SitesBLAST
Comparing Echvi_2507 FitnessBrowser__Cola:Echvi_2507 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1kgzB Crystal structure analysis of the anthranilate phosphoribosyltransferase from erwinia carotovora (current name, pectobacterium carotovorum) (see paper)
35% identity, 96% coverage: 2:326/338 of query aligns to 3:327/330 of 1kgzB
- binding manganese (ii) ion: S92 (= S91), D222 (= D223), E223 (= E224), E223 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V79 (≠ C78), G82 (= G81), G83 (= G82), N90 (= N89), I91 (= I90), S92 (= S91), T93 (= T92), K108 (= K107), S118 (= S119)
4n5vA Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 8:342/347 of 4n5vA
- active site: V84 (≠ C78)
- binding 2-amino-4-fluorobenzoic acid: V84 (≠ C78), G85 (= G79), H114 (= H108), G115 (= G109), N116 (= N110), A157 (= A151), A157 (= A151), P158 (= P152), H161 (= H155), Y164 (≠ M158), R165 (≠ K159), A168 (≠ G162), R171 (= R165), G184 (= G178)
- binding magnesium ion: S97 (= S91), D229 (= D223), E230 (= E224), E230 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G85 (= G79), G87 (= G81), G88 (= G82), N95 (= N89), S97 (= S91), T98 (= T92), K113 (= K107), A119 (≠ V113), S120 (= S114), S121 (= S115), G124 (= G118)
3r88B Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs145) (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:339/344 of 3r88B
- active site: V82 (≠ C78)
- binding 2-amino-4,5-dimethoxybenzoic acid: N114 (= N110), A155 (= A151), P156 (= P152), H159 (= H155), Y162 (≠ M158), R163 (≠ K159), A166 (≠ G162)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (≠ C78), G83 (= G79), G85 (= G81), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), N114 (= N110), A117 (≠ V113), S118 (= S114), S119 (= S115)
5c1rA Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:339/343 of 5c1rA
- active site: V82 (≠ C78)
- binding 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose: V82 (≠ C78), G83 (= G79), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), R115 (≠ N111), A117 (≠ V113), S118 (= S114), S119 (= S115)
- binding magnesium ion: D87 (= D83), V89 (≠ K85), S95 (= S91), E228 (= E224)
4n93A Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 7:341/346 of 4n93A
- active site: V83 (≠ C78)
- binding 2-amino-6-methylbenzoic acid: V83 (≠ C78), G84 (= G79), T85 (= T80), H113 (= H108), N115 (= N110), N115 (= N110), A156 (= A151), P157 (= P152), H160 (= H155), Y163 (≠ M158), A167 (≠ G162), R170 (= R165), G183 (= G178), P184 (= P179)
- binding magnesium ion: S96 (= S91), D228 (= D223), E229 (= E224), E229 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G79), G86 (= G81), G87 (= G82), N94 (= N89), S96 (= S91), T97 (= T92), K112 (= K107), A117 (≠ G112), A118 (≠ V113), S120 (= S115), G123 (= G118)
P9WFX5 Anthranilate phosphoribosyltransferase; EC 2.4.2.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
32% identity, 96% coverage: 4:328/338 of query aligns to 30:365/370 of P9WFX5
- G107 (= G79) binding
- T115 (= T87) binding
- G147 (≠ S119) binding
4owoA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 6-fluoroanthranilate, prpp and magnesium (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 8:343/348 of 4owoA
- active site: V84 (≠ C78)
- binding 2-azanyl-6-fluoranyl-benzoic acid: V84 (≠ C78), G85 (= G79), T86 (= T80), H114 (= H108), N116 (= N110), N116 (= N110), A157 (= A151), P158 (= P152), H161 (= H155), Y164 (≠ M158), A168 (≠ G162), R171 (= R165), G184 (= G178)
- binding magnesium ion: S97 (= S91), D229 (= D223), E230 (= E224), E230 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V84 (≠ C78), G85 (= G79), G87 (= G81), G88 (= G82), N95 (= N89), S97 (= S91), T98 (= T92), K113 (= K107), A118 (≠ G112), A119 (≠ V113), S120 (= S114), S121 (= S115), G124 (= G118)
4owuA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 5-methylanthranilate, prpp and magnesium (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 7:342/347 of 4owuA
- active site: V83 (≠ C78)
- binding 2-azanyl-5-methyl-benzoic acid: N115 (= N110), P157 (= P152), Y163 (≠ M158), R164 (≠ K159), A167 (≠ G162)
- binding magnesium ion: S96 (= S91), D228 (= D223), E229 (= E224), E229 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G79), G86 (= G81), G87 (= G82), N94 (= N89), S96 (= S91), T97 (= T92), K112 (= K107), A118 (≠ V113), S120 (= S115), G123 (= G118)
4owqA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-methylanthranilate, prpp and magnesium (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 7:342/347 of 4owqA
- active site: V83 (≠ C78)
- binding 2-azanyl-3-methyl-benzoic acid: P157 (= P152), H160 (= H155), Y163 (≠ M158), A167 (≠ G162), R171 (≠ K166)
- binding magnesium ion: S96 (= S91), D228 (= D223), E229 (= E224), E229 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V83 (≠ C78), G84 (= G79), G86 (= G81), G87 (= G82), N94 (= N89), S96 (= S91), T97 (= T92), K112 (= K107), A117 (≠ G112), A118 (≠ V113), S120 (= S115), G123 (= G118)
5c2lA Magnesium soaked into the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
32% identity, 96% coverage: 4:328/338 of query aligns to 8:343/349 of 5c2lA
4giuA Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd). (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 7:342/346 of 4giuA
- active site: V83 (≠ C78)
- binding 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid: G114 (= G109), N115 (= N110), A156 (= A151), H160 (= H155), Y163 (≠ M158), R170 (= R165), G183 (= G178)
- binding magnesium ion: S96 (= S91), D228 (= D223), E229 (= E224), E229 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G84 (= G79), G86 (= G81), G87 (= G82), N94 (= N89), S96 (= S91), T97 (= T92), K112 (= K107), N115 (= N110), A117 (≠ G112), A118 (≠ V113), S119 (= S114), S120 (= S115), G123 (= G118)
4owmA Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-fluoroanthranilate, prpp and magnesium (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 4owmA
- active site: V82 (≠ C78)
- binding 2-azanyl-3-fluoranyl-benzoic acid: P156 (= P152), H159 (= H155), Y162 (≠ M158), R163 (≠ K159), A166 (≠ G162), R170 (≠ K166)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G79), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118)
4gkmA Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd) (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 4gkmA
- active site: V82 (≠ C78)
- binding 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid: N114 (= N110), A155 (= A151), P156 (= P152), Y162 (≠ M158), R163 (≠ K159), A166 (≠ G162), R169 (= R165), R170 (≠ K166)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118)
3r6cA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs179) (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 3r6cA
- active site: V82 (≠ C78)
- binding 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid: M62 (= M60), N114 (= N110), A155 (= A151), P156 (= P152), H159 (= H155), Y162 (≠ M158), A166 (≠ G162), R169 (= R165), G182 (= G178), T185 (≠ V181), R239 (≠ K232), A241 (≠ I234), D246 (≠ E239), V301 (= V295), A310 (= A297), W312 (≠ Q299)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G79), G85 (= G81), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), N114 (= N110), R115 (≠ N111), A116 (≠ G112), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118), G123 (≠ S119)
3qsaA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor tamu-a7)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 3qsaA
- active site: V82 (≠ C78)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G79), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118)
- binding 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione: M62 (= M60), N114 (= N110), A155 (= A151), P156 (= P152), H159 (= H155), Y162 (≠ M158), R163 (≠ K159), A166 (≠ G162), G182 (= G178)
3qs8A Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174) (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 3qs8A
- active site: V82 (≠ C78)
- binding 2-benzylbenzoic acid: M62 (= M60), G83 (= G79), N114 (= N110), N114 (= N110), A155 (= A151), A155 (= A151), P156 (= P152), Y162 (≠ M158), Y162 (≠ M158), A166 (≠ G162), R169 (= R165), R169 (= R165), R170 (≠ K166), L181 (= L177), G182 (= G178)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G79), G85 (= G81), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), N114 (= N110), A116 (≠ G112), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118), E228 (= E224)
3qqsA Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs172) (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 3qqsA
- active site: V82 (≠ C78)
- binding 2,2'-iminodibenzoic acid: P156 (= P152), H159 (= H155), Y162 (≠ M158), R163 (≠ K159), A166 (≠ G162), R169 (= R165), R170 (≠ K166)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V82 (≠ C78), G85 (= G81), G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), R115 (≠ N111), A117 (≠ V113), S118 (= S114), S119 (= S115), G122 (= G118)
1zvwA The crystal structure of trpd (rv2192c) from mycobacterium tuberculosis in complex with prpp and magnesium (see paper)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:341/346 of 1zvwA
- active site: V82 (≠ C78)
- binding benzamidine: T46 (≠ M44), M47 (= M45), K48 (≠ R46), P50 (≠ I48), D201 (≠ E197)
- binding magnesium ion: S95 (= S91), D227 (= D223), E228 (= E224), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G83 (= G79), N93 (= N89), S95 (= S91), T96 (= T92), A117 (≠ V113), S118 (= S114), S119 (= S115)
5c7sA Prpp complexed with two mn2+ in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
32% identity, 96% coverage: 4:328/338 of query aligns to 7:340/344 of 5c7sA
- active site: V83 (≠ C78)
- binding manganese (ii) ion: G84 (= G79), S96 (= S91), D228 (= D223), E229 (= E224), E229 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: V83 (≠ C78), G84 (= G79), G86 (= G81), G87 (= G82), N94 (= N89), S96 (= S91), T97 (= T92), K112 (= K107), N115 (= N110), S120 (= S115)
4zokA Methylsulfonyl-containing inhibitor bound in the substrate capture site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
32% identity, 96% coverage: 4:328/338 of query aligns to 6:338/342 of 4zokA
- active site: V82 (≠ C78)
- binding 4-methyl-2-{[2-methyl-6-(methylsulfonyl)phenyl]amino}benzoic acid: P156 (= P152), R163 (≠ K159), A166 (≠ G162), A167 (≠ P163)
- binding magnesium ion: S95 (= S91), E228 (= E224)
- binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: G86 (= G82), N93 (= N89), S95 (= S91), T96 (= T92), K111 (= K107), A116 (≠ G112), A117 (≠ V113), S119 (= S115), G122 (= G118)
Query Sequence
>Echvi_2507 FitnessBrowser__Cola:Echvi_2507
MKDILNHLIEHRTLGKEEAKSTLKKITSGAYNQSQMAAFMTVYMMRSITVEELEGFREAM
LEQCIPVEIPEYDAMDLCGTGGDGKDTFNISTLSSFVVAGAGQNVAKHGNNGVSSICGSS
NLLAQFGYNFTNDINVIRKNLDEAGICFLHAPLFHPAMKNVGPIRKELGVKTFFNMLGPM
VNPSFPKKQLVGVFSLELARLYGYLYQNSRVDFSILHSLDGYDEVSLTGDFKMISNSGER
LISPESIGLPRLDAKSIEGGKTIEASAKIFQDILKGEGTEAQRAVVLANSAAALVTADQS
LSFEEGIVKAAESLDSGKALQTFKKLVNSKTSVSLAKS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory