SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Echvi_3131 FitnessBrowser__Cola:Echvi_3131 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
29% identity, 87% coverage: 31:338/356 of query aligns to 19:275/284 of Q57757

query
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Q57757

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C71 (≠ I105) mutation to S: 24% of wild-type activity in the presence of DTT.
C136 (≠ A185) mutation to A: 89% of wild-type activity in the presence of DTT.
C151 (≠ S200) mutation to S: 5% of wild-type activity in the presence of DTT.
C229 (≠ G292) mutation to A: 96% of wild-type activity in the presence of DTT.

3lhlA Crystal structure of a putative agmatinase from clostridium difficile
28% identity, 58% coverage: 138:342/356 of query aligns to 74:267/276 of 3lhlA

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active site: H95 (= H159), D118 (= D182), H120 (= H184), D122 (= D186), H134 (= H198), D199 (= D274), D201 (= D276), E245 (= E320)
binding manganese (ii) ion: H95 (= H159), D118 (= D182), D118 (= D182), H120 (= H184), D122 (= D186), D122 (= D186), H134 (= H198), D199 (= D274), D199 (= D274), D201 (= D276)

3pzlB The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
25% identity, 87% coverage: 31:339/356 of query aligns to 21:278/293 of 3pzlB

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active site: H112 (= H159), D132 (= D182), H134 (= H184), D136 (= D186), H148 (= H198), D217 (= D274), D219 (= D276), E260 (= E320)
binding manganese (ii) ion: H112 (= H159), D132 (= D182), D132 (= D182), H134 (= H184), D136 (= D186), D217 (= D274), D217 (= D274), D219 (= D276)

P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
26% identity, 90% coverage: 26:344/356 of query aligns to 21:307/313 of P0DJQ3

query
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P0DJQ3

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H121 (= H159) binding
D144 (= D182) binding ; binding
H146 (= H184) binding
D148 (= D186) binding
D235 (= D274) binding ; binding
D237 (= D276) binding

1gq6B Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
26% identity, 90% coverage: 26:344/356 of query aligns to 13:299/301 of 1gq6B

query
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1gq6B

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G

I

I

H

D

M

R

L

G

P

P

I

-

P

-

E

-

N

-

V

-

Y

-

S

-

N

-

T

-

K

-

Y

-

R

-

I

-

L

-

A

-

G

G

N

T

Y

F

-

D

-

L

I

I

D

N

W

C

L

V

E

D

R

A

G

G

S

D

P

-

K

-

E

-

R

-

E

-

R

-

F

-

G

-

A

-

V

-

P

-

A

-

L

-

I

I

D

N

K

L

A

T

C

P

Q

F

S

D

M

M

N

N

D

I

W

A

V

I

Y

-

E

D

T

T

A

A

K

Q

D

S

Q

H

L

L

N

S

Q

-

G

G

K

L

L

L

V

K

A

A

-

N

-

A

-

F

-

L

L

M

V

I

G

G

D

D

H
|
H

S

S

T

L

P

T

L

V

G

A

H

A

I

L

K

R

A

A

L

V

S

A

E

E

R

Q

Y

H

S

G

S

P

F

L

G

A

I

V

L

V

Q

H

I

L

D
|
D

A

A

H
|
H

A

S

D
|
D

L

T

R

N

D

P

Q

A

Y

F

E

Y

G

G

F

G

N

R

Y

Y

S

H

H
|
H

A

G

S

T

I

P

S

F

H

R

N

H

F

G

L

I

N

D

I

E

P

K

Q

L

V

I

E

D

-

P

-

A

K

A

L

M

V

V

Q

Q

V

I

G

G

V

I

R

R

-

G

-

H

-

N

-

P

-

K

-

P

-

D

-

S

-

L

D

D

Y

Y

C

A

E

R

E

G

E

H

S

G

D

V

R

R

I

V

D

V

G

T

D

A

D

D

R

E

I

F

T

G

T

-

F

-

D

-

H

-

I

-

K

-

E

-

Q

E

L

L

Y

G

E

V

G

G

V

G

T

T

W

A

R

D

T

L

I

I

C

R

D

E

Q

K

V

V

I

G

A

Q

S

-

L

-

P

-

R

R

E

P

I

V

Y

Y

I

V

T

S

I

V

D
|
D

I

I

D
|
D

G

V

L

V

D

D

P

P

K

A

L

F

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

A

P

P

G

G

F

L

D

L

L

S

N

R

Q

E

L

V

L

L

Y

A

L

L

M

L

K

R

L

C

I

V

V

-

K

-

S

G

G

D

R

L

K

K

I

P

I

V

G

G

F

F

D

D

L

V

V

M

E
|
E

V

V

A

S

P

P

-

L

-

Y

-

D

-

H

G

G

E

G

D

I

D

T

S

S

E

I

W

L

D

A

G

T

N

E

V

I

G

G

A

A

R

E

L

L

Y

Y

R

Q

M

Y

S

A

N

R

active site: H113 (= H159), D136 (= D182), H138 (= H184), D140 (= D186), H152 (= H198), D227 (= D274), D229 (= D276), E271 (= E320)
binding manganese (ii) ion: H113 (= H159), D136 (= D182), D136 (= D182), H138 (= H184), D140 (= D186), D227 (= D274), D227 (= D274), D229 (= D276)

5hjaA Crystal structure of leishmania mexicana arginase in complex with inhibitor abhdp (see paper)
28% identity, 57% coverage: 138:339/356 of query aligns to 81:295/303 of 5hjaA

query
sites
5hjaA

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R

N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G
|
G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D
x
A

Y
x
V

C

-

E
x
D

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T

T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

G

L

E

L

D

N

D

D

S

T

E

I

W

S

D

V

G

G

N

C

V

A

G

I

A

A

R

R

L

C

L

M

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)
binding (R)-2-amino-6-borono-2-(1-(3,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), S138 (vs. gap), H142 (≠ E192), G143 (= G193), A180 (≠ D221), V181 (≠ Y222), D182 (≠ E224), D231 (= D274), D233 (= D276)

Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
29% identity, 55% coverage: 146:342/356 of query aligns to 116:309/319 of Q9I3S3

query
sites
Q9I3S3

L

L

N

G

Q

H

G

G

K

I

L

L

V

P

A

L

L

T

V

L

G

G

D

D

H
|
H

S

T

T

I

P

T

L

L

G

P

H

I

I

L

K

R

A

A

L

I

S

K

E

K

R

K

Y

H

S

G

S

K

F

V

G

G

I

L

L

V

Q

H

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

V

R

N

D

D

Q

H

Y
x
M

E

F

G

G

F

E

N

K

Y

I

S

A

H

H

A

G

S

T

I

T

S

F

H

R

N

R

F

A

L

V

-

E

N

D

I

L

P

L

Q

D

V

C

E

D

K

R

L

V

V

V

Q

Q

V

I

G

G

V

L

R

R

-

A

-

Q

D

G

Y

Y

C

T

E

A

E

E

E

D

S

F

D

N

R

W

I

-

D

-

G

-

D

-

D

S

R

R

I

K

T

Q

T

G

F

F

F

R

D

V

H

V

H

Q

I

A

K

E

E

E

Q

-

L

-

Y

-

E

-

G

-

V

-

T

C

W

W

R

H

T

K

I

S

C

L

D

E

Q

P

V

L

I

M

A

A

S

E

L

V

P

R

R

E

E

K

-

V

-

G

-

P

I

V

Y

Y

I

L

T

S

I

F

D
|
D

I

I

D
|
D

G

G

L

I

D

D

P

P

K

A

L

W

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

E

P

I

G

G

F

L

D

T

L

T

N

I

Q

Q

L

A

L

M

Y

E

L

I

M

I

K

R

L

G

I

C

V

-

K

-

S

Q

G

G

R

L

K

D

I

L

I

I

G

G

F

C

D

D

L

L

V

V

E

E

V

V

A

S

P

P

G

P

E

Y

D

D

D

T

S

T

E

G

W

N

D

T

G

S

N

L

V

L

G

G

A

A

R

N

L

L

Y

Y

R

E

M

M

H129 (= H159) binding
D152 (= D182) binding ; binding
H154 (= H184) binding
D156 (= D186) binding
M161 (≠ Y191) mutation to Y: Loss of activity.
D243 (= D274) binding
D245 (= D276) binding

3nioA Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
29% identity, 55% coverage: 146:342/356 of query aligns to 113:306/316 of 3nioA

query
sites
3nioA

L

L

N

G

Q

H

G

G

K

I

L

L

V

P

A

L

L

T

V

L

G

G

D

D

H
|
H

S

T

T

I

P

T

L

L

G

P

H

I

I

L

K

R

A

A

L

I

S

K

E

K

R

K

Y

H

S

G

S

K

F

V

G

G

I

L

L

V

Q

H

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

V

R

N

D

D

Q

H

Y

M

E

F

G

G

F

E

N

K

Y

I

S

A

H
|
H

A

G

S

T

I

T

S

F

H

R

N

R

F

A

L

V

-

E

N

D

I

L

P

L

Q

D

V

C

E

D

K

R

L

V

V

V

Q

Q

V

I

G

G

V

L

R

R

-

A

-

Q

D

G

Y

Y

C

T

E

A

E

E

E

D

S

F

D

N

R

W

I

-

D

-

G

-

D

-

D

S

R

R

I

K

T

Q

T

G

F

F

F

R

D

V

H

V

H

Q

I

A

K

E

E

E

Q

-

L

-

Y

-

E

-

G

-

V

-

T

C

W

W

R

H

T

K

I

S

C

L

D

E

Q

P

V

L

I

M

A

A

S

E

L

V

P

R

R

E

E

K

-

V

-

G

-

P

I

V

Y

Y

I

L

T

S

I

F

D
|
D

I

I

D
|
D

G

G

L

I

D

D

P

P

K

A

L

W

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

E

P

I

G

G

F

L

D

T

L

T

N

I

Q

Q

L

A

L

M

Y

E

L

I

M

I

K

R

L

G

I

C

V

-

K

-

S

Q

G

G

R

L

K

D

I

L

I

I

G

G

F

C

D

D

L

L

V

V

E
|
E

V

V

A

S

P

P

G

P

E

Y

D

D

D

T

S

T

E

G

W

N

D

T

G

S

N

L

V

L

G

G

A

A

R

N

L

L

Y

Y

R

E

M

M

active site: H126 (= H159), D149 (= D182), H151 (= H184), D153 (= D186), H165 (= H198), D240 (= D274), D242 (= D276), E284 (= E320)
binding manganese (ii) ion: H126 (= H159), D149 (= D182), D149 (= D182), H151 (= H184), D153 (= D186), D240 (= D274), D240 (= D274), D242 (= D276)

5hj9A Crystal structure of leishmania mexicana arginase in complex with inhibitor abhpe (see paper)
28% identity, 52% coverage: 138:323/356 of query aligns to 81:279/311 of 5hj9A

query
sites
5hj9A

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R

N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G
|
G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D

A

Y

V

C

-

E
x
D

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T

T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)
binding [(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-): H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), S138 (vs. gap), H142 (≠ E192), G143 (= G193), D182 (≠ E224), D231 (= D274), E276 (= E320)

4iu5A Crystal structure of leishmania mexicana arginase in complex with catalytic product l-ornithine (see paper)
28% identity, 52% coverage: 138:323/356 of query aligns to 81:279/310 of 4iu5A

query
sites
4iu5A

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R

N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G

G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D

A

Y

V

C

-

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T

T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)
binding L-ornithine: H127 (= H184), D129 (= D186), S138 (vs. gap), H142 (≠ E192)

4iu4A Crystal structure of leishmania mexicana arginase in complex with inhibitor bec (see paper)
28% identity, 52% coverage: 138:323/356 of query aligns to 81:279/310 of 4iu4A

query
sites
4iu4A

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R

N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G

G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D

A

Y

V

C

-

E
x
D

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T

T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)
binding s-2-(boronoethyl)-l-cysteine: D125 (= D182), H127 (= H184), D129 (= D186), S138 (vs. gap), H142 (≠ E192), D182 (≠ E224), D231 (= D274), D233 (= D276), E276 (= E320)

4iu1A Crystal structure of leishmania mexicana arginase in complex with inhibitor nor-noha (see paper)
28% identity, 52% coverage: 138:323/356 of query aligns to 81:279/310 of 4iu1A

query
sites
4iu1A

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R
x
N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G

G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D

A

Y

V

C

-

E
x
D

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T
|
T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)
binding nor-n-omega-hydroxy-l-arginine: H127 (= H184), D129 (= D186), N131 (≠ R188), S138 (vs. gap), H142 (≠ E192), D182 (≠ E224), T245 (= T288)

4iu0A Crystal structure of leishmania mexicana arginase in complex with inhibitor abh (see paper)
28% identity, 52% coverage: 138:323/356 of query aligns to 81:279/310 of 4iu0A

query
sites
4iu0A

V

I

Y

Y

E

K

T

C

A

V

K

R

D

R

Q

V

L

A

N

E

Q

Q

G

G

K

R

L

F

V

P

A

L

L

T

V

I

G

G

D

D

H
|
H

S

S

T

I

P

A

L

L

G

G

H

T

I

V

K

A

A

G

L

V

S

L

E

S

R

V

Y

H

S

P

S

D

F

A

G

G

I

V

L

I

Q

W

I

V

D
|
D

A

A

H
|
H

A

A

D
|
D

L

I

R

N

D

T

-

M

-

S

-

G

-

T

-

V

-
x
S

-

G

Q

N

Y

L

E
x
H

G

G

F

C

N

P

Y

L

S

S

-

I

-

L

-

G

-

L

-

D

H

R

A

E

S

N

I

I

S

P

H

E

N

C

F

F

L

S

N

W

I

V

P

P

Q

Q

V

V

-

L

-

K

-

P

E

N

K

K

L

I

V

A

Q

Y

V

I

G

G

V

L

R

R

D

A

Y

V

C

-

E

D

E

E

S

E

D

K

R

K

I

I

D

L

G

H

D

D

D

L

R

N

I

I

T

A

F

F

F

S

D

M

H

H

I

V

K

D

E

R

Q

Y

L

G

Y

I

E

D

G

K

V

V

T

V

W

S

R

M

T

A

I

I

C

-

D

E

Q

A

V

V

I

S

A

P

S

K

L

G

P

T

R

E

E

P

I

V

Y

M

I

V

T

S

I

Y

D
|
D

I

V

D
|
D

G

T

L

I

D

D

P

P

K

L

L

Y

C

V

P

P

H

A

T

T

G

G

T

T

P

P

V

V

P

R

G

G

F

L

D

S

L

F

N

R

Q

E

L

A

L

L

Y

F

L

L

M

C

K

E

L

R

I

I

V

A

K

E

S

C

G

G

R

R

K

-

I

L

I

V

G

A

F

L

D

D

L

V

V

V

E
|
E

V

C

A

N

P

P

active site: H102 (= H159), D125 (= D182), H127 (= H184), D129 (= D186), H142 (≠ E192), D231 (= D274), D233 (= D276), E276 (= E320)
binding 2(s)-amino-6-boronohexanoic acid: D125 (= D182), H127 (= H184), D129 (= D186), S138 (vs. gap), H142 (≠ E192), D231 (= D274), E276 (= E320)
binding manganese (ii) ion: H102 (= H159), D125 (= D182), D125 (= D182), H127 (= H184), D129 (= D186), D231 (= D274), D231 (= D274), D233 (= D276)

P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see paper)
26% identity, 90% coverage: 11:329/356 of query aligns to 7:283/306 of P60651

query
sites
P60651

K

Q

F

Y

D

D

P

N

N

S

G

L

V

V

S

S

S

N

E

A

G

F

S

G

I

F

F

L

G

R

L

L

P

P

F

M

D

N

-

F

-

Q

-

P

-

Y

E

D

E

S

T

D

A

A

S

D

V

W

V

V

I

I

V

T

P

G

V

V

P

P

W

F

E

D

V

M

T

A

V

T

S

S

Y

G

A

R

P

A

G

G

T

G

A

R

N

H

G

G

P

P

Q

A

A

A

I

I

L

R

D

Q

A

V

S

S

S

T

Q

N

V

L

D

-

L

-

F

-

Q

-

D

-

I

-

T

-

D

-

A

A

W

W

T

E

M

H

G

N

I

-

H

-

M

-

L

-

P

R

I

F

P

P

E

W

N

N

V

F

Y

D

S

M

N

R

N

E

T

R

K

L

Y

N

R

V

I

V

L

D

A

C

G

G

N

D

Y

L

I

V

D

-

W

-

L

Y

E

A

R

F

G

G

S

D

P

A

K

R

E

E

E

M

R

S

E

E

R

K

F

L

G

Q

A

A

V

-

P

-

A

-

L

-

I

-

D

-

K

-

A

-

C

-

Q

-

S

-

M

-

N

-

D

-

W

-

V

-

Y

-

E

-

T

H

A

A

K

E

D

K

Q

L

L

L

N

A

Q

A

G

G

K

K

L

R

V

M

A

L

L

S

V

F

G

G

D

D

H

H

S

F

T

V

P

T

L

L

G

P

H

L

I

L

K

R

A

A

L

H

S

A

E

K

R

H

Y

F

S

G

S

K

F

M

G

A

I

L

L

V

Q

H

I

F

D

D

A

A

H

H

A

T

D

D

L

T

R

-

D

-

Q

Y

Y

A

E

N

G

G

F

C

N

E

Y

F

S

D

H
|
H

A

G

S

T

I

M

S

-

H

-

N

-

F

F

L

Y

N

T

I

A

P

P

Q

K

V

-

E

E

K

G

L

L

-

I

-

D

-

P

-

N

-

H

-

S

V

V

Q

Q

V

I

G

G

V

I

R

R

D

T

Y

-

C

-

E

-

S

-

D

-

R

E

I

F

D

D

G

K

D

D

D

N

R

G

I

F

T

T

T

V

F

L

F

D

D

A

H

C

H

Q

I

V

K

N

E

D

Q

R

L

S

Y

V

E

D

G

D

V

V

T

I

W

A

R

Q

T

V

I

-

C

-

D

K

Q

Q

V

I

I

V

A

G

S

D

L

M

P

P

R

-

E

-

I

V

Y

Y

I

L

T

T

I

F

D

D

I

I

D

D

G

C

L

L

D

D

P

P

K

A

L

F

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

V

P

I

G

G

F

L

D

T

L

S

N

D

Q

R

L

A

L

I

Y

K

L

L

M

V

K

R

L

G

I

L

V

-

K

-

S

K

G

D

R

L

K

N

I

I

I

V

G

G

F

M

D

D

L

V

V

V

E

E

V

V

A

A

P

P

G

A

E

Y

D

D

D

Q

S

S

E

E

H163 (= H198) mutation to F: Loss of activity.

7lbaB E. Coli agmatinase (see paper)
26% identity, 90% coverage: 11:329/356 of query aligns to 14:290/310 of 7lbaB

query
sites
7lbaB

K

Q

F

Y

D

D

P

N

N

S

G

L

V

V

S

S

S

N

E

A

G

F

S

G

I

F

F

L

G

R

L

L

P

P

F

M

D

N

-

F

-

Q

-

P

-

Y

E

D

E

S

T

D

A

A

S

D

V

W

V

V

I

I

V

T

P

G

V

V

P

P

W

F

E

D

V

M

T

A

V

T

S

S

Y

G

A

R

P

A

G

G

T

G

A

R

N

H

G

G

P

P

Q

A

A

A

I

I

L

R

D

Q

A

V

S

S

S

T

Q

N

V

L

D

-

L

-

F

-

Q

-

D

-

I

-

T

-

D

-

A

A

W

W

T

E

M

H

G

N

I

-

H

-

M

-

L

-

P

R

I

F

P

P

E

W

N

N

V

F

Y

D

S

M

N

R

N

E

T

R

K

L

Y

N

R

V

I

V

L

D

A

C

G

G

N

D

Y

L

I

V

D

-

W

-

L

Y

E

A

R

F

G

G

S

D

P

A

K

R

E

E

E

M

R

S

E

E

R

K

F

L

G

Q

A

A

V

-

P

-

A

-

L

-

I

-

D

-

K

-

A

-

C

-

Q

-

S

-

M

-

N

-

D

-

W

-

V

-

Y

-

E

-

T

H

A

A

K

E

D

K

Q

L

L

L

N

A

Q

A

G

G

K

K

L

R

V

M

A

L

L

S

V

F

G

G

D

D

H
|
H

S

F

T

V

P

T

L

L

G

P

H

L

I

L

K

R

A

A

L

H

S

A

E

K

R

H

Y

F

S

G

S

K

F

M

G

A

I

L

L

V

Q

H

I

F

D
|
D

A

A

H
|
H

A

T

D
|
D

L

T

R

-

D

-

Q

Y

Y

A

E

N

G

G

F

C

N

E

Y

F

S

D

H

H

A

G

S

T

I

M

S

-

H

-

N

-

F

F

L

Y

N

T

I

A

P

P

Q

K

V

-

E

E

K

G

L

L

-

I

-

D

-

P

-

N

-

H

-

S

V

V

Q

Q

V

I

G

G

V

I

R

R

D

T

Y

-

C

-

E

-

S

-

D

-

R

E

I

F

D

D

G

K

D

D

D

N

R

G

I

F

T

T

T

V

F

L

F

D

D

A

H

C

H

Q

I

V

K

N

E

D

Q

R

L

S

Y

V

E

D

G

D

V

V

T

I

W

A

R

Q

T

V

I

-

C

-

D

K

Q

Q

V

I

I

V

A

G

S

D

L

M

P

P

R

-

E

-

I

V

Y

Y

I

L

T

T

I

F

D
|
D

I

I

D
|
D

G

C

L

L

D

D

P

P

K

A

L

F

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

V

P

I

G

G

F

L

D

T

L

S

N

D

Q

R

L

A

L

I

Y

K

L

L

M

V

K

R

L

G

I

L

V

-

K

-

S

K

G

D

R

L

K

N

I

I

I

V

G

G

F

M

D

D

L

V

V

V

E

E

V

V

A

A

P

P

G

A

E

Y

D

D

D

Q

S

S

E

E

binding manganese (ii) ion: H133 (= H159), D156 (= D182), D156 (= D182), H158 (= H184), D160 (= D186), D237 (= D274), D237 (= D274), D239 (= D276)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine (see paper)
26% identity, 85% coverage: 27:329/356 of query aligns to 18:273/294 of 7lolA

query
sites
7lolA

P

P

F

Y

D

D

E

S

E

D

T

-

A

A

S

D

V

W

V

V

I

I

V

T

P

G

V

V

P

P

W

F

E

D

V

M

T

A

V

T

S

S

Y

G

A

R

P

A

G

G

T

G

A

R

N

H

G

G

P

P

Q

A

A

A

I

I

L

R

D

Q

A

V

S

S

S

T

Q

N

V

L

D

-

L

-

F

-

Q

-

D

-

I

-

T

-

D

-

A

A

W

W

T

E

M

H

G

N

I

-

H

-

M

-

L

-

P

R

I

F

P

P

E

W

N

N

V

F

Y

D

S

M

N

R

N

E

T

R

K

L

Y

N

R

V

I

V

L

D

A

C

G

G

N

D

Y

L

I

V

D

-

W

-

L

Y

E

A

R

F

G

G

S

D

P

A

K

R

E

E

E

M

R

S

E

E

R

K

F

L

G

Q

A

A

V

-

P

-

A

-

L

-

I

-

D

-

K

-

A

-

C

-

Q

-

S

-

M

-

N

-

D

-

W

-

V

-

Y

-

E

-

T

H

A

A

K

E

D

K

Q

L

L

L

N

A

Q

A

G

G

K

K

L

R

V

M

A

L

L

S

V

F

G

G

D

D

H
|
H

S

F

T

V

P

T

L

L

G

P

H

L

I

L

K

R

A

A

L

H

S

A

E

K

R

H

Y

F

S

G

S

K

F

M

G

A

I

L

L

V

Q

H

I

F

D
|
D

A

A

H
|
H

A

T

D
|
D

L

T

R

-

D

-

Q
x
Y

Y

A

E

N

G

G

F

C

N

E

Y

F

S

D

H
|
H

A

G

S

T

I

M

S

-

H

-

N

-

F

F

L

Y

N

T

I

A

P

P

Q

K

V

-

E

E

K

G

L

L

-

I

-

D

-

P

-

N

-

H

-

S

V

V

Q

Q

V

I

G

G

V

I

R

R

D

T

Y

-

C

-

E

-

S

-

D

-

R

E

I

F

D

D

G

K

D

D

D

N

R

G

I

F

T

T

T

V

F

L

F

D

D

A

H

C

H

Q

I

V

K

N

E

D

Q

R

L

S

Y

V

E

D

G

D

V

V

T

I

W

A

R

Q

T

V

I

-

C

-

D

K

Q

Q

V

I

I

V

A

G

S

D

L

M

P

P

R

-

E

-

I

V

Y

Y

I

L

T

T

I

F

D
|
D

I

I

D
|
D

G

C

L

L

D

D

P

P

K

A

L

F

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

V

P

I

G

G

F

L

D

T

L

S

N

D

Q

R

L

A

L

I

Y

K

L

L

M

V

K

R

L

G

I

L

V

-

K

-

S

K

G

D

R

L

K

N

I

I

I

V

G

G

F

M

D

D

L

V

V

V

E
|
E

V

V

A

A

P

P

G

A

E

Y

D

D

D

Q

S

S

E

E

binding agmatine: Y145 (≠ Q190), H153 (= H198)
binding manganese (ii) ion: H116 (= H159), D139 (= D182), D139 (= D182), H141 (= H184), D143 (= D186), D220 (= D274), D220 (= D274), D222 (= D276)
binding urea: D143 (= D186), H153 (= H198), D220 (= D274), E264 (= E320)

7loxA The structure of agmatinase from e. Coli at 3.2 a displaying guanidine in the active site (see paper)
29% identity, 56% coverage: 131:329/356 of query aligns to 78:263/284 of 7loxA

query
sites
7loxA

C

A

Q

R

S

E

M

M

N

S

D

E

W

K

V

L

Y

Q

E

A

T

H

A

A

K

E

D

K

Q

L

L

L

N

A

Q

A

G

G

K

K

L

R

V

M

A

L

L

S

V

F

G

G

D

D

H
|
H

S

F

T

V

P

T

L

L

G

P

H

L

I

L

K

R

A

A

L

H

S

A

E

K

R

H

Y

F

S

G

S

K

F

M

G

A

I

L

L

V

Q

H

I

F

D
|
D

A

A

H
|
H

A

T

D
|
D

L

T

R

-

D

-

Q

Y

Y

A

E

N

G

G

F

C

N

E

Y

F

S

D

H
|
H

A

G

S

T

I

M

S

-

H

-

N

-

F

F

L

Y

N

T

I

A

P

P

Q

K

V

-

E

E

K

G

L

L

-

I

-

D

-

P

-

N

-

H

-

S

V

V

Q

Q

V

I

G

G

V

I

R

R

D

T

Y

-

C

-

E

-

S

-

D

-

R

E

I

F

D

D

G

K

D

D

D

N

R

G

I

F

T

T

T

V

F

L

F

D

D

A

H

C

H

Q

I

V

K

N

E

D

Q

R

L

S

Y

V

E

D

G

D

V

V

T

I

W

A

R

Q

T

V

I

-

C

-

D

K

Q

Q

V

I

I

V

A

G

S

D

L

M

P

P

R

-

E

-

I

V

Y

Y

I

L

T

T

I

F

D
|
D

I

I

D
|
D

G

C

L

L

D

D

P

P

K

A

L

F

C

A

P

P

H

G

T

T

G

G

T

T

P

P

V

V

P

I

G

G

F

L

D

T

L

S

N

D

Q

R

L

A

L

I

Y

K

L

L

M

V

K

R

L

G

I

L

V

-

K

-

S

K

G

D

R

L

K

N

I

I

I

V

G

G

F

M

D

D

L

V

V

V

E

E

V

V

A

A

P

P

G

A

E

Y

D

D

D

Q

S

S

E

E

binding guanidine: H106 (= H159), H131 (= H184), H131 (= H184), D133 (= D186), D133 (= D186), H143 (= H198), D210 (= D274)
binding manganese (ii) ion: H106 (= H159), D129 (= D182), D129 (= D182), H131 (= H184), D133 (= D186), D210 (= D274), D210 (= D274), D212 (= D276)

6vstD Arginase from medicago truncatula in complex with ornithine (see paper)
29% identity, 60% coverage: 132:346/356 of query aligns to 111:318/320 of 6vstD

query
sites
6vstD

Q

K

S

R

M

L

N

A

D

N

W

V

V

I

Y

S

E

E

T

S

A

V

K

K

D

L

Q

V

L

M

N

D

Q

E

G

D

K

P

L

L

V

R

A

P

L

L

V

V

-

L

G

G

D

D

H
|
H

S

S

T

I

P

S

L

F

G

P

H

V

I

V

K

R

A

A

L

V

S

S

E

E

R

K

Y

L

S

G

-

G

S

A

F

V

G

D

I

I

L

L

Q

H

I

F

D
|
D

A

A

H
|
H

A

P

D
|
D

L

L

R

Y

D

H

Q

D

Y

F

E

E

G

G

F

N

N

Y

Y

Y

S

S

H

H

A

A

S

S

I

P

S

F

H

A

N

R

F

I

L

M

N

E

I

G

P

G

Q

Y

V

A

E

R

K

R

L

L

V

V

Q

Q

V

V

G

G

V

I

R

R

D

S

Y

I

C

T

E

N

E

D

E

V

S

R

D

E

R

Q

-

V

-

K

-

Y

-

G

I

V

D

E

G

T

D

H

D

E

R

M

I

R

T

T

T

L

F

S

F

R

D

D

H

R

H

P

I

I

K

L

E

E

-

N

-

L

Q

K

L

L

Y

G

E

E

G

G

V

V

T

-

W

-

R

-

T

-

I

-

C

-

D

-

Q

-

V

-

I

-

A

-

S

-

L

-

P

-

R

K

E

G

I

V

Y

Y

I

V

T

S

I

I

D
|
D

I

V

D
|
D

G

S

L

L

D

D

P

P

K

S

L

I

C

A

P

P

H

G

T

V

G

S

T

H

P

H

V

E

P

P

G

G

F

L

D

L

L

F

N

R

Q

D

L

I

L

L

Y

N

L

I

M

L

K

Q

L

N

I

L

V

Q

K

G

S

D

G

-

R

-

K

-

I

I

I

V

G

G

F

G

D

D

L

V

V

V

E

E

V

Y

A

N

P

P

G

Q

E

R

D

D

D

-

S

-

E

T

W

Y

D

D

G

G

N

I

-

T

-

A

-

L

V

V

G

A

A

A

R

K

L

L

L

V

Y

R

R

E

M

L

S

A

N

A

L

K

M

M

binding manganese (ii) ion: H139 (= H159), D163 (= D182), D163 (= D182), H165 (= H184), D167 (= D186), D248 (= D274), D248 (= D274), D250 (= D276)

6vstA Arginase from medicago truncatula in complex with ornithine (see paper)
29% identity, 60% coverage: 132:346/356 of query aligns to 108:315/317 of 6vstA

query
sites
6vstA

Q

K

S

R

M

L

N

A

D

N

W

V

V

I

Y

S

E

E

T

S

A

V

K

K

D

L

Q

V

L

M

N

D

Q

E

G

D

K

P

L

L

V

R

A

P

L

L

V

V

-

L

G

G

D

D

H
|
H

S

S

T

I

P

S

L

F

G

P

H

V

I

V

K

R

A

A

L

V

S

S

E

E

R

K

Y

L

S

G

-

G

S

A

F

V

G

D

I

I

L

L

Q

H

I

F

D
|
D

A

A

H
|
H

A

P

D
|
D

L

L

R
x
Y

D

H

Q

D

Y

F

E

E

G

G

F

N

N

Y

Y

Y

S

S

H
|
H

A

A

S

S

I

P

S

F

H

A

N

R

F

I

L

M

N

E

I

G

P

G

Q

Y

V

A

E

R

K

R

L

L

V

V

Q

Q

V

V

G

G

V

I

R

R

D

S

Y

I

C

T

E

N

E

D

E

V

S

R

D

E

R

Q

-

V

-

K

-

Y

-

G

I

V

D

E

G

T

D

H

D

E

R

M

I

R

T

T

T

L

F

S

F

R

D

D

H

R

H

P

I

I

K

L

E

E

-

N

-

L

Q

K

L

L

Y

G

E

E

G

G

V

V

T

-

W

-

R

-

T

-

I

-

C

-

D

-

Q

-

V

-

I

-

A

-

S

-

L

-

P

-

R

K

E

G

I

V

Y

Y

I

V

T

S

I

I

D
|
D

I

V

D
|
D

G

S

L

L

D

D

P

P

K

S

L

I

C

A

P

P

H

G

T

V

G

S

T
x
H

P

H

V

E

P

P

G

G

F

L

D

L

L

F

N

R

Q

D

L

I

L

L

Y

N

L

I

M

L

K

Q

L

N

I

L

V

Q

K

G

S

D

G

-

R

-

K

-

I

I

I

V

G

G

F

G

D

D

L

V

V

V

E

E

V

Y

A

N

P

P

G

Q

E

R

D

D

D

-

S

-

E

T

W

Y

D

D

G

G

N

I

-

T

-

A

-

L

V

V

G

A

A

A

R

K

L

L

L

V

Y

R

R

E

M

L

S

A

N

A

L

K

M

M

binding manganese (ii) ion: H136 (= H159), D160 (= D182), D160 (= D182), H162 (= H184), D164 (= D186), D245 (= D274), D245 (= D274), D247 (= D276)
binding L-ornithine: H162 (= H184), Y166 (≠ R188), H176 (= H198), H259 (≠ T288)

G7JFU5 Arginase, mitochondrial; Agmatinase ARGAH; Arginine amidohydrolase; MtARGAH; EC 3.5.3.1; EC 3.5.3.11 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
29% identity, 60% coverage: 132:346/356 of query aligns to 129:336/338 of G7JFU5

query
sites
G7JFU5

Q

K

S

R

M

L

N

A

D

N

W

V

V

I

Y

S

E

E

T

S

A

V

K

K

D

L

Q

V

L

M

N

D

Q

E

G

D

K

P

L

L

V

R

A

P

L

L

V

V

-

L

G

G

D

D

H
|
H

S

S

T

I

P

S

L

F

G

P

H

V

I

V

K

R

A

A

L

V

S

S

E

E

R

K

Y

L

S

G

-

G

S

A

F

V

G

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F

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N

Y

Y

Y

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H

A

A

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M

H157 (= H159) binding
D181 (= D182) binding ; binding
H183 (= H184) binding
D185 (= D186) binding
DLY 185:187 (≠ DLR 186:188) binding
S220 (≠ D221) binding
D266 (= D274) binding ; binding
D268 (= D276) binding

Sites not aligning to the query:

73 binding
92:95 binding

Query Sequence

>Echvi_3131 FitnessBrowser__Cola:Echvi_3131
MTTKKQKAIDKFDPNGVSSEGSIFGLPFDEETASVVIVPVPWEVTVSYAPGTANGPQAIL
DASSQVDLFQDDITDAWTMGIHMLPIPENVYSNNTKYRILAGNYIDWLERGSPKEERERF
GAVPALIDKACQSMNDWVYETAKDQLNQGKLVALVGGDHSTPLGHIKALSERYSSFGILQ
IDAHADLRDQYEGFNYSHASISHNFLNIPQVEKLVQVGVRDYCEEESDRIDGDDRITTFF
DHHIKEQLYEGVTWRTICDQVIASLPREIYITIDIDGLDPKLCPHTGTPVPGGFDLNQLL
YLMKLIVKSGRKIIGFDLVEVAPGEDDSEWDGNVGARLLYRMSNLMGVSHGKLWWK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory