Comparing Echvi_2301 FitnessBrowser__Cola:Echvi_2301 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P40806 Polyketide synthase PksJ; PKS from Bacillus subtilis (strain 168) (see paper)
34% identity, 50% coverage: 1:1116/2214 of query aligns to 1154:2273/5043 of P40806
O31782 Polyketide synthase PksN; EC 2.3.1.- from Bacillus subtilis (strain 168) (see paper)
34% identity, 50% coverage: 3:1108/2214 of query aligns to 468:1597/5488 of O31782
4mz0A Structure of a ketosynthase-acyltransferase di-domain from module curl of the curacin a polyketide synthase (see paper)
36% identity, 40% coverage: 602:1479/2214 of query aligns to 33:896/896 of 4mz0A
I6XD69 Mycoketide-CoA synthase; Polyketide synthase Pks12; EC 2.3.1.295 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
35% identity, 42% coverage: 543:1479/2214 of query aligns to 1991:2921/4151 of I6XD69
B2HIL7 Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; Beta-ketoacyl-acyl-carrier-protein synthase I; EC 2.3.1.41 from Mycobacterium marinum (strain ATCC BAA-535 / M) (see paper)
36% identity, 40% coverage: 604:1486/2214 of query aligns to 40:922/2104 of B2HIL7
Sites not aligning to the query:
Q03132 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4; DEBS 2; 6-deoxyerythronolide B synthase II; Erythronolide synthase; ORF B; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see 4 papers)
34% identity, 43% coverage: 537:1488/2214 of query aligns to 1417:2368/3567 of Q03132
Sites not aligning to the query:
Q03131 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2; DEBS 1; 6-deoxyerythronolide B synthase I; Erythronolide synthase; ORF C; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see paper)
34% identity, 42% coverage: 542:1481/2214 of query aligns to 439:1384/3491 of Q03131
Sites not aligning to the query:
Q9ZGI5 Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2; Narbonolide/10-deoxymethynolide synthase PikAI; Pikromycin polyketide synthase component PikAI; Pikromycin PKS component PikAI; Type I modular polyketide synthase PikAI; PKS; EC 2.3.1.239; EC 2.3.1.240 from Streptomyces venezuelae (see paper)
34% identity, 42% coverage: 543:1482/2214 of query aligns to 2523:3561/4613 of Q9ZGI5
Sites not aligning to the query:
4mz0B Structure of a ketosynthase-acyltransferase di-domain from module curl of the curacin a polyketide synthase (see paper)
34% identity, 40% coverage: 602:1479/2214 of query aligns to 24:823/823 of 4mz0B
7s6cB Cryoem structure of modular pks holo-lsd14 stalled at the condensation step and bound to antibody fragment 1b2, composite structure (see paper)
33% identity, 39% coverage: 608:1481/2214 of query aligns to 33:891/891 of 7s6cB
7m7fA 6-deoxyerythronolide b synthase (debs) module 1 in complex with antibody fragment 1b2: state 1 (see paper)
34% identity, 39% coverage: 608:1481/2214 of query aligns to 35:912/1390 of 7m7fA
8in9A The structure of the gfsa ksq-at didomain in complex with the gfsa acp domain (see paper)
32% identity, 39% coverage: 608:1480/2214 of query aligns to 6:820/820 of 8in9A
7vefA The structure of gfsa ksq-at didomain in complex with a malonate substrate analog (see paper)
33% identity, 39% coverage: 608:1480/2214 of query aligns to 6:828/828 of 7vefA
Q03133 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6; DEBS 3; 6-deoxyerythronolide B synthase III; Erythronolide synthase; ORF C; EC 2.3.1.94 from Saccharopolyspora erythraea (Streptomyces erythraeus) (see 2 papers)
33% identity, 40% coverage: 604:1482/2214 of query aligns to 37:902/3172 of Q03133
Sites not aligning to the query:
2qo3B Crystal structure of [ks3][at3] didomain from module 3 of 6- deoxyerthronolide b synthase (see paper)
32% identity, 39% coverage: 608:1479/2214 of query aligns to 5:872/873 of 2qo3B
Q9ZGI2 Narbonolide/10-deoxymethynolide synthase PikA4, module 6; Narbonolide/10-deoxymethynolide synthase PikAIV; Pikromycin polyketide synthase component PikAIV; Pikromycin PKS component PikAIV; Type I modular polyketide synthase PikAIV; PKS; EC 2.3.1.239; EC 2.3.1.240 from Streptomyces venezuelae (see 4 papers)
32% identity, 40% coverage: 605:1486/2214 of query aligns to 34:914/1346 of Q9ZGI2
Sites not aligning to the query:
Q9ZGI3 Narbonolide/10-deoxymethynolide synthase PikA3, module 5; Narbonolide/10-deoxymethynolide synthase PikAIII; Pikromycin polyketide synthase component PikAIII; Pikromycin PKS component PikAIII; Type I modular polyketide synthase PikAIII; PKS; EC 2.3.1.239; EC 2.3.1.240 from Streptomyces venezuelae (see paper)
32% identity, 39% coverage: 608:1479/2214 of query aligns to 37:904/1562 of Q9ZGI3
Sites not aligning to the query:
6kfuA A acp-amt fusion protein of hybrid polyketide/non-ribosomal peptide synthetase
43% identity, 20% coverage: 1703:2154/2214 of query aligns to 73:526/527 of 6kfuA
6kfrA Amino-transferase (amt) domain - arg complex of hybrid polyketide/non- ribosomal peptide synthetase
44% identity, 20% coverage: 1713:2154/2214 of query aligns to 4:448/449 of 6kfrA
B3FWS8 Non-reducing polyketide synthase hmp3; NR-PKS hmp3; Hypothemycin biosynthesis cluster protein hpm3; EC 2.3.1.- from Hypomyces subiculosus (Nectria subiculosa) (see paper)
29% identity, 39% coverage: 608:1479/2214 of query aligns to 368:1237/2049 of B3FWS8
Sites not aligning to the query:
>Echvi_2301 FitnessBrowser__Cola:Echvi_2301
MTIVDLFKEQAIIASSKPAISYGGDQISYQRLEDNSNQLAHLMIEKGVSPQDTVGLCVHR
STEMMVAILAILKCGAAYVPIAPEFPEERKKFICEAAEVKLMITDQGDLLETLAGIPLLD
IRENISSAYPILSPSVNFSTDNTAYILFTSGSTGEPKGVCMPHKALVNLLLWQKKQFNKH
VGVNTLQFSKFTFDVSFQEIFSTLTTGGILHLLDEETVKDPFALLQLMEEKQINRLFLPF
VSLQSLAHTAVAHQLYPKTLEAVITAGEQLKITEQITAFFSQLDRATLYNQYGPTEAHVV
SQLTLNPENTSSWPALPSIGYAIDNTELYVLDQNEQPVPQGSEGELYITGDCLASGYLKQ
PALTQEKFKFLDSIKGKPSLRAYKTGDIAKISAAGEVIFLGRRDDQVKIRGHRIELGEVE
AVLGKYPAIYQVAVQAKMYEDGQKYLVAYYIPAPNQQPTQKQLIEHLAQSLPEYMIPAIF
FQMEAFPKTSSGKIDRKSLPDPINKREKIEAPIVPAKTTLEKKLAKYFQQVLHFDRIGIS
DNFFEFGGNSLLAQKLSNDIRLALGLTVPVTSIYQHPTIQALTAHLSQDGSTAPGTNVAT
RTPAQKAVAIVGMTGRFPGADDIDTFWKNLVEGKETVTTFEEAALDPWIAEAVKKDENYV
KARGILKDADKFDPNFFGITPHQAALMDPQQRLFLELAWELLEKTSPLHPTPSYKTGVFA
GTNNNTYYQKNLLSNPDLIEQNGALQVMTLNEKDYIATRTAYQFDLKGPAISVYSACSTS
LLAIAQAVQSIRTGQCQMAIAGGSTITSPINSGHLYQEGAIFSKDSHCKPFDASASGTLF
SDGAAAIMLKDLDMAIQDGDRIYATIKGIGINNDGNAKGSFSAPSIQGQADVIKAALEDG
ELHPSSISYVEAHGTATPLGDPIEIEGLKLAFGKHEKHRFCGIGSVKSNFGHLTAAAGVT
GLIKTVLSIYHQKIPATVGFRELNPQIDLKDTPFYINGATTAWQAEFPRRAGVSSFGIGG
TNVHVILEEYPQVQETSDAPTSPYHLLCFSAKTANSLELYKDKLLQLVRSNPTMNLADLC
YSINLKPHQFIHRAYLTFKDSADLLSQLVRKNNTTTRQKTVKQLPQNTVFVFPGQGAQYL
NMGKDLFESAPAFREALTQCANLFDKLLDRPLLDIICPAAETAEAEALLKNTRYTQPAIF
AIEYALAKLWMAWGISPSAMVGHSIGEFVAAHLAGVFSLEDVTRLVAKRGQLVAALPGGD
MLSVRAPHSKIEHLIEGDISLAAINSPNLCVLAGPSEAIAHISSLLDQENILHKKLFTSH
AFHSSMMDPVLDDFGKEVAKTNMSAPSIPIVSTVTTKPLTDQEATSVPYWTAHLRKAVCF
SPAMEHLLEEDPNTIFVEIGPGNVLSTLIKQHQQARNAVTVHSTNRQSDKNHYQELLGNL
GEITLSGGKPDWHRFYAGQKRIRLEEVPTYAFDRKRCWIDPPVKAPISQQPAQNTPIING
KKTTTPMRTEVLRKKAVDVLERLSGLDIDHQPGDSSFLELGLDSLLLTQLSFALKKEFGV
PLSFRQLNSQVNTVNALVNFLDEALPADQFQPAAEPSPIPSPTTPLAENENRQAVPSHTT
YPSANHHSAIGLIGQQLELLSKQLALLQGSAVPAAAVSQQEPNTHLNGHAPAAPPSPAKK
PAVTLSKEDAENLKKPFGATARIDKNGQSLPEKQQNFIEAFTKKYTSKTASSKAYTQQNR
SHMADPRVVSGFNPSIKETVYSLVVNRSKGSRIWDIDGNEYLDILNGFGSILFGHKPDFI
DEALKEQIEKGYEIGPQHELSGAVCKLICDITGHDRAALCNTGSEAVMGALRIARTITQR
SLVVAFNGSYHGIFDEVIVRGTKSLKSFPAAAGIMAESVENILILDYGTAETLRIIEERK
DEIAAVLVEPVQSRRPEFQPVDFLKKVREITAAVGSALIFDEVITGFRMHPQGAQGIFGI
KADLATYGKVVGGGLPIGVIAGKAEFMDALDGGHWQYGDASVPEIDVTYFAGTFVRHPLA
LATAKASLEYIQQDDGQLQQNLAAKVQRLADGLNGFFEEHNIPAYVANFGSLWKIKFKQE
LPYTELLFATFREQGLHIYDGFPCFATGAYQDEDTDLILTVIKSGFQQLASATFWDALVP
GLSEGFQASPDVLSKDQPPVPGAKLGKTPEGKAAWFVPDPERPGKYLELAFKTA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory