Comparing Echvi_2861 FitnessBrowser__Cola:Echvi_2861 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2w90B Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase with bound 6- phosphogluconate (see paper)
51% identity, 100% coverage: 1:464/465 of query aligns to 3:469/471 of 2w90B
P96789 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
52% identity, 100% coverage: 1:464/465 of query aligns to 1:468/472 of P96789
2iyoA Structural characterization of a bacterial 6pdh reveals aspects of specificity, mechanism and mode of inhibition (see paper)
52% identity, 100% coverage: 1:464/465 of query aligns to 1:468/470 of 2iyoA
2iz1B 6pdh complexed with pex inhibitor synchrotron data (see paper)
52% identity, 100% coverage: 1:464/465 of query aligns to 3:470/471 of 2iz1B
2iypA Product rup (see paper)
52% identity, 100% coverage: 1:464/465 of query aligns to 1:468/469 of 2iypA
2iypB Product rup (see paper)
52% identity, 100% coverage: 1:464/465 of query aligns to 2:469/470 of 2iypB
P00350 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Escherichia coli (strain K12) (see paper)
49% identity, 100% coverage: 1:464/465 of query aligns to 1:466/468 of P00350
3fwnB Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
50% identity, 99% coverage: 6:464/465 of query aligns to 5:465/467 of 3fwnB
3fwnA Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
50% identity, 99% coverage: 6:464/465 of query aligns to 5:465/467 of 3fwnA
2zydA Dimeric 6-phosphogluconate dehydrogenase complexed with glucose (see paper)
50% identity, 99% coverage: 6:464/465 of query aligns to 4:464/464 of 2zydA
2p4qA Crystal structure analysis of gnd1 in saccharomyces cerevisiae (see paper)
51% identity, 96% coverage: 5:451/465 of query aligns to 4:454/476 of 2p4qA
7cb5B The 6-phosphogluconate dehydrogenase from staphylococcus aureus (6- phosphogluconate bound) (see paper)
48% identity, 99% coverage: 6:464/465 of query aligns to 5:465/467 of 7cb5B
7cb2A The 6-phosphogluconate dehydrogenase (NADP-bound) from staphylococcus aureus
48% identity, 99% coverage: 6:464/465 of query aligns to 5:465/466 of 7cb2A
P78812 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
50% identity, 96% coverage: 5:451/465 of query aligns to 8:457/492 of P78812
6fqzA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
44% identity, 99% coverage: 5:464/465 of query aligns to 3:468/468 of 6fqzA
6fqyA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
44% identity, 99% coverage: 5:464/465 of query aligns to 3:468/468 of 6fqyA
1pgqA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism (see paper)
47% identity, 99% coverage: 3:464/465 of query aligns to 2:468/473 of 1pgqA
1pgpA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism (see paper)
47% identity, 99% coverage: 3:464/465 of query aligns to 2:468/473 of 1pgpA
1pgoA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism (see paper)
47% identity, 99% coverage: 3:464/465 of query aligns to 2:468/473 of 1pgoA
1pgnA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism (see paper)
47% identity, 99% coverage: 3:464/465 of query aligns to 2:468/473 of 1pgnA
>Echvi_2861 FitnessBrowser__Cola:Echvi_2861
MKQFDFGIVGLGVMGKNLLLNMADHGFSVAGLDLDQAKAAALEEGAREGQDVKGFITAEK
FVSSLKRPRAIMLLVPAGKPVDAAIGSLLPLLEKDDIVVDGGNSYFPDTERRFAELAKKN
IHFFGMGISGGEKGARFGPSMMPGGDAQAYERLRPIFEAIAAKVDGEPCVTYLGKGSAGN
YVKMVHNGIEYGIMQLIAETYDIMKKGLGYSDDKIQSIFASWNDTELQSFLVEITGLILQ
KKDDDTGKQLLPLISDQARSKGTGKWTSQNAMDLQAPVPVIDMAVLMRDISKFKEERVAA
SKALKWAGEENVDATADMLKNALYFGMITTYAQGMVQLRLASEEYGYGLNLEEVAKIWRG
GCIIRAACLEDFRKAYKKAPDLANLMLDKEIGEDLVARQKDVREVVKVAVEKGIPAPALM
AALSYFDAYRSDRLSTNVIQAQRDFFGAHQFERIDKEGVFHAQWE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory