SitesBLAST
Comparing Echvi_2097 FitnessBrowser__Cola:Echvi_2097 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 16 hits to proteins with known functional sites (download)
6btmB Structure of alternative complex iii from flavobacterium johnsoniae (wild type) (see paper)
42% identity, 93% coverage: 65:1023/1029 of query aligns to 1:948/948 of 6btmB
- binding (2R)-3-{[(2R)-2-(decanoylamino)-3-hydroxypropyl]sulfanyl}propane-1,2-diyl ditetradecanoate: E1 (= E65), G2 (≠ A66)
- binding fe3-s4 cluster: C789 (= C850), C809 (= C870), V810 (≠ I871), T812 (= T873), C815 (= C876), M862 (= M926)
- binding iron/sulfur cluster: C777 (= C838), Q778 (= Q839), C780 (= C841), C785 (= C846), N802 (= N863), C819 (= C880), R824 (= R885)
6lodB Cryo-em structure of the air-oxidized photosynthetic alternative complex iii from roseiflexus castenholzii (see paper)
36% identity, 94% coverage: 63:1029/1029 of query aligns to 4:928/929 of 6lodB
- binding fe3-s4 cluster: V758 (= V849), C759 (= C850), P760 (= P851), C779 (= C870), V780 (≠ I871), G781 (= G872), T782 (= T873), C785 (= C876), M838 (= M926)
- binding heme c: N777 (= N868), R778 (= R869), R852 (≠ K940), I853 (≠ L941), R856 (≠ K944)
- binding iron/sulfur cluster: C692 (= C771), N693 (≠ V772), S694 (≠ G773), C695 (= C774), N696 (≠ G775), A697 (= A776), C698 (= C777), C702 (= C781), N706 (= N785), W724 (= W803), I727 (= I806), L746 (≠ M837), C747 (= C838), Q748 (= Q839), Q749 (≠ H840), C750 (= C841), P754 (= P845), C755 (= C846), N772 (= N863), C789 (= C880), Y791 (= Y882), V793 (= V884), R794 (= R885), K840 (= K928), C841 (= C929), F843 (≠ M931), C844 (= C932), T869 (≠ V957), C871 (= C959), C875 (= C963), I880 (≠ L968)
6f0kB Alternative complex iii (see paper)
34% identity, 93% coverage: 67:1025/1029 of query aligns to 3:955/961 of 6f0kB
- binding fe3-s4 cluster: C803 (= C850), V805 (= V852), M818 (= M865), C823 (= C870), I824 (= I871), G825 (= G872), C829 (= C876), M869 (= M926)
- binding heme c: Y719 (= Y757), N821 (= N868), R822 (= R869), R884 (≠ L941), N887 (≠ K944)
- binding iron/sulfur cluster: C733 (= C771), T734 (≠ V772), G735 (= G773), C736 (= C774), N737 (≠ G775), A738 (= A776), C739 (= C777), C743 (= C781), W765 (= W803), I768 (= I806), C791 (= C838), M792 (≠ Q839), H793 (= H840), C794 (= C841), P798 (= P845), C799 (= C846), N816 (= N863), C833 (= C880), C872 (= C929), Y874 (≠ M931), C875 (= C932), A901 (= A958), C902 (= C959), C906 (= C963)
6cz7B The arsenate respiratory reductase (arr) complex from shewanella sp. Ana-3 (see paper)
30% identity, 22% coverage: 763:988/1029 of query aligns to 4:208/234 of 6cz7B
- binding iron/sulfur cluster: C12 (= C771), V13 (= V772), G14 (= G773), C15 (= C774), G16 (= G775), C18 (= C777), C22 (= C781), N26 (= N785), Y52 (≠ F833), P54 (= P835), C57 (= C838), N58 (≠ Q839), H59 (= H840), C60 (= C841), A63 (= A844), P64 (= P845), C65 (= C846), C69 (= C850), P70 (= P851), T82 (≠ N863), C89 (= C870), I90 (= I871), G91 (= G872), C92 (≠ T873), K93 (≠ R874), C95 (= C876), C99 (= C880), Y101 (= Y882), V103 (= V884), I104 (≠ R885), T161 (≠ M926), K163 (= K928), C164 (= C929), F166 (≠ M931), C167 (= C932), C179 (= C959), C183 (= C963), P184 (≠ S964), R188 (≠ L968)
Q7WTT9 Arsenate respiratory reductase iron-sulfur subunit ArrB; Arsenate respiratory reductase small subunit; ARR small subunit from Shewanella sp. (strain ANA-3) (see paper)
30% identity, 22% coverage: 763:988/1029 of query aligns to 4:208/234 of Q7WTT9
- C12 (= C771) binding
- C15 (= C774) binding
- C18 (= C777) binding
- C22 (= C781) binding
- C57 (= C838) binding
- C60 (= C841) binding
- C65 (= C846) binding
- C69 (= C850) binding
- C89 (= C870) binding
- C92 (≠ T873) binding
- C95 (= C876) binding
- C99 (= C880) binding
- C164 (= C929) binding
- C167 (= C932) binding
- C179 (= C959) binding
- C183 (= C963) binding
2vpyF Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (pcp) (see paper)
30% identity, 22% coverage: 762:988/1029 of query aligns to 4:160/193 of 2vpyF
- binding pentachlorophenol: I91 (= I871), C93 (≠ T873)
- binding iron/sulfur cluster: C13 (= C771), G15 (= G773), C16 (= C774), C19 (= C777), C23 (= C781), N27 (= N785), L36 (≠ A802), I38 (= I804), P55 (= P835), Q57 (≠ M837), C58 (= C838), L59 (≠ Q839), C61 (= C841), P65 (= P845), C66 (= C846), C70 (= C850), P71 (= P851), V83 (≠ N863), C90 (= C870), I91 (= I871), A92 (≠ G872), C93 (≠ T873), G94 (≠ R874), C96 (= C876), C100 (= C880), P101 (= P881), Y102 (= Y882), R105 (= R885), V113 (≠ M926), C116 (= C929), F118 (≠ M931), C119 (= C932), P129 (≠ A942), A130 (= A958), C131 (= C959), C135 (= C963), C139 (≠ A967), R140 (≠ L968)
Sites not aligning to the query:
2vpwF Polysulfide reductase with bound menaquinone (see paper)
30% identity, 22% coverage: 762:988/1029 of query aligns to 4:160/193 of 2vpwF
- binding iron/sulfur cluster: C13 (= C771), G15 (= G773), C16 (= C774), C19 (= C777), C23 (= C781), N27 (= N785), L36 (≠ A802), I38 (= I804), P55 (= P835), Q57 (≠ M837), C58 (= C838), L59 (≠ Q839), H60 (= H840), C61 (= C841), P65 (= P845), C66 (= C846), C70 (= C850), P71 (= P851), V83 (≠ N863), C90 (= C870), I91 (= I871), A92 (≠ G872), C93 (≠ T873), G94 (≠ R874), C96 (= C876), C100 (= C880), P101 (= P881), Y102 (= Y882), R105 (= R885), V113 (≠ M926), C116 (= C929), F118 (≠ M931), C119 (= C932), P129 (≠ A942), A130 (= A958), C131 (= C959), C135 (= C963), C139 (≠ A967), R140 (≠ L968)
Sites not aligning to the query:
P18776 Anaerobic dimethyl sulfoxide reductase chain B; DMSO reductase iron-sulfur subunit from Escherichia coli (strain K12) (see 2 papers)
23% identity, 21% coverage: 761:979/1029 of query aligns to 4:161/205 of P18776
- C102 (≠ T873) mutation C->F,S,W,Y: Loss of electron transfer from menaquinol to DMSO.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
1kqfB Formate dehydrogenase n from e. Coli (see paper)
24% identity, 23% coverage: 766:1002/1029 of query aligns to 33:210/289 of 1kqfB
- binding protoporphyrin ix containing fe: Y137 (= Y875)
- binding iron/sulfur cluster: C38 (= C771), I39 (≠ V772), G40 (= G773), C41 (= C774), K42 (≠ G775), C44 (= C777), C48 (= C781), N52 (vs. gap), T77 (≠ A802), M79 (≠ I804), C99 (= C838), M100 (≠ Q839), H101 (= H840), C102 (= C841), P105 (≠ A844), C107 (= C846), C111 (= C850), P112 (= P851), I117 (≠ T855), V125 (≠ N863), C132 (= C870), I133 (= I871), G134 (= G872), C135 (≠ T873), G136 (≠ R874), Y137 (= Y875), C138 (= C876), C142 (= C880), I146 (≠ V884), P147 (≠ R885), V156 (≠ D897), K158 (= K928), C159 (= C929), L161 (≠ M931), C162 (= C932), P172 (≠ V957), C174 (= C959), C178 (= C963), P179 (≠ S964), I183 (≠ L968)
Sites not aligning to the query:
P0AAJ3 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit; Anaerobic formate dehydrogenase iron-sulfur subunit; Formate dehydrogenase-N subunit beta; FDH-N subunit beta from Escherichia coli (strain K12) (see paper)
24% identity, 23% coverage: 766:1002/1029 of query aligns to 34:211/294 of P0AAJ3
- C39 (= C771) binding
- C42 (= C774) binding
- C45 (= C777) binding
- C49 (= C781) binding
- C100 (= C838) binding
- C103 (= C841) binding
- C108 (= C846) binding
- C112 (= C850) binding
- C133 (= C870) binding
- C136 (≠ T873) binding
- C139 (= C876) binding
- C143 (= C880) binding
- C160 (= C929) binding
- C163 (= C932) binding
- C175 (= C959) binding
- C179 (= C963) binding
3egwB The crystal structure of the narghi mutant narh - c16a
26% identity, 19% coverage: 827:1017/1029 of query aligns to 173:355/509 of 3egwB
- binding fe3-s4 cluster: P181 (= P835), C196 (= C850), S198 (≠ V852), I201 (≠ T855), C217 (= C870), R218 (≠ I871), G219 (= G872), W220 (≠ T873), R221 (= R874), C223 (= C876), S241 (≠ M926), C263 (≠ R948), G265 (= G953), R268 (≠ N956)
- binding protoporphyrin ix containing fe: W220 (≠ T873), R221 (= R874)
- binding iron/sulfur cluster: C184 (= C838), E185 (≠ Q839), H186 (= H840), C187 (= C841), P190 (≠ A844), C192 (= C846), C227 (= C880), I232 (≠ R885), K243 (= K928), C244 (= C929), F246 (≠ M931), C247 (= C932), T257 (≠ A942), C259 (≠ K944)
Sites not aligning to the query:
P11349 Respiratory nitrate reductase 1 beta chain; Nitrate reductase A subunit beta; Quinol-nitrate oxidoreductase subunit beta; EC 1.7.5.1 from Escherichia coli (strain K12) (see 2 papers)
26% identity, 19% coverage: 827:1017/1029 of query aligns to 173:355/512 of P11349
- C184 (= C838) binding
- C187 (= C841) binding
- C192 (= C846) binding
- C196 (= C850) binding
- C217 (= C870) binding
- C223 (= C876) binding
- C227 (= C880) binding
- C244 (= C929) binding
- C247 (= C932) binding
- C259 (≠ K944) binding
- C263 (≠ R948) binding
Sites not aligning to the query:
- 16 binding
- 19 binding
- 22 binding
- 26 binding
2ivfB Ethylbenzene dehydrogenase from aromatoleum aromaticum (see paper)
26% identity, 18% coverage: 828:1017/1029 of query aligns to 126:257/337 of 2ivfB
- binding fe3-s4 cluster: C148 (= C850), T150 (≠ V852), I153 (≠ T855), C169 (= C870), K170 (≠ I871), G171 (= G872), H172 (≠ T873), R173 (= R874), H174 (≠ Y875), C175 (= C876), S193 (≠ D907)
- binding protoporphyrin ix containing fe: T150 (≠ V852), K170 (≠ I871), H172 (≠ T873)
- binding iron/sulfur cluster: M135 (= M837), C136 (= C838), N137 (≠ Q839), H138 (= H840), C139 (= C841), P142 (≠ A844), C144 (= C846), V162 (≠ N863), C179 (= C880), A183 (≠ V884), I184 (≠ R885), K195 (= K928), C196 (= C929), I197 (≠ S930), L198 (≠ M931), C199 (= C932), N209 (≠ V957), C211 (= C959), C215 (= C963), V219 (≠ A967), R220 (≠ L968)
Sites not aligning to the query:
- binding iron/sulfur cluster: 13, 14, 15, 16, 17, 19, 23, 27, 38, 39, 41
7qv7B Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
26% identity, 16% coverage: 771:932/1029 of query aligns to 14:142/183 of 7qv7B
- binding iron/sulfur cluster: C14 (= C771), G16 (= G773), C17 (= C774), K18 (≠ G775), A19 (= A776), C20 (= C777), C24 (= C781), H28 (≠ N785), R48 (= R808), C63 (= C838), R64 (≠ Q839), H65 (= H840), C66 (= C841), A69 (= A844), C71 (= C846), C75 (= C850), A79 (= A854), I80 (≠ T855), C94 (= C870), I95 (= I871), C97 (≠ T873), C100 (= C876), C104 (= C880), I109 (≠ R885), C139 (= C929), L141 (≠ M931), C142 (= C932)
Sites not aligning to the query:
7z0sB Structure of the escherichia coli formate hydrogenlyase complex (anaerobic preparation, without formate dehydrogenase h) (see paper)
25% identity, 12% coverage: 767:888/1029 of query aligns to 8:100/170 of 7z0sB
- binding iron/sulfur cluster: C12 (= C771), I13 (≠ V772), G14 (= G773), C15 (= C774), H16 (≠ G775), T17 (≠ A776), C18 (= C777), C22 (= C781), H26 (≠ Q782), R36 (≠ K792), L37 (≠ E793), P48 (= P835), L50 (≠ M837), C51 (= C838), H52 (≠ Q839), H53 (= H840), C54 (= C841), C59 (= C846), C63 (= C850), P64 (= P851), I68 (≠ T855), V75 (≠ N863), L77 (≠ M865), C82 (= C870), V83 (≠ I871), C85 (≠ T873), K86 (≠ R874), C88 (= C876), C92 (= C880), I97 (≠ R885)
Sites not aligning to the query:
- binding iron/sulfur cluster: 140, 142, 143, 144, 145, 146, 153, 155, 159, 160, 161, 164
7qv7A Cryo-em structure of hydrogen-dependent co2 reductase. (see paper)
24% identity, 21% coverage: 767:985/1029 of query aligns to 8:159/174 of 7qv7A
- binding iron/sulfur cluster: C12 (= C771), L13 (≠ V772), G14 (= G773), C15 (= C774), Y16 (≠ G775), C18 (= C777), C22 (= C781), H26 (≠ G791), L37 (≠ I806), C51 (= C838), R52 (≠ Q839), C54 (= C841), C59 (= C846), C63 (= C850), C82 (= C870), I83 (= I871), G84 (= G872), C85 (≠ T873), C88 (= C876), C92 (= C880), I97 (≠ V901), F99 (≠ V903), C125 (= C929), L127 (≠ M931), C128 (= C932), A136 (= A958), C137 (= C959), C141 (= C963)
Query Sequence
>Echvi_2097 FitnessBrowser__Cola:Echvi_2097
MKENKKKYWKGLEQLTNDPEFVKNADREFPEYLPIGGQQEGGASRRDFLKLMGFSLAAAS
LAACEAPVRKAIPYVNKPVDVNPSIPNYYASTFFGGGEYASVVVKTREGRPIKVDGNKLS
PVTKGGTSAIVEASVLSLYDKERLTSPYKNGEKSDWATIDKEVAAKLKAAGNVKVVTNTI
MSPSSEKALKALTDAIGGAEVITYDASSAYGIVKANQTYYGTAVLPNYSFDKADVIVSFG
ADFLGTWIAPIEYSKQYAQGRKISKEHPEMSRHFQFESNLSLTGANADYRTPIKASQSGL
AVLALYNLLAKKAGAPSVKAAGVEVAHLSKAANELWANRGKSLVVSGSNDPNVQVVINAI
NELLGNNNNTISYTKAVNFRQGDDAAIARFTKELASGRVGGVLFYNCNPVYDTPQGEALG
QAIAKAKVSVATNGTMDETASLVQYVAPDHHYLESWNDFHPKAGEYSLSQPAISPLFDTR
QAQESFLTWAGVPTNYYDFLQDNWKELYAGQSEITTFQEFWDRALYNGYYSTPLASETAE
LTPVGDVSSAAAAVNKSYSASSNGAELIIYQKIGIGDGTFANNPWLQEMSDPISKATWDN
YLTVSQKWANENGLKMVEGETKKAKITANGKSLIVPVLIQPGQADGTIGLALGYGRTKAG
RVANGVGVNAYQLLDNSKGFVNNEITSGVSIELTGDTYRIAQTQTHQTYMDRGNVIQEAT
LPEYKEDASAGREMPKIYKDGEFVKPSKISLWNGHKYSQHHWGLAIDMNSCVGCGACTVA
CQVENNVAVVGKEEVLNRREMAWIRIDRYYSSDAEAGDLEGLEKASDNPEVTFQPMMCQH
CNNAPCETVCPVAATTHSSEGLNQMTYNRCIGTRYCANNCPYKVRRFNWFKYHDNKDFSK
VNVAQNDDLGKMVLNPDVTVRARGVMEKCSMCVQRIQAGKLAAKRENRKVKDGEINVACA
VACSTDALVFGDLNDPKSKVSQMLKIEENTTSAVKEVNEERAYHVLEEINVSPNIWYFTK
IRNKDKNEA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory