SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Echvi_1680 FitnessBrowser__Cola:Echvi_1680 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P11170 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Oryctolagus cuniculus (Rabbit) (see 2 papers)
30% identity, 84% coverage: 4:445/528 of query aligns to 21:497/662 of P11170

query
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P11170

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C255 (vs. gap) modified: Disulfide link with 608
Q457 (= Q401) mutation to W: Drasticly decreased affinity for glucose and phlorizin.
T460 (≠ L404) mutation to W: Decreased affinity for glucose and phlorizin.

Sites not aligning to the query:

608 modified: Disulfide link with 255

7wmvA Structure of human sglt1-map17 complex bound with lx2761 (see paper)
32% identity, 81% coverage: 2:429/528 of query aligns to 1:468/602 of 7wmvA

query
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7wmvA

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binding N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide: N61 (= N61), H66 (≠ M66), L70 (≠ S70), I81 (≠ A81), F84 (= F84), E85 (≠ A85), A88 (= A88), D256 (≠ N233), L257 (≠ Y234), M266 (≠ Y243), L269 (≠ M246), T270 (≠ G247), Y273 (≠ F250), W274 (= W251), K304 (= K281), F436 (= F397), D437 (= D398), Q440 (= Q401)

Sites not aligning to the query:

binding N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide: 508

P13866 Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1 from Homo sapiens (Human) (see 6 papers)
31% identity, 81% coverage: 1:429/528 of query aligns to 17:485/664 of P13866

query
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P13866

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x
F

-
x
H

-
x
I

-
x
F

-
x
R

D
|
D

P
|
P

-
x
L

-
x
T

-
x
G

N
x
D

Y
x
L

P
|
P

W
|
W

V
x
P

A
x
G

I
x
F

A
x
I

L
x
F

G
|
G

Y
x
M

P
x
S

V
x
I

M
x
L

G
x
T

V
x
L

W
|
W

F
x
Y

W
|
W

C
|
C

T
|
T

D
|
D

Q
|
Q

S
x
V

M
x
I

V
|
V

Q
|
Q

S
x
R

V
x
C

L
|
L

G
x
S

A
|
A

K
|
K

N
|
N

L
x
M

K
x
S

E
x
H

G
x
V

Q
x
K

L
x
G

G
|
G

A
x
C

N
x
I

F
x
L

T
x
C

G
|
G

W
x
Y

L
|
L

K
|
K

I
x
L

L
x
M

D
x
P

V
x
M

A
x
F

L
x
I

F
x
M

I
x
V

I
x
M

P
|
P

G
|
G

I
x
M

I
|
I

C
x
S

Y
x
R

V
x
I

L
|
L

F
x
Y

P
x
T

D
x
E

-
x
K

-
x
I

-
x
A

L
x
C

D
x
V

N
x
V

P
|
P

D
x
S

E
|
E

-
x
C

-
x
E

-
x
K

-
x
Y

-
x
C

-
x
G

-
x
T

-
x
K

-
x
V

-
x
G

-
x
C

-
x
T

-
x
N

-
x
I

A
|
A

Y
|
Y

M
x
P

T
|
T

M
x
L

V
|
V

T
x
V

K
x
E

L
|
L

F
x
M

P
|
P

V
x
N

G
|
G

M
x
L

T
x
R

G
|
G

L
|
L

V
x
M

M
x
L

A
x
S

V
|
V

L
x
M

I
x
L

A
|
A

A
x
S

L
|
L

V
x
M

S
|
S

T
x
S

I
x
L

D
x
T

S
|
S

A
x
I

L
x
F

N
|
N

A
x
S

L
x
A

S
|
S

T
|
T

V
x
L

F
|
F

T
|
T

M
|
M

D
|
D

I
|
I

Y
|
Y

V
x
A

K
|
K

K
x
V

Y
x
R

K
|
K

P

-

E
x
R

A
|
A

T
x
S

Q
x
E

K
|
K

Q
x
E

I
x
L

V
x
M

T
x
I

I
x
A

G
|
G

R
|
R

V
x
L

V
x
F

T
x
I

V
x
L

L
x
V

G
x
L

A
x
I

V
x
G

I
|
I

A
x
S

I
|
I

F
x
A

L
x
W

T
x
V

L
x
P

A
x
I

I
x
V

D
x
Q

S
|
S

I
x
A

K
x
Q

G
x
S

L
x
G

N
x
Q

L
|
L

F
|
F

D
|
D

V
x
Y

F
x
I

Q
|
Q

S
|
S

I
|
I

L
x
T

G
x
S

F
x
Y

I
x
L

A
x
G

P
|
P

M
x
I

S
x
A

V
x
A

V
|
V

F
|
F

L
|
L

F
x
L

G
x
A

V
x
I

L
x
F

W
|
W

K
|
K

K
x
R

T
x
V

T
x
N

T
x
E

K
x
P

A
x
G

A
|
A

N51 (≠ K34) to S: in GGM; slightly decreased activity; dbSNP:rs17683011
W67 (= W50) mutation to A: Strong reduction in D-glucose transporter activity.
S77 (≠ T60) mutation to A: Loss of activity.
H83 (≠ M66) mutation to L: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and C-290.; mutation to Q: Loss of D-glucose transporter activity.
R135 (= R118) to W: in GGM; loss of activity
S159 (= S141) to P: in GGM; loss of activity
A166 (≠ G148) to T: in GGM; about 90% reduction in activity
D204 (≠ N186) mutation to A: Loss of activity.
N248 (= N217) modified: carbohydrate, N-linked (GlcNAc...) asparagine; mutation to Q: Loss of N-glycosylation.
C255 (≠ N224) modified: Disulfide link with 511
W276 (= W236) to L: in GGM; about 95% reduction in activity
T287 (≠ G247) mutation to A: Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with L-83 and C-290.; mutation to N: Loss of D-glucose transporter activity. Has strict selectivity for D-galactose.; mutation T->S,A: Has normal D-glucose and D-galactose transporter activity.
Y290 (≠ F250) mutation to C: Loss of D-galactose transporter activity. Has strict selectivity for D-glucose. Acquires D-mannose, D-fructose and L-sorbose transporter activity; when associated with A-287 and L-83.
W291 (= W251) mutation to A: Loss of D-glucose transporter activity.
C292 (= C252) to Y: in GGM; loss of activity; mutation to A: Has no effect on water permeability.
Q295 (= Q255) to R: in GGM; loss of activity
R300 (≠ S260) to S: in GGM; loss of activity
A304 (= A264) to V: in GGM; impairs trafficking to the plasma membrane
K321 (= K281) mutation to Q: Acquires D-mannose and D-allose transporter activity comparable to glucose and galactose.
C345 (≠ L302) modified: Disulfide link with 351
C351 (vs. gap) modified: Disulfide link with 345
C355 (vs. gap) modified: Disulfide link with 361
C361 (vs. gap) modified: Disulfide link with 355
N363 (vs. gap) mutation to A: Loss of water permeation.
L369 (≠ M312) to S: in GGM; loss of activity
R379 (≠ T322) to Q: in GGM; loss of activity
A388 (= A331) to V: in GGM; loss of activity
S396 (= S339) mutation to A: Loss of activity.
F405 (= F348) to S: in GGM; loss of activity
A411 (≠ V354) to T: in GGM; slightly decreased activity; dbSNP:rs17683430
G426 (= G370) to R: in GGM; loss of activity
Q451 (≠ N395) mutation to A: Strong reduction in water permeation.
L452 (= L396) mutation to A: Loss of water permeation.
D454 (= D398) mutation to A: Has no effect on water permeation.
Q457 (= Q401) mutation to A: Loss of D-glucose transporter activity.; mutation to C: Strong reduction in D-glucose transporter activity.
T460 (≠ L404) mutation to A: Loss of D-glucose transporter activity.
V470 (= V414) to N: in GGM; requires 2 nucleotide substitutions; about 90% reduction in activity

Sites not aligning to the query:

191:664 natural variant: Missing (in GGM; loss of activity)
379:664 natural variant: Missing (in GGM; loss of activity)
499 R → H: in GGM; impairs trafficking to the plasma membrane; decreases the sugar affinity
511 modified: Disulfide link with 255
517 modified: Disulfide link with 522
522 modified: Disulfide link with 517
615 H → Q: in GGM; slightly decreased activity
641 W→A: Slightly reduced D-glucose transporter activity.
660:661 HA→WG: Loss of D-glucose transporter activity.

7slaA Cryoem structure of sglt1 at 3.15 angstrom resolution (see paper)
32% identity, 81% coverage: 4:429/528 of query aligns to 2:454/585 of 7slaA

query
sites
7slaA

H

H

E

E

I

L

L

I

Q

R

-

N

P

A

L

A

D

D

F

I

A

S

V

V

L

I

G

V

L

I

Y

Y

L

F

V

L

T

L

L

V

I

M

G

A

I

V

G

G

Y

L

W

W

V

S

S

M

F

F

K

K

K

R

K

-

R

-

D

-

A

-

D

-

E

-

N

-

L

-

F

-

L

-

A

-

G

-

N

-

S

S

L

M

G

V

W
|
W

P

W

S

P

I

I

G

G

F

A

T

S

M

L

W

F

G

A

T

S

N

N

V

I

G

G

P

S

S

G

M

H

L

F

I

I

A

G

S

L

A

A

S

G

I

T

G

G

Y

A

T

A

T

S

G

G

V

L

V

A

A

V

G

G

N

G

F

F

A

E

W

W

Y

N

A

A

F

L

I

V

F

L

I

L

F

L

L

V

L

L

A

G

V

W

V

V

F

F

A

V

P

P

R

I

Y

Y

L

I

G

K

A

A

R

G

V

V

Q

V

T

T

L

M

P

P

E

E

F

Y

M

L

G

R

K

K

R

R

F

F

G

G

S

G

S

-

T

-

Q

Q

N

R

I

I

L

Q

A

V

W

Y

Y

L

T

S

I

V

V

L

T

S

V

L

L

F

I

L

-

Y

-

I

-

F

S

T

W

K

L

I

S

S

L

V

T

D

L

I

F

F

A

S

G

G

G

A

I

I

L

F

I

I

R

N

Q

L

I

A

L

L

D

G

L

W

P

N

L

L

W

Y

L

L

S

S

V

I

I

L

L

L

I

L

L

A

I

I

A

T

A

A

F

L

F

Y

T

T

I

I

A

T

G

G

L

L

K

A

A

A

I

V

A

I

Y

Y

T

T

N

D

V

T

F

L

Q

Q

M

T

V

L

L

I

L

M

I

L

V

I

V

G

S

A

L

L

A

I

L

L

T

M

L

G

T

F

G

A

L

F

Y

H

K

E

V

V

G

G

V

Y

G

D

E

A

L

F

I

M

-

E

-

K

-

Y

-

M

-

K

-

A

-

I

-

P

-

T

-

I

-

V

-

S

-

D

A

G

N

N

T

T

P

T

G

F

E

Q

Y

E

W

K

N

C

L

Y

L

T

L

P

P

R

A

A

D

D

-

S

-

F

-

H

-

I

-

F

-

R

D

D

P

P

-

L

-

T

-

G

N

D

Y

L

P

P

W

W

V

P

A

G

I

F

A

I

L

F

G

G

Y

L

P

T

V

I

M

L

G

A

V

L

W

W

F

Y

W

W

C

C

T

T

D

D

Q

Q

S

V

M

I

V

V

Q

Q

S

R

V

C

L

L

G

A

A

A

K

K

N

N

L

M

K
x
S

E

H

G

V

Q

K

L

G

G

G

A

C

N

I

F

L

T

A

G

G

W
x
Y

L

L

K

K

I

L

L

L

D

P

V

M

A

F

L

I

F

M

I

V

I

M

P

P

G

G

I

M

I

I

C

S

Y

R

V

I

L

L

F

F

P

P

D

D

-

K

-

V

-

A

L

C

D

V

N

V

P

P

D

S

E

E

-

C

-

E

-

K

-

Y

-

C

-

G

-

T

-

K

-

V

-

G

-

C

-

T

-

N

-

I

A

A

Y

Y

M

P

T

T

M

L

V

V

T

V

K

E

L

L

F

M

P

P

V

N

G

G

M

L

T

R

G

G

L

L

V

M

M

L

A

A

V

V

L

M

I

L

A

A

L

L

V

M

S

S

T

S

I

L

D

T

S

S

A

I

L

F

N

N

A

S

L

A

S

S

T

T

V

L

F

F

T

T

M

M

D

D

I

I

Y

Y

V

A

K

K

K

V

Y

R

K

K

P

-

E

R

A

A

T

S

Q

E

K

K

Q

E

I

L

V

M

T

I

I

V

G

G

R

R

V

L

V

F

T

V

V

L

L

F

G

L

A

V

V

V

I

V

A

S

I

I

F

A

L

W

T

I

L

P

A

I

I

V

D

Q

S

S

I

A

K

Q

G

S

L

G

N

Q

L

L

F

F

D

D

V

Y

F

I

Q

Q

S

S

I

V

L

S

G

S

F

Y

I

L

A

A

P

P

M

V

S

A

V

A

V

V

F

F

L

L

F

L

G

A

V

I

L

F

W

W

K

K

K

R

T

V

T

N

T

E

K

Q

A

G

A

A

binding cholesterol hemisuccinate: W36 (= W50), S277 (≠ K268), Y288 (≠ W279)

Sites not aligning to the query:

binding cholesterol hemisuccinate: 554, 558, 561

7sl8A Cryoem structure of sglt1 at 3.4 a resolution (see paper)
32% identity, 81% coverage: 4:429/528 of query aligns to 1:453/582 of 7sl8A

query
sites
7sl8A

H

H

E

E

I

L

L

I

Q

R

-

N

P

A

L

A

D

D

F

I

A

S

V

V

L

I

G

V

L

I

Y

Y

L

F

V

L

T

L

L

V

I

M

G

A

I

V

G

G

Y

L

W

W

V

S

S

M

F

F

K

K

K

R

K

-

R

-

D

-

A

-

D

-

E

-

N

-

L

-

F

-

L

-

A

-

G

-

N

-

S

S

L

M

G

V

W
|
W

P

W

S

P

I

I

G

G

F

A

T

S

M

L

W

F

G

A

T

S

N

N

V

I

G

G

P

S

S

G

M

H

L

F

I

I

A

G

S

L

A

A

S

G

I

T

G

G

Y

A

T

A

T

S

G

G

V

L

V

A

A

V

G

G

N

G

F

F

A

E

W

W

Y

N

A

A

F

L

I

V

F

L

I

L

F

L

L

V

L

L

A

G

V

W

V

V

F

F

A

V

P

P

R

I

Y

Y

L

I

G

K

A

A

R

G

V

V

Q

V

T

T

L

M

P

P

E

E

F

Y

M

L

G

R

K

K

R

R

F

F

G

G

S

G

S

-

T

-

Q

Q

N

R

I

I

L

Q

A

V

W

Y

Y

L

T

S

I

V

V

L

T

S

V

L

L

F

I

L

-

Y

-

I

-

F

S

T

W

K

L

I

S

S

L

V

T

D

L

I

F

F

A

S

G

G

G

A

I

I

L

F

I

I

R

N

Q

L

I

A

L

L

D

G

L

W

P

N

L

L

W

Y

L

L

S

S

V

I

I

L

L

L

I

L

L

A

I

I

A

T

A

A

F

L

F

Y

T

T

I

I

A

T

G

G

L

L

K

A

A

A

I

V

A

I

Y

Y

T

T

N

D

V

T

F

L

Q

Q

M

T

V

L

L

I

L

M

I

L

V

I

V

G

S

A

L

L

A

I

L

L

T

M

L

G

T

F

G

A

L

F

Y

H

K

E

V

V

G

G

V

Y

G

D

E

A

L

F

I

M

-

E

-

K

-

Y

-

M

-

K

-

A

-

I

-

P

-

T

-

I

-

V

-

S

-

D

A

G

N

N

T

T

P

T

G

F

E

Q

Y

E

W

K

N

C

L

Y

L

T

L

P

P

R

A

A

D

D

-

S

-

F

-

H

-

I

-

F

-

R

D

D

P

P

-

L

-

T

-

G

N

D

Y

L

P

P

W

W

V

P

A

G

I

F

A

I

L

F

G

G

Y

L

P

T

V

I

M

L

G

A

V

L

W

W

F

Y

W

W

C

C

T

T

D

D

Q

Q

S

V

M

I

V

V

Q

Q

S

R

V

C

L

L

G

A

A

A

K

K

N

N

L

M

K

S

E

H

G

V

Q

K

L
x
G

G

G

A

C

N

I

F

L

T

A

G

G

W
x
Y

L

L

K

K

I

L

L

L

D

P

V

M

A

F

L

I

F

M

I

V

I

M

P

P

G

G

I

M

I

I

C

S

Y

R

V

I

L

L

F

F

P

P

D

D

-

K

-

V

-

A

L

C

D

V

N

V

P

P

D

S

E

E

-

C

-

E

-

K

-

Y

-

C

-

G

-

T

-

K

-

V

-

G

-

C

-

T

-

N

-

I

A

A

Y

Y

M

P

T

T

M

L

V

V

T

V

K

E

L

L

F

M

P

P

V

N

G

G

M

L

T

R

G

G

L

L

V

M

M

L

A

A

V

V

L

M

I

L

A

A

L

L

V

M

S

S

T

S

I

L

D

T

S

S

A

I

L

F

N

N

A

S

L

A

S

S

T

T

V

L

F

F

T

T

M

M

D

D

I

I

Y

Y

V

A

K

K

K

V

Y

R

K

K

P

-

E

R

A

A

T

S

Q

E

K

K

Q

E

I

L

V

M

T

I

I

V

G

G

R

R

V

L

V

F

T

V

V

L

L

F

G

L

A

V

V

V

I

V

A

S

I

I

F

A

L

W

T

I

L

P

A

I

I

V

D

Q

S

S

I

A

K

Q

G

S

L

G

N

Q

L

L

F

F

D

D

V

Y

F

I

Q

Q

S

S

I

V

L

S

G

S

F

Y

I

L

A

A

P

P

M

V

S

A

V

A

V

V

F

F

L

L

F

L

G

A

V

I

L

F

W

W

K

K

K

R

T

V

T

N

T

E

K

Q

A

G

A

A

binding cholesterol: W35 (= W50), G280 (≠ L272), Y287 (≠ W279)

Sites not aligning to the query:

binding cholesterol: 551, 554, 555, 558

7vsiA Structure of human sglt2-map17 complex bound with empagliflozin (see paper)
29% identity, 80% coverage: 8:429/528 of query aligns to 2:465/586 of 7vsiA

query
sites
7vsiA

Q

N

P

P

L

A

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D

F

I

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A

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R

R

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G

A

T

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V

E

G

N

G

L

Y

F

F

L

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A

A

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N

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S

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G

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W

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W

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P

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G

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A

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L

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F

G

A

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N
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x
H

L

F

I

V

A
x
G

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x
L

A

A

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I
x
T

G

G

Y

A

T

A

T

S

G

G

V

L

V

A

A
x
V

G

A

N

G

F
|
F

A
x
E

W

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Y

N

A
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A

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I

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F

V

I

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F

L

L

L

A

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V

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T

R

Q

I

N

R

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L

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Y

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Y

L

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S

I

L

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F

T

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L

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L

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x
V

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F

I

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R

Q

Q

Q

I

A

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A

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V

I

I

A

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F

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A

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E

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E

G

L

L

I

F

A

D

N

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T

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P

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G

G

E

A

Y

A

W

T

N

S

L

L

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T

L

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P

-

A

S

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E

D

D

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P

-

A

-

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G

-

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-

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R

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H

-

P

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T

-

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D

Y

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P

A

A

I

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A

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Y

L

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x
V

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x
S

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G

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x
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I

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F

L

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C

-

V

-

P

-

E

-

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-

R

-

V

-

C

-

G

-

T

-

E

L

V

D

G

N

C

P

S

D

N

E

I

A

A

Y

Y

M

P

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R

M

L

V

V

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K

L

L

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P

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N

G

G

M

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A

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L

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M

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A

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S

A

I

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F

N

N

A

S

L

S

S

S

T

T

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L

F

F

T

T

M

M

D

D

I

I

Y

Y

V

T

K

-

K

R

Y

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K

R

P

P

E

R

A

A

T

G

Q

D

K

R

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E

I

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A

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A

S

I

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F

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T

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A

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V

D

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S

A

I

A

K

Q

G

G

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N

Q

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F

D
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D

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Y

F

I

Q
|
Q

S

A

I

V

L

S

G

S

F

Y

I

L

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A

P

P

M

V

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S

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A

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F

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F

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G

A

V

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L

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W

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K

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Q

A

G

A

A

binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: N55 (= N61), H60 (≠ M66), G63 (≠ A69), L64 (≠ S70), T67 (≠ I73), V75 (≠ A81), F78 (= F84), E79 (≠ A85), A82 (= A88), V137 (≠ L142), V266 (≠ M246), S267 (≠ G247), Y270 (≠ F250), W271 (= W251), K301 (= K281), F433 (= F397), D434 (= D398), Q437 (= Q401)

Sites not aligning to the query:

binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: 506

P31639 Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2 from Homo sapiens (Human) (see paper)
29% identity, 80% coverage: 6:429/528 of query aligns to 20:485/672 of P31639

query
sites
P31639

I

I

L

D

Q

N

P

P

L

A

D

D

F

I

A

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V

V

L

I

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A

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Y

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F

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A

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W

S

P

I

V

G

G

F

A

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M

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W

F

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A

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N

N

V

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G

P

S

S

G

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H

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F

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A

G

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L

A

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S

G

I

T

G

G

Y

A

T

A

T

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G

G

V

L

V

A

A
x
V

G

A

N

G

F
|
F

A

E

W

W

Y

N

A

A

F

L

I

F

F

V

I

V

F

L

L

L

A

G

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F

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R

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I

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F

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K

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x
V

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F

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A

A

A

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G

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A

A

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A

L

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G

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Y
x
L

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I

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V

G

S

V

G

W

W

F

Y

W

W

C

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M

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A

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A

A

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L

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M

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S

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A

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S

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I

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F

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N

A

S

L

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F

F

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M

M

D

D

I

I

Y

Y

V

T

K

-

K

R

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P

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R

A

A

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G

Q

D

K

R

Q

E

I

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V

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V

F

A

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|
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D

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F

I

Q

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A

I

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G

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P

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S

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V

A

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V

F

F

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A

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W

V

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P

K

R

T

V

T

N

T

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K

Q

A

G

A

A

V95 (≠ A81) mutation to A: Strong reduction in D-glucose transporter activity. Confers partial resistance to empagliflozin inhibition.
F98 (= F84) mutation to A: Slightly decreases D-glucose transporter activity. Abolishes the binding to inhibitor, empagliflozin.
V157 (≠ L142) mutation to A: Decreases D-glucose transporter activity.
L283 (≠ Y243) mutation to M: Strong reduction in D-glucose transporter activity. Confers partial resistance to empagliflozin inhibition.
F453 (= F397) mutation to A: Slightly decreases D-glucose transporter activity. Greatly reduces the binding to inhibitor, empagliflozin.

Q9NY91 Probable glucose sensor protein SLC5A4; Solute carrier family 5 member 4 from Homo sapiens (Human) (see paper)
28% identity, 84% coverage: 5:448/528 of query aligns to 22:500/659 of Q9NY91

query
sites
Q9NY91

E

H

I

I

L

R

Q

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P

A

L

A

D

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F

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A

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V

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L

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V

L

I

Y

Y

L

F

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V

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V

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A

I

V

G

G

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L

W

W

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K

N

R

R

D

G

A

T

D

I

E

G

N

G

L

F

F

F

L

L

A

A

G

G

N

R

S

D

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M

G

A

W

W

P

W

S

P

I

M

G

G

F

A

T

S

M

L

W

F

G

A

T

S

N

N

V

I

G

G

P

S

S

N

M

H

L

Y

I

V

A

G

S

L

A

A

S

G

I

T

G

G

Y

A

T

A

T

S

G

G

V

V

V

A

A

T

G

V

N

T

F

F

A

E

W

W

Y

T

A

S

F

S

I

V

F

M

I

L

F

L

L

I

L

L

A

G

V

W

V

I

F

F

A

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R

I

Y

Y

L

I

G

K

A

S

R

G

V

V

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M

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T

L

M

P

P

E

E

F

Y

M

L

G

K

K

K

R

R

F

F

G

G

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G

S

E

T

R

-

L

Q

Q

N

V

I

Y

L

L

A

S

W

I

Y

L

T

S

I

L

V

F

T

I

V

C

L

V

I

V

S

L

W

L

L

I

S

S

L

A

T

D

L

I

F

F

A

A

G

G

G

A

I

I

L

F

I

I

R

K

Q

L

I

A

L

L

D

G

L

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D

L

L

W

Y

L

L

S

A

V

I

V

F

I

I

L

L

I

L

L

A

I

M

A

T

A

A

F

V

F

Y

T

T

I

T

A

T

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G

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A

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A

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Y

T

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I

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S

L

F

A

I

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F

G

A

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F

Y

N

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E

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E457 (≠ Q401) mutation to Q: Confers sugar transport activity not found in the wild-type protein. Increased sensitivity to inhibitor phlorizin.

Q9ET37 Solute carrier family 5 member 4A; SGLT3-a from Mus musculus (Mouse) (see paper)
28% identity, 93% coverage: 4:495/528 of query aligns to 21:559/656 of Q9ET37

query
sites
Q9ET37

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