SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Echvi_2954 FitnessBrowser__Cola:Echvi_2954 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 13 hits to proteins with known functional sites (download)

Q62674 Sodium/nucleoside cotransporter 1; Concentrative nucleoside transporter 1; CNT 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 from Rattus norvegicus (Rat) (see paper)
40% identity, 98% coverage: 9:427/428 of query aligns to 184:591/648 of Q62674

query
sites
Q62674

G

G

I

I

V

C

A

V

L

F

L

L

G

V

V

L

A

L

F

F

L

A

F

G

S

S

A

K

S

H

R

H

K

R

S

A

V

V

D

S

W

W

K

R

L

A

V

V

G

S

I

W

G

G

V

L

I

G

L

L

Q

Q

I

F

V

V

F

L

G

G

F

L

L

F

I

V

T

I

K

R

V

T

A

E

F

P

V

G

E

F

S

I

V

A

F

F

A

Q

S

W

I

L

S

G

G

D

A

Q

F

I

V

Q

K

V

L

F

L

L

S

S

F

Y

A

T

Q

E

A

A

G

G

A

S

I

S

F

F

L

V

F

F

G

G

D

E

-

A

L

L

A

V

T

K

D

D

S

-

F

-

G

-

T

-

I

V

F

F

A

A

F

F

Q

Q

V

V

L

L

P

P

T

I

I

I

F

F

S

S

T

C

V

V

S

M

A

S

G

V

L

L

Y

Y

L

L

G

G

V

L

L

M

Q

Q

K

W

I

V

V

I

F

L

G

K

I

I

A

A

W

W

V

L

M

M

A

Q

R

V

T

T

M

M

K

G

L

T

S

S

G

A

A

T

E

E

S

T

L

L

S

S

A

V

A

A

G

G

N

N

I

I

F

F

L

V

G

S

Q

Q

T

T

E

E

A

A

P

P

L

L

V

I

R

R

P

P

F

Y

I

L

P

A

T

D

M

M

T

T

R

L

S

S

E

E

L

V

M

H

C

V

L

V

M

M

T

T

G

G

M

Y

A

A

T

T

I

I

A

A

G

G

G

S

V

L

L

L

A

G

A

A

Y

Y

V

I

A

S

F

F

L

-

G

-

G

G

D

I

D

D

P

A

A

A

E

S

Q

-

S

-

K

-

F

-

A

-

S

-

Y

-

L

L

L

I

G

A

A

A

S

S

I

V

M

M

N

A

A

A

P

P

A

C

A

A

I

L

V

A

M

L

S

S

K

K

L

L

I

V

I

Y

P

P

E

E

T

V

N

E

K

E

E

S

G

K

L

F

N

R

D

S

K

E

L

N

E

G

V

V

S

K

-

L

S

T

E

Y

G

G

M

D

G

A

V

Q

N

N

L

L

I

L

D

E

A

A

M

A

S

S

I

A

G

G

A

A

D

I

G

S

L

V

K

K

L

V

A

V

L

A

N

N

V

I

G

A

M

N

L

L

L

I

A

A

F

F

I

L

A

A

V

V

I

L

A

A

M

F

L

V

N

N

Y

A

L

A

L

L

S

S

G

W

V

-

L

L

G

G

D

D

V

M

T

V

G

D

L

I

N

Q

Q

-

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

G

F

L

S

S

L

F

E

Q

Y

L

I

I

L

C

G

S

Q

Y

V

V

F

L

R

R

I

P

F

V

A

A

W

F

L

L

M

M

G

G

V

V

E

A

W

W

Q

E

D

D

T

C

L

P

Q

V

V

V

G

A

S

E

L

L

G

G

Q

I

K

K

T

F

V

F

I

L

N

N

E

E

F

F

V

V

A

A

Y

Y

S

Q

D

E

L

L

S

S

S

Q

M

Y

K

K

A

Q

E

R

-

R

-

L

-

A

-

G

-

A

-

E

-

W

-

L

G

G

D

D

-

K

-

Q

-

W

L

I

S

S

P

V

K

R

S

A

I

E

I

I

I

L

A

T

T

T

Y

Y

A

A

L

L

C

C

G

G

F

F

S

A

N

N

F

F

S

S

I

I

A

G

I

I

Q

M

V

L

G

G

I

L

G

T

S

S

I

L

A

V

P

P

G

Q

Q

R

G

S

N

D

L

F

S

S

K

Q

L

I

G

V

M

L

H

R

A

A

L

L

L

I

A

T

A

G

T

A

L

F

A

V

C

S

M

L

T

N

A

A

T

C

I

V

A

A

G

G

M

I

L

L

F

Y

Sites not aligning to the query:

605 modified: carbohydrate, N-linked (GlcNAc...) asparagine
643 modified: carbohydrate, N-linked (GlcNAc...) asparagine

4pd7A Structure of vccnt bound to zebularine (see paper)
41% identity, 98% coverage: 7:424/428 of query aligns to 6:401/404 of 4pd7A

query
sites
4pd7A

M

L

I

I

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L
|
L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V

V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M

V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding decyl-beta-d-maltopyranoside: L283 (= L309), L357 (≠ F380), I360 (= I383), A379 (≠ S402)
binding Zebularine: Q153 (= Q147), V187 (= V181), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382), I362 (= I385)

3tijA Crystal structure of a concentrative nucleoside transporter from vibrio cholerae (see paper)
41% identity, 98% coverage: 7:424/428 of query aligns to 6:401/404 of 3tijA

query
sites
3tijA

M

L

I

I

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I
x
L

A

G

W

G

V

G

M
x
L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N
|
N

I

I

F
|
F

L
x
V

G
|
G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T
x
S

I
|
I

A

A

G

G

V

V

L
|
L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F
|
F

I

I

A

G

V
x
L

I

I

A

A

M

L

L
x
I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L

L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V

V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N

N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding decyl-beta-d-maltopyranoside: L127 (≠ I121), L131 (≠ M125), F150 (= F144), L188 (= L182), F258 (= F271), L261 (≠ V274), I265 (≠ L278), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)
binding sodium ion: N148 (= N142), V151 (≠ L145), G152 (= G146), S182 (≠ T176), I183 (= I177)
binding uridine: Q153 (= Q147), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), S359 (= S382), I362 (= I385)

4pd5A Crystal structure of vccnt-7c8c bound to gemcitabine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 7:400/403 of 4pd5A

query
sites
4pd5A

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L

L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding decyl-beta-d-maltopyranoside: V316 (= V343), L356 (≠ F380), I359 (= I383), A378 (≠ S402), V382 (≠ M406)
binding gemcitabine: Q152 (= Q147), V186 (= V181), L246 (= L260), N318 (= N345), E319 (= E346), F320 (= F347), F353 (= F377), N355 (= N379), S358 (= S382), I361 (= I385)

4pdaA Structure of vccnt-7c8c bound to cytidine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pdaA

query
sites
4pdaA

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V

V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L

L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding 4-amino-1-beta-d-ribofuranosyl-2(1h)-pyrimidinone: Q153 (= Q147), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382), I362 (= I385)
binding decyl-beta-d-maltopyranoside: V317 (= V343), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)

4pd9A Structure of vccnt-7c8c bound to adenosine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pd9A

query
sites
4pd9A

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G
|
G

Q
|
Q

T
|
T

E
|
E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L
|
L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding adenosine: G152 (= G146), Q153 (= Q147), T154 (= T148), E155 (= E149), V187 (= V181), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382), I362 (= I385)
binding decyl-beta-d-maltopyranoside: L283 (= L309), V317 (= V343), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)

4pd8A Structure of vccnt-7c8c bound to pyrrolo-cytidine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pd8A

query
sites
4pd8A

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A
|
A

G

G

G
|
G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L

L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding decyl-beta-d-maltopyranoside: V317 (= V343), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)
binding 6-methyl-3-(beta-D-ribofuranosyl)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidin-2-one: Q153 (= Q147), A184 (= A178), G186 (= G180), V187 (= V181), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382), I362 (= I385)

4pb2A Structure of vccnt-7c8c bound to 5-fluorouridine (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pb2A

query
sites
4pb2A

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G

G

Q
|
Q

T

T

E

E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L
x
I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L

L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I

I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding 5-fluorouridine: Q153 (= Q147), V187 (= V181), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382)
binding decyl-beta-d-maltopyranoside: I265 (≠ L278), V317 (= V343), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)

4pb1A Structure of vccnt-7c8c bound to ribavirin (see paper)
41% identity, 97% coverage: 9:424/428 of query aligns to 8:401/404 of 4pb1A

query
sites
4pb1A

G

G

I

M

V

A

A

V

L

L

G

G

V

I

A

A

F

V

L

L

F

L

S

S

A

S

S

N

R

R

K

K

S

A

V

I

D

N

W

L

K

R

L

T

V

V

G

G

I

G

G

A

V

F

I

A

L

I

Q

Q

I

F

V

S

F

L

G

G

F

A

L

F

I

I

T

L

K

Y

V

V

A

P

F

W

V

G

E

Q

S

E

V

L

F

L

A

R

S

G

I

F

S

S

G

D

A

A

F

V

V

S

K

N

L

V

L

I

S

N

F

Y

A

G

Q

N

A

D

G

G

A

T

I

S

F

F

L

L

F

F

G

G

D

G

L

L

A

V

T

S

D

G

S

K

F

M

G

F

T

E

I

V

F

F

A

G

F

G

-

G

-

F

-

I

-

F

-

A

-

F

Q

R

V

V

L

L

P

P

T

T

I

L

I

I

F

F

S

S

T

A

V

L

S

I

A

S

G

V

L

L

Y

Y

L

L

G

G

V

V

L

M

Q

Q

K

W

I

V

V

I

F

R

G

I

I

L

A

G

W

G

V

G

M

L

A

Q

R

K

T

A

M

L

K

G

L

T

S

S

G

R

A

A

E

E

S

S

L

M

S

S

A

A

G

A

N

N

I

I

F

F

L

V

G
|
G

Q
|
Q

T

T

E
|
E

A

A

P

P

L

L

L

V

V

V

R

R

P

P

F

F

I

V

P

P

T

K

M

M

T

T

R

Q

S

S

E

E

L

L

M

F

C

A

L

V

M

M

T

C

G

G

M

L

A

A

T

S

I

I

A

A

G

G

V
|
V

L

L

A

A

A

G

Y

Y

V

-

A

-

F

-

L

-

G

-

D

-

P

-

A

A

E

S

Q

M

S

G

K

V

F

K

A

I

S

E

Y

Y

L

L

L

V

G

A

A

A

S

S

I

F

M

M

N

A

A

A

P

P

A

G

I

L

V

L

M

F

S

A

K

K

L

L

I

M

P

P

E

E

T

T

N

E

K

K

E

P

G

-

L

-

N

Q

D

D

K

K

L

-

E

-

V

-

S

-

E

-

G

-

M

-

G

P

V

A

N

N

L

V

I

I

D

D

A

A

M

A

S

A

I

G

G

G

A

A

A

S

D

A

G

G

L

L

K

Q

L
|
L

A

A

L

L

N

N

V

V

G

G

G

A

M

M

L

L

L

I

A

A

F

F

I

I

A

G

V

L

I

I

A

A

M

L

L

I

N

N

Y

G

L

M

L

L

S

G

G

G

V

I

L

-

G

G

D

G

V

W

T

F

G

G

L

M

N

P

Q

E

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

K

L
|
L

E

E

Y

M

I

L

L

L

G

G

Q

W

V

L

F

F

R

A

I

P

F

L

A

A

W

F

L

L

M

I

G

G

V

V

E

P

W

W

Q

N

D

E

T

A

L

T

Q

V

V

A

G

G

S

E

L

F

L

I

G

G

Q

L

K

K

T

T

V
|
V

I

A

N
|
N

E
|
E

F
|
F

V

V

A

A

Y

Y

S

S

D

Q

L

F

S

A

S

P

M

Y

K

L

A

T

E

E

G

A

D

A

-

P

-

V

L

L

S

S

P

E

K

K

S

T

I

K

I

A

I

I

A

I

T

S

Y

F

A

A

L

L

C

C

G

G

F
|
F

S

A

N
|
N

F
x
L

S

S

S
|
S

I
|
I

A

A

I
|
I

Q

L

V

L

G

G

I

L

G

G

S

S

I

L

A

A

P

P

G

K

Q

R

G

G

N

D

L

I

S
x
A

K

R

L

M

G

G

M
x
V

H

K

A

A

L

V

L

I

A

A

A

G

T

T

L

L

A

S

C

N

M

L

M

M

T

A

A

A

T

T

I

I

A

A

G

G

binding decyl-beta-d-maltopyranoside: L283 (= L309), V317 (= V343), L357 (≠ F380), I360 (= I383), A379 (≠ S402), V383 (≠ M406)
binding 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide: G152 (= G146), Q153 (= Q147), E155 (= E149), V187 (= V181), L247 (= L260), N319 (= N345), E320 (= E346), F321 (= F347), F354 (= F377), N356 (= N379), S359 (= S382), I362 (= I385)

O00337 Sodium/nucleoside cotransporter 1; Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 from Homo sapiens (Human) (see 7 papers)
40% identity, 96% coverage: 16:427/428 of query aligns to 189:591/649 of O00337

query
sites
O00337

V
|
V

A

A

F

L

L

L

F

F

S

A

A

C

S

S

R

K

K

H

-

H

-

C

S

A

V

V

D

S

W

W

K

R

L

A

V

V

G

S

I

W

G

G

V

L

I

G

L

L

Q

Q

I

F

V

V

F

L

G

G

F

L

L

L

I

V

T

I

K

R

V

T

A

E

F

P

V

G

E

F

S

I

V

A

F

F

A

E

S

W

I

L

S

G

G

E

A

Q

F

I

V

R

K

I

L

F

L

L

S

S

F

Y

A

T

Q

K

A

A

G

G

A

S

I

S

F

F

L

V

F

F

G

G

D

E

-

A

L

L

A

V

T

K

D

D

S

-

F

-

G

-

T

-

I

V

F

F

A

A

F

F

Q

Q

V

V

L

L

P

P

T

I

I

I

I

V

F

F

S

S

T

C

V

V

S

I

A

S

G

V

L

L

Y

Y

Y

H

L

V

G

G

V

L

L

M

Q

Q

K

W

I

V

V

I

F

L

G

K

I

I

A

A

W

W

V

L

M

M

A

Q

R

V

T

T

M

M

K

G

L

T

S

T

G

A

A

T

E

E

S

T

L

L

S

S

A

V

A

A

G

G

N

N

I

I

F

F

L

V

G
x
S

Q
|
Q

T

T

E

E

A

A

P

P

L

L

V

I

R

R

P

P

F

Y

I

L

P

A

T

D

M

M

T

T

R

L

S

S

E

E

L

V

M

H

C

V

L

V

M

M

T

T

G

G

M

Y

A

A

T

T

I

I

A

A

G

G

G
x
S

V

L

L

L

A

G

A

A

Y

Y

V

I

A

S

F

F

L

-

G

-

G

G

D

I

D

D

P

-

A

-

E

-

Q

-

S

-

K

-

F

-

A

A

S

T

Y

S

L

L

L

I

G

A

A

A

S

S

I

V

M

M

N

A

A

A

P

P

A

C

A

A

I

L

V

A

M

L

S

S

K

K

L

L

I

V

I

Y

P

P

E

E

T

V

N

E

K

E

E

S

G

K

L

F

N

R

D

R

K

E

L

E

E

G

V

V

S

K

-

L

S

T

E

Y

G

G

M

D

G

A

V

Q

N
|
N

L

L

I

I

D

E

A

A

M

A

S

S

I

T

G

G

A

A

D

I

G

S

L

V

K

K

L

V

A

V

L

A

N

N

V

I

G

A

M

N

L

L

L

I

A

A

F

F

I

L

A

A

V

V

I

L

A

D

M

F

L

I

N

N

Y

A

L

A

L

L

S

S

G

W

V

-

L

L

G

G

D

D

V

M

T

V

G

D

L

I

N

Q

Q

-

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

G

F

L

S

S

L

F

E

Q

Y

L

I

I

L

C

G

S

Q

Y

V

I

F

L

R

R

I

P

F

V

A

A

W

F

L

L

M

M

G

G

V

V

E

A

W

W

Q

E

D

D

T

C

L

P

Q

V

V

V

G

A

S

E

L

L

G

G

Q

I

K

K

T

L

V

F

I

L

N

N

E

E

F

F

V

V

A

A

Y

Y

S

Q

D

D

L

L

S

S

S

K

M

Y

K

K

A

Q

E
x
R

-

R

-

L

-

A

-

G

-

A

-

E

-

W

-

V

G

G

D
|
D

-

R

-

K

-

Q

-

W

L

I

S

S

P

V

K

R

S

A

I

E

I

V

I

L

A

T

T

T

Y

F

A

A

L

L

C

C

G

G

F

F

S

A

N

N

F

F

S

S

S
|
S

I

I

A

G

I

I

Q

M

V

L

G

G

I

L

G

T

S

S

I

M

A

V

P

P

G

Q

Q
x
R

Q

K

G

S

N

D

L

F

S

S

K

Q

L

I

G

V

M

L

H

R

A

A

L

L

L

F

A

T

A

G

T

A

L

C

A

V

C

S

M

L

M

V

T

N

A

A

T

C

I

M

A

A

G

G

M

I

L

L

F

Y

V189 (= V16) to I: in allele A; dbSNP:rs2290272
S318 (≠ G146) mutation to G: Changed pyrimidine- and adenosine-specific:sodium symporter activity. Decreased specificity for pyrimidine nucleosides enabling also the transport of inosine. Loss of specificity for pyrimidine nucleosides; when associated with M-319 and T-352.
Q319 (= Q147) mutation to M: Changed pyrimidine- and adenosine-specific:sodium symporter activity. Loss of specificity for pyrimidine nucleosides; when associated with G-318 and T-352.
S352 (≠ G180) mutation to T: Changed pyrimidine- and adenosine-specific:sodium symporter activity. Loss of specificity for pyrimidine nucleosides; when associated with G-318 and M-319.
N409 (= N245) to S: in allele B; dbSNP:rs1174011667
R510 (≠ E359) to C: in URCTU; changed N-glycosylation; increased protein degradation; affects urinary excretion of uridine and cytidine; dbSNP:rs2242047
D521 (= D361) to N: in alleles B and C; dbSNP:rs2242046
S546 (= S382) to P: in URCTU; no effect on localization to the cell membrane; loss of pyrimidine- and adenosine-specific:sodium symporter activity; affects urinary excretion of uridine and cytidine; dbSNP:rs45584739; mutation S->A,C,R,T: No effect on localization to the apical plasma membrane. Loss of pyrimidine- and adenosine-specific:sodium symporter activity. Probably due to sodium uncoupling in the nucleoside translocation cycle.; mutation Missing: Loss of pyrimidine- and adenosine-specific:sodium symporter activity.
R561 (≠ Q397) to Q: in URCTU; changed N-glycosylation; increased protein degradation; affects urinary excretion of uridine and cytidine

Sites not aligning to the query:

34 E → G: in allele A
140 natural variant: L -> LV (in allele A)

Q9HAS3 Solute carrier family 28 member 3; Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3 from Homo sapiens (Human) (see 5 papers)
43% identity, 85% coverage: 66:428/428 of query aligns to 263:614/691 of Q9HAS3

query
sites
Q9HAS3

L

F

L

L

S

E

F

Y

A

T

Q

D

A

A

G

G

A

A

I

S

F

F

L

V

F

F

G

G

D

E

L

K

A

Y

T

K

D

D

S

H

F

F

G

-

T

-

I

-

F

F

A

A

F

F

Q

K

V

V

L

L

P

P

T

I

I

V

F

F

S

S

T

T

V

V

S

M

A

S

G

M

L

L

Y

Y

L

L

G

G

V

L

L

M

Q

Q

K

W

I

I

V

I

F

R

G

K

I

V

A

G

W

W

V

I

M

M

A

L

R

V

T

T

M

T

K

G

L

S

S

S

G

P

A
x
I

E

E

S

S

L

V

S

V

A

A

A

S

G

G

N

N

I

I

F

F

L

V

G

G

Q

Q

T

T

E

E

A

S

P

P

L

L

V

V

R
|
R

P

P

F

Y

I

L

P

P

T

Y

M

I

T

T

R

K

S

S

E

E

L

L

M

H

C

A

L

I

M

M

T

T

G
x
A

G
|
G

M

F

A

S

T

T

I

I

A

A

G

G

G

S

V

V

L

L

A

G

A

A

Y

Y

V

I

A

S

F

F

L

-

G

-

D

G

D

V

P

P

A

-

E

-

Q

-

S

-

K

-

F

-

A

S

S

S

Y

H

L

L

G

T

A

A

S

S

I

V

M

M

N

S

A

A

P

P

A

A

A

S

I

L

V

A

M

A

S

A

K

K

L

L

I

F

I

W

P

P

E

E

T

T

N

E

K

K

E

P

G

K

L

I

N

T

D
x
L

K

K

L

N

E

A

V

M

S

K

S

M

E

E

-

S

G

G

M

D

G

S

V

G

N

N

L

L

I

L

D

E

A

A

M

A

S

T

I

Q

G

G

A

A

A

S

D

S

G

S

L

I

K

S

L

L

A

V

L

A

N

N

V

I

G

A

G

V

M

N

L

L

L

I

A

A

F

F

I

L

A

A

V

L

I

L

A

S

M

F

L

M

N

N

Y

S

L

A

L

L

S

S

G

W

V

-

L

F

G

G

D

N

V

M

T

F

G

D

L

Y

N

P

Q

Q

F

-

V

-

D

-

T

-

N

-

G

-

R

-

F

-

D

-

G

-

F

L

S

S

L

F

E

E

Y

L

I

I

L

C

G

S

Q

Y

V

I

F

F

R

M

I

P

F

F

A

S

W

F

L

M

M

M

G

G

V

V

E

E

W

W

Q

Q

D

D

T

S

L

F

Q

M

V

V

G

A

S

R

L

L

L

I

G

G

Q
x
Y

K

K

T

T

V

F

I

F

N

N

E

E

F

F

V

V

A

A

Y

Y

S

E

D

H

L

L