SitesBLAST
Comparing Echvi_1473 FitnessBrowser__Cola:Echvi_1473 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
50% identity, 100% coverage: 2:380/380 of query aligns to 1:379/380 of 4l1fA
- active site: L125 (= L126), T126 (= T127), G242 (= G243), E363 (= E364), R375 (= R376)
- binding coenzyme a persulfide: T132 (≠ S133), H179 (= H180), F232 (= F233), M236 (= M237), E237 (≠ K238), L239 (= L240), D240 (= D241), R243 (= R244), Y362 (≠ G363), E363 (= E364), G364 (= G365), R375 (= R376)
- binding flavin-adenine dinucleotide: F123 (≠ W124), L125 (= L126), T126 (= T127), G131 (= G132), T132 (≠ S133), F156 (= F157), I157 (= I158), T158 (= T159), R268 (= R269), Q270 (= Q271), F271 (= F272), I275 (= I276), F278 (≠ Y279), L281 (≠ I282), Q336 (= Q337), I337 (≠ V338), G340 (= G341), I358 (≠ L359), Y362 (≠ G363), T365 (= T366), Q367 (≠ E368)
- binding 1,3-propandiol: L5 (= L6), Q10 (≠ S11)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
49% identity, 98% coverage: 7:379/380 of query aligns to 3:373/374 of 5lnxD
- active site: L122 (= L126), T123 (= T127), G239 (= G243), E358 (= E364), K370 (≠ R376)
- binding flavin-adenine dinucleotide: L122 (= L126), T123 (= T127), G128 (= G132), S129 (= S133), F153 (= F157), T155 (= T159), R265 (= R269), Q267 (= Q271), F268 (= F272), I272 (= I276), N275 (≠ Y279), I278 (= I282), Q331 (= Q337), I332 (≠ V338), G335 (= G341), Y357 (≠ G363), T360 (= T366), E362 (= E368)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
48% identity, 97% coverage: 12:380/380 of query aligns to 10:378/378 of 5ol2F
- active site: L124 (= L126), T125 (= T127), G241 (= G243), G374 (≠ R376)
- binding calcium ion: E29 (= E31), E33 (≠ H35), R35 (≠ T37)
- binding coenzyme a persulfide: L238 (= L240), R242 (= R244), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (≠ W124), L124 (= L126), T125 (= T127), P127 (= P129), T131 (≠ S133), F155 (= F157), I156 (= I158), T157 (= T159), E198 (= E200), R267 (= R269), F270 (= F272), L274 (≠ I276), F277 (≠ Y279), Q335 (= Q337), L336 (≠ V338), G338 (= G340), G339 (= G341), Y361 (≠ G363), T364 (= T366), E366 (= E368)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
44% identity, 99% coverage: 3:380/380 of query aligns to 31:408/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
44% identity, 99% coverage: 3:380/380 of query aligns to 4:381/384 of 1jqiA
- active site: G377 (≠ R376)
- binding acetoacetyl-coenzyme a: L95 (= L94), F125 (≠ W124), S134 (= S133), F234 (= F233), M238 (= M237), Q239 (≠ K238), L241 (= L240), D242 (= D241), R245 (= R244), Y364 (≠ G363), E365 (= E364), G366 (= G365)
- binding flavin-adenine dinucleotide: F125 (≠ W124), L127 (= L126), S128 (≠ T127), G133 (= G132), S134 (= S133), W158 (≠ F157), T160 (= T159), R270 (= R269), F273 (= F272), L280 (≠ Y279), Q338 (= Q337), I339 (≠ V338), G342 (= G341), I360 (≠ L359), T367 (= T366), E369 (= E368), I370 (= I369)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
45% identity, 99% coverage: 3:380/380 of query aligns to 4:381/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ Y342), T347 (≠ K346), E348 (≠ D347)
- binding flavin-adenine dinucleotide: F125 (≠ W124), L127 (= L126), S128 (≠ T127), G133 (= G132), S134 (= S133), W158 (≠ F157), T160 (= T159), R270 (= R269), F273 (= F272), L280 (≠ Y279), V282 (≠ G281), Q338 (= Q337), I339 (≠ V338), G342 (= G341), I360 (≠ L359), Y364 (≠ G363), T367 (= T366), E369 (= E368), I370 (= I369), L373 (≠ I372)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
45% identity, 99% coverage: 3:380/380 of query aligns to 31:408/412 of P16219
- G90 (= G62) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E76) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 124:133, 50% identical) binding in other chain
- R171 (≠ T143) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FIT 157:159) binding in other chain
- A192 (≠ G164) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G181) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R269) binding
- Q308 (= Q280) binding in other chain
- R325 (≠ K297) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (= S325) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QVYGG 337:341) binding
- R380 (≠ K352) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (= TSE 366:368) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
45% identity, 99% coverage: 3:380/380 of query aligns to 7:384/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ W124), L130 (= L126), S131 (≠ T127), G136 (= G132), S137 (= S133), W161 (≠ F157), T163 (= T159), T214 (= T210), R273 (= R269), F276 (= F272), L280 (≠ I276), L283 (≠ Y279), V285 (≠ G281), Q341 (= Q337), I342 (≠ V338), G345 (= G341), I363 (≠ L359), Y367 (≠ G363), T370 (= T366), E372 (= E368), L376 (≠ I372)
2d29A Structural study on project id tt0172 from thermus thermophilus hb8
48% identity, 100% coverage: 2:380/380 of query aligns to 2:384/386 of 2d29A
- active site: L126 (= L126), T127 (= T127), G247 (= G243), E368 (= E364), R380 (= R376)
- binding flavin-adenine dinucleotide: L126 (= L126), T127 (= T127), G132 (= G132), S133 (= S133), F157 (= F157), I158 (= I158), T159 (= T159), L363 (= L359), T370 (= T366), E372 (= E368)
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
45% identity, 99% coverage: 3:380/380 of query aligns to 1:378/381 of 8sgsA
- binding coenzyme a: S131 (= S133), A133 (= A135), N177 (≠ K179), F231 (= F233), M235 (= M237), L238 (= L240), I312 (≠ T314), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (≠ W124), L124 (= L126), S125 (≠ T127), G130 (= G132), S131 (= S133), W155 (≠ F157), T157 (= T159), R267 (= R269), F270 (= F272), L274 (≠ I276), L277 (≠ Y279), Q335 (= Q337), I336 (≠ V338), G338 (= G340), G339 (= G341), I357 (≠ L359), I360 (= I362), Y361 (≠ G363), T364 (= T366), E366 (= E368)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
45% identity, 100% coverage: 2:380/380 of query aligns to 1:383/383 of 1bucA
- active site: L128 (= L126), T129 (= T127), G246 (= G243), E367 (= E364), G379 (≠ R376)
- binding acetoacetyl-coenzyme a: L96 (= L94), F126 (≠ W124), G134 (= G132), T135 (≠ S133), T162 (= T159), N182 (≠ K179), H183 (= H180), F236 (= F233), M240 (= M237), M241 (≠ K238), L243 (= L240), D244 (= D241), T317 (= T314), Y366 (≠ G363), E367 (= E364), G368 (= G365)
- binding flavin-adenine dinucleotide: F126 (≠ W124), L128 (= L126), T129 (= T127), G134 (= G132), T135 (≠ S133), F160 (= F157), T162 (= T159), Y366 (≠ G363), T369 (= T366), E371 (= E368), M375 (≠ I372)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
45% identity, 100% coverage: 2:380/380 of query aligns to 1:383/383 of Q06319
- E367 (= E364) active site, Proton acceptor; mutation to Q: Loss of activity.
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
45% identity, 99% coverage: 6:380/380 of query aligns to 1:368/371 of 2vigB
- active site: L121 (= L126), S122 (≠ T127), G231 (= G243), E352 (= E364), G364 (≠ R376)
- binding coenzyme a persulfide: S128 (= S133), F221 (= F233), M225 (= M237), Q226 (≠ K238), L228 (= L240), D229 (= D241), R232 (= R244), E352 (= E364), G353 (= G365), I357 (= I369)
- binding flavin-adenine dinucleotide: L121 (= L126), S122 (≠ T127), G127 (= G132), S128 (= S133), W152 (≠ F157), T154 (= T159), R257 (= R269), F260 (= F272), L264 (≠ I276), L267 (≠ Y279), Q325 (= Q337), I326 (≠ V338), G329 (= G341), I347 (≠ L359), Y351 (≠ G363), T354 (= T366), E356 (= E368)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
43% identity, 99% coverage: 2:378/380 of query aligns to 2:378/378 of 4n5fA
- active site: L126 (= L126), T127 (= T127), G243 (= G243), E364 (= E364), R376 (= R376)
- binding dihydroflavine-adenine dinucleotide: L126 (= L126), T127 (= T127), G132 (= G132), S133 (= S133), F157 (= F157), T159 (= T159), T210 (= T210), Y363 (≠ G363), T366 (= T366), E368 (= E368), M372 (≠ I372)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
43% identity, 99% coverage: 6:380/380 of query aligns to 3:378/379 of 6fahD
- active site: L124 (= L126), T125 (= T127), G241 (= G243), G374 (≠ R376)
- binding flavin-adenine dinucleotide: F122 (≠ W124), L124 (= L126), T125 (= T127), R152 (≠ A154), F155 (= F157), T157 (= T159), E198 (= E200), R267 (= R269), Q269 (= Q271), F270 (= F272), I274 (= I276), F277 (≠ Y279), Q335 (= Q337), I336 (≠ V338), G339 (= G341), Y361 (≠ G363), T364 (= T366), Q366 (≠ E368)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
43% identity, 99% coverage: 2:379/380 of query aligns to 1:377/379 of 1ukwB
- active site: L124 (= L126), S125 (≠ T127), T241 (≠ G243), E362 (= E364), R374 (= R376)
- binding cobalt (ii) ion: D145 (= D147), H146 (≠ Y148)
- binding flavin-adenine dinucleotide: F122 (≠ W124), L124 (= L126), S125 (≠ T127), G130 (= G132), S131 (= S133), W155 (≠ F157), S157 (≠ T159), K200 (= K202), L357 (= L359), Y361 (≠ G363), E362 (= E364), T364 (= T366), E366 (= E368), L370 (≠ I372)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
43% identity, 99% coverage: 2:379/380 of query aligns to 1:377/379 of 1ukwA
- active site: L124 (= L126), S125 (≠ T127), T241 (≠ G243), E362 (= E364), R374 (= R376)
- binding flavin-adenine dinucleotide: F122 (≠ W124), L124 (= L126), S125 (≠ T127), G130 (= G132), S131 (= S133), W155 (≠ F157), S157 (≠ T159), L357 (= L359), Y361 (≠ G363), E362 (= E364), T364 (= T366), E366 (= E368), L370 (≠ I372)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
43% identity, 96% coverage: 15:380/380 of query aligns to 6:369/369 of 3pfdC
- active site: L116 (= L126), S117 (≠ T127), T233 (≠ G243), E353 (= E364), R365 (= R376)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ W124), L116 (= L126), S117 (≠ T127), G122 (= G132), S123 (= S133), W147 (≠ F157), I148 (= I158), T149 (= T159), R259 (= R269), F262 (= F272), V266 (≠ I276), N269 (≠ Y279), Q326 (= Q337), L327 (≠ V338), G330 (= G341), I348 (≠ L359), Y352 (≠ G363), T355 (= T366), Q357 (≠ E368)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
42% identity, 98% coverage: 7:378/380 of query aligns to 5:376/376 of 4m9aB
- active site: L124 (= L126), T125 (= T127), G241 (= G243), E362 (= E364), R374 (= R376)
- binding dihydroflavine-adenine dinucleotide: F122 (≠ W124), T125 (= T127), G130 (= G132), S131 (= S133), F155 (= F157), T157 (= T159), T208 (= T210), Y361 (≠ G363), T364 (= T366), E366 (= E368), M370 (≠ I372)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
44% identity, 99% coverage: 6:380/380 of query aligns to 1:370/370 of 2dvlA
- active site: L121 (= L126), T122 (= T127), G233 (= G243), E354 (= E364), R366 (= R376)
- binding flavin-adenine dinucleotide: L121 (= L126), T122 (= T127), G127 (= G132), S128 (= S133), W152 (≠ F157), I153 (= I158), T154 (= T159), T356 (= T366), E358 (= E368)
Query Sequence
>Echvi_1473 FitnessBrowser__Cola:Echvi_1473
MMNFQLTENQSMIAQMIRDFGAKEITPFRKEWDDHQTFPLPLFKKLGELGLMGVLIPSEY
GGSGFGYLEYVTAILELAKLDPGIGLSMAAHNSLCSGHIMLFGSEEQKQKYLPKLASCEF
LGAWGLTEPNTGSDAANMKTTATAEGDYFVLNGAKNFITHGVSGDVAVVIARTGEVGDKH
GMTAFVVEKGTEGFRGGRKEDKLGMRTSETAELIFEDCRVHKSQILGEVGEGFIQSMKVL
DGGRISIAALSLGIAEGAFEAALSYSKERQQFQKPISAYQGISFKLADMATKLEAAKLLT
FKAADLKNRGEYVTLASAQAKYYASEIAVELANEAVQVYGGYGFTKDYPVEKYYRDVKLC
TIGEGTSEIQKIVISRELLK
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory