SitesBLAST
Comparing Dsui_3369 Dsui_3369 acyl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
75% identity, 99% coverage: 4:392/394 of query aligns to 3:385/385 of 3gqtC
- active site: L135 (= L135), T136 (= T136), A250 (= A251), E365 (= E372), R377 (= R384)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W166), K210 (= K211), L213 (= L214), T218 (= T219), Y364 (= Y371)
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
74% identity, 98% coverage: 4:391/394 of query aligns to 3:382/382 of 3eonC
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
74% identity, 98% coverage: 4:391/394 of query aligns to 4:380/380 of 3gncA
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
73% identity, 98% coverage: 4:391/394 of query aligns to 3:377/377 of 3d6bC
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
68% identity, 99% coverage: 4:393/394 of query aligns to 2:389/390 of 2r0nA
- active site: L133 (= L135), T134 (= T136), A247 (= A251), E368 (= E372), R380 (= R384)
- binding flavin-adenine dinucleotide: F131 (= F133), L133 (= L135), T134 (= T136), G139 (= G141), S140 (= S142), W166 (= W166), I167 (= I167), T168 (= T168), Y367 (= Y371), T370 (= T374), D372 (= D376)
- binding 3-thiaglutaryl-CoA: R92 (= R94), S93 (= S95), V97 (= V99), P142 (= P144), G238 (≠ K242), F241 (= F245), L244 (= L248), N245 (= N249), P318 (= P322), Y367 (= Y371), E368 (= E372), I377 (= I381)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
68% identity, 99% coverage: 4:393/394 of query aligns to 2:389/390 of 1sirA
- active site: L133 (= L135), T134 (= T136), A247 (= A251), E368 (= E372), R380 (= R384)
- binding flavin-adenine dinucleotide: F131 (= F133), L133 (= L135), T134 (= T136), G139 (= G141), S140 (= S142), W166 (= W166), I167 (= I167), T168 (= T168), Y367 (= Y371), T370 (= T374)
- binding s-4-nitrobutyryl-coa: S93 (= S95), S140 (= S142), F241 (= F245), G242 (≠ A246), L244 (= L248), N245 (= N249), R248 (= R252), P318 (= P322), Y367 (= Y371), E368 (= E372), R380 (= R384)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
68% identity, 99% coverage: 4:393/394 of query aligns to 2:389/390 of 2r0mA
- active site: L133 (= L135), T134 (= T136), A247 (= A251), D368 (≠ E372), R380 (= R384)
- binding 4-nitrobutanoic acid: L101 (= L103), Y367 (= Y371), D368 (≠ E372)
- binding flavin-adenine dinucleotide: F131 (= F133), L133 (= L135), T134 (= T136), G139 (= G141), S140 (= S142), W166 (= W166), I167 (= I167), T168 (= T168), L210 (= L214), Y367 (= Y371), T370 (= T374)
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
53% identity, 99% coverage: 3:392/394 of query aligns to 1:386/387 of 3sf6A
- active site: L134 (= L135), T135 (= T136), A245 (= A251), E366 (= E372), Q378 (≠ R384)
- binding dihydroflavine-adenine dinucleotide: F132 (= F133), L134 (= L135), T135 (= T136), G140 (= G141), S141 (= S142), W165 (= W166), I166 (= I167), T167 (= T168), S361 (≠ V367), T364 (= T370), Y365 (= Y371), T368 (= T374), E370 (≠ D376), M371 (≠ I377)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
51% identity, 98% coverage: 8:392/394 of query aligns to 3:380/380 of 2ebaA
- active site: L131 (= L135), T132 (= T136), A239 (= A251), E360 (= E372), R372 (= R384)
- binding flavin-adenine dinucleotide: L131 (= L135), T132 (= T136), G136 (≠ H140), G137 (= G141), S138 (= S142), W161 (= W166), T163 (= T168), R265 (= R277), L272 (= L284), K275 (≠ N287), D333 (= D345), I334 (≠ M346), G337 (= G349), T355 (≠ V367), T358 (= T370), Y359 (= Y371), T362 (= T374)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
47% identity, 97% coverage: 9:392/394 of query aligns to 6:387/388 of 3swoA
- active site: L135 (= L135), T136 (= T136), A246 (= A251), E367 (= E372), K379 (≠ R384)
- binding dihydroflavine-adenine dinucleotide: F133 (= F133), L135 (= L135), T136 (= T136), G141 (= G141), S142 (= S142), W166 (= W166), I167 (= I167), T168 (= T168), R272 (= R277), V274 (≠ Q279), F275 (= F280), L279 (= L284), Y282 (≠ N287), T340 (≠ D345), L341 (≠ M346), G344 (= G349), I347 (= I352), T365 (= T370), Y366 (= Y371), T369 (= T374), E371 (≠ D376), M372 (≠ I377)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
37% identity, 98% coverage: 8:392/394 of query aligns to 47:428/436 of Q96329
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
37% identity, 98% coverage: 7:392/394 of query aligns to 30:412/415 of 2ix5A
- active site: L158 (= L135), T159 (= T136), S271 (≠ A251), E392 (= E372), R404 (= R384)
- binding acetoacetyl-coenzyme a: S165 (= S142), A167 (≠ P144), S168 (≠ G145), F261 (≠ L241), L268 (= L248), R272 (= R252), E392 (= E372), G393 (= G373), R404 (= R384)
- binding flavin-adenine dinucleotide: L158 (= L135), T159 (= T136), G164 (= G141), S165 (= S142), W189 (= W166), N239 (≠ T219), R297 (= R277), F300 (= F280), L304 (= L284), F307 (≠ N287), L309 (= L289), N310 (≠ V290), E365 (≠ D345), L366 (≠ M346), G368 (= G348), G369 (= G349), Y391 (= Y371), T394 (= T374), D396 (= D376), I397 (= I377)
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
37% identity, 98% coverage: 7:392/394 of query aligns to 30:412/416 of 2ix6A
- active site: L158 (= L135), T159 (= T136), S271 (≠ A251), E392 (= E372), R404 (= R384)
- binding flavin-adenine dinucleotide: T159 (= T136), G164 (= G141), S165 (= S142), W189 (= W166), N239 (≠ T219), R297 (= R277), F300 (= F280), L304 (= L284), F307 (≠ N287), N310 (≠ V290), E365 (≠ D345), L366 (≠ M346), G369 (= G349), I372 (= I352), Y391 (= Y371), T394 (= T374), D396 (= D376)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
33% identity, 95% coverage: 12:385/394 of query aligns to 1:376/380 of 4l1fA
- active site: L125 (= L135), T126 (= T136), G242 (≠ A251), E363 (= E372), R375 (= R384)
- binding coenzyme a persulfide: T132 (≠ S142), H179 (≠ G189), F232 (≠ L241), M236 (≠ F245), E237 (≠ A246), L239 (= L248), D240 (≠ N249), R243 (= R252), Y362 (= Y371), E363 (= E372), G364 (= G373), R375 (= R384)
- binding flavin-adenine dinucleotide: F123 (= F133), L125 (= L135), T126 (= T136), G131 (= G141), T132 (≠ S142), F156 (≠ W166), I157 (= I167), T158 (= T168), R268 (= R277), Q270 (= Q279), F271 (= F280), I275 (≠ L284), F278 (≠ N287), L281 (≠ V290), Q336 (≠ D345), I337 (≠ M346), G340 (= G349), I358 (≠ V367), Y362 (= Y371), T365 (= T374), Q367 (≠ D376)
- binding 1,3-propandiol: L5 (= L16), Q10 (≠ R21)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
34% identity, 95% coverage: 11:384/394 of query aligns to 1:376/378 of 4n5fA
- active site: L126 (= L135), T127 (= T136), G243 (≠ A251), E364 (= E372), R376 (= R384)
- binding dihydroflavine-adenine dinucleotide: L126 (= L135), T127 (= T136), G132 (= G141), S133 (= S142), F157 (≠ W166), T159 (= T168), T210 (= T219), Y363 (= Y371), T366 (= T374), E368 (≠ D376), M372 (≠ L380)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
36% identity, 93% coverage: 19:384/394 of query aligns to 5:370/374 of 5lnxD
- active site: L122 (= L135), T123 (= T136), G239 (≠ A251), E358 (= E372), K370 (≠ R384)
- binding flavin-adenine dinucleotide: L122 (= L135), T123 (= T136), G128 (= G141), S129 (= S142), F153 (≠ W166), T155 (= T168), R265 (= R277), Q267 (= Q279), F268 (= F280), I272 (≠ L284), N275 (= N287), I278 (≠ V290), Q331 (≠ D345), I332 (≠ M346), G335 (= G349), Y357 (= Y371), T360 (= T374), E362 (≠ D376)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
37% identity, 94% coverage: 16:384/394 of query aligns to 1:366/370 of 2dvlA
- active site: L121 (= L135), T122 (= T136), G233 (≠ A251), E354 (= E372), R366 (= R384)
- binding flavin-adenine dinucleotide: L121 (= L135), T122 (= T136), G127 (= G141), S128 (= S142), W152 (= W166), I153 (= I167), T154 (= T168), T356 (= T374), E358 (≠ D376)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
33% identity, 95% coverage: 12:385/394 of query aligns to 1:380/383 of 1bucA
- active site: L128 (= L135), T129 (= T136), G246 (≠ A251), E367 (= E372), G379 (≠ R384)
- binding acetoacetyl-coenzyme a: L96 (= L103), F126 (= F133), G134 (= G141), T135 (≠ S142), T162 (= T168), N182 (≠ G188), H183 (≠ G189), F236 (≠ L241), M240 (≠ F245), M241 (≠ A246), L243 (= L248), D244 (≠ N249), T317 (≠ P322), Y366 (= Y371), E367 (= E372), G368 (= G373)
- binding flavin-adenine dinucleotide: F126 (= F133), L128 (= L135), T129 (= T136), G134 (= G141), T135 (≠ S142), F160 (≠ W166), T162 (= T168), Y366 (= Y371), T369 (= T374), E371 (≠ D376), M375 (≠ L380)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
33% identity, 95% coverage: 12:385/394 of query aligns to 1:380/383 of Q06319
- E367 (= E372) active site, Proton acceptor; mutation to Q: Loss of activity.
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
30% identity, 94% coverage: 14:382/394 of query aligns to 2:372/378 of 5ol2F
- active site: L124 (= L135), T125 (= T136), G241 (≠ A251)
- binding calcium ion: E29 (≠ Q41), E33 (≠ H45), R35 (≠ Q47)
- binding coenzyme a persulfide: L238 (= L248), R242 (= R252), E362 (= E372), G363 (= G373)
- binding flavin-adenine dinucleotide: F122 (= F133), L124 (= L135), T125 (= T136), P127 (= P138), T131 (≠ S142), F155 (≠ W166), I156 (= I167), T157 (= T168), E198 (≠ Q209), R267 (= R277), F270 (= F280), L274 (= L284), F277 (≠ N287), Q335 (≠ D345), L336 (≠ M346), G338 (= G348), G339 (= G349), Y361 (= Y371), T364 (= T374), E366 (≠ D376)
Sites not aligning to the query:
Query Sequence
>Dsui_3369 Dsui_3369 acyl-CoA dehydrogenase
MSRFNWEDPLQLDDQLSAEERQVRDTARQYSQDRLLPRIVQAFRHEQTDPAIFRELGELG
LLGATLDGYGCAGASYVSYGLLAREIERVDSGYRSMVSVQSSLAMYPIHAFGSEALKERL
LPKMATGELIGCFGLTEPNHGSDPGSMESRAEAVPGGWELTGAKMWITNSPIADVFVVWA
KDGQDEDGGEIRGFVLEKGMKGLSAPVIQGKMGLRASVTGEIVMDKVFVPEENLLPKVKG
LKGPFACLNQARYGIAWGALGAAEACWHAARQYTLDRPQFGRPLAANQLVQKKLADMQTE
IALGLQGCLRLGRLKDEGKDAPEMTSLLKRNSCGKALEIARTARDMHGGNGISDEFHVVR
HMLNLEVVNTYEGTHDIHALILGRAQTGIAAFAN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory