Comparing Echvi_2954 FitnessBrowser__Cola:Echvi_2954 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
Q62674 Sodium/nucleoside cotransporter 1; Concentrative nucleoside transporter 1; CNT 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 from Rattus norvegicus (Rat) (see paper)
40% identity, 98% coverage: 9:427/428 of query aligns to 184:591/648 of Q62674
Sites not aligning to the query:
4pd7A Structure of vccnt bound to zebularine (see paper)
41% identity, 98% coverage: 7:424/428 of query aligns to 6:401/404 of 4pd7A
3tijA Crystal structure of a concentrative nucleoside transporter from vibrio cholerae (see paper)
41% identity, 98% coverage: 7:424/428 of query aligns to 6:401/404 of 3tijA
4pd5A Crystal structure of vccnt-7c8c bound to gemcitabine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 7:400/403 of 4pd5A
4pdaA Structure of vccnt-7c8c bound to cytidine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pdaA
4pd9A Structure of vccnt-7c8c bound to adenosine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pd9A
4pd8A Structure of vccnt-7c8c bound to pyrrolo-cytidine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pd8A
4pb2A Structure of vccnt-7c8c bound to 5-fluorouridine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pb2A
4pb1A Structure of vccnt-7c8c bound to ribavirin (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pb1A
O00337 Sodium/nucleoside cotransporter 1; Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 from Homo sapiens (Human) (see 7 papers)
40% identity, 96% coverage: 16:427/428 of query aligns to 189:591/649 of O00337
Sites not aligning to the query:
Q9HAS3 Solute carrier family 28 member 3; Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3 from Homo sapiens (Human) (see 5 papers)
43% identity, 85% coverage: 66:428/428 of query aligns to 263:614/691 of Q9HAS3
Sites not aligning to the query:
5l26A Structure of cntnw in an inward-facing substrate-bound state (see paper)
39% identity, 99% coverage: 1:425/428 of query aligns to 3:411/419 of 5l26A
5l2aA Structure of cntnw n149s,f366a in an outward-facing state (see paper)
38% identity, 99% coverage: 1:425/428 of query aligns to 4:417/422 of 5l2aA
>Echvi_2954 FitnessBrowser__Cola:Echvi_2954
MDYLRGMIGIVALLGVAFLFSASRKSVDWKLVGIGVILQIVFGFLITKVAFVESVFASIS
GAFVKLLSFAQAGAIFLFGDLATDSFGTIFAFQVLPTIIFFSTVSAGLYYLGVLQKIVFG
IAWVMARTMKLSGAESLSAAGNIFLGQTEAPLLVRPFIPTMTRSELMCLMTGGMATIAGG
VLAAYVAFLGGDDPAEQSKFASYLLGASIMNAPAAIVMSKLIIPETNKEGLNDKLEVSSE
GMGVNLIDAMSIGAADGLKLALNVGGMLLAFIAVIAMLNYLLSGVLGDVTGLNQFVVDTT
NGRFDGFSLEYILGQVFRIFAWLMGVEWQDTLQVGSLLGQKTVINEFVAYSDLSSMKAEG
DLSPKSIIIATYALCGFSNFSSIAIQVGGIGSIAPGQQGNLSKLGMHALLAATLACMMTA
TIAGMLFS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory