SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_2086 Dsui_2086 cytochrome c to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q47945 Alcohol dehydrogenase (quinone), cytochrome c subunit; ADH; Alcohol dehydrogenase (quinone), subunit II; Cytochrome c-553; Cytochrome c553; Ethanol:Q2 reductase; G3-ADH subunit II; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
42% identity, 59% coverage: 20:430/696 of query aligns to 18:434/478 of Q47945

query
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Q47945

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Q37 (≠ E41) modified: Pyrrolidone carboxylic acid

Sites not aligning to the query:

1:36 signal peptide

8gy2B Cryo-em structure of membrane-bound alcohol dehydrogenase from gluconobacter oxydans
43% identity, 56% coverage: 43:430/696 of query aligns to 1:396/433 of 8gy2B

query
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8gy2B

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binding heme c: C18 (= C60), C21 (= C63), H22 (= H64), T46 (= T88), I48 (= I90), Y59 (= Y101), L68 (≠ M110), R73 (≠ A115), V79 (≠ L121), Y80 (= Y122), M83 (= M125), F88 (≠ Y130), R126 (= R168), H165 (= H206), C166 (= C207), C169 (= C210), H170 (= H211), I201 (≠ R243), A202 (= A244), P203 (≠ L245), L205 (= L247), W216 (= W251), F224 (= F259), A234 (≠ T269), V235 (≠ A270), F236 (≠ S271), F236 (≠ S271), M239 (= M274), N301 (≠ F337), C302 (= C338), C305 (= C341), H306 (= H342), M316 (≠ I352), F317 (= F353), P318 (= P354), L320 (= L356), P324 (= P360), G342 (≠ W378), S352 (≠ R388), V354 (≠ F390), M356 (= M392), F359 (= F395), M375 (≠ V410)
binding ubiquinone-10: C21 (= C63), L34 (≠ R76), P39 (= P81), P81 (= P123), L129 (= L171), W132 (= W174), E168 (≠ A209), R173 (= R214), I197 (≠ V239), D241 (≠ E276)

Sites not aligning to the query:

binding heme c: 428

7w2jC Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
38% identity, 55% coverage: 48:431/696 of query aligns to 1:387/418 of 7w2jC

query
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7w2jC

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M
|
M

P
|
P

G

A

F
|
F

A

G

-

P

-

D

-

S

-

L

-

V

-

Q

R

P

L

L

N

T

D

D

Q

E

E

Q

L

I

A

A

E

T

L

I

I

A

T

D

F

Y

V

V

R

L

S

S

S

H

W

F

G

G

N

N

G

A

G

Q

E

A

A

T

V

V

T

S

A

A

S

D

Q

A

V

V

K

K

K

Q

M

V

R

R

A

A

binding heme c: C13 (= C60), C16 (= C63), H17 (= H64), T42 (= T88), I44 (= I90), Y55 (= Y101), L75 (= L121), Y76 (= Y122), A78 (= A124), M79 (= M125), R122 (= R168), H161 (= H206), C162 (= C207), C165 (= C210), H166 (= H211), A191 (= A244), P192 (≠ L245), R223 (≠ T269), P227 (≠ N273), M228 (= M274), V289 (≠ F337), C290 (= C338), C293 (= C341), H294 (= H342), Y305 (≠ I352), Y306 (≠ F353), P307 (= P354), L309 (= L356), N312 (= N359), T313 (≠ P360), T314 (≠ A361), D322 (≠ T369), I327 (≠ T374), V331 (≠ W378), R333 (≠ T380), I340 (≠ F390), M342 (= M392), P343 (= P393), F345 (= F395)

8jejC Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
38% identity, 55% coverage: 48:431/696 of query aligns to 1:401/413 of 8jejC

query
sites
8jejC

I

I

A

S

R

R

G

G

E

H

Y

Y

L

L

A

A

R

I

L

A

G

A

D

D

C
|
C

V

A

A

A

C
|
C

H
|
H

T

T

-

N

A

G

E

R

G

D

G

G

K

Q

S

F

M

L

A

A

G

G

R

Y

E

A

L

I

A

S

T

S

P

P

F
x
M

G

G

V

N

L

I

F

Y

S

S

T
|
T

N

N

I
|
I

T

T

P

P

D

S

K

K

E

T

T

H

G

G

I

I

G

G

N

N

Y

Y

T

T

F

L

A

E

Q

Q

F
|
F

D

S

R

K

A

A

M
x
L

R

R

K

H

G

G

V

I

A

R

A

A

D

D

G

G

H

A

N

Q

L
|
L

Y
|
Y

P
|
P

A

A

M
|
M

P
|
P

Y

Y

P

D

S

A

Y
|
Y

A

N

K

R

M

L

T

T

G

D

E

E

D

D

M

V

Q

K

A

S

L

L

Y

Y

A

A

Y

Y

L

I

M

M

Q

T

G

E

L

V

A

K

P

P

V

V

K

D

Q

A

A

P

N

S

K

P

P

K

T

T

A

Q

M

L

R

P

W

F

P

P

F

F

N

S

Q

I

R
|
R

W

A

G
x
S

L

L

S

G

L

I

W
|
W

N

K

W

I

A

A

F

A

-

R

L

I

D

E

A

G

T

K

P

P

F

Y

Q

V

P

F

D

D

A

H

G

T

K

H

D

N

A

D

T

D

W

W

N

N

R

R

G

G

A

R

Y

Y

L

L

V

V

Q

D

G

E

L

L

G

A

H

H

C
|
C

G

G

A

E

C
|
C

H
|
H

T

T

P

P

R

R

G

N

I

F

A

L

F
x
L

Q

A

E

P

K

N

A

Q

M

S

S

A

D

-

A

-

G

-

S

-

K

-

G

-

K

-

H

-

F

Y

L

L

A

A

G

G

E

A

T

D

V
x
I

E

G

S

S

W
|
W

R

R

A
|
A

L
x
P

S

N

L
x
I

R

T

-

N

-

A

-

P

-

Q

-

S

-

G

-

I

G

G

L

S

W
|
W

T

S

V

D

E

Q

D

D

T

L

A

F

L

Q

F
x
Y

L

L

K

K

T

T

G

G

Q

K

N

T

R

A

F

H

A

A

T
x
R

A

A

S

A

G

G

N

P

M
|
M

A

A

E

E

V

A

I

I

H

E

H

H

S

S

T

L

Q

Q

H

Y

V

L

K

P

D

D

E

A

D

D

L

I

V

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A

A

I

I

A

V

T

T

Y

Y

L

L

K

R

S

S

L

V

P

P

P

A

G

K

E

A

H

E

E

S

L

-

P

-

A

G

P

Q

S

T

V

V

P

A

R

N

S

F

E

E

V

H

A

A

G

G

K

R

-

P

-

S

-

Y

V

S

P

V

G

A

N

N

L

A

F

N

S

S

S

R

R

R

-

S

-

N

-

S

-

T

-

L

-

T

-

K

-

T

-

D

G

G

G

A

L

A

A

L

Y

Y

V

E

Q

A

F
x
V

C
|
C

G

A

D

S

C
|
C

H
|
H

R

Q

Q

S

D

D

G

G

N

K

G

G

V

S

S

K

K

D

-

G

I

Y

F
x
Y

P
|
P

P

S

L
|
L

A

V

G

G

N

N

P
x
T

A
x
T

V

T

T

G

A

Q

K

L

D

N

P

P

A

N

T
x
D

L

L

L

I

H

A

I

S

T
x
I

L

L

T

Y

G

G

W
x
V

K

D

T
x
R

A

-

S

T

T

T

A

D

A

N

H

H

P

E

R

-

V

-

F
x
I

T

L

M
|
M

P

P

G

A

F
|
F

A

G

-

P

-

D

-

S

-

L

-

V

-

Q

R

P

L

L

N

T

D

D

Q

E

E

Q

L

I

A

A

E

T

L
x
I

I

A

T

D

F

Y

V

V

R

L

S

S

S

H

W

F

G

G

N

N

G

A

G

Q

E

A

A

T

V

V

T

S

A

A

S

D

Q

A

V

V

K

K

K

Q

M

V

R

R

A

A

binding heme c: C13 (= C60), C16 (= C63), H17 (= H64), T42 (= T88), I44 (= I90), F60 (= F106), L64 (≠ M110), L75 (= L121), Y76 (= Y122), M79 (= M125), P80 (= P126), Y84 (= Y130), R122 (= R168), C162 (= C207), C165 (= C210), H166 (= H211), I186 (≠ V239), W189 (= W242), A191 (= A244), P192 (≠ L245), I194 (≠ L247), W205 (= W251), Y213 (≠ F259), R223 (≠ T269), M228 (= M274), V303 (≠ F337), C304 (= C338), C307 (= C341), H308 (= H342), Y320 (≠ F353), P321 (= P354), L323 (= L356), T327 (≠ P360), T328 (≠ A361), D336 (≠ T369), I341 (≠ T374), V345 (≠ W378), R347 (≠ T380), I354 (≠ F390), M356 (= M392), F359 (= F395), I376 (≠ L406)
binding ubiquinone-10: M36 (≠ F82), P77 (= P123), S124 (≠ G170), W128 (= W174), C165 (= C210), L173 (≠ F218)

Sites not aligning to the query:

binding ubiquinone-10: 408, 411

8gy3A Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
34% identity, 54% coverage: 40:413/696 of query aligns to 33:410/440 of 8gy3A

query
sites
8gy3A

A

A

E

S

A

S

A

F

D

S

A

A

G

D

Q

A

I

I

A

S

R

R

G

G

E

E

Y

I

L

V

A

A

R

N

L

G

G

G

D
x
Y

C
|
C

V

A

A
x
E

C
|
C

H
|
H

T

T

A

R

E

V

G

D

G

G

K

K

-

P

-

G

-

P

S

E

M

L

A

A

G

G

G

D

R

F

E

K

L

M

A

A

T
|
T

P

P

F
|
F

G

G

V

D

L

I

F

F

S

S

T
x
S

N

N

I
|
I

T

T

P

P

D

D

K

E

E

E

T

W

G

G

I

I

G

G

N

N

Y
x
W

T

S

F

L

A

A

Q

A

F
|
F

D

K

R

R

A

A

M

M

R

N

K

K

G

G

V

I

A

A

A

R

D

D

G

G

H

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N

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|
L

Y
|
Y

P
|
P

A

A

M
x
F

P

P

Y

F

P

D

S

H

Y
x
F

A

T

K

K

M

V

T

S

G

D

E

Q

D

D

M

V

Q

S

A

D

L

L

Y

Y

A

A

Y

Y

L

L

M

M

Q

T

G

R

L

P

A

A

P

-

V

V

K

H

Q

L

A

K

N

P

K

R

P

D

T

N

A

T

M

V

R

P

W

F

P

P

F
x
I

N

N

Q

I

R
|
R

W

L

-

I

G
|
G

L
x
Q

S

G

L
x
F

W
|
W

N

K

W

L

A

L

F

F

L

F

D

T

A

P

T

G

P

R

F

Y

Q

Q

P

N

D

D

A

P

G

K

K

H

D

D

A

A

T

Q

W

W

N

N

R

R

G

G

A

A

Y

Y

L

L

V

A

Q

E

G

G

L

N

G

E

H
|
H

C
|
C

G

G

A

A

C
|
C

H
|
H

T

T

P

P

R
|
R

G

N

I

L

A
x
L

F

G

Q

A

E

E

K

K

A

M

M

S

S

S

D

-

A

-

G

-

S

-

K

-

G

-

K

-

H

-

F

V

L

Y

A

D

G

G

E

A

T

V

V

I

E

D

S

G

W

W

R

I

A
|
A

L
x
P

S

P

L
|
L

R

N

G

D

-

H

-

N

-

P

-

T

-

P

-

V

L

V

W
|
W

T

T

V

E

E

D

D

E

T

L

A

F

L

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F
x
Y

L
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L

K

R

T

F

G

G

Q

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N

A

R

P

F

L

-

H

A
x
G

T
x
S

A

A

S

A

G

G

N

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M
|
M

A

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E

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V

I

P

H

H

H

R

S

F

T

L

Q

S

H

K

V

I

K

P

D

E

E

E

D

D

L

V

V

H

A

A

I

I

A

A

T

H

Y

Y

L
x
Y

K

A

S

D

L

V

P

D

P

K

G

A

E

A

H

Q

E

R

L

S

P

S

A

G

-

D

-

Q

P

A

S

A

V

I

P

T

R

R

S

A

-

M

E

Q

V

M

A

S

G

G

K

R

-

D

V

L

P

T

G

G

N

P

L

Q

F

P

S

L

S

D

R

E

G

D

G

A

L

R

A

L

Y

Y

V

Q

Q

G

F

A

C
|
C

G

G

D

A

C
|
C

H
|
H

R

Y

Q

N

D

S

G

G

N

P

G

N

V

P

S

V

K

L

I

G

F

R

P
|
P

P

E

L
|
L

A

A

G

L

N
|
N

P
x
N

A

A

V

L

T

W

A

L

K

D

D

E

P

P

A

N

T

N

L

L

L

Y

H

Q

I
x
V

T

M

L

L

T

H

G

G

W
x
I

K

T

T

A

A

E

S

E

T
x
G

A
x
Q

A

D

H

H

P

-

R

-

V

-

F
x
I

T

S

M
|
M

P

P

G

S

F
|
F

-

Y

A

S

R

G

L

L

N

S

D

D

Q

H

E

D

L

M

A

A

E

R

L

I

I

A

T

A

F

Y

V

L

R

R

S

R

S

T

binding heme c: Y52 (≠ D59), C53 (= C60), C56 (= C63), H57 (= H64), S84 (≠ T88), I86 (= I90), W97 (≠ Y101), F102 (= F106), L117 (= L121), F121 (≠ M125), F126 (≠ Y130), R163 (= R168), C203 (= C207), C206 (= C210), H207 (= H211), A232 (= A244), P233 (≠ L245), L235 (= L247), W245 (= W251), Y253 (≠ F259), L254 (= L260), G263 (≠ A268), S264 (≠ T269), M269 (= M274), Y292 (≠ L297), C337 (= C338), C340 (= C341), H341 (= H342), P353 (= P354), L355 (= L356), N358 (= N359), N359 (≠ P360), V372 (≠ I373), I377 (≠ W378), G382 (≠ T383), Q383 (≠ A384), I386 (≠ F390), M388 (= M392), F391 (= F395)
binding ubiquinone-10: E55 (≠ A62), T76 (= T80), F78 (= F82), Y118 (= Y122), P119 (= P123), I160 (≠ F165), G166 (= G170), Q167 (≠ L171), F169 (≠ L173), W170 (= W174), H202 (= H206), R210 (= R214), L213 (≠ A217)

D3RVD4 Thiosulfate dehydrogenase; Tetrathionate synthase; EC 1.8.2.2 from Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) (Chromatium vinosum) (see 2 papers)
43% identity, 32% coverage: 461:684/696 of query aligns to 50:270/270 of D3RVD4

query
sites
D3RVD4

E

E

Q

S

L

I

V

V

R

R

G

G

M

R

R

R

L

Y

H

L

L

S

E

D

T

T

K

P

D

A

L

Q

L

L

P

P

N

D

H

F

V

V

G

G

D

N

Q

G

L

L

N

A

C

C

T

R

S

H

C

C

H

H

L

P

-

G

-

R

-

D

-

G

N

E

A

V

G

G

T

T

V

E

A

A

D

N

G

A

S

A

P

P

F

F

V

V

G

G

V

V

S

V

A

G

F

R

F

F

P

P

S

Q

Y

Y

A

S

P

A

R

R

A

H

G

G

R

R

I

L

I

I

T

T

L

L

E

E

D

Q

R

R

I

I

N

G

G

D

C
|
C

F

F

K

E

R

R

S

S

M

L

N

N

G

G

K

R

P

A

L

L

P

A

V

L

E

D

S

H

A

P

D

A

M

L

K

I

A

D

M

M

V

L

A

A

Y

Y

F

M

D

S

W

W

M

L

K

S

G

Q

A

G

T

V

K

P

P

V

E

G

D

A

K

V

V

V

P

A

G

G

R

H

G

G

I

I

G

P

K

T

I

L

D

T

R

L

S

E

L

R

K

E

P

P

D

D

S

G

D

V

N

H

G

G

K

E

K

A

I

L

Y

Y

A

Q

E

A

Q

R

C

C

A

L

V

A

C

C

H

H

G

G

E

A

N

D

G

G

E

S

G

G

L

T

K

L

S

D

A

A

D

D

G

G

K

R

M

Y

V

L

Y

F

P

P

L

L

W

W

G

G

D

P

E

R

S

S

F

F

N

N

I

T

G

G

A

A

G

G

M

M

A

N

R

R

T

Q

Y

A

T

T

A

A

A

G

F

F

V

I

K

K

R

H

N

K

M

M

P

P

I

L

G

G

F

-

H

-

G

-

K

-

F

-

P

-

L

-

G

A

Q

D

G

D

G

S

L

L

S

S

D

D

Q

E

E

E

A

A

L

W

D

D

V

V

A

A

E

G

Y

F

F

V

S

L

H

T

Q

H

P

P

R

R

P

P

D

L

F

F

P

Q

E

E

K

P

V

T

K

G

D

D

C123 (= C530) mutation to G: Loss of function.

Sites not aligning to the query:

1:27 signal peptide

4v2kA Crystal structure of the thiosulfate dehydrogenase tsda in complex with thiosulfate (see paper)
43% identity, 31% coverage: 461:678/696 of query aligns to 20:234/235 of 4v2kA

query
sites
4v2kA

E

E

Q

S

L

I

V

V

R

R

G

G

M

R

R

R

L

Y

H

L

L

S

E

D

T

T

K

P

D

A

L

Q

L

L

P

P

N

D

H

F

V

V

G

G

D

N

Q

G

L

L

N

A

C
|
C

T

R

S
x
H

C
|
C

H
|
H

L
x
P

-

G

-

R

-

D

-

G

N

E

A

V

G

G

T

T

V

E

A

A

D

N

G

A

S

A

P

P

F
|
F

V

V

G

G

V

V

S

V

A

G

F

R

F

F

P

P

S

Q

Y

Y

A

S

P

A

R
|
R

A

H

G

G

R

R

I

L

I

I

T

T

L

L

E

E

D

Q

R
|
R

I

I

N

G

G

D

C
|
C

F
|
F

K

E

R
|
R

S
|
S

M
x
L

N

N

G

G

K

R

P

A

L

L

P

A

V

L

E

D

S

H

A

P

D

A

M

L

K

I

A

D

M

M

V

L

A

A

Y

Y

F

M

D

S

W

W

M

L

K

S

G

Q

A

G

T

V

K

P

P

V

E

G

D

A

K

V

V

V

P

A

G

G

R

H

G
|
G

I
|
I

G

P

K

T

I

L

D

T

R

L

S

E

L

R

K

E

P

P

D

D

S

G

D

V

N

H

G

G

K

E

K

A

I

L

Y

Y

A

Q

E

A

Q
x
R

C
|
C

A

L

V

A

C
|
C

H
|
H

G

G

E

A

N

D

G

G

E

S

G

G

L

T

K

L

S

D

A

A

D

D

G

G

K

R

M

Y

V

L

Y
x
F

P
|
P

L
|
L

W

W

G

G

D

P

E

R

S

S

F
|
F

N

N

I

T

G

G

A
|
A

G
|
G

M

M

A

N

R

R

T

Q

Y

A

T

T

A

A

A

G

F
|
F

V

I

K

K

R

H

N

K

M
|
M

P
|
P

I
x
L

G

G

F

-

H

-

G

-

K

-

F

-

P

-

L

-

G

A

Q

D

G

D

G

S

L

L

S

S

D

D

Q

E

E

E

A

A

L

W

D

D

V

V

A

A

E

G

Y

F

F

V

S

L

H

T

Q

H

P

P

R

R

P

P

D

L

F

F

active site: R79 (= R516), R89 (= R526), C93 (= C530), S97 (= S534)
binding heme c: C46 (= C487), H48 (≠ S489), C49 (= C490), C49 (= C490), H50 (= H491), P51 (≠ L492), F66 (= F503), C93 (= C530), F94 (= F531), S97 (= S534), L98 (≠ M535), G134 (= G571), I135 (= I572), R156 (≠ Q593), C157 (= C594), C160 (= C597), H161 (= H598), F177 (≠ Y614), P178 (= P615), P179 (= P616), L180 (= L617), F186 (= F623), F201 (= F638), M206 (= M643), P207 (= P644), L208 (≠ I645)
binding thiosulfate: R79 (= R516), R89 (= R526), C93 (= C530), R96 (= R533), S97 (= S534), A190 (= A627), G191 (= G628)

4wqaA Thiosulfate dehydrogenase (tsda) from allochromatium vinosum - tetrathionate co-crystallization (see paper)
42% identity, 31% coverage: 461:678/696 of query aligns to 19:227/227 of 4wqaA

query
sites
4wqaA

E

E

Q

S

L

I

V

V

R

R

G

G

M

R

R

R

L

Y

H

L

L

S

E

D

T

T

K

P

D

A

L

Q

L

L

P

P

N

D

H

F

V

V

G

G

D

N

Q

G

L

L

N

A

C
|
C

T

R

S
x
H

C
|
C

H
|
H

L

P

-

G

-

R

-

D

-

G

N

E

A

V

G

G

T

T

V

E

A

A

D

N

G

A

S

A

P

P

F
|
F

V

V

G

G

V

V

S

V

A

G

F

R

F

F

P

P

S

Q

Y

Y

A

S

P

A

R
|
R

A

H

G

G

R

R

I

L

I

I

T

T

L

L

E

E

D

Q

R
|
R

I

I

N

G

G

D

C
|
C

F
|
F

K

E

R
|
R

S
|
S

M
x
L

N

N

G

G

K

R

P

A

L

L

P

A

V

L

E

D

S

H

A

P

D

A

M

L

K

I

A

D

M

M

V

L

A

A

Y

Y

F

M

D

S

W

W

M

L

K

S

G

Q

A

G

T

V

K

P

P

V

E

G

D

A

K

V

V

V

P

A

G

G

R

H

G
|
G

I
|
I

G

P

K

T

I

L

D

T

R

L

S

E

L

R

K

E

P

P

D

D

S

G

D

V

N

H

G

G

K

E

K

A

I

L

Y

Y

A

Q

E

A

Q
x
R

C
|
C

A

L

V

A

C
|
C

H
|
H

G

G

E

A

N

D

G

G

E

S

G

G

L

T

K

L

S

D

A

A

D

D

G

G

K

R

M

Y

V

L

Y
x
F

P
|
P

L
|
L

W

W

G

G

D

P

E

R

S

S

F
|
F

N

N

I

T

G

G

A
|
A

G
|
G

M

M

A

N

R

R

T

Q

Y

A

T

T

A

A

A

G

F
|
F

V

I

K

K

R

H

N
x
K

M
|
M

P

-

I

-

G

-

F

-

H

-

G

-

K

-

F

-

P

-

L

-

G

-

Q

-

G

-

G

S

L

L

S

S

D

D

Q

E

E

E

A

A

L

W

D

D

V

V

A

A

E

G

Y

F

F

V

S

L

H

T

Q

H

P

P

R

R

P

P

D

L

F

F

binding heme c: C45 (= C487), H47 (≠ S489), C48 (= C490), C48 (= C490), H49 (= H491), F65 (= F503), R88 (= R526), C92 (= C530), F93 (= F531), S96 (= S534), L97 (≠ M535), G133 (= G571), I134 (= I572), R155 (≠ Q593), C156 (= C594), C159 (= C597), H160 (= H598), F176 (≠ Y614), P177 (= P615), P178 (= P616), L179 (= L617), F185 (= F623), F185 (= F623), F200 (= F638), K204 (≠ N642), M205 (= M643)
binding sulfite ion: R78 (= R516), R88 (= R526), C92 (= C530), R95 (= R533), S96 (= S534), A189 (= A627), G190 (= G628)

5lo9A Thiosulfate dehydrogenase (tsdba) from marichromatium purpuratum - "as isolated" form (see paper)
33% identity, 49% coverage: 338:680/696 of query aligns to 121:436/471 of 5lo9A

query
sites
5lo9A

C
|
C

G

V

D
x
R

C
|
C

H
|
H

R

G

Q

P

D

G

G

G

N

V

G

G

V

A

S

G

K

A

I

V

F
|
F

P
|
P

P

P

L
|
L

A

A

G

G

N

Q

P

P

A

Y

V

-

T

-

A

-

K

-

D

-

P

-

A

-

T

S

L
x
Y

L

L

H

L

I

A

T
x
Q

L

L

T

Q

G

A

W
|
W

K

G

T

T

A

G

S

R

T
x
R

A

H

A

G

H
x
E

P

P

R

M

V

A

F

L

T
x
M

M

G

P

A

G

V

F

A

A

G

R

R

L

L

N

D

D

A

Q

D

E

E

L

Q

A

R

E

A

L

L

I

A

T

A

F

Y

V

F

R

A

S

T

S

R

W

-

G

-

N

-

G

-

E

-

A

-

V

-

T

-

A

-

S

-

Q

-

V

-

K

P

K

L

M

A

R

R

A

A

E

E

V

A

K

-

Q

-

D

-

P

-

K

-

A

-

I

-

D

-

N

-

S

S

K

R

F

F

E

T

T

P

P

P

R

S

L

R

A

D

D

A

M

L

L

P

A

E

K

G

P

P

N

L

A

G

E

E

Q

M

L

V

V

R

R

L

G

G

M

A

R

R

L

L

-

F

-
x
R

H

H

L

T

E

N

T

T

K

D

D

P

L

R

L

S

P

A

N

P

H

H

V

V

G

G

D

N

Q

D

L
x
Q

N

T

C
|
C

T
x
A

S
x
G

C
|
C

H
|
H

L

L

N

D

A

N

G

G

T

R

V

R

A

A

D

D

G

A

S

S

P

P

F
x
M

V

W

G

A

V
x
A

S

W

A

V

F

A

F
x
Y

P

P

S

A

Y

Y

A

R

P

G

R

K

A

N

G

Q

R

R

I

V

I

D

T

T

L

M

E

A

D

E

R
|
R

I

I

N

Q

G

G

C
|
C

F
|
F

K

R

R

Y

S
|
S

M
|
M

N

N

-

A

-

Q

-

D

-

S

-

V

-

S

G

G

K

Q

P

V

L

P

P

E

V

T

E

N

S

G

A

L

D

V

M

L

K

D

A

A

M

L

V

Q

A

S

Y

Y

F

I

D

F

W

W

M

L

-

A

K

T

G

G

A

A

T

P

K

T

P

G

E

D

D

T

K

A

V

M

P

S

G

G

R
|
R

G

G

I
x
Y

G

P

K

R

I

L

D

Q

R

P

S

P

L

A

K

E

P

G

-

F

D

D

S

R

D

T

N

R

G

G

K

A

I

L

Y

Y

A

A

E

E

Q
x
H

C
|
C

A

A

V

L

C
|
C

H
|
H

G

G

E

A

N

E

G

G

E

E

G

G

L

L

K

L

S

-

A

V

D

D

G

G

K

E

M

V

V

V

Y
x
F

P
|
P

P

P

L
|
L

W

W

G

G

D

P

E

R

S

S

F
x
Y

N

N

I

W

G

G

A

A

G

G

M

M

A

H

R

R

T

V

Y

D

T

T

A

A

F
|
F

V
x
I

K

A

R

A

N

N

M
|
M

P
|
P

I

L

G

-

F

-

H

-

G

-

K

-

F

-

P

-

L

L

G

D

Q

T

G

V

G

R

L

L

S

T

D

P

Q

Q

E

E

A

A

L

W

D

D

V

V

A

A

E

A

Y

Y

F

I

S

N

H

A

Q

H

P

E

R

R

P

P

D

Q

F

D

P

P

E

R

binding heme c: C121 (= C338), R123 (≠ D340), C124 (= C341), H125 (= H342), F136 (= F353), P137 (= P354), L139 (= L356), Y146 (≠ L370), Y146 (≠ L370), Q150 (≠ T374), W154 (= W378), R159 (≠ T383), E162 (≠ H386), M167 (≠ T391), R225 (vs. gap), Q241 (≠ L485), C243 (= C487), A244 (≠ T488), G245 (≠ S489), C246 (= C490), C246 (= C490), H247 (= H491), M259 (≠ F503), A262 (≠ V506), Y266 (≠ F510), R282 (= R526), C286 (= C530), F287 (= F531), S290 (= S534), M291 (= M535), R333 (= R570), Y335 (≠ I572), H357 (≠ Q593), C358 (= C594), C361 (= C597), H362 (= H598), F377 (≠ Y614), P378 (= P615), L380 (= L617), Y386 (≠ F623), Y386 (≠ F623), F401 (= F638), I402 (≠ V639), M406 (= M643), P407 (= P644)
binding thiosulfate: R282 (= R526), C286 (= C530), S290 (= S534)

Sites not aligning to the query:

binding heme c: 21, 24, 25, 36, 37, 40, 47, 47, 51, 54, 60, 62, 64, 65, 68, 80

4ax3D Structure of three-domain heme-cu nitrite reductase from ralstonia pickettii at 1.6 a resolution (see paper)
38% identity, 14% coverage: 338:432/696 of query aligns to 363:457/457 of 4ax3D

query
sites
4ax3D

C
|
C

G

S

D

V

C
|
C

H
|
H

R

Q

Q

G

D

N

G

G

N

A

G

G

V

L

S

P

K

G

I

V

F

F

P
|
P

L
|
L

A

A

G

K

N
x
S

P

D

A
x
F

V

L

T

A

A

A

K

-

D

D

P

P

A

K

T

R

L

A

L

M

H

N

I

I

T

V

L

L

T

H

G

G

W

L

K
x
N

-
x
G

T

K

A

I

S

K

T

V

A

N

A

G

H

Q

P

E

R

Y

V

D

F
x
S

T

V

M
|
M

P

P

G

P

F
x
M

A

T

R

Q

L

L

N

N

D

D

Q

D

E

E

L

V

A

A

E

N

L

I

I

L

T

T

F

Y

V

V

R

L

S

N

S

S

W

W

G

D

N

N

G

P

G

G

E

G

A

R

V

V

T

S

A

A

S

E

Q

D

V

V

K

K

M

V

R

R

A

A

E

Q

binding heme c: C363 (= C338), C366 (= C341), H367 (= H342), P379 (= P354), P380 (= P355), L381 (= L356), S384 (≠ N359), F386 (≠ A361), N403 (≠ K379), G404 (vs. gap), S415 (≠ F390), M417 (= M392), M420 (≠ F395)

Sites not aligning to the query:

active site: 93, 96, 98, 133, 134, 142, 147, 239, 261, 262, 288
binding copper (ii) ion: 93, 98, 133, 134, 142, 147

5oboA Crystal structure of nitrite bound d97n mutant of three-domain heme-cu nitrite reductase from ralstonia pickettii
38% identity, 14% coverage: 338:432/696 of query aligns to 361:455/456 of 5oboA

query
sites
5oboA

C
|
C

G

S

D

V

C
|
C

H
|
H

R

Q

Q

G

D

N

G

G

N

A

G

G

V

L

S

P

K

G

I

V

F

F

P
|
P

L
|
L

A

A

G

K

N
x
S

P

D

A
x
F

V

L

T

A

A

A

K

-

D

D

P

P

A

K

T

R

L

A

L

M

H

N

I
|
I

T

V

L

L

T

H

G

G

W

L

K
x
N

-
x
G

T

K

A

I

S

K

T

V

A

N

A

G

H

Q

P

E

R

Y

V

D

F
x
S

T

V

M
|
M

P

P

G

P

F
x
M

A

T

R

Q

L

L

N

N

D

D

Q

D

E

E

L

V

A

A

E

N

L

I

I

L

T

T

F

Y

V

V

R

L

S

N

S

S

W

W

G

D

N

N

G

P

G

G

E

G

A

R

V

V

T

S

A

A

S

E

Q

D

V

V

K

K

M

V

R

R

A

A

E

Q

binding heme c: C361 (= C338), C364 (= C341), H365 (= H342), P377 (= P354), P378 (= P355), L379 (= L356), S382 (≠ N359), F384 (≠ A361), I395 (= I373), N401 (≠ K379), G402 (vs. gap), S413 (≠ F390), M415 (= M392), M418 (≠ F395)

Sites not aligning to the query:

active site: 91, 94, 96, 131, 132, 140, 145, 237, 259, 260, 286
binding copper (ii) ion: 91, 96, 131, 132, 140, 145
binding heme c: 360
binding nitrite ion: 94, 96, 131

6fjaA Crystal structure of t2d three-domain heme-cu nitrite reductase from ralstonia pickettii
38% identity, 14% coverage: 338:432/696 of query aligns to 360:454/455 of 6fjaA

query
sites
6fjaA

C
|
C

G

S

D

V

C
|
C

H
|
H

R

Q

Q

G

D

N

G

G

N

A

G

G

V

L

S

P

K

G

I

V

F

F

P
|
P

L
|
L

A

A

G

K

N

S

P

D

A
x
F

V

L

T

A

A

A

K

-

D

D

P

P

A

K

T

R

L

A

L

M

H

N

I

I

T

V

L

L

T

H

G

G

W

L

K
x
N

-
x
G

T

K

A

I

S

K

T

V

A

N

A

G

H

Q

P

E

R
x
Y

V

D

F
x
S

T

V

M
|
M

P

P

G

P

F
x
M

A

T

R

Q

L

L

N

N

D

D

Q

D

E

E

L

V

A

A

E

N

L

I

I

L

T

T

F

Y

V

V

R

L

S

N

S

S

W

W

G

D

N

N

G

P

G

G

E

G

A

R

V

V

T

S

A

A

S

E

Q

D

V

V

K

K

M

V

R

R

A

A

E

Q

binding protoporphyrin ix containing fe: C360 (= C338), C363 (= C341), H364 (= H342), P376 (= P354), P377 (= P355), L378 (= L356), F383 (≠ A361), N400 (≠ K379), G401 (vs. gap), Y410 (≠ R388), S412 (≠ F390), M414 (= M392), M417 (≠ F395)

Sites not aligning to the query:

active site: 90, 93, 95, 130, 131, 139, 144, 236, 258, 259, 285
binding copper (ii) ion: 90, 131, 139, 144
binding protoporphyrin ix containing fe: 359

1r0qA Characterization of the conversion of the malformed, recombinant cytochrome rc552 to a 2-formyl-4-vinyl (spirographis) heme (see paper)
34% identity, 15% coverage: 330:432/696 of query aligns to 3:113/130 of 1r0qA

query
sites
1r0qA

G

G

G

A

L

K

A

I

Y

Y

V

A

Q

Q

F

-

C

C

G

A

D

G

C
|
C

H
|
H

R

Q

Q

Q

D

N

G

G

N

Q

G

G

V

I

S

P

K

G

I

A

F

F

P
|
P

P

P

L
|
L

A

A

G

G

N
x
H

P

V

A

A

-

E

V

I

T

L

A

A

K

K

D

E

P

G

A

G

T

R

-

E

-
x
Y

L

L

L

I

H

L

I
x
V

T

L

L

L

T

Y

G

G

W

L

K
x
Q

-
x
G

T

Q

A

I

S

E

T

V

A

K

A

G

H

M

P

K

R

Y

V

N

F
x
G

T

V

M
|
M

P

S

G

S

F

F

A

A

R

Q

L

L

N

K

D

D

Q

E

E

E

L

I

A

A

E

A

L

V

I

L

T

N

F

H

V

I

R

A

S

T

S

A

W

W

G

G

N

D

-

A

-

K

-

V

-

K

G

G

G

F

E

K

A

P

V

F

T

T

A

A

S

E

Q

E

V

V

K

K

M

L

R

R

A

A

E

K

binding 2-formyl-protoporphryn ix: C13 (= C341), H14 (= H342), P26 (= P354), L28 (= L356), H31 (≠ N359), Y44 (vs. gap), V48 (≠ I373), Q54 (≠ K379), G55 (vs. gap), G66 (≠ F390), M68 (= M392)

Sites not aligning to the query:

binding 2-formyl-protoporphryn ix: 124

1qyzA Characterization of the malformed, recombinant cytochrome rc552 (see paper)
34% identity, 15% coverage: 330:432/696 of query aligns to 3:113/130 of 1qyzA

query
sites
1qyzA

G

G

G

A

L

K

A

I

Y
|
Y

V

A

Q

Q

F

-

C
|
C

G

A

D

G

C
|
C

H
|
H

R

Q

Q

Q

D

N

G

G

N

Q

G

G

V

I

S

P

K

G

I

A

F

F

P
|
P

P

P

L

L

A

A

G

G

N
x
H

P

V

A

A

-

E

V

I

T

L

A

A

K

K

D

E

P

G

A

G

T

R

-

E

-
x
Y

L

L

L

I

H

L

I

V

T

L

L

L

T

Y

G

G

W

L

K
x
Q

-
x
G

T

Q

A

I

S

E

T

V

A

K

A

G

H

M

P

K

R

Y

V

N

F
x
G

T

V

M
|
M

P

S

G

S

F
|
F

A

A

R

Q

L

L

N

K

D

D

Q

E

E

E

L

I

A

A

E

A

L

V

I

L

T

N

F

H

V

I

R

A

S

T

S

A

W

W

G

G

N

D

-

A

-

K

-

V

-

K

G

G

G

F

E

K

A

P

V

F

T

T

A

A

S

E

Q

E

V

V

K

K

M

L

R

R

A

A

E

K

binding 2-acetyl-protoporphyrin ix: Y7 (= Y334), C10 (= C338), C13 (= C341), H14 (= H342), P26 (= P354), H31 (≠ N359), Y44 (vs. gap), Q54 (≠ K379), G55 (vs. gap), G66 (≠ F390), M68 (= M392), F71 (= F395)

Sites not aligning to the query:

binding 2-acetyl-protoporphyrin ix: 124

1dt1A Thermus thermophilus cytochrome c552 synthesized by escherichia coli (see paper)
34% identity, 15% coverage: 330:432/696 of query aligns to 2:112/129 of 1dt1A

query
sites
1dt1A

G

G

G

A

L

K

A

I

Y

Y

V

A

Q

Q

F

-

C
|
C

G

A

D

G

C
|
C

H
|
H

R

Q

Q

Q

D

N

G

G

N

Q

G

G

V

I

S

P

K

G

I

A

F

F

P
|
P

P

P

L

L

A

A

G

G

N
x
H

P

V

A

A

-

E

V

I

T

L

A

A

K

K

D

E

P

G

A

G

T

R

-

E

-
x
Y

L

L

L

I

H

L

I
x
V

T

L

L

L

T

Y

G

G

W

L

K
x
Q

-
x
G

T

Q

A

I

S

E

T

V

A

K

A

G

H

M

P

K

R

Y

V

N

F
x
G

T

V

M
|
M

P

S

G

S

F
|
F

A

A

R

Q

L

L

N

K

D

D

Q

E

E

E

L

I

A

A

E

A

L

V

I

L

T

N

F

H

V

I

R

A

S

T

S

A

W

W

G

G

N

D

-

A

-

K

-

V

-

K

G

G

G

F

E

K

A

P

V

F

T

T

A

A

S

E

Q

E

V

V

K

K

M

L

R

R

A

A

E

K

binding heme c: C9 (= C338), C12 (= C341), H13 (= H342), P25 (= P354), H30 (≠ N359), Y43 (vs. gap), V47 (≠ I373), Q53 (≠ K379), G54 (vs. gap), G65 (≠ F390), M67 (= M392), F70 (= F395)

Sites not aligning to the query:

binding heme c: 123

1c52A Thermus thermophilus cytochrome-c552: a new highly thermostable cytochromE-C structure obtained by mad phasing (see paper)
34% identity, 15% coverage: 330:432/696 of query aligns to 4:114/131 of 1c52A

query
sites
1c52A

G

G

G

A

L

K

A

I

Y

Y

V

A

Q

Q

F

-

C
|
C

G

A

D

G

C
|
C

H
|
H

R

Q

Q

Q

D

N

G

G

N

Q

G

G

V

I

S

P

K

G

I

A

F
|
F

P
|
P

P

P

L
|
L

A

A

G

G

N
x
H

P

V

A

A

-

E

V

I

T

L

A

A

K

K

D

E

P

G

A

G

T

R

-

E

-
x
Y

L

L

L

I

H

L

I

V

T

L

L

L

T

Y

G

G

W
x
L

K
x
Q

-
x
G

T

Q

A

I

S

E

T

V

A

K

A

G

H

M

P

K

R

Y

V

N

F
x
G

T

V

M
|
M

P

S

G

S

F
|
F

A

A

R

Q

L

L

N

K

D

D

Q

E

E

E

L

I

A

A

E

A

L

V

I

L

T

N

F

H

V

I

R

A

S

T

S

A

W

W

G

G

N

D

-

A

-

K

-

V

-

K

G

G

G

F

E

K

A

P

V

F

T

T

A

A

S

E

Q

E

V

V

K

K

M

L

R

R

A

A

E

K

binding protoporphyrin ix containing fe: C11 (= C338), C14 (= C341), H15 (= H342), F26 (= F353), P27 (= P354), L29 (= L356), H32 (≠ N359), Y45 (vs. gap), L54 (≠ W378), Q55 (≠ K379), G56 (vs. gap), G67 (≠ F390), M69 (= M392), F72 (= F395)

Sites not aligning to the query:

binding protoporphyrin ix containing fe: 125

2zooA Crystal structure of nitrite reductase from pseudoalteromonas haloplanktis tac125
31% identity, 15% coverage: 330:430/696 of query aligns to 339:438/438 of 2zooA

query
sites
2zooA

G

G

G

Q

L

R

A

V

Y

Y

V

E

Q

A

F

N

C
|
C

G

M

D

A

C
|
C

H
|
H

R

Q

Q

A

D

N

G

G

N

E

G

G

V

I

S

P

K

G

I

A

F
|
F

P
|
P

L
|
L

A

A

G

K

N
x
S

P

D

A
x
Y

V

L

T

N

A

-

K

N

D

N

P

P

A

L

T

L

L

G

L

V

H

N

I

A

T
x
I

L

I

T

K

G

G

W
x
L

K
x
S

T
x
G

A

P

S
x
I

T

K

A
x
V

A

N

H

N

P

V

R

N

V
x
Y

F
x
N

T
x
G

M
x
V

P
x
M

G

P

F

A

A

M

R

N

L

L

N

N

D

D

Q

E

E

D

L

I

A

A

E

N

L

V

I

I

T

T

F

F

V

V

R

L

S

N

W

W

G

D

N

N

G

A

G

G

E

G

A

K

V

V

T

S

A

A

S

E

Q

Q

V

V

K

A

K

K

M

Q

R

R

binding protoporphyrin ix containing fe: C347 (= C338), C350 (= C341), H351 (= H342), F362 (= F353), P363 (= P354), P364 (= P355), L365 (= L356), S368 (≠ N359), Y370 (≠ A361), I382 (≠ T374), L386 (≠ W378), S387 (≠ K379), G388 (≠ T380), I390 (≠ S382), V392 (≠ A384), Y397 (≠ V389), N398 (≠ F390), G399 (≠ T391), V400 (≠ M392), M401 (≠ P393)

Sites not aligning to the query:

active site: 81, 84, 86, 121, 122, 130, 135, 227, 249, 250, 276
binding copper (ii) ion: 81, 86, 121, 122, 130, 135

8hddB Complex structure of catalytic, small, and a partial electron transfer subunits from burkholderia cepacia fad glucose dehydrogenase
31% identity, 14% coverage: 334:430/696 of query aligns to 26:121/121 of 8hddB

query
sites
8hddB

Y

Y

V

L

Q

G

F

N

C
|
C

G

A

D

T

C
|
C

H
|
H

R

Q

Q

M

D

Q

G

G

N

K

G

G

V

T

-

P

S

D

K

G

I

Y

F
x
Y

P
|
P

P

S

L

L

A

F

G

H

N

N

P

S

A
x
T

V

V

T

G

A

A

K

S

D

N

P

P

A

S

T

N

L

L

L

V

H

Q

I
x
V

T
x
I

L

L

T

N

G

G

W

V

K

Q

T
x
R

A

K

S

I

T

G

A

S

A

E

H

D

P

-

R

-

V

-

F
x
I

T

G

M
|
M

P
|
P

G

A

F

F

A

R

-

Y

R

D

L

L

N

N

D

D

Q

A

E

Q

L

I

A

A

E

A

L

L

I

T

T

N

F

Y

V

V

R

T

S

A

S

Q

W

F

G

G

N

N

G

P

G

A

E

A

A

K

V

V

T

T

A

E

S

Q

Q

D

V

V

K

A

K

K

M

L

R

R

binding protoporphyrin ix containing fe: C30 (= C338), C33 (= C341), H34 (= H342), Y46 (≠ F353), P47 (= P354), T54 (≠ A361), V66 (≠ I373), I67 (≠ T374), R73 (≠ T380), I80 (≠ F390), M82 (= M392), P83 (= P393)

O33434 L-cysteine S-thiosulfotransferase subunit SoxA; Cytochrome c551 subunit diheme; Protein SoxA; SoxAX cytochrome complex subunit A; Sulfur oxidizing protein A; Thiosulfate-oxidizing multienzyme system protein SoxA; TOMES protein SoxA; EC 2.8.5.2 from Paracoccus pantotrophus (Thiosphaera pantotropha) (see 2 papers)
27% identity, 18% coverage: 486:609/696 of query aligns to 105:221/290 of O33434

query
sites
O33434

N
x
S

C
|
C

T
x
A

S
|
S

C
|
C

H
|
H

L
x
Q

N
x
G

A
x
P

G
x
E

T
x
S

V
x
M

A
|
A

D

-

G

-

S

-

P

-

F

-

V

-

G
|
G

V
x
L

S
x
R

A
|
A

F
x
V

F
x
M

P
|
P

S
x
R

Y
x
V

A
x
D

P
x
E

R
x
H

A
x
T

G
|
G

R
x
K

I
x
L

I
x
M

T
x
I

L
x
M

E
|
E

D
|
D

R
x
Y

I
x
V

N
|
N

G
x
A

C
|
C

F
x
V

K
x
T

R
x
E

S
x
R

M
|
M

N
x
G

G
x
L

K
x
E

P
x
K

L
x
W

P
x
G

V
|
V

E
x
T

S
|
S

A
x
D

D
x
N

M
|
M

K
|
K

A
x
D

M
|
M

V
x
L

A
x
S

Y
x
L

F
x
I

D

-

W

-

M

-

K

-

G

-

A

-

T

-

K

-

P

-

E

-

D

-

K
x
S

V
x
L

P
x
Q

G
x
S

R
|
R

G
|
G

I
x
M

G
x
A

-
x
V

-
x
N

-
x
V

K
|
K

I
|
I

D
|
D

R
x
G

S
x
P

L
x
A

K
x
A

P
|
P

D
x
Y

S
x
W

D
x
E

N
x
H

G
|
G

K
|
K

K
x
E

I
|
I

Y
|
Y

A
x
Y

E
x
T

Q
x
R

-
x
Y

-
x
G

-
x
Q

-
x
L

-
x
E

-
x
M

-
x
S

C
|
C

A
|
A

V
x
N

C
|
C

H
|
H

G
x
E

E
x
D

N
|
N

G
x
A

E
x
G

G
x
N

L
x
M

K
x
I

S
x
R

A
|
A

D
|
D

C106 (= C487) binding covalent
C109 (= C490) binding covalent
H110 (= H491) binding axial binding residue
C143 (= C530) binding axial binding residue
H190 (≠ N585) binding
C206 (= C594) binding covalent
H210 (= H598) binding axial binding residue

Sites not aligning to the query:

1:26 signal peptide
27:290 modified: mature protein, L-cysteine S-thiosulfotransferase subunit SoxA
78 binding
81 binding
251 active site, Cysteine persulfide intermediate; binding axial binding residue
266 binding

2c1dA Crystal structure of soxxa from p. Pantotrophus (see paper)
27% identity, 18% coverage: 486:609/696 of query aligns to 79:195/264 of 2c1dA

query
sites
2c1dA

N

S

C
|
C

T

A

S

S

C
|
C

H
|
H

L

Q

N

G

A

P

G

E

T

S

V
x
M

A

A

D

-

G

-

S

-

P

-

F

-

V

-

G

G

V

L

S

R

A

A

F

V

F

M

P

P

S
x
R

Y

V

A

D

P

E

R
x
H

A

T

G

G

R

K

I

L

I

M

T

I

L

M

E

E

D

D

R
x
Y

I

V

N

N

G

A

C
|
C

F

V

K

T

R

E

S
x
R

M
|
M

N

G

G

L

K

E

P

K

L

W

P

G

V

V

E

T

S

S

A

D

D

N

M

M

K

K

A

D

M
|
M

V

L

A

S

Y

L

F

I

D

-

W

-

M

-

K

-

G

-

A

-

T

-

K

-

P

-

E

-

D

-

K

S

V

L

P

Q

G

S

R

R

G

G

I

M

G

A

-

V

-

N

-

V

K

K

I

I

D

D

R

G

S

P

L

A

K

A

P

P

D

Y

S

W

D

E

N
x
H

G

G

K

K

K

E

I

I

Y

Y

A

Y

E

T

Q

R

-

Y

-

G

-

Q

-

L

-

E

-

M

-

S

C
|
C

A

A

V

N

C
|
C

H
|
H

G

E

E

D

N

N

G

A

E

G

G

N

L

M

K

I

S

R

A

A

D

D

binding heme c: C80 (= C487), C83 (= C490), H84 (= H491), M90 (≠ V497), R99 (≠ S512), H103 (≠ R516), Y113 (≠ R526), C117 (= C530), R121 (≠ S534), M122 (= M535), M137 (= M550), C180 (= C594), C183 (= C597), H184 (= H598)
binding zinc ion: H164 (≠ N585)

Sites not aligning to the query:

binding heme c: 42, 197, 198, 200, 201, 221, 222, 225, 263
binding zinc ion: 52, 55, 240

Query Sequence

>Dsui_2086 Dsui_2086 cytochrome c
MTHVPSVPAGAPAGALTRLWRSAAATFLLSALAAAGLGRAEAADAGQIARGEYLARLGDC
VACHTAEGGKSMAGGRELATPFGVLFSTNITPDKETGIGNYTFAQFDRAMRKGVAADGHN
LYPAMPYPSYAKMTGEDMQALYAYLMQGLAPVKQANKPTAMRWPFNQRWGLSLWNWAFLD
ATPFQPDAGKDATWNRGAYLVQGLGHCGACHTPRGIAFQEKAMSDAGSKGKHFLAGETVE
SWRALSLRGLWTVEDTALFLKTGQNRFATASGNMAEVIHHSTQHVKDEDLVAIATYLKSL
PPGEHELPAPSVPRSEVAGKVPGNLFSSRGGLAYVQFCGDCHRQDGNGVSKIFPPLAGNP
AVTAKDPATLLHITLTGWKTASTAAHPRVFTMPGFARLNDQELAELITFVRSSWGNGGEA
VTASQVKKMRAEVVKQDPKAIDNSKFETPRLADMLAKPNAEQLVRGMRLHLETKDLLPNH
VGDQLNCTSCHLNAGTVADGSPFVGVSAFFPSYAPRAGRIITLEDRINGCFKRSMNGKPL
PVESADMKAMVAYFDWMKGATKPEDKVPGRGIGKIDRSLKPDSDNGKKIYAEQCAVCHGE
NGEGLKSADGKMVYPPLWGDESFNIGAGMARTYTAAAFVKRNMPIGFHGKFPLGQGGLSD
QEALDVAEYFSHQPRPDFPEKVKDWPNGKKPEDARY

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory