D

R

T

P

A

D

T

S

G

G

G

T

S

L

S

S

K

V

I

A

D

G

G

Q

K

D

E

I

T

A

I

A

E

L

L

E

T

E

N

A

D

E

Q

L

L

A

S

A

D

W

L

R

R

A

S

E

Q

N

K

V

F

G

G

F

F

I

I

F

F

Q
|
Q

F

R

Y

Y

N

N

L

L

M

L

P

S

V

S

L

L

T

T

A

A

L

A

E

E

N

N

V

V

E

A

L

L

P

P

L

A

L

I

L

Y

K

A

N

G

L

M

G

P

K

Q

A

S

E

Q

R

R

R

L

E

E

R

R

A

A

E

K

L

Q

A

L

L

L

S

E

M

K

V

L

G

G

L

L

A

G

D

D

R
x
K

M

W

D

Q

H

N

T

K

P

P

N

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

D

G

P

G

T

E

L

I

I

I

V

L

A

A

D

D

E

Q

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

H

S

S

A

G

G

E

D

N

I

V

L

M

H

E

L

I

L

L

Q

R

R

Q

L

L

N

H

D

E

E

E

L

-

G

G

K

H

T

T

I

I

V

I

M

M

V

V

T

T

H

H

D

D

Q

K

R

H

A

I

A

A

E

A

S

S

A

A

H

N

A

R

I

I

M

I

H

E

L

I

E

K

K

D

G

G

E

E

L

I

S

I

A

S

R

D

Q

T

E

Q

I

K

R

R

binding adenosine-5'-triphosphate: F13 (≠ Y50), V22 (= V59), S42 (= S79), G43 (= G80), G45 (= G82), K46 (= K83), S47 (= S84), T48 (= T85), Q92 (= Q129), K136 (≠ R173), Q143 (≠ E180), S145 (= S182), G147 (= G184), Q148 (= Q185)
binding magnesium ion: S47 (= S84), Q92 (= Q129)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
43% identity, 85% coverage: 40:265/267 of query aligns to 3:227/592 of 5lj7A

query
sites
5lj7A

L

I

I

I

V

E

L

I

D

K

N

Q

L

L

S

N

K

R

S

Y

Y

F

R

G

R

E

G

G

Q

E

Q

N

V

R

V

V

P

H

V
|
V

L

L

E

K

R

D

I

I

S

S

F

L

N

S

I

I

A

E

A

R

G

G

E

D

F

F

L

V

A

A

L

I

M

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

N

N

L

I

I

I

A

G

G

C

I

L

D

D

R

T

P

A

D

T

S

G

G

G

T

S

L

S

S

K

V

I

A

D

G

G

Q

K

D

E

I

T

A

I

A

E

L

L

E

T

E

N

A

D

E

Q

L

L

A

S

A

D

W

L

R

R

A

S

E

Q

N

K

V

F

G

G

F

F

I

I

F

F

Q
|
Q

F

R

Y

Y

N

N

L

L

M

L

P

S

V

S

L

L

T

T

A

A

L

A

E

E

N

N

V

V

E

A

L

L

P

P

L

A

L

I

L

Y

K

A

N

G

L

M

G

P

K

Q

A

S

E

Q

R

R

R

L

E

E

R

R

A

A

E

K

L

Q

A

L

L

L

S

E

M

K

V

L

G

G

L

L

A

G

D

D

R
x
K

M

W

D

Q

H

N

T

K

P

P

N

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

D

G

P

G

T

E

L

I

I

I

V

L

A

A

D

D

E

Q

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

H

S

S

A

G

G

E

D

N

I

V

L

M

H

E

L

I

L

L

Q

R

R

Q

L

L

N

H

D

E

E

E

L

-

G

G

K

H

T

T

I

I

V

I

M

M

V

V

T

T

H

H

D

D

Q

K

R

H

A

I

A

A

E

A

S

S

A

A

H

N

A

R

I

I

M

I

H

E

L

I

E

K

K

D

G

G

E

E

L

I

S

I

A

S

R

D

Q

T

E

Q

I

K

R

R

binding adenosine-5'-triphosphate: V22 (= V59), S42 (= S79), G43 (= G80), G45 (= G82), K46 (= K83), S47 (= S84), T48 (= T85), Q92 (= Q129), K136 (≠ R173), Q143 (≠ E180), S145 (= S182), G147 (= G184), Q148 (= Q185)
binding magnesium ion: S47 (= S84), Q92 (= Q129)

7tchB Bceab e169q variant atp-bound conformation (see paper)
42% identity, 82% coverage: 44:261/267 of query aligns to 6:223/245 of 7tchB

query
sites
7tchB

D

N

N

K

L

I

S

R

K

K

S

S

Y
|
Y

R

G

R

N

G

K

Q

L

Q

N

V

K

V
x
Q

P

E

V
|
V

L

L

E

K

R

G

I

I

S

D

F

I

N

H

I

I

A

E

A

K

G

G

E

E

F

F

L

V

A

S

L

I

M

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

L

L

N

N

L

V

I

L

A

S

G

S

I

I

D

D

R

Q

P

V

D

S

S

H

G

G

T

T

L

I

S

H

V

I

A

N

G

G

Q

N

D

D

I

M

A

T

A

A

L

M

E

K

E

E

A

K

E

Q

L

L

A

A

A

E

W

F

R

R

A

K

E

Q

N

H

V

L

G

G

F

F

I

I

F

F

Q

Q

F

D

Y

Y

N

N

L

L

M

L

P

D

V

T

L

L

T

T

A

V

L

K

E

E

N

N

V

I

E

L

L

L

P

P

L

L

L

S

L

I

K

T

N

K

L

L

G

S

K

K

A

K

E

E

R

A

R

N

E

R

R

K

A

F

E

E

L

E

A

V

L

A

S

K

M

E

V

L

G

G

L

I

A

Y

D

E

R

L

M

R

D

D

H

K

T

Y

P

P

N

N

E
|
E

L

I

S

S

G
|
G

Q

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

I

I

T

H

D

D

P

P

T

S

L

I

I

I

V

F

A

A

D

D

E

Q

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

K

S

S

A

A

G

S

D

D

I

L

L

L

H

N

L

K

L

L

Q

S

R

Q

L

L

N

N

D

Q

E

K

L

R

G

N

K

A

T

T

I

I

V

I

M

M

V

V

T

T

H

H

D

D

Q

P

R

V

A

A

E

S

S

Y

A

C

H

G

A

R

I

V

M

I

H

F

L

I

E

K

K

D

G

G

E

Q

L

M

S

Y

A

T

R

Q

binding adenosine-5'-triphosphate: Y12 (= Y50), Q19 (≠ V57), V21 (= V59), S41 (= S79), G42 (= G80), S43 (= S81), K45 (= K83), T46 (≠ S84), E142 (= E180), G145 (= G183), G146 (= G184)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
43% identity, 82% coverage: 40:258/267 of query aligns to 4:221/650 of 5ws4A

query
sites
5ws4A

L

L

I

L

V

E

L

V

D

S

N

N

L

L

S

V

K

R

S

E

Y

F

R

P

R

A

G

G

Q

E

Q

S

V

T

V

I

P

Q

V

I

L

L

E

K

R

G

I

I

S

D

F

L

N

T

I

I

A

Y

A

E

G

G

E

E

F

L

L

V

A

A

L

I

M

V

G

G

P

Q

S
|
S

G
|
G

S

S

G

G

K

K

S
|
S

T

T

L

L

L

M

N

N

L

I

I

L

A

G

G

C

I

L

D

D

R

R

P

P

D

T

S

S

G

G

T

S

L

Y

S

K

V

V

A

N

G

G

Q

Q

D

E

I

T

A

G

A

K

L

L

E

E

E

P

A

D

E

Q

L

L

A

A

A

Q

W

L

R

R

A

R

E

E

N

Y

V

F

G

G

F

F

I

I

F

F

Q

Q

F

R

Y

Y

N

H

L

L

M

L

P

G

V

D

L

L

T

S

A

A

L

E

E

G

N

N

V

V

E

E

L

V

P

P

L

A

L

V

L

Y

K

A

N

G

L

V

G

T

K

P

A

A

E

D

R

R

R

K

E

Q

R

R

A

A

E

T

L

A

A

L

L

L

S

T

M

E

V

L

G

G

L

L

A

G

D

T

R

K

M

T

D

Q

H

N

T

R

P

P

N

S

E

Q

L

L

S

S

G

G

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

I

M

T

N

D

G

P

G

T

D

L

V

I

I

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

E

H

S

S

A

G

G

V

D

E

I

V

L

M

H

R

L

I

L

L

Q

R

R

E

L

L

N

N

D

-

E

A

L

A

G

G

K

H

T

T

I

I

V

I

M

L

V

V

T

T

H

H

D

D

Q

M

R

Q

A

V

A

A

E

K

S

N

A

A

H

T

A

R

I

I

M

I

H

E

L

I

E

S

K

D

G

G

E

E

L

I

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S79), G44 (= G80), S48 (= S84)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
45% identity, 75% coverage: 59:258/267 of query aligns to 18:216/223 of 2pclA

query
sites
2pclA

V

I

L

L

E

K

R

G

I

I

S

S

F

L

N

S

I

V

A

K

G

G

E

E

F

F

L

V

A

S

L

I

M

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

N

Y

L

I

I

L

A

G

G

L

I

L

D

D

R

A

P

P

D

T

S

E

G

G

T

K

L

V

S

F

V

L

A

E

G

G

Q

K

D

E

I

V

A

D

A

Y

L

T

E

N

E

E

A

K

E

E

L

L

A

S

A

L

W

L

R

R

A

N

E

R

N

K

V

L

G

G

F

F

I

V

F

F

Q

Q

F

F

Y

H

N

Y

L

L

M

I

P

P

V

E

L

L

T

T

A

A

L

L

E

E

N

N

V

V

E

I

L

V

P

P

L

M

L

L

L

K

K

M

N

G

L

K

G

P

K

K

A

K

E

E

R

A

R

K

E

E

R

R

A

G

E

E

L

Y

A

L

L

L

S

S

M

E

V

L

G

G

L

L

A

G

D

D

R

K

M

L

D

S

H

R

T

K

P

P

N

Y

E

E

L

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

N

D

E

P

P

T

I

L

L

I

L

V

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

D

N

L

L

D

D

R

S

E

A

S

N

A

T

G

K

D

R

I

V

L

M

H

D

L

I

L

F

Q

L

R

K

L

I

N

N

D

-

E

E

L

G

G

G

K

T

T

S

I

I

V

V

M

M

V

V

T
|
T

H

H

D

E

Q

R

R

E

A

L

A

A

E

E

S

L

A

T

H

H

A

R

I

T

M

L

H

E

L

M

E

K

K

D

G

G

E

K

L

V

binding magnesium ion: E165 (= E206), P166 (= P207), T167 (= T208), T196 (= T238)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
40% identity, 82% coverage: 40:258/267 of query aligns to 1:219/343 of P30750

query
sites
P30750

L

M

I

I

V

K

L

L

D

S

N

N

L

I

S

T

K

K

S

V

Y

F

R

H

R

Q

G

G

Q

T

Q

R

V

T

V

I

P

Q

V

A

L

L

E

N

R

N

I

V

S

S

F

L

N

H

I

V

A

P

A

A

G

G

E

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

L

C

I

V

A

N

G

L

I

L

D

E

R

R

P

P

D

T

S

E

G

G

T

S

L

V

S

L

V

V

A

D

G

G

Q

Q

D

E

I

L

A

T

L

L

E

S

E

E

A

S

E

E

L

L

A

T

A

K

W

A

R

R

A

R

E

Q

N

-

V

I

G

G

F

M

I

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

V

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

K

D

N

N

L

T

G

P

K

K

A

D

E

E

R

V

R

K

E

R

R

R

A

V

E

T

L

E

A

L

L

L

S

S

M

L

V

V

G

G

L

L

A

G

D

D

R

K

M

H

D

D

H

S

T

Y

P

P

N

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

S

D

N

P

P

T

K

L

V

I

L

V

L

A

C

D

D

E
|
E

P

A

T

T

G

S

D

A

L

L

D

D

R

P

E

A

S

T

A

T

G

R

D

S

I

I

L

L

H

E

L

L

Q

K

R

D

L

I

N

N

D

R

E

R

L

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

Q

M

R

D

A

V

E

K

S

R

-

I

A

C

H

D

A

C

I

V

M

A

H

V

L

I

E

S

K

N

G

G

E

E

L

L

40:46 (vs. 79:85, 86% identical) binding
E166 (= E206) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
44% identity, 79% coverage: 43:253/267 of query aligns to 6:215/330 of P9WQK5

query
sites
P9WQK5

L

I

D

Q

N

N

L

L

S

V

K

V

S

E

Y

Y

R

Y

R

S

G

G

Q

G

Q

Y

V

A

V

L

P

R

V

P

L

I

E

N

R

G

I

L

S

N

F

L

N

D

I

V

A

A

G

G

E

S

F

L

L

V

A

M

L

L

M

L

G

G

P

P

S

S

G

G

S

C

G

G

K

K

S

T

T

T

L

L

N

S

L

C

I

L

A

G

G

G

I

I

D

L

R

R

P

P

D

K

S

S

G

G

T

A

L

I

S
x
K

V

F

A

D

G

E

Q

V

D

D

I

I

A

T

L

L

E

Q

E

G

A

A

E

E

L

L

A

A

A

N

W

Y

R

R

A

R

E

N

N

K

V

V

G

G

F

I

I

V

F

F

Q

Q

F

A

Y

F

N

N

L

L

M

V

P

P

V

S

L

L

T

T

A

A

L

V

E

E

N

N

V

V

E

M

L

V

P

P

L

L

L

R

L

S

K

A

N

G

L

M

G

S

K

R

A

R

E

A

R

S

R

R

E

R

R

R

A

A

E

E

L

E

A

L

L

L

S

A

M

R

V

V

G

N

L

L

A

A

D

E

R

R

M

M

D

N

H

H

T

R

P

P

N

G

E

D

L

L

S

S

G

G

Q

Q

R

R

V

V

A

A

I

V

A

A

R

R

A

A

L

I

I

A

T

L

D

D

P

P

T

P

L

L

I

I

V

L

A

A

D

D

E

E

P

P

T

T

G

A

D

H

L

L

D

D

R

F

E

I

S

Q

A

V

G

E

D

E

I

V

L

L

H

R

L

L

L

I

Q

R

R

E

L

L

N

A

D

D

E

G

L

-

G

E

K

R

T

V

I

V

V

V

M

V

V

A

T

T

H

H

D

D

Q

S

R

R

A

M

A

L

E

P

S

M

A

A

H

D

A

R

I

V

M

V

H

E

L

L

K65 (≠ S102) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
41% identity, 75% coverage: 40:240/267 of query aligns to 2:201/344 of 3tuzC

query
sites
3tuzC

L

M

I

I

V

K

L

L

D

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

R

H

R
x
Q

G

G

Q

T

Q

R

V

T

V

I

P

Q

V

A

L

L

E

N

R

N

I

V

S

S

F

L

N

H

I

V

A

P

A

A

G

G

E

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

L

C

I

V

A

N

G

L

I

L

D

E

R

R

P

P

D

T

S

E

G

G

T

S

L

V

S

L

V

V

A

D

G

G

Q

Q

D

E

I

L

A

T

L

L

E

S

E

E

A

S

E

E

L

L

A

T

A

K

W

A

R

R

A

R

E

Q

N

-

V

I

G

G

F

M

I

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

V

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

K

D

N

N

L

T

G

P

K

K

A

D

E

E

R

V

R

K

E

R

R

R

A

V

E

T

L

E

A

L

L

L

S

S

M

L

V

V

G

G

L

L

A

G

D

D

R

K

M

H

D

D

H

S

T

Y

P

P

N

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

S

D

N

P

P

T

K

L

V

I

L

V

L

A

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

E

A

S

T

A

T

G

R

D

S

I

I

L

L

H

E

L

L

Q

K

R

D

L

I

N

N

D

R

E

R

L

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

binding adenosine-5'-diphosphate: F12 (≠ Y50), Q14 (≠ R52), G42 (= G80), G44 (= G82), K45 (= K83), S46 (= S84), T47 (= T85)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
41% identity, 75% coverage: 40:240/267 of query aligns to 2:201/344 of 3tuiC

query
sites
3tuiC

L

M

I

I

V

K

L

L

D

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

R

H

R

Q

G

G

Q

T

Q

R

V

T

V

I

P

Q

V

A

L

L

E

N

R

N

I

V

S

S

F

L

N

H

I

V

A

P

A

A

G

G

E

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

L

C

I

V

A

N

G

L

I

L

D

E

R

R

P

P

D

T

S

E

G

G

T

S

L

V

S

L

V

V

A

D

G

G

Q

Q

D

E

I

L

A

T

L

L

E

S

E

E

A

S

E

E

L

L

A

T

A

K

W

A

R

R

A

R

E

Q

N

-

V

I

G

G

F

M

I

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

V

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

K

D

N

N

L

T

G

P

K

K

A

D

E

E

R

V

R

K

E

R

R

R

A

V

E

T

L

E

A

L

L

L

S

S

M

L

V

V

G

G

L

L

A

G

D

D

R

K

M

H

D

D

H

S

T

Y

P

P

N

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

S

D

N

P

P

T

K

L

V

I

L

V

L

A

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

E

A

S

T

A

T

G

R

D

S

I

I

L

L

H

E

L

L

Q

K

R

D

L

I

N

N

D

R

E

R

L

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

binding adenosine-5'-diphosphate: F12 (≠ Y50), G42 (= G80), A43 (≠ S81), G44 (= G82), K45 (= K83), S46 (= S84), T47 (= T85)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
41% identity, 75% coverage: 40:240/267 of query aligns to 2:201/344 of 6cvlD

query
sites
6cvlD

L

M

I

I

V

K

L

L

D

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

R

H

R
x
Q

G

G

Q

T

Q

R

V

T

V
x
I

P

Q

V

A

L

L

E

N

R

N

I

V

S

S

F

L

N

H

I

V

A

P

A

A

G

G

E

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

N

R

L

C

I

V

A

N

G

L

I

L

D

E

R

R

P

P

D

T

S

E

G

G

T

S

L

V

S

L

V

V

A

D

G

G

Q

Q

D

E

I

L

A

T

L

L

E

S

E

E

A

S

E

E

L

L

A

T

A

K

W

A

R

R

A

R

E

Q

N

-

V

I

G

G

F

M

I

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

V

S

L

R

T

T

A

V

L

F

E

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

K

D

N

N

L

T

G

P

K

K

A

D

E

E

R

V

R

K

E

R

R

R

A

V

E

T

L

E

A

L

L

L

S

S

M

L

V

V

G

G

L

L

A

G

D

D

R

K

M

H

D

D

H

S

T

Y

P

P

N

S

E
x
N

L

L

S
|
S

G

G

Q
|
Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

I

A

T

S

D

N

P

P

T

K

L

V

I

L

V

L

A

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

E

A

S

T

A

T

G

R

D

S

I

I

L

L

H

E

L

L

Q

K

R

D

L

I

N

N

D

R

E

R

L

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H
|
H

D

E

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y50), Q14 (≠ R52), I19 (≠ V57), S41 (= S79), G42 (= G80), A43 (≠ S81), G44 (= G82), K45 (= K83), S46 (= S84), T47 (= T85), N141 (≠ E180), S143 (= S182), Q146 (= Q185), H200 (= H239)

8tzjA Cryo-em structure of vibrio cholerae ftse/ftsx complex (see paper)
40% identity, 81% coverage: 40:254/267 of query aligns to 2:211/220 of 8tzjA

query
sites
8tzjA

L

V

I

I

V

R

L

F

D

Q

N

Q

L

V

S

S

K

K

S

A

Y
|
Y

R

R

R

G

G

G

Q
x
R

Q

Q

V
x
A

V

-

P

-

V

-

L

L

E

Q

R

K

I

V

S

D

F

F

N

H

I

L

A

R

G

G

E

E

F

M

L

A

A

F

L

L

M

G

G

G

P

H

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T

T

L

L

N

K

L

L

I

I

A

C

G

A

I

I

D

E

R

R

P

P

D

T

S

D

G

G

T

K

L

I

S

S

V

F

A

N

G

G

Q

H

D

D

I

I

A

T

A

R

L

I

E

P

E

N

A

K

E

D

L

I

A

P

A

F

W

L

R

R

A

-

E

R

N

N

V

I

G

G

F

I

I

V

F

F

Q

Q

F

D

Y

H

N

R

L

L

M

L

P

M

V

D

L

R

T

S

A

I

L

Y

E

D

N

N

V

V

E

A

L

L

P

P

L

M

L

R

L

I

K

E

N

S

L

I

G

S

K

E

A

N

E

E

R

I

R

K

E

R

R

R

A

V

E

S

L

A

A

A

L

L

S

D

M

K

V

T

G

G

L

L

A

L

D

D

R

K

M

A

D

R

H

C

T

L

P

P

N

S

E

Q

L

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

G

I

I

A

A

R

R

A

A

L

V

I

V

T

N

D

R

P

P

T

T

L

L

I

L

V

L

A

A

D

D

E

E

P

P

T

T

G

G

D

N

L

L

D

D

R

P

E

E

S

L

A

S

G

S

D

R

I

V

L

L

H

R

L

L

L

F

Q

E

R

E

L

F

N

N

D

-

E

R

L

A

G

G

K

V

T

T

I

I

V

L

M

L

V

A

T

T

H

H

D

D

Q

I

R

H

A

L

A

V

E

N

S

S

A

R

H

P

A

Q

I

Y

M

R

H

H

L

L

E

E

binding adenosine-5'-diphosphate: Y12 (= Y50), R16 (≠ Q54), A18 (≠ V56), G39 (= G80), G41 (= G82), K42 (= K83), S43 (= S84)

Query Sequence

>Dsui_1462 Dsui_1462 ABC-type antimicrobial peptide transport system, ATPase component
MSGAVDGSAAAGSVLNAVGHQAGLGAGTGDTGSGTPAAPLIVLDNLSKSYRRGQQVVPVL
ERISFNIAAGEFLALMGPSGSGKSTLLNLIAGIDRPDSGTLSVAGQDIAALEEAELAAWR
AENVGFIFQFYNLMPVLTALENVELPLLLKNLGKAERRERAELALSMVGLADRMDHTPNE
LSGGQQQRVAIARALITDPTLIVADEPTGDLDRESAGDILHLLQRLNDELGKTIVMVTHD
QRAAESAHAIMHLEKGELSARQEIRPR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory