SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Dsui_2877 Dsui_2877 ABC-type antimicrobial peptide transport system, ATPase component to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
52% identity, 90% coverage: 13:234/248 of query aligns to 3:224/226 of 5xu1B

query
sites
5xu1B

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binding magnesium ion: G45 (= G55), K46 (= K56), S47 (= S57)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
50% identity, 92% coverage: 12:239/248 of query aligns to 3:230/650 of 5ws4A

query
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5ws4A

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binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: S43 (= S52), G44 (= G53), S48 (= S57)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
49% identity, 90% coverage: 13:234/248 of query aligns to 3:224/615 of 5lilA

query
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5lilA

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binding adenosine-5'-triphosphate: F13 (≠ Y23), V22 (= V32), S42 (= S52), G43 (= G53), G45 (= G55), K46 (= K56), S47 (= S57), T48 (= T58), Q92 (= Q102), K136 (≠ Y146), Q143 (≠ R153), S145 (= S155), G147 (= G157), Q148 (= Q158)
binding magnesium ion: S47 (= S57), Q92 (= Q102)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
49% identity, 90% coverage: 13:234/248 of query aligns to 3:224/592 of 5lj7A

query
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5lj7A

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binding adenosine-5'-triphosphate: V22 (= V32), S42 (= S52), G43 (= G53), G45 (= G55), K46 (= K56), S47 (= S57), T48 (= T58), Q92 (= Q102), K136 (≠ Y146), Q143 (≠ R153), S145 (= S155), G147 (= G157), Q148 (= Q158)
binding magnesium ion: S47 (= S57), Q92 (= Q102)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
48% identity, 90% coverage: 13:235/248 of query aligns to 4:226/648 of P75831

query
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P75831

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K47 (= K56) mutation to L: Lack of activity.
D169 (= D178) mutation to N: Lack of activity.

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
48% identity, 88% coverage: 13:230/248 of query aligns to 1:223/232 of 1f3oA

query
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1f3oA

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A

E

L

L

P

P

L

L

V

I

Y

F

C

K

-

Y

-

R

-

G

G

A

V

M

D

S

K

G

E

E

R

R

Q

K

R

R

A

A

R

L

E

E

L

C

L

L

A

K

K

M

V

A

G

E

L

L

G

E

Q

E

-

R

Y

F

A

A

K

N

S

H

L

K

P

P

N

N

R

Q

I

L

S

S

G

G

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

A

N

N

R

N

P

P

R

P

L

I

I

I

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

H

K

T

T

S

G

E

E

E

K

I

I

M

M

A

Q

L

L

F

L

E

K

L

L

N

N

R

E

E

E

-

D

G

G

I

K

T

T

I

V

V

V

L

V

V

V

T

T

H

H

E

D

P

I

D

N

I

V

A

A

Q

R

H

F

A

G

K

E

R

R

Q

I

V

I

R

Y

F

L

L

K

D

D

G

G

R

E

I

V

binding adenosine-5'-diphosphate: Y11 (= Y23), G41 (= G53), G43 (= G55), K44 (= K56), S45 (= S57), T46 (= T58)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
48% identity, 88% coverage: 13:230/248 of query aligns to 1:223/230 of 1l2tA

query
sites
1l2tA

V

M

I

I

E

K

V

L

A

K

G

N

L

V

D

T

K

K

A

T

Y
|
Y

D

K

T

M

P

G

M

E

G

E

P

I

F

I

P

Y

V

A

L

L

K

K

G

N

V

V

S

N

L

L

A

N

I

I

H

K

A

E

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

M

M

L

N

N

I

I

L

I

G

G

C

C

L

L

D

D

R

K

P

P

S

T

G

E

G

G

D

E

Y

V

I

Y

L

I

D

D

G

N

K

I

H

K

V

T

S

N

A

D

L

L

D

D

K

D

D

D

Q

E

T

L

A

T

L

K

L

I

R

R

N

R

R

D

T

K

I

I

G

G

F

F

V

V

F

F

Q

Q

G

Q

F

F

N

N

L

L

L

I

P

P

R

L

M

L

S

T

L

A

E

L

D

E

N

N

V

V

A

E

L

L

P

P

L

L

V

I

Y

F

C

K

-

Y

-

R

-

G

G

A

V

M

D

S

K

G

E

E

R

R

Q

K

R

R

A

A

R

L

E

E

L

C

L

L

A

K

K

M

V

A

G

E

L

L

G

E

Q

E

-

R

Y
x
F

A

A

K

N

S

H

L

K

P

P

N

N

R
x
Q

I

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

A

N

N

R

N

P

P

R

P

L

I

I

I

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

H

K

T

T

S

G

E

E

E

K

I

I

M

M

A

Q

L

L

F

L

E

K

L

L

N

N

R

E

E

E

-

D

G

G

I

K

T

T

I

V

V

V

L

V

V

V

T

T

H
|
H

E

D

P

I

D

N

I

V

A

A

Q

R

H

F

A

G

K

E

R

R

Q

I

V

I

R

Y

F

L

L

K

D

D

G

G

R

E

I

V

binding adenosine-5'-triphosphate: Y11 (= Y23), S40 (= S52), G41 (= G53), S42 (= S54), G43 (= G55), K44 (= K56), S45 (= S57), T46 (= T58), F138 (≠ Y146), Q145 (≠ R153), S147 (= S155), G149 (= G157), Q150 (= Q158), H204 (= H211)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
47% identity, 82% coverage: 30:233/248 of query aligns to 16:219/223 of 2pclA

query
sites
2pclA

F

Y

P

E

V

I

L

L

K

K

G

G

V

I

S

S

L

L

A

S

I

V

H

K

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

F

L

M

L

N

Y

I

I

L

L

G

G

C

L

L

L

D

D

R

A

P

P

S

T

G

E

G

G

D

K

Y

V

I

F

L

L

D

E

G

G

K

K

H

E

V

V

S

D

A

Y

L

T

D

N

K

E

D

K

Q

E

T

L

A

S

L

L

R

R

N

N

R

R

T

K

I

L

G

G

F

F

V

V

F

F

Q

Q

G

F

F

H

N

Y

L

L

L

I

P

P

R

E

M

L

S

T

L

A

E

L

D

E

N

N

V

V

A

I

L

V

P

P

L

M

V

L

Y

K

C

M

G

G

V

K

D

P

K

K

E

K

E

E

R

A

R

K

Q

E

R

R

A

G

R

E

E

Y

L

L

A

S

K

E

V

L

G

G

L

L

G

G

Q

D

Y

K

A

L

K

S

S

R

L

K

P

P

N

Y

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

A

N

N

R

E

P

P

R

I

L

L

I

L

L

F

A

A

D

D

E
|
E

P
|
P

T
|
T

G

G

N

N

L

L

D

D

S

S

H

A

T

N

S

T

E

K

E

R

I

V

M

M

A

D

L

I

F

F

E

L

E

K

L

I

N

N

R

E

E

G

G

G

I

T

T

S

I

I

V

V

L

M

V

V

T
|
T

H

H

E

E

P

R

D

E

I

L

A

A

Q

E

H

L

A

T

K

H

R

R

Q

T

V

L

R

E

F

M

L

K

D

D

G

G

R

K

I

V

V

V

H

G

D

E

binding magnesium ion: E165 (= E179), P166 (= P180), T167 (= T181), T196 (= T210)

7mdyC Lolcde nucleotide-bound
45% identity, 88% coverage: 13:231/248 of query aligns to 2:221/226 of 7mdyC

query
sites
7mdyC

V

L

I

L

E

Q

V

C

A

D

G

N

L

L

D

C

K

K

A

R

Y
|
Y

D

Q

T

E

P

G

M

S

G

V

P

Q

F

T

P

D

V

V

L

L

K

H

G

N

V

V

S

S

L

F

A

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

P

S

S

S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

I

L

F

D

N

G

G

K

Q

H

P

V

M

S

S

A

K

L

L

D

S

K

S

D

A

Q

A

T

K

A

A

L

E

L

L

R

R

N

N

R

Q

T

K

I

L

G

G

F

F

V

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

P

P

R

D

M

F

S

T

L

A

E

L

D

E

N

N

V

V

A

A

L

M

P

P

L

L

V

L

Y

I

C

G

G

K

V

K

D

K

K

P

E

A

E

E

R

I

R

N

Q

S

R

R

A

A

R

L

E

E

L

M

L

L

A

K

K

A

V

V

G

G

L

L

G

D

Q

H

Y

R

A

A

K

N

S
x
H

L

R

P

P

N

S

R
x
E

I

L

S
|
S

G
|
G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

V

N

N

R

N

P

P

R

R

L

L

I

V

L

L

A

A

D

D

E
|
E

P

P

T

T

G

G

N
|
N

L

L

D

D

S

A

H

R

T

N

S

A

E

D

E

S

I

I

M

F

A

Q

L

L

F

L

E

G

E

E

L

L

N

N

R

R

-

L

E

Q

G

G

I

T

T

A

I

F

V

L

L

V

V

V

T

T

H
|
H

E

D

P

L

D

Q

I

L

A

A

Q

K

H

R

A

M

K

S

R

R

Q

Q

V

L

R

E

F

M

L

R

D

D

G

G

R

R

I

L

V

T

binding adp orthovanadate: Y12 (= Y23), G42 (= G53), S43 (= S54), G44 (= G55), K45 (= K56), S46 (= S57), T47 (= T58), Q91 (= Q102), H138 (≠ S149), E142 (≠ R153), S144 (= S155), G145 (= G156), G146 (= G157), E168 (= E179), N172 (= N183), H201 (= H211)
binding magnesium ion: S46 (= S57), Q91 (= Q102)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
45% identity, 88% coverage: 13:231/248 of query aligns to 5:224/233 of P75957

query
sites
P75957

V

L

I

L

E

Q

V

C

A

D

G

N

L

L

D

C

K

K

A

R

Y

Y

D

Q

T

E

P

G

M

S

G

V

P

Q

F

T

P

D

V

V

L

L

K

H

G

N

V

V

S

S

L

F

A

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G
|
G

P

S

S

S

G

G

S

S

G

G

K

K

S

S

T

T

F

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

I

L

F

D

N

G

G

K

Q

H

P

V

M

S

S

A

K

L

L

D

S

K

S

D

A

Q

A

T

K

A

A

L

E

L

L

R

R

N

N

R

Q

T

K

I

L

G

G

F

F

V

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

P

P

R

D

M

F

S

T

L

A

E

L

D

E

N

N

V

V

A

A

L

M

P

P

L

L

V

L

Y

I

C

G

G

K

V

K

D

K

K

P

E

A

E

E

R

I

R

N

Q

S

R

R

A

A

R

L

E

E

L

M

L

L

A

K

K

A

V

V

G

G

L

L

G

D

Q

H

Y

R

A

A

K

N

S

H

L

R

P

P

N

S

R

E

I

L

S

S

G

G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

V

N

N

R

N

P

P

R

R

L

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

A

H

R

T

N

S

A

E

D

E

S

I

I

M

F

A

Q

L

L

F

L

E

G

E

E

L

L

N

N

R

R

-

L

E

Q

G

G

I

T

T

A

I

F

V

L

L

V

V

V

T

T

H

H

E

D

P

L

D

Q

I

L

A

A

Q

K

H

R

A

M

K

S

R

R

Q

Q

V

L

R

E

F

M

L

R

D

D

G

G

R

R

I

L

V

T

G42 (= G50) mutation to D: Loss of lipoprotein release when overexpressed.

7arlD Lolcde in complex with lipoprotein and adp (see paper)
45% identity, 88% coverage: 13:231/248 of query aligns to 2:221/222 of 7arlD

query
sites
7arlD

V

L

I

L

E

Q

V

C

A

D

G

N

L

L

D

C

K

K

A

R

Y

Y

D

Q

T

E

P

G

M

S

G

V

P

Q

F

T

P

D

V

V

L

L

K

H

G

N

V

V

S

S

L

F

A

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

P

S

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T

T

F

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

I

L

F

D

N

G

G

K

Q

H

P

V

M

S

S

A

K

L

L

D

S

K

S

D

A

Q

A

T

K

A

A

L

E

L

L

R

R

N

N

R

Q

T

K

I

L

G

G

F

F

V

I

F

Y

Q

Q

G

F

F

H

N

H

L

L

P

P

R

D

M

F

S

T

L

A

E

L

D

E

N

N

V

V

A

A

L

M

P

P

L

L

V

L

Y

I

C

G

G

K

V

K

D

K

K

P

E

A

E

E

R

I

R

N

Q

S

R

R

A

A

R

L

E

E

L

M

L

L

A

K

K

A

V

V

G

G

L

L

G

D

Q

H

Y

R

A

A

K

N

S

H

L

R

P

P

N

S

R

E

I

L

S

S

G

G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

V

N

N

R

N

P

P

R

R

L

L

I

V

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

A

H

R

T

N

S

A

E

D

E

S

I

I

M

F

A

Q

L

L

F

L

E

G

E

E

L

L

N

N

R

R

-

L

E

Q

G

G

I

T

T

A

I

F

V

L

L

V

V

V

T

T

H

H

E

D

P

L

D

Q

I

L

A

A

Q

K

H

R

A

M

K

S

R

R

Q

Q

V

L

R

E

F

M

L

R

D

D

G

G

R

R

I

L

V

T

binding adenosine-5'-diphosphate: G42 (= G53), G44 (= G55), K45 (= K56), S46 (= S57)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
44% identity, 88% coverage: 13:231/248 of query aligns to 4:223/229 of 7v8iD

query
sites
7v8iD

V

L

I

L

E

Q

V

C

A

D

G

N

L

L

D

C

K

K

A

R

Y

Y

D

Q

T

E

P

G

M

S

G

V

P

Q

F

T

P

D

V
|
V

L

L

K

H

G

N

V

V

S

S

L

F

A

S

I

V

H

G

A

E

G

G

E

E

F

M

V

M

A

A

I

I

M

V

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

M

L

N

H

I

L

L

L

G

G

C

G

L

L

D

D

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

I

L

F

D

N

G

G

K

Q

H

P

V

M

S

S

A

K

L

L

D

S

K

S

D

A

Q

A

T

K

A

A

L

E

L

L

R

R

N

N

R

Q

T

K

I

L

G

G

F

F

V

I

F

Y

Q
|
Q

G

F

F

H

N

H

L

L

P

P

R

D

M

F

S

T

L

A

E

L

D

E

N

N

V

V

A

A

L

M

P

P

L

L

V

L

Y

I

C

G

G

K

V

K

D

K

K

P

E

A

E

E

R

I

R

N

Q

S

R

R

A

A

R

L

E

E

L

M

L

L

A

K

K

A

V

V

G

G

L

L

G

D

Q

H

Y
x
R

A

A

K

N

S
x
H

L

R

P

P

N

S

R
x
E

I

L

S
|
S

G

G

G
|
G

Q
x
E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

V

V

N

N

R

N

P

P

R

R

L

L

I

V

L

L

A

A

D

D

E

Q

P

P

T

T

G

G

N

N

L

L

D

D

S

A

H

R

T

N

S

A

E

D

E

S

I

I

M

F

A

Q

L

L

F

L

E

G

E

E

L

L

N

N

R

R

-

L

E

Q

G

G

I

T

T

A

I

F

V

L

L

V

V

V

T

T

H
|
H

E

D

P

L

D

Q

I

L

A

A

Q

K

H

R

A

M

K

S

R

R

Q

Q

V

L

R

E

F

M

L

R

D

D

G

G

R

R

I

L

V

T

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V32), S43 (= S52), G44 (= G53), G46 (= G55), K47 (= K56), S48 (= S57), T49 (= T58), Q93 (= Q102), R137 (≠ Y146), H140 (≠ S149), E144 (≠ R153), S146 (= S155), G148 (= G157), E149 (≠ Q158), H203 (= H211)
binding magnesium ion: S48 (= S57), Q93 (= Q102)

8g4cB Bceabs atpgs high res tm (see paper)
36% identity, 88% coverage: 12:230/248 of query aligns to 2:221/248 of 8g4cB

query
sites
8g4cB

A

V

V

I

I

L

E

E

V

A

A

N

G

K

L

I

D

R

K

K

A

S

Y
|
Y

D

G

T

N

P

K

M

L

G

N

P

K

F

Q

P

E

V

V

L

L

K

K

G

G

V

I

S

D

L

I

A

H

I

I

H

E

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

P

A

S
|
S

G

G

S
|
S

G

G

K

K

S
x
T

T

T

F

L

M

L

N

N

I

V

L

L

G

S

C

S

L

I

D

D

R

Q

P

V

S

S

G

H

G

G

D

T

Y

I

I

H

L

I

D

N

G

G

K

N

H

D

V

M

S

T

A

A

L

M

D

K

K

E

D

K

Q

Q

T

L

A

A

L

E

L

F

R

R

N

K

R

Q

T

H

I

L

G

G

F

F

V

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

P

D

R

T

M

L

S

T

L

V

E

K

D

E

N

N

V

I

A

L

L

L

P

P

L

L

V

S

Y

I

C

T

G

K

V

L

D

S

K

K

E

K

E

E

R

A

R

N

Q

R

R

K

A

F

R

E

E

E

L

V

L

A

A

K

K

E

V

L

G

G

L

I

G

Y

Q

E

Y

L

A

R

K

D

S

K

L

Y

P

P

N

N

R

E

I

I

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

V

I

N

H

R

D

P

P

R

S

L

I

I

I

L

F

A

A

D
|
D

E

E

P

P

T

T

G

G

N

A

L

L

D

D

S

S

H

K

T

S

S

A

E

S

E

D

I

L

M

L

A

N

L

K

F

L

E

S

E

Q

L

L

N

N

-

Q

R

K

E

R

G

N

I

A

T

T

I

I

V

I

L

M

V

V

T

T

H

H

E

D

P

P

D

V

I

A

A

A

Q

S

H

Y

A

C

K

G

R

R

Q

V

V

I

R

F

F

I

L

K

D

D

G

G

R

Q

I

M

binding phosphothiophosphoric acid-adenylate ester: Y13 (= Y23), S42 (= S52), S44 (= S54), T47 (≠ S57), D168 (= D178)

6z4wA Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
40% identity, 90% coverage: 12:233/248 of query aligns to 2:220/230 of 6z4wA

query
sites
6z4wA

A

S

V

I

I

I

E

E

V

M

A

R

G

D

L

V

D

V

K

K

A

K

Y
|
Y

D

D

T

N

P

G

M
x
T

G

-

P

-

F

-

P

T

V
x
A

L

L

K

R

G

G

V

V

S

S

L

V

A

S

I

V

H

Q

A

P

G

G

E

E

F

F

V

A

A

Y

I

I

M

V

G

G

P

P

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

F

F

M

I

N

R

I

S

L

L

G

Y

C

R

L

E

D

V

R

K

P

I

S

D

G

K

G

G

D

S

Y

L

I

S

L

V

D

A

G

G

K

F

H

N

V

L

S

V

A

K

L

I

D

K

K

K

D

K

Q

D

T

V

A

P

L

L

R

R

N

-

R

R

T

S

I

V

G

G

F

V

V

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

P

P

R

K

M

K

S

T

L

V

E

Y

D

E

N

N

V

I

A

A

L

Y

P

A

L

M

V

E

Y

V

C

I

G

G

V

E

D

N

K

R

E

R

E

N

R

I

R

K

Q

R

R

R

A

V

R

M

E

E

L

V

L

L

A

D

K

L

V

V

G

G

L

L

G

K

Q

H

Y

K

A

V

K

R

S

S

L

F

P

P

N

N

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

L

I

V

V

N

N

R

N

P

P

R

K

L

V

I

L

L

I

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

H

D

T

N

S

S

E

W

E

E

I

I

M

M

A

N

L

L

F

L

E

E

E

R

L

I

N

N

R

L

E

Q

G

G

I

T

T

T

I

I

V

L

L

M

V

A

T

T

H

H

E

N

P

S

D

Q

I

I

A

V

Q

N

H

T

A

L

K

R

-

H

R

R

Q

V

V

I

R

A

F

I

L

E

D

N

G

G

R

R

I

V

V

V

H

R

D

D

binding adenosine-5'-diphosphate: Y13 (= Y23), T17 (≠ M27), A19 (≠ V32), G40 (= G53), G42 (= G55), K43 (= K56), S44 (= S57), T45 (= T58)

7tchB Bceab e169q variant atp-bound conformation (see paper)
36% identity, 88% coverage: 12:230/248 of query aligns to 1:220/245 of 7tchB

query
sites
7tchB

A

V

V

I

I

L

E

E

V

A

A

N

G

K

L

I

D

R

K

K

A

S

Y
|
Y

D

G

T

N

P

K

M

L

G

N

P

K

F
x
Q

P

E

V
|
V

L

L

K

K

G

G

V

I

S

D

L

I

A

H

I

I

H

E

A

K

G

G

E

E

F

F

V

V

A

S

I

I

M

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G

G

K
|
K

S
x
T

T

T

F

L

M

L

N

N

I

V

L

L

G

S

C

S

L

I

D

D

R

Q

P

V

S

S

G

H

G

G

D

T

Y

I

I

H

L

I

D

N

G

G

K

N

H

D

V

M

S

T

A

A

L

M

D

K

K

E

D

K

Q

Q

T

L

A

A

L

E

L

F

R

R

N

K

R

Q

T

H

I

L

G

G

F

F

V

I

F

F

Q

Q

G

D

F

Y

N

N

L

L

P

D

R

T

M

L

S

T

L

V

E

K

D

E

N

N

V

I

A

L

L

L

P

P

L

L

V

S

Y

I

C

T

G

K

V

L

D

S

K

K

E

K

E

E

R

A

R

N

Q

R

R

K

A

F

R

E

E

E

L

V

L

A

A

K

K

E

V

L

G

G

L

I

G

Y

Q

E

Y

L

A

R

K

D

S

K

L

Y

P

P

N

N

R
x
E

I

I

S

S

G
|
G

Q

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

L

F

V

I

N

H

R

D

P

P

R

S

L

I

I

I

L

F

A

A

D

D

E

Q

P

P

T

T

G

G

N

A

L

L

D

D

S

S

H

K

T

S

S

A

E

S

E

D

I

L

M

L

A

N

L

K

F

L

E

S

E

Q

L

L

N

N

-

Q

R

K

E

R

G

N

I

A

T

T

I

I

V

I

L

M

V

V

T

T

H

H

E

D

P

P

D

V

I

A

A

A

Q

S

H

Y

A

C

K

G

R

R

Q

V

V

I

R

F

F

I

L

K

D

D

G

G

R

Q

I

M

binding adenosine-5'-triphosphate: Y12 (= Y23), Q19 (≠ F30), V21 (= V32), S41 (= S52), G42 (= G53), S43 (= S54), K45 (= K56), T46 (≠ S57), E142 (≠ R153), G145 (= G156), G146 (= G157)

6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution (see paper)
40% identity, 90% coverage: 11:233/248 of query aligns to 1:220/229 of 6z67B

query
sites
6z67B

A

G

A

S

V

I

I

I

E

E

V

M

A

R

G

D

L

V

D

V

K

K

A

K

Y
|
Y

D

D

T

N

P
x
G

M

T

G

-

P

-

F

-

P

T

V
x
A

L

L

K

R

G

G

V

V

S

S

L

V

A

S

I

V

H

Q

A

P

G

G

E

E

F

F

V

A

A

Y

I

I

M

V

G

G

P

P

S
|
S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

F

F

M

I

N

R

I

S

L

L

G

Y

C

R

L

E

D

V

R

K

P

I

S

D

G

K

G

G

D

S

Y

L

I

S

L

V

D

A

G

G

K

F

H

N

V

L

S

V

A

K

L

I

D

K

K

K

D

K

Q

D

T

V

A

P

L

L

R

R

N

-

R

R

T

S

I

V

G

G

F

V

V

V

F

F

Q

Q

G

D

F

Y

N

K

L

L

P

P

R

K

M

K

S

T

L

V

E

Y

D

E

N

N

V

I

A

A

L

Y

P

A

L

M

V

E

Y

V

C

I

G

G

V

E

D

N

K

R

E

R

E

N

R

I

R

K

Q

R

R

R

A

V

R

M

E

E

L

V

L

L

A

D

K

L

V

V

G

G

L

L

G

K

Q

H

Y

K

A

V

K

R

S

S

L

F

P

P

N

N

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

I

A

A

I

I

A

A

R

R

A

A

L

I

V

V

N

N

R

N

P

P

R

K

L

V

I

L

L

I

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

H

D

T

N

S

S

E

W

E

E

I

I

M

M

A

N

L

L

F

L

E

E

E

R

L

I

N

N

R

L

E

Q

G

G

I

T

T

T

I

I

V

L

L

M

V

A

T

T

H

H

E

N

P

S

D

Q

I

I

A

V

Q

N

H

T

A

L

K

R

-

H

R

R

Q

V

V

I

R

A

F

I

L

E

D

N

G

G

R

R

I

V

V

V

H

R

D

D

binding phosphoaminophosphonic acid-adenylate ester: Y13 (= Y23), G16 (≠ P26), A19 (≠ V32), S39 (= S52), G40 (= G53), G42 (= G55), K43 (= K56), S44 (= S57), T45 (= T58)

8iddA Cryo-em structure of mycobacterium tuberculosis atp bound ftsex/ripc complex in peptidisc (see paper)
46% identity, 82% coverage: 31:233/248 of query aligns to 18:220/225 of 8iddA

query
sites
8iddA

P

P

V

A

L

L

K

D

G

D

V

I

S

N

L

V

A

K

I

I

H

D

A

K

G

G

E

E

F

F

V

V

A

F

I

L

M

I

G

G

P

P

S
|
S

G

G

S

S

G
|
G

K
|
K

S
|
S

T

T

F

F

M

M

N

R

I

L

L

L

G

L

C

A

L

A

D

E

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

R

L

V

D

S

G

K

K

F

H

H

V

V

S

N

A

K

L

L

D

R

K

G

D

R

Q

H

T

V

A

P

L

K

L

L

R

R

N

-

R

Q

T

V

I

I

G

G

F

C

V

V

F

F

Q

Q

G

D

F

F

N

R

L

L

P

Q

R

Q

M

K

S

T

L

V

E

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

V

E

Y

V

C

I

G

G

V

K

D

R

K

T

E

D

E

A

R

I

R

N

Q

R

R

V

A

V

R

P

E

E

L

V

L

L

A

E

K

T

V

V

G

G

L

L

G

S

Q

G

Y

K

A

A

K

N

S

R

L

L

P

P

N

D

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

F

V

V

N

N

R

R

P

P

R

L

L

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

H

E

T

T

S

S

E

R

E

D

I

I

M

M

A

D

L

L

F

L

E

E

E

R

L

I

N

N

R

R

E

T

G

G

I

T

T

T

I

V

V

L

L

M

V

A

T

T

H

H

E

D

P

H

D

H

I

I

A

V

Q

D

H

S

A

M

K

R

R

Q

Q

R

V

V

R

V

F

E

L

L

D

S

-

L

G

G

R

R

I

L

V

V

H

R

D

D

binding adenosine-5'-triphosphate: S39 (= S52), G42 (= G55), K43 (= K56), S44 (= S57)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 12

8igqA Cryo-em structure of mycobacterium tuberculosis adp bound ftsex/ripc complex in peptidisc (see paper)
46% identity, 82% coverage: 31:233/248 of query aligns to 18:220/227 of 8igqA

query
sites
8igqA

P

P

V

A

L

L

K

D

G

D

V

I

S

N

L

V

A

K

I

I

H

D

A

K

G

G

E

E

F

F

V

V

A

F

I

L

M

I

G

G

P

P

S

S

G
|
G

S
|
S

G

G

K
|
K

S
|
S

T

T

F

F

M

M

N

R

I

L

L

L

G

L

C

A

L

A

D

E

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

R

L

V

D

S

G

K

K

F

H

H

V

V

S

N

A

K

L

L

D

R

K

G

D

R

Q

H

T

V

A

P

L

K

L

L

R

R

N

-

R

Q

T

V

I

I

G

G

F

C

V

V

F

F

Q

Q

G

D

F

F

N

R

L

L

P

Q

R

Q

M

K

S

T

L

V

E

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

V

E

Y

V

C

I

G

G

V

K

D

R

K

T

E

D

E

A

R

I

R

N

Q

R

R

V

A

V

R

P

E

E

L

V

L

L

A

E

K

T

V

V

G

G

L

L

G

S

Q

G

Y

K

A

A

K

N

S

R

L

L

P

P

N

D

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

F

V

V

N

N

R

R

P

P

R

L

L

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

H

E

T

T

S

S

E

R

E

D

I

I

M

M

A

D

L

L

F

L

E

E

E

R

L

I

N

N

R

R

E

T

G

G

I

T

T

T

I

V

V

L

L

M

V

A

T

T

H

H

E

D

P

H

D

H

I

I

A

V

Q

D

H

S

A

M

K

R

R

Q

Q

R

V

V

R

V

F

E

L

L

D

S

-

L

G

G

R

R

I

L

V

V

H

R

D

D

binding adenosine-5'-diphosphate: G40 (= G53), S41 (= S54), K43 (= K56), S44 (= S57)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

A5U7B7 Cell division ATP-binding protein FtsE from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) (see 2 papers)
46% identity, 82% coverage: 31:233/248 of query aligns to 17:219/229 of A5U7B7

query
sites
A5U7B7

P

P

V

A

L

L

K

D

G

D

V

I

S

N

L

V

A

K

I

I

H

D

A

K

G

G

E

E

F

F

V

V

A

F

I

L

M

I

G

G

P

P

S

S

G

G

S

S

G

G

K
|
K

S

S

T

T

F

F

M

M

N

R

I

L

L

L

G

L

C

A

L

A

D

E

R

T

P

P

S

T

G

S

G

G

D

D

Y

V

I

R

L

V

D

S

G

K

K

F

H

H

V

V

S

N

A

K

L

L

D

R

K

G

D

R

Q

H

T

V

A

P

L

K

L

L

R

R

N

-

R

Q

T

V

I

I

G

G

F
x
C

V

V

F

F

Q

Q

G

D

F

F

N

R

L

L

P

Q

R

Q

M

K

S

T

L

V

E

Y

D

D

N

N

V

V

A

A

L

F

P

A

L

L

V

E

Y

V

C

I

G

G

V

K

D

R

K

T

E

D

E

A

R

I

R

N

Q

R

R

V

A

V

R

P

E

E

L

V

L

L

A

E

K

T

V

V

G

G

L

L

G

S

Q

G

Y

K

A

A

K

N

S

R

L

L

P

P

N

D

R

E

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

F

V

V

N

N

R

R

P

P

R

L

L

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

P

H

E

T

T

S

S

E

R

E

D

I

I

M

M

A

D

L

L

F

L

E

E

E

R

L

I

N

N

R

R

E

T

G

G

I

T

T

T

I

V

V

L

L

M

V

A

T

T

H

H

E

D

P

H

D

H

I

I

A

V

Q

D

H

S

A

M

K

R

R

Q

Q

R

V

V

R

V

F

E

L

L

D

S

-

L

G

G

R

R

I

L

V

V

H

R

D

D

K42 (= K56) mutation to R: Does not bind ATP. Does not affect dimerization.
C84 (≠ F99) mutation to A: Does not affect ATPase activity.

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
41% identity, 88% coverage: 13:230/248 of query aligns to 1:215/222 of P0A9R7

query
sites
P0A9R7

V

M

I

I

E

R

V

F

A

E

G

H

L

V

D

S

K

K

A

A

Y

Y

D

-

T

-

P

-

M

L

G

G

P

G

F

R

P

Q

V

A

L

L

K

Q

G

G

V

V

S

T

L

F

A

H

I

M

H

Q

A

P

G

G

E

E

F

M

V

A

A

F

I

L

M

T

G

G

P

H

S

S

G

G

S

A

G

G

K
|
K

S

S

T

T

F

L

M

L

N

K

I

L

L

I

G
x
C

C

G

L

I

D

E

R

R

P

P

S

S

G

A

G

G

D

K

Y

I

I

W

L

F

D

S

G

G

K

H

H

D

V

I

S

T

A

R

L

L

D

K

K

N

D

R

Q

E

T

V

A

P

L

F

L

L

R

R

N

-

R

R

T

Q

I

I

G

G

F

M

V

I

F

F

Q

Q

G

D

F

H

N

H

L

L

P

M

R

D

M

R

S

T

L

V

E

Y

D

D

N

N

V

V

A

A

L

I

P

P

L

L

V

I

Y

I

C

A

G

G

V

A

D

S

K

G

E

D

R

I

R

R

Q

R

R

R

A

V

R

S

E

A

L

A

L

L

A

D

K

K

V

V

G

G

L

L

G

L

Q

D

Y

K

A

A

K

K

S

N

L

F

P

P

N

I

R

Q

I

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

G

I

I

A

A

R

R

A

A

L

V

V

V

N

N

R

K

P

P

R

A

L

V

I

L

L

L

A

A

D

D

E

E

P

P

T

T

G

G

N

N

L

L

D

D

S

D

H

A

T

L

S

S

E

E

E

G

I

I

M

L

A

R

L

L

F

F

E

E

L

F

N

N

R

R

E

V

G

G

I

V

T

T

I

V

V

L

L

M

V

A

T

T

H

H

E

D

P

I

D

N

-

L

I

I

A

S

Q

R

H

R

A

S

K

Y

R

R

Q

M

V

L

R

T

F

L

L

S

D

D

G

G

R

H

I

L

K41 (= K56) mutation to R: Does not bind ATP.
C49 (≠ G64) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

Query Sequence

>Dsui_2877 Dsui_2877 ABC-type antimicrobial peptide transport system, ATPase component
MSAATASADAAAVIEVAGLDKAYDTPMGPFPVLKGVSLAIHAGEFVAIMGPSGSGKSTFM
NILGCLDRPSGGDYILDGKHVSALDKDQTALLRNRTIGFVFQGFNLLPRMSLEDNVALPL
VYCGVDKEERRQRARELLAKVGLGQYAKSLPNRISGGQQQRVAIARALVNRPRLILADEP
TGNLDSHTSEEIMALFEELNREGITIVLVTHEPDIAQHAKRQVRFLDGRIVHDAPTHHDL
PAGEAQPC

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory