SitesBLAST
Comparing Echvi_3865 FitnessBrowser__Cola:Echvi_3865 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
24% identity, 53% coverage: 13:533/982 of query aligns to 23:467/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P72), G75 (≠ T74), S76 (≠ A75), G77 (= G76), T78 (= T77), G79 (≠ S78), L80 (= L79), A83 (≠ Q82), C84 (= C83), P137 (≠ S136), G138 (≠ T137), E139 (≠ A138), A142 (= A141), T143 (≠ M142), G146 (= G145), N147 (≠ M146), S149 (≠ G148), T150 (≠ N149), A152 (≠ S151), G153 (≠ C152), E203 (= E263), G204 (= G264), I209 (≠ T269), E422 (= E488), H423 (= H489)
- binding fe (iii) ion: H377 (= H444), H384 (= H451), E422 (= E488)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
23% identity, 51% coverage: 29:530/982 of query aligns to 24:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ A37), P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W322 (≠ G394), E413 (= E488), H414 (= H489), N450 (= N525)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R391), H369 (= H444), H376 (= H451), H414 (= H489)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E413 (= E488)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
24% identity, 51% coverage: 29:530/982 of query aligns to 24:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R391), W322 (≠ G394), H369 (= H444), H376 (= H451), H414 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W322 (≠ G394), E413 (= E488), N450 (= N525)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E413 (= E488)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
24% identity, 51% coverage: 29:530/982 of query aligns to 24:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ S78), R317 (= R391), W321 (≠ G394), H368 (= H444), H375 (= H451), H413 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W321 (≠ G394), Y322 (≠ L395), E412 (= E488), H413 (= H489), N449 (= N525)
- binding manganese (ii) ion: H368 (= H444), H375 (= H451), E412 (= E488)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
24% identity, 51% coverage: 29:530/982 of query aligns to 24:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ A37), P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W323 (≠ G394), E414 (= E488), H415 (= H489), N451 (= N525)
- binding manganese (ii) ion: H370 (= H444), H377 (= H451), E414 (= E488)
- binding pyruvic acid: R319 (= R391), H370 (= H444), H377 (= H451), H415 (= H489)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
24% identity, 51% coverage: 29:530/982 of query aligns to 24:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R391), H369 (= H444), H376 (= H451), H414 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W322 (≠ G394), E413 (= E488), H414 (= H489), N450 (= N525)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E413 (= E488)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
23% identity, 51% coverage: 29:530/982 of query aligns to 24:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R391), W322 (≠ G394), H369 (= H444), H376 (= H451), H413 (= H489)
- binding flavin-adenine dinucleotide: E32 (≠ A37), P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W322 (≠ G394), E412 (= E488), H413 (= H489), N449 (= N525)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E412 (= E488)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
23% identity, 51% coverage: 29:530/982 of query aligns to 24:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R391), W322 (≠ G394), S336 (≠ I411), H369 (= H444), H376 (= H451), H413 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), E412 (= E488), N449 (= N525)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E412 (= E488)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
23% identity, 51% coverage: 29:530/982 of query aligns to 24:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), W322 (≠ G394), E413 (= E488), H414 (= H489), N450 (= N525)
- binding lactic acid: R318 (= R391), H369 (= H444), H376 (= H451), H414 (= H489)
- binding manganese (ii) ion: H369 (= H444), H376 (= H451), E413 (= E488)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), Y324 (≠ L395), H370 (= H444), E414 (= E488), N451 (= N525)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R391), W323 (≠ G394), H415 (= H489)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R391), W323 (≠ G394), H370 (= H444), H415 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), H370 (= H444), E414 (= E488), N451 (= N525)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R391), W323 (≠ G394), H415 (= H489)
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), Y324 (≠ L395), H370 (= H444), E414 (= E488), N451 (= N525)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), H370 (= H444), E414 (= E488), N451 (= N525)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R391), W323 (≠ G394), H415 (= H489)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), H370 (= H444), E414 (= E488), N451 (= N525)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R391), H415 (= H489)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), Y324 (≠ L395), H370 (= H444), E414 (= E488), N451 (= N525)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ S78), R319 (= R391), W323 (≠ G394), H415 (= H489)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
24% identity, 50% coverage: 36:530/982 of query aligns to 31:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P72), G70 (≠ R73), T71 (= T74), G72 (≠ A75), T73 (≠ G76), G74 (≠ T77), G78 (= G81), V79 (≠ Q82), L90 (≠ S93), P132 (≠ S136), G133 (≠ T137), A134 (= A138), G140 (= G145), M141 (= M146), A143 (≠ G148), T144 (≠ N149), A146 (≠ S151), S147 (≠ C152), E200 (= E263), G201 (= G264), I206 (≠ T269), H369 (= H444), E413 (= E488), N450 (= N525)
- binding deaminohydroxyvaline: R319 (= R391), H414 (= H489)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
22% identity, 53% coverage: 8:530/982 of query aligns to 2:465/465 of 3pm9A
- active site: A149 (≠ S151), L159 (≠ S161)
- binding flavin-adenine dinucleotide: P69 (= P72), Q70 (≠ R73), G71 (≠ T74), G72 (≠ A75), N73 (≠ G76), T74 (= T77), G75 (≠ S78), L76 (= L79), G79 (= G81), Q80 (= Q82), L91 (≠ S93), L133 (≠ T135), G134 (≠ S136), A135 (≠ T137), C139 (≠ A141), T140 (≠ M142), G142 (= G144), G143 (= G145), S146 (≠ G148), T147 (≠ N149), A149 (≠ S151), G150 (≠ C152), E200 (= E263), G201 (= G264), I205 (≠ F268), I206 (≠ T269), E423 (= E488)
P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
21% identity, 50% coverage: 40:530/982 of query aligns to 64:496/496 of P39976
Sites not aligning to the query:
- 17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
24% identity, 54% coverage: 1:529/982 of query aligns to 1:455/459 of P9WIT1
- K354 (≠ D423) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
21% identity, 49% coverage: 50:532/982 of query aligns to 53:466/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R391), T337 (≠ L395), K348 (≠ I411), Y379 (= Y442), H381 (= H444), H388 (= H451), H423 (= H489)
- binding flavin-adenine dinucleotide: P75 (= P72), Q76 (≠ R73), G77 (≠ T74), G78 (≠ A75), N79 (≠ G76), T80 (= T77), G81 (≠ S78), M82 (≠ L79), G85 (≠ Q82), S86 (≠ C83), L139 (≠ T135), G140 (≠ S136), A141 (≠ T137), C145 (≠ A141), G149 (= G145), N150 (≠ M146), A152 (≠ G148), T153 (≠ N149), G157 (= G153), G207 (= G264), I212 (≠ T269), E422 (= E488), N459 (= N525)
- binding zinc ion: H381 (= H444), H388 (= H451), E422 (= E488)
Sites not aligning to the query:
Query Sequence
>Echvi_3865 FitnessBrowser__Cola:Echvi_3865
MSNKPANLSPFLVGLAKELEGDFYYDQLMKTLYATDASVYREMPLAVAMPKTKGDIKKLI
HFANTHKTSLIPRTAGTSLAGQCVGDGIVVDVSKYFTKILEFNKEEGWVRVQPGVVRDEL
NAFLKPHGYFFSPVTSTANRAMIGGMVGNNSCGTTSIIYGSTREHTLELQTILSDGSEVT
FRALSKAEFEEKKKLETLEGKLYREIYHELSQPEQQENIRKQFPKPSIQRRNTGYAVDYL
LETAVFSEHDTAFDFCKLLCGSEGTLAFTTEIKIHLDPLPAPKDVVVAAHFGTIHESMKA
TQLAMKHFPTACELMDKIILDCTKENIEQSKNRYFVEGDPEGILMVEFRDETEEGALGQA
QKMIDAMKAAGLGYAYPIITGERTKNVWTLRSAGLGLLANIPGDRKAVACIEDTAVDIDD
LADFIDEFGEIMKGFGQKPVHYAHAGAGEIHLRPILDLKKSEDVEDFYKITEAVAKLVKK
YDGSLSGEHGDGRVRAAFIPIMVGEENYQLFRRIKQSWDPNAIFNPGKIVDTAPMNSFLR
YERDMVTPEFETTMDFGHVGGILRAAEKCNGSGDCRKLPVSGGTMCPSYMATKNERDTTR
GRANTLREFLTKNTQPNPFDHPEIKEVMDLCLSCKGCTSECPSNVDMSSLKAEFLHQYHK
THGIPLRSKAFAYINNLNELGSLVPGMTNFLMTNKATGNMMKKVLGVAEKRQLPTIAKVN
LRKWYNKHYGNLPAPSKKVGAVHFFCDEFTNFNDTEIGIKAIQLLHHLGYEVKLADHPES
GRGAISKGLLDRAKKLANQNVQLFKDKVTLDEPLVGVEPSAILTFKDEYPRLVDKYLVED
AKKLKRHSMMVDEFLAKEAMRGNISADQFTKAHKKVLLHGHCHQKSLSSVSFTQKLLTLP
ENYTLETIPSGCCGMAGSFGYEEEHYEVSMNVGELVLFPTIRKADKATVVAAPGTSCRHQ
IADGTGRKALHPVEVLFDAAGL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory