Comparing Echvi_0200 FitnessBrowser__Cola:Echvi_0200 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
35% identity, 40% coverage: 476:794/804 of query aligns to 5:323/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
35% identity, 40% coverage: 476:794/804 of query aligns to 5:323/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
35% identity, 40% coverage: 476:794/804 of query aligns to 5:323/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
35% identity, 40% coverage: 476:794/804 of query aligns to 5:323/324 of 1w85B
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
38% identity, 33% coverage: 475:737/804 of query aligns to 7:267/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
38% identity, 33% coverage: 475:737/804 of query aligns to 7:267/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
38% identity, 33% coverage: 475:737/804 of query aligns to 7:267/323 of 1umbD
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
38% identity, 33% coverage: 475:737/804 of query aligns to 8:268/324 of Q5SLR3
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
33% identity, 38% coverage: 475:781/804 of query aligns to 9:326/338 of 1qs0B
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
34% identity, 33% coverage: 481:747/804 of query aligns to 81:348/392 of P21953
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
34% identity, 33% coverage: 481:747/804 of query aligns to 18:285/329 of 2j9fD
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
34% identity, 33% coverage: 481:747/804 of query aligns to 15:282/326 of 1dtwB
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
29% identity, 39% coverage: 474:786/804 of query aligns to 7:321/330 of 6cfoB
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
29% identity, 39% coverage: 474:786/804 of query aligns to 36:350/359 of P11177
Sites not aligning to the query:
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
29% identity, 39% coverage: 474:786/804 of query aligns to 8:322/331 of 6cerD
Q5SLR4 2-oxoisovalerate dehydrogenase subunit alpha; Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
26% identity, 40% coverage: 14:331/804 of query aligns to 31:309/367 of Q5SLR4
1umdA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
26% identity, 40% coverage: 14:331/804 of query aligns to 26:304/362 of 1umdA
1umcA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
26% identity, 40% coverage: 14:331/804 of query aligns to 26:304/362 of 1umcA
1umbA Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
26% identity, 40% coverage: 14:331/804 of query aligns to 26:304/362 of 1umbA
3dufA Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
29% identity, 22% coverage: 180:355/804 of query aligns to 161:329/365 of 3dufA
Sites not aligning to the query:
>Echvi_0200 FitnessBrowser__Cola:Echvi_0200
MIELETLPTHKVKLDLEKDQILFDYKIVQQSRQASLMGRKEVFMGKAKFGIFGDGKELAQ
VVMARYFKKGDWRSGYYRDQTFMLAIEELKLQEYFAQLYAHTVVEEEPASGGRLMNGHFA
TRSLNEDGTWKDIRNTKNSGGDISPTAGQVPRLIGLGYASKLFKENEALQRLEQFKGLGK
EIAWGTIGNASCAEGMFLETINAAGVLQIPLVLSVWDDDYGISVPNEFQTTKGSISEALA
GYQRTEEKPGVEIIVAKGWDYESLHAAYRKAETLAREASVPSLVHVIEMTQPQGHSTSGS
HERYKSKERLQWEADHDCNMMFRSYILENGLATEEELDEIDKEAVRFVREQKDKAWKSFT
EDIKSDLKTVVGLIKEAAGQSKQQNALNQLADDLAKTLNPIRKDVFGAVRKTLLLMRFDA
EEARGPLKAWYEEQKKRNYDRYNSHLYSESEEGSQHVQVIAPVYTEQSPTVDGREVLQAC
FDQMLSNDPRVFAFGEDVGKIGDVNQAFAGLQEKHGELRVTDTGIREMTIIGQGIGTALR
GLRPIAEIQYLDYIYYALMTLTDDLACLHYRTKGGQKAPMIVRTRGHRLEGVWHSGSPMS
AILGSLRGLLVCVPRNMTQAAGMYNTLLRSDEPALMIECLNAYRQKELMPTNVGEFTVPL
GRPEVLREGTDITVVTYGAMCRIVLDAAEQLVEYGVSVEVIDVQTLLPFDVDHVILESIK
KTSRVIFADEDVPGGASAYMMQQVLEKQKAYYQLDSEPVTLSAQPHRPAYSSDGDYFSKP
SVDDVIEKAYLIMHEVDPISYPMW
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory