SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Echvi_2206 FitnessBrowser__Cola:Echvi_2206 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

3al0C Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state. (see paper)
33% identity, 87% coverage: 11:93/95 of query aligns to 10:92/564 of 3al0C

query
sites
3al0C

I

L

A

E

H

N

L

L

A

A

R

R

L

L

E

E

F

L

D

S

E

E

N

D

S

Q

A

R

K

E

K

S

M

L

T

M

R

K

D

D

M

F

T

Q

Q

E

I

I

L

L

D

D

W

Y

V

V

E

E

H

L

L

L

E

N

Q

E

V

V

D

D

T

V

E

E

G

G

V

V

A

E

P

P

I

M

T

Y

T

T

M

P

S

V

S

E

E

D

V

S

N

A

V

K

L

L

R

R

E

K

D

G

A

D

V

P

G

R

S

F

H

F

L

E

S

M

H

R

E

D

K

L

G

I

L

K

K

K

N

N

A

F

P

P

Q

E

K

E

D

K

S

D

D

G

Y

H

F

I

R

K

V

V

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P

K

G

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I

Sites not aligning to the query:

active site: 110, 335
binding o5'-(l-glutamyl-sulfamoyl)-adenosine: 106, 108, 109, 118, 122, 142, 276, 294, 295, 297, 298, 324, 325, 333
binding : 144, 145, 148, 208, 213, 252, 255, 266, 269, 270, 276, 297, 298, 299, 300, 301, 304, 330, 332, 363, 364, 365, 370, 387, 389, 391, 392, 397, 400, 407, 446, 447, 453, 457, 509, 520, 524, 527, 535, 536, 538, 539

Query Sequence

>Echvi_2206 FitnessBrowser__Cola:Echvi_2206
MKIDINTLKKIAHLARLEFDENSAKKMTRDMTQILDWVEHLEQVDTEGVAPITTMSSEVN
VLREDAVGSHLSHEKGLKNAPQKDSDYFRVPKVLE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory