SitesBLAST

8raiA Crystal structure of d-amino acid transaminase from haliscomenobacter hydrossis point mutant r90i complexed with phenylhydrazine
36% identity, 93% coverage: 12:264/273 of query aligns to 13:271/282 of 8raiA

query
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binding [6-methyl-5-oxidanyl-4-[(2-phenylhydrazinyl)methyl]pyridin-3-yl]methyl dihydrogen phosphate: F34 (= F33), R53 (= R52), R138 (= R137), K144 (= K143), Y148 (= Y147), E177 (= E175), A179 (≠ S177), R180 (= R178), S181 (= S179), N182 (= N180), L200 (= L197), G202 (= G199), I203 (= I200), T204 (= T201), T240 (= T233)

5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
32% identity, 96% coverage: 12:272/273 of query aligns to 12:287/290 of 5e25A

query
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5e25A

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active site: F33 (= F33), G35 (≠ F35), K151 (= K143), E184 (= E175), L207 (= L197)
binding 2-oxoglutaric acid: Y88 (≠ G88), K151 (= K143), T247 (= T233), A248 (≠ T234)
binding pyridoxal-5'-phosphate: R52 (= R52), K151 (= K143), Y155 (= Y147), E184 (= E175), G187 (≠ R178), D188 (≠ S179), L207 (= L197), G209 (= G199), I210 (= I200), T211 (= T201), G246 (≠ S232), T247 (= T233)

5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
30% identity, 97% coverage: 4:269/273 of query aligns to 3:282/290 of 5mr0D

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5mr0D

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active site: F32 (= F33), G34 (≠ F35), K150 (= K143), E183 (= E175), L206 (= L197)
binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: R51 (= R52), G100 (≠ H101), L101 (≠ F102), K150 (= K143), Y154 (= Y147), E183 (= E175), G186 (≠ R178), D187 (≠ S179), L206 (= L197), I209 (= I200), T210 (= T201), G245 (≠ S232), T246 (= T233)

8aieB Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
31% identity, 95% coverage: 5:264/273 of query aligns to 4:266/275 of 8aieB

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binding 3-azanyloxy-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]propanoic acid: T34 (≠ F35), R51 (= R52), K142 (= K143), Y146 (= Y147), E172 (= E175), H175 (≠ R178), S176 (= S179), T198 (≠ I200), T199 (= T201), G234 (≠ S232), T235 (= T233), V236 (≠ T234), K237 (= K235)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R51 (= R52), Y146 (= Y147), E172 (= E175), S174 (= S177), H175 (≠ R178), S176 (= S179), L195 (= L197), T198 (≠ I200), T199 (= T201), G234 (≠ S232), T235 (= T233)

8aykA Crystal structure of d-amino acid aminotrensferase from aminobacterium colombiense complexed with d-glutamate (see paper)
31% identity, 95% coverage: 5:264/273 of query aligns to 5:267/276 of 8aykA

query
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8aykA

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D

G

L

C

K

E

Q

T

G

-

G

M

I

V

R

R

M

P

V

Y

L

I

S

T

G

G

N

D

S

S

-

F

-

G

-

K

D

D

N

H

H

L

F

F

S

S

P

S

T

S

K

R

G

-

S

-

L

Y

F

F

I

V

F

I

C

F

E

E

A

E

L

I

Q

R

M

K

P

P

S

D

D

P

D

I

K

L

Y

Y

R

E

N

K

G

G

V

V

H

A

L

L

L

H

T

P

T

I

E

N

Y

A

I

E

R
|
R

P

Y

V

L

P

P

E

S

I

T

K
|
K

T

S

T

I

N

N

Y

Y

A

M

L

L

P

S

V

F

Y

T

L

G

S

Q

K

R

D

D

W

S

K

K

A

G

N

-

A

A

E

Y

D

E

V

I

L

L

Y

Y

H

C

A

P

D

E

G

G

I

E

I

I

S

V

E
|
E

S

G

S
|
S

R
x
H

S
|
S

N

T

I

F

F

F

I

L

V

I

K

K

D

N

G

G

-

H

T

L

I

I

S

T

T

A

P

P

K

T

T

S

N

R

I

A

L
|
L

K

S

G
|
G

I
x
T

T
|
T

R

R

K

Q

N

I

I

V

L

L

A

E

L

L

V

A

P

R

D

R

A

G

Q

N

I

I

-

Q

-

V

-

E

R

R

D

C

I

P

T

L

L

L

E

T

E

E

V

L

M

P

A

E

A

A

D

E

E

E

V

A

F

F

M

I

S

T

S
x
G

T
|
T

T
x
V

K
|
K

R

E

I

L

L

L

P

P

I

V

T

V

K

R

I

I

D

G

H

D

Q

Q

P

I

I

I

S

G

N

N

G

G

A

V

V

P

G

G

T

K

R

L

T

T

T

K

A

H

L

L

M

H

E

Q

Q

V

F

Y

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R52 (= R52), R137 (= R137), K143 (= K143), E173 (= E175), S175 (= S177), H176 (≠ R178), S177 (= S179), L196 (= L197), T199 (≠ I200), T200 (= T201), G235 (≠ S232), T236 (= T233)
binding (~{Z})-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]pent-2-enedioic acid: T35 (≠ F35), R52 (= R52), R137 (= R137), K143 (= K143), E173 (= E175), H176 (≠ R178), S177 (= S179), L196 (= L197), G198 (= G199), T199 (≠ I200), T200 (= T201), G235 (≠ S232), T236 (= T233), V237 (≠ T234), K238 (= K235)

8ayjA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiens complexed with 3-aminooxypropionic acid (see paper)
31% identity, 95% coverage: 5:264/273 of query aligns to 5:267/276 of 8ayjA

query
sites
8ayjA

C

C

F

Y

A

I

I

D

D

G

R

K

I

F

I

L

P

P

S

L

E

E

D

E

A

A

S

K

L

L

H

P

P

V

L

T

D

D

I

L

G

I

L

I

I

Q

R

R

G

G

Y

V

A

G

V

V

F

F

D

E

F
x
T

F

I

R

S

T

T

V

H

D

S

Y

R

H

R

P

P

L

L

F

M

L

L

E

T

D

P

Y

H

L

L

D

K

R
|
R

F

L

I

E

A

G

S

S

A

A

A

T

K

A

A

S

H

S

L

I

V

V

L

M

D

P

Q

A

G

T

H

L

E

D

E

E

L

M

K

A

S

R

I

I

V

I

L

R

E

E

L

G

I

I

Q

K

K

K

N

M

D

G

L

C

K

E

Q

T

G

-

G
x
M

I

V

R
|
R

M

P

V

Y

L

I

S

T

G

G

N

D

S

S

-

F

-

G

-

K

D

D

N

H

H

L

F

F

S

S

P

S

T

S

K

R

G

-

S

-

L

Y

F

F

I

V

F

I

C

F

E

E

A

E

L

I

Q

R

M

K

P

P

S

D

D

P

D

I

K

L

Y

Y

R

E

N

K

G

G

V

V

H

A

L

L

L

H

T

P

T

I

E

N

Y

A

I

E

R
|
R

P

Y

V

L

P

P

E

S

I

T

K
|
K

T

S

T

I

N

N

Y
|
Y

A

M

L

L

P

S

V

F

Y

T

L

G

S

Q

K

R

D

D

W

S

K

K

A

G

N

-

A

A

E

Y

D

E

V

I

L

L

Y

Y

H

C

A

P

D

E

G

G

I

E

I

I

S

V

E
|
E

S

G

S
|
S

R
x
H

S
|
S

N

T

I

F

F

F

I

L

V

I

K

K

D

N

G

G

-

H

T

L

I

I

S

T

T

A

P

P

K

T

T

S

N

R

I

A

L
|
L

K

S

G
|
G

I
x
T

T
|
T

R

R

K

Q

N

I

I

V

L

L

A

E

L

L

V

A

P

R

D

R

A

G

Q

N

I

I

-

Q

-

V

-

E

R

R

D

C

I

P

T

L

L

L

E

T

E

E

V

L

M

P

A

E

A

A

D

E

E

E

V

A

F

F

M

I

S

T

S
x
G

T
|
T

T
x
V

K
|
K

R

E

I

L

L

L

P

P

I

V

T

V

K

R

I

I

D

G

H

D

Q

Q

P

I

I

I

S

G

N

N

G

G

A

V

V

P

G

G

T

K

R

L

T

T

T

K

A

H

L

L

M

H

E

Q

Q

V

F

Y

binding 3-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxypropanoic acid: T35 (≠ F35), T35 (≠ F35), R52 (= R52), M87 (≠ G88), R89 (= R90), R137 (= R137), K143 (= K143), Y147 (= Y147), Y147 (= Y147), E173 (= E175), H176 (≠ R178), H176 (≠ R178), S177 (= S179), L196 (= L197), G198 (= G199), T199 (≠ I200), T200 (= T201), G235 (≠ S232), T236 (= T233), T236 (= T233), V237 (≠ T234), K238 (= K235)
binding pyridoxal-5'-phosphate: R52 (= R52), R137 (= R137), Y147 (= Y147), E173 (= E175), S175 (= S177), H176 (≠ R178), S177 (= S179), L196 (= L197), G198 (= G199), T199 (≠ I200), T200 (= T201), T236 (= T233)

8aieA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense complexed with d-cycloserine
31% identity, 95% coverage: 5:264/273 of query aligns to 5:267/276 of 8aieA

query
sites
8aieA

C

C

F

Y

A

I

I

D

D

G

R

K

I

F

I

L

P

P

S

L

E

E

D

E

A

A

S

K

L

L

H

P

P

V

L

T

D

D

I

L

G

I

L

I

I

Q

R

R

G

G

Y

V

A

G

V

V

F

F

D

E

F
x
T

F

I

R

S

T

T

V

H

D

S

Y

R

H

R

P

P

L

L

F

M

L

L

E

T

D

P

Y

H

L

L

D

K

R
|
R

F

L

I

E

A

G

S

S

A

A

A

T

K

A

A

S

H

S

L

I

V

V

L

M

D

P

Q

A

G

T

H

L

E

D

E

E

L

M

K

A

S

R

I

I

V

I

L

R

E

E

L

G

I

I

Q

K

K

K

N

M

D

G

L

C

K

E

Q

T

G

-

G

M

I

V

R

R

M

P

V

Y

L

I

S

T

G

G

N

D

S

S

-

F

-

G

-

K

D

D

N

H

H

L

F

F

S

S

P

S

T

S

K

R

G

-

S

-

L

Y

F

F

I

V

F

I

C

F

E

E

A

E

L

I

Q

R

M

K

P

P

S

D

D

P

D

I

K

L

Y

Y

R

E

N

K

G

G

V

V

H

A

L

L

L

H

T

P

T

I

E

N

Y

A

I

E

R
|
R

P

Y

V

L

P

P

E

S

I

T

K
|
K

T

S

T

I

N

N

Y
|
Y

A

M

L

L

P

S

V

F

Y

T

L

G

S

Q

K

R

D

D

W

S

K

K

A

G

N

-

A

A

E

Y

D

E

V

I

L

L

Y

Y

H

C

A

P

D

E

G

G

I

E

I

I

S

V

E
|
E

S

G

S
|
S

R
x
H

S
|
S

N

T

I

F

F

F

I

L

V

I

K

K

D

N

G

G

-

H

T

L

I

I

S

T

T

A

P

P

K

T

T

S

N

R

I

A

L
|
L

K

S

G
|
G

I
x
T

T
|
T

R

R

K

Q

N

I

I

V

L

L

A

E

L

L

V

A

P

R

D

R

A

G

Q

N

I

I

-

Q

-

V

-

E

R

R

D

C

I

P

T

L

L

L

E

T

E

E

V

L

M

P

A

E

A

A

D

E

E

E

V

A

F

F

M

I

S

T

S
x
G

T
|
T

T
x
V

K
|
K

R

E

I

L

L

L

P

P

I

V

T

V

K

R

I

I

D

G

H

D

Q

Q

P

I

I

I

S

G

N

N

G

G

A

V

V

P

G

G

T

K

R

L

T

T

T

K

A

H

L

L

M

H

E

Q

Q

V

F

Y

binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: T35 (≠ F35), R52 (= R52), K143 (= K143), Y147 (= Y147), S175 (= S177), H176 (≠ R178), S177 (= S179), T199 (≠ I200), T200 (= T201), G235 (≠ S232), T236 (= T233), V237 (≠ T234), K238 (= K235)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R52 (= R52), R137 (= R137), K143 (= K143), Y147 (= Y147), E173 (= E175), S177 (= S179), L196 (= L197), G198 (= G199), T199 (≠ I200), T200 (= T201), G235 (≠ S232), T236 (= T233)

8onjA Crystal structure of d-amino acid aminotransferase from aminobacterium colombiense point mutant r88l (see paper)
32% identity, 95% coverage: 5:264/273 of query aligns to 6:268/277 of 8onjA

query
sites
8onjA

C

C

F

Y

A

I

I

D

D

G

R

K

I

F

I

L

P

P

S

L

E

E

D

E

A

A

S

K

L

L

H

P

P

V

L

T

D

D

I

L

G

I

L

I

I

Q

R

R

G

G

Y

V

A

G

V

V

F

F

D

E

F

T

F

I

R

S

T

T

V

H

D

S

Y

R

H

R

P

P

L

L

F

M

L

L

E

T

D

P

Y

H

L

L

D

K

R
|
R

F

L

I

E

A

G

S

S

A

A

A

T

K

A

A

S

H

S

L

I

V

V

L

M

D

P

Q

A

G

T

H

L

E

D

E

E

L

M

K

A

S

R

I

I

V

I

L

R

E

E

L

G

I

I

Q

K

K

K

N

-

D

-

L

-

K

-

Q

M

G

G

G

C

I

E

R

T

M

M

V

V

L

L

-

P

-

Y

-

I

S

T

G

G

N

D

S

S

-

F

-

G

-

K

D

D

N

H

H

L

F

F

S

S

P

S

T

S

K

R

G

-

S

-

L

Y

F

F

I

V

F

I

C

F

E

E

A

E

L

I

Q

R

M

K

P

P

S

D

D

P

D

I

K

L

Y

Y

R

E

N

K

G

G

V

V

H

A

L

L

L

H

T

P

T

I

E

N

Y

A

I

E

R
|
R

P

Y

V

L

P

P

E

S

I

T

K
|
K

T

S

T

I

N

N

Y

Y

A

M

L

L

P

S

V

F

Y

T

L

G

S

Q

K

R

D

D

W

S

K

K

A

G

N

-

A

A

E

Y

D

E

V

I

L

L

Y

Y

H

C

A

P

D

E

G

G

I

E

I

I

S

V

E
|
E

S

G

S

S

R
x
H

S
|
S

N

T

I

F

F

F

I

L

V

I

K

K

D

N

G

G

-

H

T

L

I

I

S

T

T

A

P

P

K

T

T

S

N

R

I

A

L
|
L

K

S

G

G

I
x
T

T
|
T

R

R

K

Q

N

I

I

V

L

L

A

E

L

L

V

A

P

R

D

R

A

G

Q

N

I

I

-

Q

-

V

-

E

R

R

D

C

I

P

T

L

L

L

E

T

E

E

V

L

M

P

A

E

A

A

D

E

E

E

V

A

F

F

M

I

S

T

S
x
G

T
|
T

T

V

K

K

R

E

I

L

L

L

P

P

I

V

T

V

K

R

I

I

D

G

H

D

Q

Q

P

I

I

I

S

G

N

N

G

G

A

V

V

P

G

G

T

K

R

L

T

T

T

K

A

H

L

L

M

H

E

Q

Q

V

F

Y

binding pyridoxal-5'-phosphate: R53 (= R52), R138 (= R137), K144 (= K143), E174 (= E175), H177 (≠ R178), S178 (= S179), L197 (= L197), T200 (≠ I200), T201 (= T201), G236 (≠ S232), T237 (= T233)

5fr9A Structure of transaminase ata-117 arrmut11 from arthrobacter sp. Knk168 inhibited with 1-(4-bromophenyl)-2-fluoroethylamine (see paper)
26% identity, 96% coverage: 12:273/273 of query aligns to 35:312/319 of 5fr9A

query
sites
5fr9A

I

V

P

P

S

P

E

S

D

E

A

A

S

R

L

I

H

S

P

I

L

F

D

D

I

Q

G

G

L

F

I

Y

R

T

G

S

Y

D

A

A

V

T

F
x
Y

D

T

F

T

F

F

R

H

T

V

V

W

D

N

Y

G

H

N

P

A

L

F

F

R

L

L

E

G

D

D

Y

H

L

I

D

E

R
|
R

F

L

I

F

A

S

S

N

A

A

A

E

K

S

A

I

H

R

L

L

V

I

L

P

D

P

Q

L

G

T

H

Q

E

D

E

E

L

V

K

K

S

E

I

I

V

A

L

L

E

E

L

L

I

V

Q

A

K

K

N

T

D

E

L

L

K

R

Q

E

G

A

G

M

I

V

R

T

M

V

V

T

L

I

S

T

G

R

G

G

N

Y

S

S

D

S

N

T

H

P

F

F

S

E

P

R

-

D

-

I

T

T

K

K

G

H

S

R

L

P

F

Q

I

V

F

Y

-

M

-

S

-

A

C

C

E

P

A

Y

L

Q

Q

W

M

I

P

V

S

P

D

F

D

D

K

R

Y

I

R

R

N

D

G

G

V

V

H

H

L

L

L

M

T

V

T

A

E

Q

Y

S

I

V

R

R

P

R

V

T

-

P

-

R

-

S

-

I

-

D

P

P

E

Q

I

V

K
|
K

T

N

T

F

N

Q

Y

W

A

G

L

D

P

L

V

I

Y

R

L

A

S

I

K

Q

D

E

W

T

K

H

A

D

N

R

N

G

A

F

E

E

-

L

D

P

V

L

L

L

Y

L

H

D

A

C

D

D

G

N

I

L

S

A

E
|
E

S

G

S

P

R
x
G

S
x
F

N

N

I

V

F

V

I

V

V

I

K

K

D

D

G

G

T

V

I

V

S

R

T

S

P

P

K

G

T

R

N

A

I

A

L
|
L

K

P

G
|
G

I
|
I

T
|
T

R

R

K

K

N

T

I

V

L

L

-

E

-

I

-

A

-

E

A

S

L

L

V

G

P

H

D

E

A

A

Q

I

I

L

R

A

D

D

I

I

T

T

L

P

E

A

E

E

V

L

M

Y

A

D

A

A

D

D

E

E

V

V

F

L

M

G

S

C

S

S

T
|
T

T

G

K

G

R

G

I

V

L

W

P

P

I

F

T

V

K

S

I

V

D

D

H

G

Q

N

P

S

I

I

S

S

N

D

G

G

A

V

V

P

G

G

T

P

R

V

T

T

T

Q

A

S

L

I

M

I

E

R

Q

R

F

Y

K

W

R

E

M

L

E

N

E

V

E

E

T

P

V

S

S

S

active site: Y56 (≠ F33), K177 (= K143), E210 (= E175), L232 (= L197)
binding [4-[3-(4-bromophenyl)-3-oxidanylidene-propyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl phosphate: R75 (= R52), K177 (= K143), E210 (= E175), G213 (≠ R178), F214 (≠ S179), L232 (= L197), G234 (= G199), I235 (= I200), T236 (= T201), T272 (= T233)

3lqsA Complex structure of d-amino acid aminotransferase and 4-amino-4,5- dihydro-thiophenecarboxylic acid (adta) (see paper)
28% identity, 96% coverage: 4:265/273 of query aligns to 2:273/280 of 3lqsA

query
sites
3lqsA

Y

Y

C

T

F

L

A

W

I

N

D

D

R

Q

I

I

I

V

P

K

S

D

E

E

D

E

A

V

S

K

L

I

H

D

P

K

L

E

D

D

I

R

G

G

L

Y

I

Q

R

F

G

G

Y

D

A

G

V

V

F
x
Y

D

E

F
x
V

F

V

R

K

T

V

V

Y

D

N

Y

G

H

E

P

M

L

F

F

T

L

V

E

N

D

E

Y

H

L

I

D

D

R
|
R

F

L

I

Y

A

A

S

S

A

A

A

E

K

K

A

I

H

R

L

I

V

T

L

I

D

P

Q

Y

G

T

H

K

E

D

E

K

L

F

K

H

S

Q

I

L

V

L

L

H

E

E

L

L

I

V

Q

E

K

K

N

N

D

E

L

L

K

N

Q

T

G

G

G

H

I

I

R

Y

M

F

V

Q

L

V

S

T

G

R

G

G

N

T

S

S

-

P

-

R

D

A

N

H

H

Q

F

F

S

P

P

E

T

N

K

T

G

V

S

K

L

P

F

V

I

I

F

I

C

G

E

Y

A

T

L

K

Q

E

M

N

P

P

S

R

D

P

-

L

D

E

K

N

Y

L

R

E

N

K

G

G

V

V

H

K

L

A

L

T

T

F

T

V

E

E

Y

D

I

I

R

R

P

W

V

L

-

R

P

C

E

D

I

I

K
|
K

T

S

T

L

N

N

Y

L

A

L

L

G

P

A

V

V

Y

L

L

A

S

K

K

Q

D

E

W

A

K

H

A

E

N

K

N

G

A

C

E

Y

D

E

V

A

L

I

Y

L

H

H

A

R

D

N

G

N

I

T

I

V

S

T

E
|
E

S

G

S

S

R
x
S

S
|
S

N
|
N

I

V

F

F

I

G

V

I

K

K

D

D

G

G

T

I

I

L

S

Y

T

T

P

H

K

P

T

A

N

N

-

N

-

M

I

I

L
|
L

K

K

G
|
G

I
|
I

T
|
T

R

R

K

D

N

V

I

V

L

I

A

A

L

C

V

A

P

N

D

E

A

I

Q

N

-

M

-

P

I

V

R

K

D

E

I

I

-

P

-

F

T

T

L

T

E

H

E

E

V

A

M

L

A

K

A

M

D

D

E

E

V

L

F

F

M

V

S

T

S
|
S

T
|
T

K

S

R

E

I

I

L

T

P

P

I

V

T

I

K

E

I

I

D

D

H

G

Q

K

P

L

I

I

S

R

N

D

G

G

A

K

V

V

G

G

T

E

R

W

T

T

T

R

A

K

L

L

M

Q

E

K

Q

Q

F

F

K

E

active site: Y31 (≠ F33), V33 (≠ F35), K145 (= K143), E177 (= E175), L201 (= L197)
binding 4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]thiophene-2-carboxylic acid: V33 (≠ F35), R50 (= R52), E177 (= E175), S180 (≠ R178), S181 (= S179), N182 (= N180), L201 (= L197), G203 (= G199), I204 (= I200), T205 (= T201), S240 (= S232), T241 (= T233), T242 (= T234)

3daaA Crystallographic structure of d-amino acid aminotransferase inactivated by pyridoxyl-d-alanine (see paper)
28% identity, 96% coverage: 4:265/273 of query aligns to 2:273/277 of 3daaA

query
sites
3daaA

Y

Y

C

T

F

L

A

W

I

N

D

D

R

Q

I

I

I

V

P

K

S

D

E

E

D

E

A

V

S

K

L

I

H

D

P

K

L

E

D

D

I

R

G

G

L

Y

I

Q

R

F

G

G

Y

D

A

G

V

V

F
x
Y

D

E

F
x
V

F

V

R

K

T

V

V

Y

D

N

Y

G

H

E

P

M

L

F

F

T

L

V

E

N

D

E

Y

H

L

I

D

D

R
|
R

F

L

I

Y

A

A

S

S

A

A

A

E

K

K

A

I

H

R

L

I

V

T

L

I

D

P

Q

Y

G

T

H

K

E

D

E

K

L

F

K

H

S

Q

I

L

V

L

L

H

E

E

L

L

I

V

Q

E

K

K

N

N

D

E

L

L

K

N

Q

T

G

G

G

H

I

I

R

Y

M

F

V

Q

L

V

S

T

G

R

G

G

N

T

S

S

-

P

-

R

D

A

N

H

H

Q

F

F

S

P

P

E

T

N

K

T

G

V

S

K

L

P

F

V

I

I

F

I

C

G

E

Y

A

T

L

K

Q

E

M

N

P

P

S

R

D

P

-

L

D

E

K

N

Y

L

R

E

N

K

G

G

V

V

H

K

L

A

L

T

T

F

T

V

E

E

Y

D

I

I

R

R

P

W

V

L

-

R

P

C

E

D

I

I

K
|
K

T

S

T

L

N

N

Y

L

A

L

L

G

P

A

V

V

Y

L

L

A

S

K

K

Q

D

E

W

A

K

H

A

E

N

K

N

G

A

C

E

Y

D

E

V

A

L

I

Y

L

H

H

A

R

D

N

G

N

I

T

I

V

S

T

E
|
E

S

G

S

S

R
x
S

S
|
S

N

N

I

V

F

F

I

G

V

I

K

K

D

D

G

G

T

I

I

L

S

Y

T

T

P

H

K

P

T

A

N

N

-

N

-

M

I

I

L
|
L

K

K

G
|
G

I
|
I

T
|
T

R

R

K

D

N

V

I

V

L

I

A

A

L

C

V

A

P

N

D

E

A

I

Q

N

-

M

-

P

I

V

R

K

D

E

I

I

-

P

-

F

T

T

L

T

E

H

E

E

V

A

M

L

A

K

A

M

D

D

E

E

V

L

F

F

M

V

S

T

S
|
S

T
|
T

T

T

K

S

R

E

I

I

L

T

P

P

I

V

T

I

K

E

I

I

D

D

H

G

Q

K

P

L

I

I

S

R

N

D

G

G

A

K

V

V

G

G

T

E

R

W

T

T

T

R

A

K

L

L

M

Q

E

K

Q

Q

F

F

K

E

active site: Y31 (≠ F33), V33 (≠ F35), K145 (= K143), E177 (= E175), L201 (= L197)
binding n-(5'-phosphopyridoxyl)-d-alanine: Y31 (≠ F33), R50 (= R52), K145 (= K143), E177 (= E175), S180 (≠ R178), S181 (= S179), L201 (= L197), G203 (= G199), I204 (= I200), T205 (= T201), S240 (= S232), T241 (= T233)

2daaA Crystallographic structure of d-amino acid aminotransferase inactivated by d-cycloserine
28% identity, 96% coverage: 4:265/273 of query aligns to 2:273/277 of 2daaA

query
sites
2daaA

Y

Y

C

T

F

L

A

W

I

N

D

D

R

Q

I

I

I

V

P

K

S

D

E

E

D

E

A

V

S

K

L

I

H

D

P

K

L

E

D

D

I

R

G

G

L

Y

I

Q

R

F

G

G

Y

D

A

G

V

V

F
x
Y

D

E

F
x
V

F

V

R

K

T

V

V

Y

D

N

Y

G

H

E

P

M

L

F

F

T

L

V

E

N

D

E

Y

H

L

I

D

D

R
|
R

F

L

I

Y

A

A

S

S

A

A

A

E

K

K

A

I

H

R

L

I

V

T

L

I

D

P

Q

Y

G

T

H

K

E

D

E

K

L

F

K

H

S

Q

I

L

V

L

L

H

E

E

L

L

I

V

Q

E

K

K

N

N

D

E

L

L

K

N

Q

T

G

G

G

H

I

I

R

Y

M

F

V

Q

L

V

S

T

G

R

G

G

N

T

S

S

-

P

-
x
R

D

A

N
x
H

H

Q

F

F

S

P

P

E

T

N

K

T

G

V

S

K

L

P

F

V

I

I

F

I

C

G

E

Y

A

T

L

K

Q

E

M

N

P

P

S

R

D

P

-

L

D

E

K

N

Y

L

R

E

N

K

G

G

V

V

H

K

L

A

L

T

T

F

T

V

E

E

Y

D

I

I

R

R

P

W

V

L

-

R

P

C

E

D

I

I

K
|
K

T

S

T

L

N

N

Y

L

A

L

L

G

P

A

V

V

Y

L

L

A

S

K

K

Q

D

E

W

A

K

H

A

E

N

K

N

G

A

C

E

Y

D

E

V

A

L

I

Y

L

H

H

A

R

D

N

G

N

I

T

I

V

S

T

E
|
E

S

G

S

S

R
x
S

S
|
S

N
|
N

I

V

F

F

I

G

V

I

K

K

D

D

G

G

T

I

I

L

S

Y

T

T

P

H

K

P

T

A

N

N

-

N

-

M

I

I

L
|
L

K

K

G
|
G

I
|
I

T
|
T

R

R

K

D

N

V

I

V

L

I

A

A

L

C

V

A

P

N

D

E

A

I

Q

N

-

M

-

P

I

V

R

K

D

E

I

I

-

P

-

F

T

T

L

T

E

H

E

E

V

A

M

L

A

K

A

M

D

D

E

E

V

L

F

F

M

V

S

T

S

S

T
|
T

T

T

K

S

R

E

I

I

L

T

P

P

I

V

T

I

K

E

I

I

D

D

H

G

Q

K

P

L

I

I

S

R

N

D

G

G

A

K

V

V

G

G

T

E

R

W

T

T

T

R

A

K

L

L

M

Q

E

K

Q

Q

F

F

K

E

active site: Y31 (≠ F33), V33 (≠ F35), K145 (= K143), E177 (= E175), L201 (= L197)
binding d-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-n,o-cycloserylamide: Y31 (≠ F33), V33 (≠ F35), R50 (= R52), R98 (vs. gap), H100 (≠ N100), K145 (= K143), E177 (= E175), S180 (≠ R178), S181 (= S179), N182 (= N180), L201 (= L197), G203 (= G199), I204 (= I200), T205 (= T201), T241 (= T233)

1daaA Crystallographic structure of d-amino acid aminotransferase complexed with pyridoxal-5'-phosphate (see paper)
28% identity, 96% coverage: 4:265/273 of query aligns to 2:273/277 of 1daaA

query
sites
1daaA

Y

Y

C

T

F

L

A

W

I

N

D

D

R

Q

I

I

I

V

P

K

S

D

E

E

D

E

A

V

S

K

L

I

H

D

P

K

L

E

D

D

I

R

G

G

L

Y

I

Q

R

F

G

G

Y

D

A

G

V

V

F
x
Y

D

E

F
x
V

F

V

R

K

T

V

V

Y

D

N

Y

G

H

E

P

M

L

F

F

T

L

V

E

N

D

E

Y

H

L

I

D

D

R
|
R

F

L

I

Y

A

A

S

S

A

A

A

E

K

K

A

I

H

R

L

I

V

T

L

I

D

P

Q

Y

G

T

H

K

E

D

E

K

L

F

K

H

S

Q

I

L

V

L

L

H

E

E

L

L

I

V

Q

E

K

K

N

N

D

E

L

L

K

N

Q

T

G

G

G

H

I

I

R

Y

M

F

V

Q

L

V

S

T

G

R

G

G

N

T

S

S

-

P

-

R

D

A

N

H

H

Q

F

F

S

P

P

E

T

N

K

T

G

V

S

K

L

P

F

V

I

I

F

I

C

G

E

Y

A

T

L

K

Q

E

M

N

P

P

S

R

D

P

-

L

D

E

K

N

Y

L

R

E

N

K

G

G

V

V

H

K

L

A

L

T

T

F

T

V

E

E

Y

D

I

I

R

R

P

W

V

L

-

R

P

C

E

D

I

I

K
|
K

T

S

T

L

N

N

Y

L

A

L

L

G

P

A

V

V

Y

L

L

A

S

K

K

Q

D

E

W

A

K

H

A

E

N

K

N

G

A

C

E

Y

D

E

V

A

L

I

Y

L

H

H

A

R

D

N

G

N

I

T

I

V

S

T

E
|
E

S

G

S

S

R
x
S

S
|
S

N

N

I

V

F

F

I

G

V

I

K

K

D

D

G

G

T

I

I

L

S

Y

T

T

P

H

K

P

T

A

N

N

-

N

-

M

I

I

L
|
L

K

K

G
|
G

I
|
I

T
|
T

R

R

K

D

N

V

I

V

L

I

A

A

L

C

V

A

P

N

D

E

A

I

Q

N

-

M

-

P

I

V

R

K

D

E

I

I

-

P

-

F

T

T

L

T

E

H

E

E

V

A

M

L

A

K

A

M

D

D

E

E

V

L

F

F

M

V

S

T

S
|
S

T
|
T

T

T

K

S

R

E

I

I

L

T

P

P

I

V

T

I

K

E

I

I

D

D

H

G

Q

K

P

L

I

I

S

R

N

D

G

G

A

K

V

V

G

G

T

E

R

W

T

T

T

R

A

K

L

L

M

Q

E

K

Q

Q

F

F

K

E

active site: Y31 (≠ F33), V33 (≠ F35), K145 (= K143), E177 (= E175), L201 (= L197)
binding pyridoxal-5'-phosphate: R50 (= R52), K145 (= K143), E177 (= E175), S180 (≠ R178), S181 (= S179), L201 (= L197), G203 (= G199), I204 (= I200), T205 (= T201), S240 (= S232), T241 (= T233)

P19938 D-alanine aminotransferase; D-amino acid aminotransferase; D-amino acid transaminase; DAAT; D-aspartate aminotransferase; EC 2.6.1.21 from Bacillus sp. (strain YM-1) (see 5 papers)
28% identity, 96% coverage: 4:265/273 of query aligns to 3:274/283 of P19938

query
sites
P19938

Y

Y

C

T

F

L

A

W

I

N

D

D

R

Q

I

I

I

V

P

K

S

D

E

E

D

E

A

V

S

K

L

I

H

D

P

K

L

E

D

D

I

R

G

G

L

Y

I

Q

R

F

G

G

Y

D

A

G

V

V

F
x
Y

D

E

F

V

R

K

T

V

V

Y

D

N

Y

G

H

E

P

M

L

F

F

T

L

V

E

N

D

E

Y

H

L

I

D

D

R
|
R

F

L

I

Y

A

A

S

S

A

A

A

E

K

K

A

I

H

R

L

I

V

T

L

I

D

P

Q

Y

G

T

H

K

E

D

E

K

L

F

K

H

S

Q

I

L

V

L

L

H

E

E

L

L

I

V

Q

E

K

K

N

N

D

E

L

L

K

N

Q

T

G

G

G

H

I

I

R

Y

M

F

V

Q

L

V

S

T

G

R

G

G

N

T

S

S

-

P

-
x
R

D

A

N
x
H

H

Q

F

F

S

P

P

E

T

N

K

T

G

V

S

K

L

P

F

V

I

I

F

I

C

G

E

Y

A

T

L

K

Q

E

M

N

P

P

S

R

D

P

-

L

D

E

K

N

Y

L

R

E

N

K

G

G

V

V

H

K

L

A

L

T

T

F

T

V

E

E

Y

D

I

I

R

R

P

W

V

L

-

R

P

C

E

D

I

I

K
|
K

T

S

T

L

N

N

Y

L

A

L

L

G

P

A

V

V

Y

L

L

A

S

K

K

Q

D

E

W

A

K

H

A

E

N

K

N

G

A

C

E

Y

D

E

V

A

L

I

Y

L

H

H

A

R

D

N

G

N

I

T

I

V

S

T

E
|
E

S

G

S

S

R

S

S

S

N

N

I

V

F

F

I

G

V

I

K

K

D

D

G

G

T

I

I

L

S

Y

T

T

P

H

K

P

T

A

N

N

-

N

-

M

I

I

L
|
L

K

K

G

G

I

I

T

T

R

R

K

D

N

V

I

V

L

I

A

A

L

C

V

A

P

N

D

E

A

I

Q

N

-

M

-

P

I

V

R

K

D

E

I

I

-

P

-

F

T

T

L

T

E

H

E

E

V

A

M

L

A

K

A

M

D

D

E

E

V

L

F

F

M

V

S

T

S

S

T

T

K

S

R

E

I

I

L

T

P

P

I

V

T

I

K

E

I

I

D

D

H

G

Q

K

P

L

I

I

S

R

N

D

G

G

A

K

V

V

G

G

T

E

R

W

T

T

T

R

A

K

L

L

M

Q

E

K

Q

Q

F

F

K

E

Y32 (≠ F33) binding
R51 (= R52) binding
R99 (vs. gap) binding
H101 (≠ N100) binding
K146 (= K143) active site, Proton acceptor; modified: N6-(pyridoxal phosphate)lysine
E178 (= E175) binding ; mutation to K: Loss of transaminase activity and small gain in racemase activity.
L202 (= L197) mutation to A: Inactivates enzyme.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

7p3tB Transaminase of gamma-proteobacterium (see paper)
29% identity, 95% coverage: 12:269/273 of query aligns to 13:284/299 of 7p3tB

query
sites
7p3tB

I

L

P

P

S

L

E

S

D

Q

A

A

S

R

L

V

H

S

P

P

L

V

D

D

I

Q

G

G

L

F

I

L

R

L

G

G

Y

D

A

G

V

V

F

F

D

D

F

V

R

S

T

A

V

W

D

K

Y

G

H

N

P

I

L

F

F

K

L

L

E

D

D

A

Y

H

L

L

D

D

R
|
R

F

F

I

F

A

D

S

S

A

I

A

Q

K

A

A

A

H

R

L

L

V

N

L

H

D

D

Q

M

G

S

H

R

E

D

E

A

L

W

K

K

S

E

I

A

V

I

L

I

E

E

L

T

I

T

Q

R

K

R

N

N

D

G

L

L

K

D

Q

D

G

A

G

S

I

I

R

R

M

F

V

I

L

V

S

T

G

R

G

G

N

E

S

P

D

K

N

G

-

V

-

A

-

D

-

P

-

R

H

D

F

F

S

K

P

P

T

T

K

-

G

-

S

C

L

I

F

V

I

W

F

V

C

A

E

P

A

Y

L

I

Q

F

M

L

P

A

S

D

D

E

K

K

Y

R

R

R

N

N

G

G

V

I

H

R

L

L

L

M

T

I

T

S

E

A

Y

T

I

R

R

G

-

F

P

P

V

A

-

D

-

T

-

L

-

D

P

P

E

R

I

Y

K
|
K

T

C

T

L

N

D

Y
x
R

A

L

L

H

P

S

V

Q

Y

L

L

I

S

R

K

L

D

E

W

A

K

L

A

E

N

A

N

G

A

Y

E

D

D

D

V

A

L

L

Y

W

-

L

-

D

H

H

A

S

D

-

G

G

I

H

I

V

S

S

E
|
E

S
|
S

S
x
A

R
x
A

S
|
S

N

N

I

L

F

F

I

I

V

V

K

K

D

N

G

G

T

V

I

L

S

Y

T

T

P

P

K

S

T

A

N

G

I

I

L

L

K

R

G
|
G

I
|
I

T
|
T

R

R

K

D

N

T

I

I

L

L

A

E

L

L

V

A

P

T

D

E

A

L

Q

D

I

I

-

P

-

W

-

K

-

E

R

R

D

Q

I

L

T

S

L

A

E

F

E

D

V

V

M

Y

A

I

A

A

D

D

E

E

V

V

F

F

M

T

S

C

S

S

T
|
T

T

A

K

G

R

G

I

A

L

L

P

P

I

V

T

R

K

E

I

V

D

A

H

G

Q

R

P

T

I

I

S

R

N

G

G

T

A

T

V

P

G

G

T

P

R

I

T

T

T

Q

A

A

L

I

M

D

E

N

Q

A

F

Y

K

W

R

A

M

M

E

R

E

E

binding pyridoxal-5'-phosphate: R53 (= R52), K153 (= K143), R157 (≠ Y147), E186 (= E175), S187 (= S176), A188 (≠ S177), A189 (≠ R178), S190 (= S179), G210 (= G199), I211 (= I200), T212 (= T201), T248 (= T233)

6xu3B (R)-selective amine transaminase from shinella sp. (see paper)
25% identity, 93% coverage: 12:264/273 of query aligns to 36:303/321 of 6xu3B

query
sites
6xu3B

I

V

P

P

S

L

E

H

D

E

A

A

S

R

L

I

H

P

P

I

L

L

D

D

I

Q

G

G

L

F

I

L

R

H

G

S

Y

D

A

L

V

T

F
x
Y

D

D

F

V

F

P

R

A

T

V

V

W

D

N

Y

G

H

R

P

F

L

F

F

R

L

L

E

E

D

D

Y

H

L

L

D

D

R
|
R

F

F

I

E

A

K

S

S

A

C

A

A

K

Q

A

L

H

R

L

L

V

K

L

S

D

P

Q

L

G

S

H

R

E

E

L

I

K

R

S

D

I

R

V

L

L

V

E

E

L

M

I

T

Q

V

K

K

N

S

D

G

L

I

K

R

Q

D

G

A

G
x
Y

I

V

R

M

M

M

V

I

L

V

S

T

G

R

G

G

-

L

N

R

S

F

D

V

N

R

H

Q

F

Y

S

A

P

P

T

E

K

E

G

C

S

D

L

-

F

-

I

N

F

F

C

C

E

Y

A

L

L

M

Q

V

M

M

P

P

-

Y

-

L

-

W

-

V

-

M

S

D

D

E

D

A

K

T

Y

Q

R

K

N

N

G

G

V

G

H

S

L

A

L

V

T

I

T

T

E

R

Y

T

I

V

R

R

P

R

V

V

P

P

-
x
P

-

G

-

A

-

I

-
x
D

-

P

-

T

-

V

-
x
K

E

N

I

L

K

Q

T

W

T

G

N

D

Y
x
F

A

T

L

R

P

G

V

L

Y

M

L

E

S

A

K

R

D

D

W

R

K

G

A

A

N

M

N

Y

A

P

E

-

D

-

V

I

L

L

Y

T

H

D

A

G

D

D

G

A

I

N

I

L

S

T

E
|
E

S

G

S

S

R
x
G

S
x
F

N
|
N

I

V

F

I

I

L

V

I

K

K

D

D

G

G

T

K

I

L

S

Y

T

T

P

P

K

R

T
x
K

N

G

I

V

L
|
L

K

E

G
|
G

I
x
V

T
|
T

R

R

K

K

N

S

I

V

L

L

A

A

L

V

V

A

P

E

D

K

A

L

-

G

-

Y

-

P

-

Y

Q

T

I

I

R

D

D

D

I

V

T

P

L

V

E

E

E

L

V

A

M

Y

A

Q

A

C

D

D

E

E

V

I

F

L

M

F

S

V

S

T

T
|
T

T

A

K

G

R

G

I

V

L

M

P

P

I

I

T

T

K

T

I

L

D

D

H

G

Q

Q

P

P

I

V

S

G

N

D

G

G

A

Q

V

V

G

G

T

P

R

I

T

S

T

K

A

A

L

L

M

W

E

K

Q

G

F

Y

active site: Y57 (≠ F33), K177 (vs. gap), E210 (= E175), L232 (= L197)
binding 3-aminobenzoic acid: P169 (vs. gap), D173 (vs. gap), K229 (≠ T194)
binding n-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]: R76 (= R52), Y112 (≠ G88), K177 (vs. gap), F184 (≠ Y147), E210 (= E175), G213 (≠ R178), F214 (≠ S179), N215 (= N180), L232 (= L197), G234 (= G199), V235 (≠ I200), T236 (= T201), T272 (= T233)

6xu3A (R)-selective amine transaminase from shinella sp. (see paper)
25% identity, 93% coverage: 12:264/273 of query aligns to 35:302/320 of 6xu3A

query
sites
6xu3A

I

V

P

P

S

L

E

H

D

E

A

A

S

R

L

I

H

P

P

I

L

L

D

D

I

Q

G

G

L

F

I

L

R

H

G

S

Y

D

A

L

V

T

F
x
Y

D

D

F

V

F

P

R

A

T

V

V

W

D

N

Y

G

H

R

P

F

L

F

F

R

L

L

E

E

D

D

Y

H

L

L

D

D

R
|
R

F

F

I

E

A

K

S

S

A

C

A

A

K

Q

A

L

H

R

L

L

V

K

L

S

D

P

Q

L

G

S

H

R

E

E

L

I

K

R

S

D

I

R

V

L

L

V

E

E

L

M

I

T

Q

V

K

K

N

S

D

G

L

I

K

R

Q

D

G

A

G

Y

I

V

R

M

M

M

V

I

L

V

S

T

G

R

G

G

-

L

N

R

S

F

D

V

N

R

H

Q

F

Y

S

A

P

P

T

E

K

E

G

C

S

D

L

-

F

-

I

N

F

F

C

C

E

Y

A

L

L

M

Q

V

M

M

P

P

-

Y

-

L

-

W

-

V

-

M

S

D

D

E

D

A

K

T

Y

Q

R

K

N

N

G

G

V

G

H

S

L

A

L

V

T

I

T

T

E

R

Y

T

I

V

R

R

P

R

V

V

P

P

-

P

-

G

-

A

-

I

-

D

-

P

-

T

-

V

-
x
K

E

N

I

L

K

Q

T

W

T

G

N

D

Y
x
F

A

T

L

R

P

G

V

L

Y

M

L

E

S

A

K

R

D

D

W

R

K

G

A

A

N

M

N

Y

A

P

E

-

D

-

V

I

L

L

Y

T

H

D

A

G

D

D

G

A

I

N

I

L

S

T

E
|
E

S

G

S

S

R
x
G

S
x
F

N

N

I

V

F

I

I

L

V

I

K

K

D

D

G

G

T

K

I

L

S

Y

T

T

P

P

K

R

T

K

N

G

I

V

L
|
L

K

E

G
|
G

I
x
V

T
|
T

R

R

K

K

N

S

I

V

L

L

A

A

L

V

V

A

P

E

D

K

A

L

-

G

-

Y

-

P

-

Y

Q

T

I

I

R

D

D

D

I

V

T

P

L

V

E

E

E

L

V

A

M

Y

A

Q

A

C

D

D

E

E

V

I

F

L

M

F

S

V

S

T

T
|
T

T

A

K

G

R

G

I

V

L

M

P

P

I

I

T

T

K

T

I

L

D

D

H

G

Q

Q

P

P

I

V

S

G

N

D

G

G

A

Q

V

V

G

G

T

P

R

I

T

S

T

K

A

A

L

L

M

W

E

K

Q

G

F

Y

active site: Y56 (≠ F33), K176 (vs. gap), E209 (= E175), L231 (= L197)
binding pyridoxal-5'-phosphate: R75 (= R52), K176 (vs. gap), F183 (≠ Y147), E209 (= E175), G212 (≠ R178), F213 (≠ S179), L231 (= L197), G233 (= G199), V234 (≠ I200), T235 (= T201), T271 (= T233)

6xu3C (R)-selective amine transaminase from shinella sp. (see paper)
25% identity, 93% coverage: 12:264/273 of query aligns to 37:304/322 of 6xu3C

query
sites
6xu3C

I

V

P

P

S

L

E

H

D

E

A

A

S

R

L

I

H

P

P

I

L

L

D

D

I

Q

G

G

L

F

I

L

R

H

G

S

Y

D

A

L

V

T

F
x
Y

D

D

F
x
V

F

P

R

A

T

V

V

W

D

N

Y

G

H

R

P

F

L

F

F

R

L

L

E

E

D

D

Y

H

L

L

D

D

R
|
R

F

F

I

E

A

K

S

S

A

C

A

A

K

Q

A

L

H

R

L

L

V

K

L

S

D

P

Q

L

G

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active site: Y58 (≠ F33), K178 (vs. gap), E211 (= E175), L233 (= L197)
binding n-glycine-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-yl-methane]: V60 (≠ F35), R77 (= R52), K178 (vs. gap), F185 (≠ Y147), E211 (= E175), G214 (≠ R178), N216 (= N180), L233 (= L197), G235 (= G199), V236 (≠ I200), T237 (= T201), T272 (≠ S232), T273 (= T233), A274 (≠ T234)

Query Sequence

>Echvi_0009 FitnessBrowser__Cola:Echvi_0009
MKPYCFAIDRIIPSEDASLHPLDIGLIRGYAVFDFFRTVDYHPLFLEDYLDRFIASAAKA
HLVLDQGHEELKSIVLELIQKNDLKQGGIRMVLSGGNSDNHFSPTKGSLFIFCEALQMPS
DDKYRNGVHLLTTEYIRPVPEIKTTNYALPVYLSKDWKANNAEDVLYHADGIISESSRSN
IFIVKDGTISTPKTNILKGITRKNILALVPDAQIRDITLEEVMAADEVFMSSTTKRILPI
TKIDHQPISNGAVGTRTTALMEQFKRMEEETVS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory