SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_2058 Dsui_2058 ABC-type branched-chain amino acid transport systems, ATPase component to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
35% identity, 95% coverage: 9:256/260 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

S

R

I

T

R

E

N

N

V

I

G

V

K

K

H

Y

F
|
F

G

G

G

E

L
x
F

H

K

V

A

L

L

Q

D

D

G

V

V

S

S

F

I

E

S

V

V

P

C

A

K

G

G

S

D

I

V

Y

T

G

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

N

L

V

I

I

T

T

G

G

L

F

L

L

T

K

P

A

S

D

A

E

G

G

Q

R

I

V

D

Y

F

F

Q

E

G

N

Q

K

T

D

L

I

I

T

G

N

L

K

E

E

P

P

H

A

R

E

I

L

T

Y

H

H

Q

Y

G

G

I

I

A

V

R

R

T

T

F

F

Q

Q

N

T

I

P

R

Q

I

P

F

L

K

K

E

E

M

M

D

T

L

V

L

L

E

E

N

N

V

L

M

L

V

I

G

G

M

-

H

-

D

-

H

E

L

I

N

N

Y

P

G

G

G

E

F

S

G

P

I

-

F

-

L

L

N

N

S

S

P

L

A

F

C

Y

R

K

A

K

-

W

-

I

-

P

A

K

E

E

K

E

A

M

R

V

E

E

R

K

A

A

L

F

E

K

L

I

L

L

S

E

W

F

V

L

G

K

L

L

D

S

H

H

K

L

A

Y

D

D

M

R

L

K

A

A

D

G

N

E

L

L

S

S

Y

G

G

G

D

Q

Q

M

R

K

K

L

L

V

E

E

F

I

A

G

R

R

A

A

L

L

A

M

T

T

E

N

P

P

K

K

L

M

L

I

L

V

L

M

D

D

E
|
E

P

P

V

I

A

A

G

G

M

V

N

A

P

P

S

G

E

L

K

A

T

H

I

D

L

I

M

F

E

N

E

H

I

V

N

L

N

E

I

L

R

K

N

A

R

K

G

G

Y

I

G

T

V

F

F

L

M

I

I

I

E

E

H

H

D

R

M

L

R

D

F

I

V

V

M

L

G

N

L

Y

C

I

D

D

R

H

I

L

A

Y

V

V

L

M

N

F

F

N

G

G

R

Q

I

I

A

A

E

E

G

G

T

R

P

G

D

E

E

E

-

E

-

I

-

K

-

N

V

V

R

L

N

S

N

D

P

P

D

K

V

V

I

V

E

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (= F19), F17 (≠ L22), N39 (= N44), G40 (= G45), S41 (≠ A46), G42 (= G47), K43 (= K48), S44 (≠ T49), T45 (= T50)
binding magnesium ion: S44 (≠ T49), E176 (= E183)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
34% identity, 96% coverage: 9:257/260 of query aligns to 4:254/254 of 1g6hA

query
sites
1g6hA

L

I

L

L

S

R

I

T

R

E

N

N

V

I

G

V

K

K

H

Y

F
|
F

G

G

G

E

L
x
F

H

K

V

A

L

L

Q

D

D

G

V

V

S

S

F

I

E

S

V

V

P

N

A

K

G

G

S

D

I

V

Y

T

G

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

N

L

V

I

I

T

T

G

G

L

F

L

L

T

K

P

A

S

D

A

E

G

G

Q

R

I

V

D

Y

F

F

Q

E

G

N

Q

K

T

D

L

I

I

T

G

N

L

K

E

E

P

P

H

A

R

E

I

L

T

Y

H

H

Q

Y

G

G

I

I

A

V

R

R

T

T

F

F

Q

Q

N

T

I

P

R

Q

I

P

F

L

K

K

E

E

M

M

D

T

L

V

L

L

E

E

N

N

V

L

M

L

V

I

G

G

M

E

-

I

-

C

-

P

-

G

H

E

D

S

H

P

L

L

N

N

Y

-

G

-

F

-

G

S

I

L

F

F

L

Y

N

K

S

K

P

W

A

I

C

P

R

K

A

-

E

E

K

E

A

M

R

V

E

E

R

K

A

A

L

F

E

K

L

I

L

L

S

E

W

F

V

L

G

K

L

L

D

S

H

H

K

L

A

Y

D

D

M

R

L

K

A

A

D

G

N

E

L

L

S

S

Y

G

G

G

D

Q

Q

M

R

K

K

L

L

V

E

E

F

I

A

G

R

R

A

A

L

L

A

M

T

T

E

N

P

P

K

K

L

M

L

I

L

V

L

M

D

D

E

E

P

P

V

I

A

A

G

G

M

V

N

A

P

P

S

G

E

L

K

A

T

H

I

D

L

I

M

F

E

N

E

H

I

V

N

L

N

E

I

L

R

K

N

A

R

K

G

G

Y

I

G

T

V

F

F

L

M

I

I

I

E

E

H

H

D

R

M

L

R

D

F

I

V

V

M

L

G

N

L

Y

C

I

D

D

R

H

I

L

A

Y

V

V

L

M

N

F

F

N

G

G

R

Q

I

I

A

A

E

E

G

G

T

R

P

G

D

E

E

E

-

E

-

I

-

K

-

N

V

V

R

L

N

S

N

D

P

P

D

K

V

V

I

V

E

E

A

I

Y

Y

L

I

G

G

K

E

binding adenosine-5'-diphosphate: F14 (= F19), F17 (≠ L22), N39 (= N44), G40 (= G45), S41 (≠ A46), G42 (= G47), K43 (= K48), S44 (≠ T49), T45 (= T50)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
34% identity, 96% coverage: 10:258/260 of query aligns to 3:237/238 of 6s8nB

query
sites
6s8nB

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F

Y

G

K

G

G

L

R

H

R

V

V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

I

I

F

F

K
x
R

E

R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L
x
M

A
x
G

D
x
Q

N

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

E

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

K

E

E

D

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ K97), M133 (≠ L154), G134 (≠ A155), Q135 (≠ D156)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
34% identity, 96% coverage: 10:258/260 of query aligns to 3:237/238 of 6s8gA

query
sites
6s8gA

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L
x
R

H

R

V
|
V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

I

I

F

F

K

R

E

R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D

Q

N
x
S

L

L

S
|
S

Y

G

G

G

D
x
E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

E

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H
|
H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

K

E

E

D

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F19), R15 (≠ L22), V17 (= V24), N37 (= N44), G38 (= G45), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50), Q84 (= Q91), S136 (≠ N157), S138 (= S159), E141 (≠ D162), H194 (= H215)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
35% identity, 95% coverage: 10:256/260 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L

R

H

R

V

V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

I

I

F

F

K

R

E

R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D

Q

N
x
S

L

L

S
|
S

Y
x
G

G
|
G

D
x
E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E
|
E

P

P

V

F

A

A

G
|
G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H
|
H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (≠ F19), P36 (= P43), N37 (= N44), G38 (= G45), A39 (= A46), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50), Q84 (= Q91), S136 (≠ N157), S138 (= S159), G139 (≠ Y160), G140 (= G161), E141 (≠ D162), E162 (= E183), G166 (= G187), H194 (= H215)

6mbnA Lptb e163q in complex with atp (see paper)
34% identity, 96% coverage: 10:258/260 of query aligns to 4:238/241 of 6mbnA

query
sites
6mbnA

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L
x
R

H

R

V
|
V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

I

I

F

F

K

R

E

R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D

Q

N

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

Q

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H
|
H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

K

E

E

D

binding adenosine-5'-triphosphate: Y13 (≠ F19), R16 (≠ L22), V18 (= V24), P37 (= P43), N38 (= N44), G39 (= G45), A40 (= A46), G41 (= G47), K42 (= K48), T43 (= T49), T44 (= T50), Q85 (= Q91), H195 (= H215)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
34% identity, 95% coverage: 10:255/260 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L
x
R

H

R

V
|
V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P
x
L

H
|
H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R
x
Y

T

L

F
x
P

Q
|
Q

N
x
E

I
x
A

R
x
S

I

I

F
|
F

K
x
R

E
x
R

M
x
L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-
x
V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D
x
Q

N

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R
|
R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

E

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F19), R15 (≠ L22), V17 (= V24), N37 (= N44), G38 (= G45), A39 (= A46), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding magnesium ion: T42 (= T49), Q84 (= Q91)
binding novobiocin: L71 (≠ P78), H72 (= H79), Y81 (≠ R88), P83 (≠ F90), E85 (≠ N92), A86 (≠ I93), S87 (≠ R94), F89 (= F96), F89 (= F96), R90 (≠ K97), R91 (≠ E98), L92 (≠ M99), V101 (vs. gap), Q135 (≠ D156), R149 (= R170)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
34% identity, 95% coverage: 10:255/260 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L
x
R

H

R

V
|
V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

I

A

R

S

I

I

F

F

K

R

E

R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D

Q

N

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

E

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F19), R15 (≠ L22), V17 (= V24), N37 (= N44), G38 (= G45), A39 (= A46), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding magnesium ion: T42 (= T49), Q84 (= Q91)

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 96% coverage: 9:258/260 of query aligns to 2:237/240 of 6mjpB

query
sites
6mjpB

L

I

L

L

S

K

I

A

R

Q

N

H

V

L

G

A

K

K

H

S

F

Y

G

K

L

R

H

K

V

V

L

V

Q

S

D

D

V

V

S

S

F

L

E

Q

V

V

P

E

A

S

G

G

S

Q

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

V

S

F

F

N

Y

L

M

I

I

T

V

G

G

L

L

L

V

T

A

P

R

S

D

A

E

G

G

Q

T

I

I

D

T

F

I

Q

D

G

D

Q

N

T

D

L

I

I

S

G

I

L

L

E

P

P

M

H

H

R

S

I

R

T

S

H

R

Q

M

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

I

I

F

F

K
x
R

E
x
K

M

L

D

S

L

V

L

E

E

D

N

N

V

I

M

M

V

A

G

V

M

L

H

Q

D

T

H

R

L

E

N

E

Y

L

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

-

A

T

E

H

K

E

A

R

R

Q

E

D

R

K

A

L

L

E

E

D

L

L

S

E

W

E

V

F

G

H

L

I

D

Q

H

H

K

I

A

R

D

K

M

S

L

A

A

G

D

M

N

A

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

Q

L

F

L

I

L

L

D

D

E

Q

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

K

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

R

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

D

L

V

C

C

D

E

R

K

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

R

I

L

I

I

A

A

E

E

G

G

T

T

P

P

D

Q

E

D

V

V

R

L

N

N

P

E

D

Q

V

V

I

K

E

Q

A

V

Y

Y

L

L

G

G

K

E

E

Q

binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (≠ K97), K91 (≠ E98)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 96% coverage: 9:258/260 of query aligns to 2:237/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

S

K

I

A

R

Q

N

H

V

L

G

A

K

K

H

S

F

Y

G

K

L

R

H

K

V

V

L

V

Q

S

D

D

V

V

S

S

F

L

E

Q

V

V

P

E

A

S

G

G

S

Q

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

V

S

F

F

N

Y

L

M

I

I

T

V

G

G

L

L

L

V

T

A

P

R

S

D

A

E

G

G

Q

T

I

I

D

T

F

I

Q

D

G

D

Q

N

T

D

L

I

I

S

G

I

L

L

E

P

P

M

H

H

R

S

I

R

T

S

H

R

Q

M

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

I

I

F

F

K

R

E

K

M

L

D

S

L

V

L

E

E

D

N

N

V

I

M

M

V

A

G

V

M

L

H

Q

D

T

H

R

L

E

N

E

Y

L

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

-

A

T

E

H

K
x
E

K

E

A

R

R

Q

E
x
D

R

K

A

L

L

E

E

D

L

L

S

E

W

E

V

F

G

H

L

I

D

Q

H

H

K

I

A

R

D

K

M

S

L

A

A

G

D

M

N

A

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

Q

L

F

L

I

L

L

D

D

E

Q

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

K

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

R

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

D

L

V

C

C

D

E

R

K

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

R

I

L

I

I

A

A

E

E

G

G

T

T

P

P

D

Q

E

D

V

V

R

L

N

N

P

E

D

Q

V

V

I

K

E

Q

A

V

Y

Y

L

L

G

G

K

E

E

Q

binding calcium ion: E111 (≠ K132), D115 (≠ E136)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
34% identity, 94% coverage: 10:254/260 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

S

T

I

A

R

K

N

N

V

L

G

A

K

K

H

A

F
x
Y

G

K

G

G

L
x
R

H

R

V
|
V

L

V

Q

E

D

D

V

V

S

S

F

L

E

T

V

V

P

N

A

S

G

G

S

E

I

I

Y

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

F

N

Y

L

M

I

V

T

V

G

G

L

I

L

V

T

P

P

R

S

D

A

A

G

G

Q

N

I

I

D

I

F

I

Q

D

G

D

Q

D

T

D

L

I

I

S

G

L

L

L

E

P

P

L

H

H

R

A

I

R

T

A

H

R

Q

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

I

I

F
|
F

K
x
R

E
x
R

M

L

D

S

L

V

L

Y

E

D

N

N

V

L

M

M

-

A

-

V

V

L

G

Q

M

I

H

R

D

D

H

D

L

L

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

S

A

A

E

E

K

Q

K

R

A

-

R

E

E

D

R

R

A

A

L

N

E

E

L

L

L

M

S

E

W

E

V

F

G

H

L

I

D

E

H

H

K

L

A

R

D

D

M

S

L

M

A

G

D

Q

N

S

L

L

S

S

Y

G

G

G

D

E

Q

R

R

R

K

R

L

V

E

E

F

I

A

A

R

R

A

A

L

L

A

A

T

A

E

N

P

P

K

K

L

F

L

I

L

L

D

D

E

E

P

P

V

F

A

A

G

G

M

V

N

D

P

P

S

I

E

S

K

V

T

I

I

D

L

I

M

K

E

R

E

I

I

I

N

E

N

H

I

L

R

R

N

D

R

S

G

G

Y

L

G

G

V

V

F

L

M

I

I

T

E

D

H

H

D

N

M

V

R

R

F

E

V

T

M

L

G

A

L

V

C

C

D

E

R

R

I

A

A

Y

V

I

L

V

N

S

F

Q

G

G

R

H

I

L

I

I

A

A

E

H

G

G

T

T

P

P

D

T

E

E

V

I

R

L

N

Q

N

D

P

E

D

H

V

V

I

K

E

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F19), R15 (≠ L22), V17 (= V24), N37 (= N44), G38 (= G45), A39 (= A46), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F96), R90 (≠ K97), R91 (≠ E98)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
32% identity, 95% coverage: 9:256/260 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

L

V

L

L

S

E

I

V

R

Q

N

S

V

L

G

H

K

V

H

Y

F
x
Y

G

G

G

A

L
x
I

H

H

V
x
A

L

I

Q

K

D

G

V

I

S

D

F

L

E

K

V

V

P

P

A

R

G

G

S

Q

I

I

Y

V

G

T

L

L

I

I

G

G

P

A

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

L

N

S

L

A

I

I

T

A

G

G

L

L

L

V

T

R

P

A

S

Q

A

K

G

G

Q

K

I

I

D

I

F

F

Q

N

G

G

Q

Q

T

D

L

I

I

T

G

N

L

K

E

P

P

A

H

H

R

V

I

I

T

N

H

R

Q

M

G

G

I

I

A

A

R

L

T

V

F

P

Q
x
E

N

G

I

R

R

R

I

I

F

F

K

P

E

E

M

L

D

T

L

V

L

Y

E

E

N

N

V

L

M

M

V

M

G

G

M

A

H

Y

D

N

H

R

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

-

A

K

E

D

K

K

K

E

A

G

R

I

E

K

R

R

A

D

L

L

E

E

L

-

S

-

W

W

V

I

-

F

-

S

-

L

-

F

-

P

G

R

L

L

D

K

H

E

K

R

A

L

D

K

M

Q

L

L

A

G

D

G

N

T

L

L

S

S

Y

G

G

G

D

E

Q

Q

R

Q

K

M

L

L

E

A

F

I

A

G

R

R

A

A

L

L

A

M

T

S

E

R

P

P

K

K

L

L

L

M

D
|
D

E
|
E

P

P

V

S

A

L

G

G

M

L

N

A

P

P

S

I

E

L

K

V

T

S

I

E

L

V

M

F

E

E

E

V

I

I

N

Q

N

K

I

I

R

N

N

Q

R

E

G

G

Y

T

G

T

V

I

F

L

M

L

I

V

E

E

H

Q

D

N

M

A

R

L

F

G

V

A

M

L

G

K

L

V

C

A

D

H

R

Y

I

G

A

Y

V

V

L

L

N

E

F

T

G

G

R

Q

I

I

I

V

A

L

E

E

G

G

T

K

P

A

D

S

E

E

V

L

R

L

N

D

N

N

P

E

D

M

V

V

I

R

E

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (≠ F19), I19 (≠ L22), A21 (≠ V24), N41 (= N44), G42 (= G45), A43 (= A46), G44 (= G47), K45 (= K48), T46 (= T49), T47 (= T50), E88 (≠ Q91), D164 (= D182), E165 (= E183)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
32% identity, 92% coverage: 9:248/260 of query aligns to 1:232/343 of P30750

query
sites
P30750

L

M

L

I

S

K

I

L

R

S

N

N

V

I

G

T

K

K

H

V

F

F

G

H

-

Q

-

G

-

T

-

R

G

T

L

I

H

Q

V

A

L

L

Q

N

D

N

V

V

S

S

F

L

E

H

V

V

P

P

A

A

G

G

S

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

L

C

I

V

T

N

G

L

L

L

L

E

T

R

P

P

S

T

A

E

G

G

Q

S

I

V

D

L

F

V

Q

D

G

G

Q

Q

T

E

L

L

I

T

G

T

L

L

E

S

P

E

H

S

R

E

I

L

T

T

-

K

-

A

H

R

Q

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

I

L

F

L

K

S

E

S

M

R

D

T

L

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

M

L

H

E

D

-

H

-

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

L

L

D

N

N

S

T

P

P

A

-

C

-

R

-

A

-

E

K

K

D

K

E

A

V

R

K

E

R

R

R

A

V

L

T

E

E

L

L

S

S

W

L

V

V

G

G

L

L

D

G

H

D

K

K

A

H

D

D

M

S

L

Y

A

P

D

S

N

N

L

L

S

S

Y

G

G

G

D

Q

Q

K

R

Q

K

R

L

V

E

A

F

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

L

C

D

D

E
|
E

P

A

V

T

A

S

G

A

M

L

N

D

P

P

S

A

E

T

K

T

T

R

I

S

L

I

M

L

E

E

E

L

I

L

N

K

N

D

I

I

R

N

N

R

R

R

-

L

G

G

Y

L

G

T

V

I

F

L

M

L

I

I

E

T

H

H

D

E

M

M

R

D

F

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

I

V

A

A

V

V

L

I

N

S

F

N

G

G

R

E

I

L

I

I

A

E

E

Q

G

D

T

T

P

V

D

S

E

E

V

V

R

F

N

S

N

H

P

P

40:46 (vs. 44:50, 71% identical) binding
E166 (= E183) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
31% identity, 93% coverage: 8:248/260 of query aligns to 1:233/344 of 3tuzC

query
sites
3tuzC

N

H

L

M

L

I

S

K

I

L

R

S

N

N

V

I

G

T

K

K

H

V

F
|
F

G

H

-
x
Q

-

G

-

T

-

R

G

T

L

I

H

Q

V
x
A

L

L

Q

N

D

N

V

V

S

S

F

L

E

H

V

V

P

P

A

A

G

G

S

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

L

C

I

V

T

N

G

L

L

L

L

E

T

R

P

P

S

T

A

E

G

G

Q

S

I

V

D

L

F

V

Q

D

G

G

Q

Q

T

E

L

L

I

T

G

T

L

L

E

S

P

E

H

S

R

E

I

L

T

T

-

K

-

A

H

R

Q

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

I

L

F

L

K

S

E

S

M

R

D

T

L

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

M

L

H

E

D

-

H

-

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

L

L

D

N

N

S

T

P

P

A

-

C

-

R

-

A

-

E

K

K

D

K

E

A

V

R

K

E

R

R

R

A

V

L

T

E

E

L

L

S

S

W

L

V

V

G

G

L

L

D

G

H

D

K

K

A

H

D

D

M

S

L

Y

A

P

D

S

N

N

L

L

S

S

Y

G

G

G

D

Q

Q

K

R

Q

K

R

L

V

E

A

F

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

L

C

D

D

E

Q

P

A

V

T

A

S

G

A

M

L

N

D

P

P

S

A

E

T

K

T

T

R

I

S

L

I

M

L

E

E

E

L

I

L

N

K

N

D

I

I

R

N

N

R

R

R

-

L

G

G

Y

L

G

T

V

I

F

L

M

L

I

I

E

T

H

H

D

E

M

M

R

D

F

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

I

V

A

A

V

V

L

I

N

S

F

N

G

G

R

E

I

L

I

I

A

E

E

Q

G

D

T

T

P

V

D

S

E

E

V

V

R

F

N

S

N

H

P

P

binding adenosine-5'-diphosphate: F12 (= F19), Q14 (vs. gap), A21 (≠ V24), G42 (= G45), A43 (= A46), G44 (= G47), K45 (= K48), S46 (≠ T49), T47 (= T50)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 312, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
31% identity, 93% coverage: 8:248/260 of query aligns to 1:233/344 of 3tuiC

query
sites
3tuiC

N

H

L

M

L

I

S

K

I

L

R

S

N

N

V

I

G

T

K

K

H

V

F
|
F

G

H

-
x
Q

-

G

-

T

-

R

G

T

L

I

H

Q

V

A

L

L

Q

N

D

N

V

V

S

S

F

L

E

H

V

V

P

P

A

A

G

G

S

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

L

C

I

V

T

N

G

L

L

L

L

E

T

R

P

P

S

T

A

E

G

G

Q

S

I

V

D

L

F

V

Q

D

G

G

Q

Q

T

E

L

L

I

T

G

T

L

L

E

S

P

E

H

S

R

E

I

L

T

T

-

K

-

A

H

R

Q

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

I

L

F

L

K

S

E

S

M

R

D

T

L

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

M

L

H

E

D

-

H

-

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

L

L

D

N

N

S

T

P

P

A

-

C

-

R

-

A

-

E

K

K

D

K

E

A

V

R

K

E

R

R

R

A

V

L

T

E

E

L

L

S

S

W

L

V

V

G

G

L

L

D

G

H

D

K

K

A

H

D

D

M

S

L

Y

A

P

D

S

N

N

L

L

S

S

Y

G

G

G

D

Q

Q

K

R

Q

K

R

L

V

E

A

F

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

L

C

D

D

E

Q

P

A

V

T

A

S

G

A

M

L

N

D

P

P

S

A

E

T

K

T

T

R

I

S

L

I

M

L

E

E

E

L

I

L

N

K

N

D

I

I

R

N

N

R

R

R

-

L

G

G

Y

L

G

T

V

I

F

L

M

L

I

I

E

T

H

H

D

E

M

M

R

D

F

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

I

V

A

A

V

V

L

I

N

S

F

N

G

G

R

E

I

L

I

I

A

E

E

Q

G

D

T

T

P

V

D

S

E

E

V

V

R

F

N

S

N

H

P

P

binding adenosine-5'-diphosphate: F12 (= F19), Q14 (vs. gap), S41 (≠ N44), G42 (= G45), A43 (= A46), G44 (= G47), K45 (= K48), S46 (≠ T49), T47 (= T50)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
31% identity, 93% coverage: 8:248/260 of query aligns to 1:233/344 of 6cvlD

query
sites
6cvlD

N

H

L

M

L

I

S

K

I

L

R

S

N

N

V

I

G

T

K

K

H

V

F
|
F

G

H

-
x
Q

-

G

-

T

-

R

G

T

L
x
I

H

Q

V

A

L

L

Q

N

D

N

V

V

S

S

F

L

E

H

V

V

P

P

A

A

G

G

S

Q

I

I

Y

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

L

C

I

V

T

N

G

L

L

L

L

E

T

R

P

P

S

T

A

E

G

G

Q

S

I

V

D

L

F

V

Q

D

G

G

Q

Q

T

E

L

L

I

T

G

T

L

L

E

S

P

E

H

S

R

E

I

L

T

T

-

K

-

A

H

R

Q

R

G

Q

I

I

A

G

R

M

T

I

F

F

Q

Q

N

H

I

F

R

N

I

L

F

L

K

S

E

S

M

R

D

T

L

V

L

F

E

G

N

N

V

V

M

A

V

L

G

P

M

L

H

E

D

-

H

-

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

L

L

D

N

N

S

T

P

P

A

-

C

-

R

-

A

-

E

K

K

D

K

E

A

V

R

K

E

R

R

R

A

V

L

T

E

E

L

L

S

S

W

L

V

V

G

G

L

L

D

G

H

D

K

K

A

H

D

D

M

S

L

Y

A

P

D

S

N
|
N

L
|
L

S
|
S

Y
x
G

G
|
G

D
x
Q

Q

K

R

Q

K

R

L

V

E

A

F

I

A

A

R

R

A

A

L

L

A

A

T

S

E

N

P

P

K

K

L

V

L

L

L

C

D

D

E

Q

P

A

V

T

A

S

G

A

M

L

N

D

P

P

S

A

E

T

K

T

T

R

I

S

L

I

M

L

E

E

E

L

I

L

N

K

N

D

I

I

R

N

N

R

R

R

-

L

G

G

Y

L

G

T

V

I

F

L

M

L

I

I

E

T

H
|
H

D

E

M

M

R

D

F

V

V

V

M

K

G

R

L

I

C

C

D

D

R

C

I

V

A

A

V

V

L

I

N

S

F

N

G

G

R

E

I

L

I

I

A

E

E

Q

G

D

T

T

P

V

D

S

E

E

V

V

R

F

N

S

N

H

P

P

binding phosphothiophosphoric acid-adenylate ester: F12 (= F19), Q14 (vs. gap), I19 (≠ L22), S41 (≠ N44), G42 (= G45), A43 (= A46), G44 (= G47), K45 (= K48), S46 (≠ T49), T47 (= T50), N141 (= N157), L142 (= L158), S143 (= S159), G144 (≠ Y160), G145 (= G161), Q146 (≠ D162), H200 (= H215)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 92% coverage: 9:248/260 of query aligns to 2:227/241 of 4u00A

query
sites
4u00A

L

I

S

R

I

I

R

R

N

N

V

L

G

H

K

K

H

W

F
|
F

G

G

G

P

L
|
L

H

H

V
|
V

L

L

Q

K

D

G

V

I

S

H

F

L

E

E

V

V

P

A

A

P

G

G

S

E

I

K

Y

L

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

L

T

I

I

T

N

G

R

L

L

L

E

T

D

P

F

S

Q

A

E

G

G

Q

E

I

V

D

V

F

V

Q

D

G

G

Q

L

T

S

L

V

I

K

G

D

L

D

E

R

P

A

H

L

R

R

I

E

T

I

H

R

Q

R

G

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

Q

I

F

R

N

I

L

F

F

K

P

E

H

M

M

D

T

L

V

L

L

E

E

N

N

V

V

M

T

V

L

G

A

M

-

H

-

D

-

H

-

L

-

N

-

Y

-

G

-

F

-

G

-

I

-

F

-

L

-

N

P

S

M

P

R

A

V

C

R

R

R

A

W

A

P

E

R

K

E

K

K

A

A

R

E

E

K

R

K

A

A

L

L

E

E

L

L

S

E

W

R

V

V

G

G

L

I

D

L

H

D

K

Q

A

A

D

R

M

K

L

Y

A

P

D

A

N

Q

L

L

S

S

Y

G

G

G

D

Q

Q

Q

R

Q

K

R

L

V

E

A

F

I

A

A

R

R

A

A

L

L

A

A

T

M

E

E

P

P

K

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

V

T

A

S

G

A

M

L

N

D

P

P

S

E

E

M

K

V

T

G

I

E

L

V

M

L

E

D

E

V

I

M

N

R

N

D

I

L

R

A

N

Q

R

G

G

G

Y

M

G

T

V

M

F

V

M

V

I

V

E

T

H

H

D

E

M

M

R

G

F

F

V

A

M

R

G

E

L

V

C

A

D

D

R

R

I

V

A

V

V

F

L

M

N

D

F

G

G

G

R

Q

I

I

I

V

A

E

E

E

G

G

T

R

P

P

D

E

E

E

V

I

R

F

N

T

N

R

P

P

binding adenosine-5'-diphosphate: F12 (= F19), L15 (= L22), V17 (= V24), S37 (≠ N44), G38 (= G45), S39 (≠ A46), G40 (= G47), K41 (= K48), S42 (≠ T49), T43 (= T50)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
34% identity, 92% coverage: 8:245/260 of query aligns to 3:224/285 of 4yerA

query
sites
4yerA

N

D

L

I

S

V

I

V

R

E

N

N

V

L

G

V

K

K

H

K

F
|
F

G

G

G

D

L
x
F

H

E

V
x
A

L

V

Q

K

D

G

V

V

S

S

F

F

E

S

V

V

P

K

A

K

G

G

S

E

I

I

Y

F

G

A

L

F

I

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

V

T

F

I

N

H

L

M

I

L

T

T

G

T

L

L

T

K

P

P

S

T

A

S

G

G

Q

K

I

A

D

W

F

V

Q

A

G

G

Q

H

T

D

L

V

I

L

G

K

L

-

E

E

P

P

H

-

R

R

I

E

T

V

H

R

Q

R

G

K

I

I

A

G

R

I

T

V

F

F

Q

Q

N

D

I

Q

R

S

I

L

F

D

K

R

E

E

M

L

D

T

L

A

L

Y

E

E

N

N

V

-

M

-

V

-

G

-

M

M

H

Y

D

I

H

H

L

G

N

K

Y

I

G

Y

G

G

F

Y

G

G

I

-

F

-

L

-

N

-

S

-

P

-

A

-

C

-

R

-

A

-

E

G

K

E

K

K

A

L

R

K

E

K

R

R

A

I

L

L

E

E

L

L

S

E

W

F

V

V

G

E

L

L

D

L

H

E

K

F

A

K

D

D

M

K

L

P

A

V

D

K

N
x
T

L
x
F

S
|
S

Y

G

G

G

D

M

Q

A

R

R

K

R

L

L

E

E

F

I

A

A

R

R

A

S

L

L

A

I

T

H

E

E

P

P

K

E

L

V

L

L

L

F

L

L

D

D

E

E

P

P

V

T

A

I

G

G

M

L

N

D

P

P

S

H

E

T

K

R

T

A

I

H

L

M

M

W

E

E

E

Y