Comparing Echvi_2515 Echvi_2515 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
34% identity, 97% coverage: 3:233/239 of query aligns to 2:237/246 of 5abtA
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
34% identity, 97% coverage: 3:233/239 of query aligns to 2:234/241 of 5ab3A
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
36% identity, 97% coverage: 1:233/239 of query aligns to 4:234/240 of 5dn1A
P16250 Phosphoribosyl isomerase A; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16; EC 5.3.1.24 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
36% identity, 97% coverage: 1:233/239 of query aligns to 4:234/240 of P16250
4tx9A Crystal structure of hisap from streptomyces sviceus with degraded profar (see paper)
37% identity, 97% coverage: 1:233/239 of query aligns to 9:239/246 of 4tx9A
3zs4A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound prfar
32% identity, 97% coverage: 3:233/239 of query aligns to 5:237/244 of 3zs4A
2y88A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase (variant d11n) with bound prfar (see paper)
31% identity, 97% coverage: 3:233/239 of query aligns to 5:237/244 of 2y88A
2y85A Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound rcdrp (see paper)
30% identity, 97% coverage: 3:233/239 of query aligns to 5:228/234 of 2y85A
Q9X0C7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; EC 5.3.1.16 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
27% identity, 100% coverage: 1:238/239 of query aligns to 1:240/241 of Q9X0C7
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
30% identity, 85% coverage: 1:204/239 of query aligns to 5:210/253 of 1h5yB
Sites not aligning to the query:
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
23% identity, 85% coverage: 3:204/239 of query aligns to 6:207/253 of Q9X0C6
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
23% identity, 85% coverage: 3:204/239 of query aligns to 6:207/252 of 7ac8A
Sites not aligning to the query:
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
21% identity, 98% coverage: 3:237/239 of query aligns to 6:247/258 of P60664
Sites not aligning to the query:
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
23% identity, 85% coverage: 3:204/239 of query aligns to 6:207/253 of 1gpwC
Sites not aligning to the query:
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
23% identity, 83% coverage: 3:200/239 of query aligns to 6:194/244 of 3zr4E
Sites not aligning to the query:
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
25% identity, 71% coverage: 31:200/239 of query aligns to 20:189/237 of 2wjzE
Sites not aligning to the query:
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
23% identity, 85% coverage: 3:204/239 of query aligns to 6:207/250 of 7qc8A
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
23% identity, 83% coverage: 3:200/239 of query aligns to 5:196/243 of 4ewnD
Sites not aligning to the query:
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
21% identity, 79% coverage: 16:204/239 of query aligns to 14:205/251 of 5d2tA
Sites not aligning to the query:
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
21% identity, 79% coverage: 16:204/239 of query aligns to 15:206/250 of 6dnjA
>Echvi_2515 Echvi_2515 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
MEIIPAIDIIGGKCVRLTQGDYGQKKEYADNPLEVAKKFEGAGIKRLHLVDLDGAKAKTI
VNRAVLENITSHTSLKVDFGGGVQSDETIQMAFDAGASQVTGGSIAVKNPALFEGWLEKH
GSEKIILGADAKNRKIAISGWEETTEADVVDFIKDYHAKGARYVICTDVAKDGLLQGPSV
DLYREIIQEIPGIRLIASGGVAEVRDLEVLEKIGVFGTIVGKAFYEGRVSLEELATFAD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory