SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Echvi_4597 Echvi_4597 ribose-phosphate pyrophosphokinase to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A717 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Escherichia coli (strain K12) (see 4 papers)
50% identity, 100% coverage: 1:308/309 of query aligns to 1:313/315 of P0A717

query
sites
P0A717

M
|
M

P

P

E

D

V

M

K

K

L

L

F

F

A

A

G

G

T

N

N

A

T

T

K

P

K

E

L

L

A

A

D

Q

S

R

I

I

A

A

G

N

N

R

Y

L

G

Y

Q

T

D

S

L

L

G

G

A

D

M

A

T

A

L

V

S

G

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

S

P

V

S

Q

F

I

D

N

E

E

S

N

V

V

R

R

G

G

C

G

H

D

V

I

F

F

L

I

I

I

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

V

L

V

M

M

I

V

D

D

A

A

A

L

K

R

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R

R

Q

Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

F

I

L

M

S

S

S

A

V

G

G

A

V

D

D

R

R

I

V

M

L

T

T

C

V

D
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D

L

L

H

H

A

A

G

E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

V

P

P

L

V

D

D

H

N

L

V

N

F

G

G

S

S

A

P

I

I

F

L

V

L

P

E

Y

D

L

M

K

L

S

Q

L

L

D

N

L

L

G

-

D

D

N

N

L

P

I

I

F

V

A

V

S

S

P

P

D

D

V

I

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

I

A

A

K

K

H

L

F

L

-

N

E

D

V

T

D

D

M

M

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

P

R

R

A

A

N

N

E

V

V

S

A

Q

S

V

M

M

Q

H

V

I

I

I

G

G

D

D

V

V

E

A

G

G

K

R

D

D

V

C

V

V

L

L

V

V

D
|
D

L

M

V

I

D
|
D

T

T

A

G

G

G

T

T

M

L

C

C

K

K

A

A

E

E

I

A

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

R

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

I

L

F

S

S

G

G

K

N

A

A

Y

A

E

N

N

N

I

L

E

R

N

N

S

S

K

V

L

I

S

D

E

E

L

V

V

V

I

V

T

C

D

D

T

T

I

I

P

P

I

L

K

S

K

D

E

E

S

I

S

K

-

S

-

L

-

P

K

N

I

V

K

R

V

T

L

L

T

T

V

L

A

S

E

G

L

M

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

I

T

S

G

N

N

E

D

E

S

S

I

I

S

S

A

A

L

M

F

F

M1 (= M1) modified: Initiator methionine, Removed
D129 (= D127) to A: in mutant PRSA1; alters the binding of divalent cations, especially magnesium. Little alteration in the affinity for ribose 5-phosphate and 27-fold decrease of the affinity for ATP. Absence of inhibition by AMP
D220 (= D218) mutation to E: 4-fold decrease in the affinity binding for Rib-5-P in the presence of magnesium ions. In the presence of cobalt ions, it shows a 15-fold decrease in the affinity binding for Rib-5-P.; mutation to F: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.
D221 (= D219) mutation to A: The affinity binding for ATP is comparable to those of the wild-type, apart from a slight decrease in the presence of manganese ions. The affinity binding for Rib-5-P is greatly decreased in the presence of both manganese and cobalt ions but only about 2-fold in the presence of magnesium ions.
D224 (= D222) mutation to A: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.; mutation to S: With magnesium or manganese ions, the affinity binding values for ATP and Rib-5-P are comparable to those of the wild-type.

6asvC E. Coli prpp synthetase (see paper)
50% identity, 99% coverage: 3:308/309 of query aligns to 1:311/311 of 6asvC

query
sites
6asvC

E

D

V

M

K

K

L

L

F

F

A

A

G

G

T

N

N

A

T

T

K

P

K

E

L

L

A

A

D

Q

S

R

I

I

A

A

G

N

N

R

Y

L

G

Y

Q

T

D

S

L

L

G

G

A

D

M

A

T

A

L

V

S

G

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

S

P

V

S

Q

F

I

D

N

E

E

S

N

V

V

R

R

G

G

C

G

H

D

V

I

F

F

L

I

I

I

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

V

L

V

M

M

I

V

D

D

A

A

A

L

K

R

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R

R

Q

Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

F

I

L

M

S

S

S

A

V

G

G

A

V

D

D

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H

H

A

A

G

E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

V

P

P

L

V

D

D

H

N

L

V

N

F

G

G

S

S

A

P

I

I

F

L

V

L

P

E

Y

D

L

M

K

L

S

Q

L

L

D

N

L

L

G

-

D

D

N

N

L

P

I

I

F

V

A

V

S

S

P

P

D
|
D

V

I

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

I

A

A

K

K

H

L

F

L

-

N

E

D

V

T

D

D

M

M

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

P

R

R

A

A

N

N

E

V

V

S

A

Q

S

V

M

M

Q

H

V

I

I

I

G

G

D

D

V

V

E

A

G

G

K

R

D

D

V

C

V

V

L

L

V

V

D
|
D

L

M

V

I

D
|
D

T
|
T

A
x
G

G

G

T
|
T

M
x
L

C

C

K

K

A

A

E

E

I

A

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

R

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

I

L

F

S

S

G

G

K

N

A

A

Y

A

E

N

N

N

I

L

E

R

N

N

S

S

K

V

L

I

S

D

E

E

L

V

V

V

I

V

T

C

D

D

T

T

I

I

P

P

I

L

K

S

K

D

E

E

S

I

S

K

-

S

-

L

-

P

K

N

I

V

K

R

V

T

L

L

T

T

V

L

A

S

E

G

L

M

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

I

T

S

G

N

N

E

D

E

S

S

I

I

S

S

A

A

L

M

F

F

binding phosphate ion: D168 (= D169), D218 (= D218), D219 (= D219), D222 (= D222), T223 (= T223), G224 (≠ A224), T226 (= T226), L227 (≠ M227)

4s2uA Crystal structure of the phosphorybosylpyrophosphate synthetase from e. Coli
50% identity, 98% coverage: 2:304/309 of query aligns to 1:308/308 of 4s2uA

query
sites
4s2uA

P

P

E

D

V

M

K

K

L

L

F

F

A

A

G

G

T

N

N

A

T

T

K

P

K

E

L

L

A

A

D

Q

S

R

I

I

A

A

G

N

N

R

Y

L

G

Y

Q

T

D

S

L

L

G

G

A

D

M

A

T

A

L

V

S

G

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

S

P

V

S

Q

F

I

D

N

E

E

S

N

V

V

R

R

G

G

C

G

H

D

V

I

F

F

L

I

I

I

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

V

L

V

M

M

I

V

D

D

A

A

A

L

K

R

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R

R

Q

Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

F

I

L

M

S

S

S

A

V

G

G

A

V

D

D

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H

H

A

A

G

E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

V

P

P

L

V

D

D

H

N

L

V

N

F

G

G

S

S

A

P

I

I

F

L

V

L

P

E

Y

D

L

M

K

L

S

Q

L

L

D

N

L

L

G

-

D

D

N

N

L

P

I

I

F

V

A

V

S

S

P

P

D

D

V

I

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

I

A

A

K

K

H

L

F

L

-

N

E

D

V

T

D

D

M

M

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

P

R

R

A

A

N

N

E

V

V

S

A

Q

S

V

M

M

Q

H

V

I

I

I

G

G

D

D

V

V

E

A

G

G

K

R

D

D

V

C

V

V

L

L

V

V

D

D

L

M

V

I

D
|
D

T

T

A

G

G

G

T
|
T

M

L

C

C

K

K

A

A

E

E

I

A

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

R

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

I

L

F

S

S

G

G

K

N

A

A

Y

A

E

N

N

N

I

L

E

R

N

N

S

S

K

V

L

I

S

D

E

E

L

V

V

V

I

V

T

C

D

D

T

T

I

I

P

P

I

L

K

S

K

D

E

E

S

I

S

K

-

S

-

L

-

P

K

N

I

V

K

R

V

T

L

L

T

T

V

L

A

S

E

G

L

M

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

I

T

S

G

N

N

E

D

E

S

S

I

I

binding magnesium ion: D223 (= D222), T227 (= T226)

7xmvA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a(amp/adp) filament bound with adp, amp and r5p (see paper)
49% identity, 99% coverage: 3:308/309 of query aligns to 1:305/307 of 7xmvA

query
sites
7xmvA

E

D

V

M

K

K

L

L

F

F

A

A

G

G

T

N

N

A

T

T

K

P

K

E

L

L

A

A

D

Q

S

R

I

I

A

A

G

N

N

R

Y

L

G

Y

Q

T

D

S

L

L

G

G

A

D

M

A

T

A

L

V

S

G

M

R

F
|
F

S

S

D
|
D

G

G

E
|
E

M

V

S

S

P

V

S

Q

F

I

D

N

E

E

S

N

V

V

R

R

G

G

C

G

H

D

V

I

F

F

L

I

I

I

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

V

L

V

M

M

I

V

D

D

A

A

A

L

K

R

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q

Q

D

D

R
|
R

K

R

D
x
V

R
|
R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

F

I

L

M

S

S

S

A

V

G

G

A

V

D

D

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H
|
H

A

A

G
x
E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

V

P

P

L

V

D

D

H

N

L

V

N
x
F

G

G

S
|
S

A

P

I

I

F

L

V

L

P

E

Y

D

L

M

K

L

S

Q

L

L

D

N

L

L

G

-

D

D

N

N

L

P

I

I

F

V

A

V

S

S

P

P

D

D

V

I

G

G

V

V

S
x
V

R

R

A

A

R

R

A
|
A

Y

I

A

A

K

K

H

L

F

L

-

N

E

D

V

T

D

D

M

M

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

Q

R

-

A

-

N

-

E

-

V

-

A

-

S

V

M

M

Q

H

V

I

I

I

G

G

D

D

V

V

E

A

G

G

K

R

D

D

V

C

V

V

L

L

V

V

D
|
D

L
x
M

V

I

D
|
D

T
|
T

A

G

G
|
G

T
|
T

M

L

C

C

K

K

A

A

E

E

I

A

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

R

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

I

L

F

S

S

G

G

K

N

A

A

Y

A

E

N

N

N

I

L

E

R

N

N

S

S

K

V

L

I

S

D

E

E

L

V

V

V

I

V

T

C

D

D

T

T

I

I

P

P

I

L

K

S

K

D

E

E

S

I

S

K

-

S

-

L

-

P

K

N

I

V

K

R

V

T

L

L

T

T

V

L

A

S

E

G

L

M

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

I

T

S

G

N

N

E

D

E

S

S

I

I

S

S

A

A

L

M

F

F

binding adenosine-5'-diphosphate: F33 (= F35), D35 (= D37), E37 (= E39), R94 (= R95), R97 (= R98), H129 (= H129)
binding adenosine monophosphate: R97 (= R98), V99 (≠ D100), R100 (= R101), E131 (≠ G131), F145 (≠ N145), S147 (= S147), V173 (≠ S174), A177 (= A178)
binding 5-O-phosphono-alpha-D-ribofuranose: D212 (= D218), D213 (= D219), M214 (≠ L220), D216 (= D222), T217 (= T223), G219 (= G225), T220 (= T226)

7xmuA E.Coli phosphoribosylpyrophosphate (prpp) synthetase type a filament bound with adp, pi and r5p (see paper)
49% identity, 99% coverage: 3:308/309 of query aligns to 1:305/307 of 7xmuA

query
sites
7xmuA

E

D

V

M

K

K

L

L

F

F

A

A

G

G

T

N

N

A

T

T

K

P

K

E

L

L

A

A

D

Q

S

R

I

I

A

A

G

N

N

R

Y

L

G

Y

Q

T

D

S

L

L

G

G

A

D

M

A

T

A

L

V

S

G

M

R

F
|
F

S

S

D
|
D

G

G

E
|
E

M

V

S

S

P

V

S

Q

F

I

D

N

E

E

S

N

V

V

R

R

G

G

C

G

H

D

V

I

F

F

L

I

I

I

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

V

L

V

M

M

I

V

D

D

A

A

A

L

K

R

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

R

D

V

R
|
R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

F

I

L

M

S

S

S

A

V

G

G

A

V

D

D

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H
|
H

A

A

G
x
E

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

V

P

P

L

V

D

D

H

N

L

V

N
x
F

G

G

S
|
S

A

P

I

I

F

L

V

L

P

E

Y

D

L

M

K

L

S

Q

L

L

D

N

L

L

G

-

D

D

N

N

L

P

I

I

F

V

A

V

S

S

P

P

D
|
D

V

I

G

G

V

V

S
x
V

R

R

A

A

R

R

A

A

Y

I

A

A

K

K

H

L

F

L

-

N

E

D

V

T

D

D

M

M

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

Q

R

-

A

-

N

-

E

-

V

-

A

-

S

V

M

M

Q

H

V

I

I

I

G

G

D

D

V

V

E

A

G

G

K

R

D

D

V

C

V

V

L

L

V

V

D
|
D

D

D

L
x
M

V

I

D
|
D

T
|
T

A

G

G

G

T

T

M

L

C

C

K

K

A

A

E

E

I

A

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

R

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

I

L

F

S

S

G

G

K

N

A

A

Y

A

E

N

N

N

I

L

E

R

N

N

S

S

K

V

L

I

S

D

E

E

L

V

V

V

I

V

T

C

D

D

T

T

I

I

P

P

I

L

K

S

K

D

E

E

S

I

S

K

-

S

-

L

-

P

K

N

I

V

K

R

V

T

L

L

T

T

V

L

A

S

E

G

L

M

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

I

T

S

G

N

N

E

D

E

S

S

I

I

S

S

A

A

L

M

F

F

binding adenosine-5'-diphosphate: F33 (= F35), D35 (= D37), E37 (= E39), R94 (= R95), Q95 (= Q96), R97 (= R98), R97 (= R98), R100 (= R101), H129 (= H129), E131 (≠ G131), F145 (≠ N145), S147 (= S147), V173 (≠ S174)
binding 5-O-phosphono-alpha-D-ribofuranose: D168 (= D169), D212 (= D218), M214 (≠ L220), D216 (= D222), T217 (= T223)

Q63XL8 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Burkholderia pseudomallei (strain K96243) (see paper)
49% identity, 98% coverage: 6:308/309 of query aligns to 9:315/318 of Q63XL8

query
sites
Q63XL8

L

V

F

F

A

T

G

G

T

N

N

A

T

N

K

P

K

A

L

L

A

A

D

Q

S

E

I

V

A

V

G

K

N

I

Y

L

G

G

Q

I

D

P

L

L

G

G

A

K

M

A

T

M

L

V

S

S

M

R

F

F

S

S

D

D

G

G

E

E

M

I

S

Q

P

V

S

E

F

I

D

Q

E

E

S

N

V

V

R

R

G

G

C

K

H

D

V

V

F

F

L

V

I

L

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

M

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

A

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

R

D

P

R

R

P

S

-

A

R

R

V

V

S

A

I

I

A

S

A

A

K

K

L

V

I

V

A

A

N

N

M

M

I

L

M

E

S

I

A

A

G

G

A

V

D

E

R

R

I

I

M

I

T

T

C

M

D

D

L

L

H

H

A

A

G

D

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

V

D

D

H

N

L

I

N

Y

G

A

S

T

A

P

I

I

F

L

V

L

P

G

Y

D

L

L

K

R

S

K

L

Q

D

N

L

Y

G

P

D

D

N

-

L

L

I

L

F

V

A

V

S

S

P

P

D

D

V

V

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

L

A

A

K

K

H

Q

F

L

E

N

V

C

D

D

M

L

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

P

R

K

A

A

N

N

E

V

V

A

A

E

S

V

M

M

Q

N

V

I

I

I

G

G

D

E

V

V

E

E

G

G

K

R

D

T

V

C

V

V

L

I

V

M

D

D

L

M

V

V

D

D

T

T

A

A

G

G

T

T

M

L

C

C

K

K

A

A

E

Q

I

V

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

Q

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

G

A

A

Y

A

E

D

N

R

I

I

E

A

N

A

S

S

K

A

L

L

S

D

E

E

L

L

V

V

I

V

T

T

D

D

T

T

I

I

P

P

I

L

K

S

K

A

E

E

S

S

-

L

-

A

-

C

S

P

K

K

I

I

K

R

V

A

L

L

T

S

V

S

A

A

E

G

L

L

F

L

A

A

K

E

A

T

I

F

H

S

A

R

V

I

T

R

G

R

N

G

D

D

S

S

I

V

S

M

A

S

L

L

F

F

RQ 99:100 (= RQ 95:96) binding

P14193 Ribose-phosphate pyrophosphokinase; RPPK; 5-phospho-D-ribosyl alpha-1-diphosphate synthase; Phosphoribosyl diphosphate synthase; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PPRibP synthase; PRPP synthase; PRPPase; EC 2.7.6.1 from Bacillus subtilis (strain 168) (see 4 papers)
47% identity, 99% coverage: 4:308/309 of query aligns to 10:316/317 of P14193

query
sites
P14193

V

L

K

K

L

I

F

F

A

S

G

L

T

N

N

S

T

N

K

P

K

E

L

L

A

A

D

K

S

E

I

I

A

A

G

D

N

I

Y

V

G

G

Q

V

D

Q

L

L

G

G

A

K

M

C

T

S

L

V

S

T

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

Q

P

I

S

N

F

I

D

E

E

E

S

S

V

I

R

R

G

G

C

C

H

D

V

C

F

Y

L

I

I

I

Q

Q

S

S

T

T

-

S

N

D

P

P

N

V

A

N

D

E

N

H

L

I

L

M

E

E

L

L

C

L

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

K

K

T

V

I

C

N

A

I

V

V

V

I

P

P

Y

Y

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

K

D

A

R

R

P

S

R

R

V

E

S

P

I

I

A

T

A

A

K

K

L

L

I

F

A

A

N

N

M

L

I

L

M

E

S

T

A

A

G

G

A

A

D

T

R

R

I

V

M

I

T

A

C

L

D

D

L

L

H

H

A

A

G

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

I

D

D

H

H

L

L

N

M

G

G

S

V

A

P

I

I

F

L

V

G

P

E

Y

Y

L

F

K

E

S

G

L

K

D

N

L

L

G

E

D

D

N

-

L

I

I

V

F

I

A

V

S

S

P

P

D

D

V

H

G

G

V

V

S

T

R

R

A

A

R

R

A

K

Y

L

A

A

K

D

H

R

F

L

E

K

V

A

D

P

M

I

V

A

V

I

C

I

D

D

K
|
K

H

R

R
|
R

K

P

R
|
R

A

P

N
|
N

E

V

V

A

A
x
E

S

V

M

M

Q

N

V

I

I

V

G

G

D

N

V

I

E

E

G

G

K

K

D

T

V

A

V

I

L

L

V

I

D

D

L

I

V

I

D
|
D

T
|
T

A
|
A

G
|
G

T
|
T

M

I

C

T

K

L

A

A

E

N

I

A

L

L

L

V

D

E

K

N

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

C

A

C

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

E

N

R

I

I

E

N

N

N

S

S

K

T

L

I

S

K

E

E

L

L

V

V

I

V

T

T

D

N

T

S

I

I

-

K

-

L

P

P

I

E

K

E

K

K

E

K

S

I

S

E

K

R

I

F

K

K

V

Q

L

L

T

S

V

V

A

G

E

P

L

L

F

L

A

A

K

E

A

A

I

I

H

I

A

R

V

V

T

H

G

E

N

Q

D

Q

S

S

I

V

S

S

A

Y

L

L

F

F

RQ 102:103 (= RQ 95:96) binding
K198 (= K192) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type. The cooperativity of ADP binding is reduced.
R200 (= R194) mutation to A: Strong decrease of the Vmax value compared to that of the wild-type enzyme. The affinity binding for ATP and Rib-5-P are slightly altered compared to the wild-type.
R202 (= R196) mutation to A: 3-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
N204 (= N198) mutation to A: 4.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
E207 (≠ A201) mutation to A: 2.5-fold decrease in the affinity binding for ATP. Slight decrease of the Vmax value.
DTAGT 228:232 (= DTAGT 222:226) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

3dahC 2.3 a crystal structure of ribose-phosphate pyrophosphokinase from burkholderia pseudomallei (see paper)
49% identity, 97% coverage: 6:304/309 of query aligns to 4:299/300 of 3dahC

query
sites
3dahC

L

V

F

F

A

T

G

G

T

N

N

A

T

N

K

P

K

A

L

L

A

A

D

Q

S

E

I

V

A

V

G

K

N

I

Y

L

G

G

Q

I

D

P

L

L

G

G

A

K

M

A

T

M

L

V

S

S

M

R

F
|
F

S

S

D
|
D

G

G

E
|
E

M

I

S

Q

P

V

S

E

F

I

D

Q

E

E

S

N

V

V

R

R

G

G

C

K

H

D

V

V

F

F

L

V

I

L

Q

Q

S

S

T

T

-

C

N

A

P

P

N

T

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

M

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

A

V

I

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

R

D

P

R

R

P

S

-

A

R

R

V

V

S

A

I

I

A

S

A

A

K

K

L

V

I

V

A

A

N

N

M

M

I

L

M

E

S

I

A

A

G

G

A

V

D

E

R

R

I

I

M

I

T

T

C

M

D

D

L

L

H

H

A

A

G

D

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

V

D

D

H

N

L

I

N

Y

G

A

S

T

A

P

I

I

F

L

V

L

P

G

Y

D

L

L

K

R

S

K

L

Q

D

N

L

Y

G

P

D

D

N

-

L

L

I

L

F

V

A

V

S

S

P

P

D

D

V

V

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

L

A

A

K

K

H

Q

F

L

E

N

V

C

D

D

M

L

V

A

V

I

C

I

D

D

K

K

H

R

R

R

K

-

R

-

A

-

N

-

E

-

V

-

A

-

S

V

M

M

Q

N

V

I

I

I

G

G

D

E

V

V

E

E

G

G

K

R

D

T

V

C

V

V

L

I

V

M

D

D

L

M

V

V

D

D

T

T

A

A

G

G

T

T

M

L

C

C

K

K

A

A

E

Q

I

V

L

L

L

K

D

E

K

R

G

G

A

A

N

K

S

Q

V

V

R

F

A

A

I

Y

A

A

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

G

A

A

Y

A

E

D

N

R

I

I

E

A

N

A

S

S

K

A

L

L

S

D

E

E

L

L

V

V

I

V

T

T

D

D

T

T

I

I

P

P

I

L

K

S

K

A

E

E

S

S

-

L

-

A

-

C

S

P

K

K

I

I

K

R

V

A

L

L

T

S

V

S

A

A

E

G

L

L

F

L

A

A

K

E

A

T

I

F

H

S

A

R

V

I

T

R

G

R

N

G

D

D

S

S

I

V

binding adenosine monophosphate: F33 (= F35), D35 (= D37), E37 (= E39), R94 (= R95), Q95 (= Q96)

1dkuA Crystal structures of bacillus subtilis phosphoribosylpyrophosphate synthetase: molecular basis of allosteric inhibition and activation. (see paper)
46% identity, 99% coverage: 4:308/309 of query aligns to 2:295/295 of 1dkuA

query
sites
1dkuA

V

L

K

K

L

I

F

F

A

S

G

L

T

N

N

S

T

N

K

P

K

E

L

L

A

A

D

K

S

E

I

I

A

A

G

D

N

I

Y

V

G

G

Q

V

D

Q

L

L

G

G

A

K

M

C

T

S

L

V

S

T

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

Q

P

I

S

N

F

I

D

E

E

E

S

S

V

I

R

R

G

G

C

C

H

D

V

C

F

Y

L

I

I

I

Q

Q

S

S

T

T

-

S

N

D

P

P

N

V

A

N

D

E

N

H

L

I

L

M

E

E

L

L

C

L

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

K

K

T

V

I

C

N

A

I

V

V

V

I

P

P

Y

Y

G

G

Y

Y

A

A

R
|
R

Q

Q

D

D

R

R

K
|
K

D

A

R

R

P
x
S

R
|
R

V

E

S

P

I

I

A

T

A

A

K

K

L

L

I

F

A

A

N

N

M

L

I

L

M

E

S

T

A

A

G

G

A

A

D

T

R

R

I

V

M

I

T

A

C

L

D

D

L

L

H
|
H

A

A

G

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

I

D
|
D

H

H

L

L

N

M

G

G

S

V

A

P

I

I

F

L

V

G

P

E

Y

Y

L

F

K

E

S

G

L

K

D

N

L

L

G

E

D

D

N

-

L

I

I

V

F

I

A

V

S

S

P

P

D

D

V

H

G

G

V

V

S

T

R

R

A

A

R

R

A

K

Y

L

A

A

K

D

H

R

F

L

E

K

V

A

D

P

M

I

V

A

V

I

C

I

D

D

K

K

H

R

R

-

K

-

R

-

A

-

N

-

E

-

V

-

A

-

S

-

M

M

Q

N

V

I

I

V

G

G

D

N

V

I

E

E

G

G

K

K

D

T

V

A

V

I

L

L

V

I

D

D

L

I

V

I

D

D

T

T

A

A

G

G

T

T

M

I

C

T

K

L

A

A

E

N

I

A

L

L

L

V

D

E

K

N

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

C

A

C

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

E

N

R

I

I

E

N

N

N

S

S

K

T

L

I

S

K

E

E

L

L

V

V

I

V

T

T

D

N

T

S

I

I

P

K

I

L

K

K

K

I

E

E

S

-

K

R

I

F

K

K

V

Q

L

L

T

S

V

V

A

G

E

P

L

L

F

L

A

A

K

E

A

A

I

I

H

I

A

R

V

V

T

H

G

E

N

Q

D

Q

S
|
S

I
x
V

S
|
S

A

Y

L

L

F
|
F

binding methyl phosphonic acid adenosine ester: R94 (= R95), H128 (= H129)
binding phosphomethylphosphonic acid adenosyl ester: K98 (= K99), S101 (≠ P102), R102 (= R103), D141 (= D142), S290 (= S303), V291 (≠ I304), S292 (= S305), F295 (= F308)

1ibsA Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
45% identity, 99% coverage: 4:308/309 of query aligns to 2:297/297 of 1ibsA

query
sites
1ibsA

V

L

K

K

L

I

F

F

A

S

G

L

T

N

N

S

T

N

K

P

K

E

L

L

A

A

D

K

S

E

I

I

A

A

G

D

N

I

Y

V

G

G

Q

V

D

Q

L

L

G

G

A

K

M

C

T

S

L

V

S

T

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

Q

P

I

S

N

F

I

D

E

E

E

S

S

V

I

R

R

G

G

C

C

H

D

V

C

F

Y

L

I

I

I

Q

Q

S

S

T

T

-

S

N

D

P

P

N

V

A

N

D

E

N

H

L

I

L

M

E

E

L

L

C

L

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

K

K

T

V

I

C

N

A

I

V

V

V

I

P

P

Y

Y

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

K

D

S

R

R

P

E

R

-

V

-

S

P

I

I

A

T

A

A

K

K

L

L

I

F

A

A

N

N

M

L

I

L

M

E

S

T

A

A

G

G

A

A

D

T

R

R

I

V

M

I

T

A

C

L

D

D

L

L

H
|
H

A

A

G

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

I

D

D

H

H

L

L

N

M

G

G

S

V

A

P

I

I

F

L

V

G

P

E

Y

Y

L

F

K

E

S

G

L

K

D

N

L

L

G

E

D

D

N

-

L

I

I

V

F

I

A

V

S

S

P

P

D

D

V

H

G

G

V

V

S

T

R

R

A

A

R

R

A

K

Y

L

A

A

K

D

H

R

F

L

E

K

V

A

D

P

M

I

V

A

V

I

C

I

D

D

K

K

H

R

R

-

K

-

R

-

A

-

N

-

E

-

V

-

A

-

S

-

M

M

Q

N

V

I

I

V

G

G

D

N

V

I

E

E

G

G

K

K

D

T

V

A

V

I

L

L

V

I

D

D

L

I

V

I

D
|
D

T
|
T

A
|
A

G

G

T
|
T

M

I

C

T

K

L

A

A

E

N

I

A

L

L

L

V

D

E

K

N

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

C

A

C

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

E

N

R

I

I

E

N

N

N

S

S

K

T

L

I

S

K

E

E

L

L

V

V

I

V

T

T

D

N

T

S

I

I

-

K

-

L

P

P

I

E

K

E

K

K

E

K

S

I

S

E

K

R

I

F

K

K

V

Q

L

L

T

S

V

V

A

G

E

P

L

L

F

L

A

A

K

E

A

A

I

I

H

I

A

R

V

V

T

H

G

E

N

Q

D

Q

S

S

I

V

S

S

A

Y

L

L

F

F

binding methyl phosphonic acid adenosine ester: R94 (= R95), Q95 (= Q96), R97 (= R98), H126 (= H129)
binding sulfate ion: D209 (= D222), T210 (= T223), A211 (= A224), T213 (= T226)

1ibsB Phosphoribosyldiphosphate synthetase in complex with cadmium ions (see paper)
45% identity, 99% coverage: 4:308/309 of query aligns to 4:299/299 of 1ibsB

query
sites
1ibsB

V

L

K

K

L

I

F

F

A

S

G

L

T

N

N

S

T

N

K

P

K

E

L

L

A

A

D

K

S

E

I

I

A

A

G

D

N

I

Y

V

G

G

Q

V

D

Q

L

L

G

G

A

K

M

C

T

S

L

V

S

T

M

R

F

F

S

S

D

D

G

G

E

E

M

V

S

Q

P

I

S

N

F

I

D

E

E

E

S

S

V

I

R

R

G

G

C

C

H

D

V

C

F

Y

L

I

I

I

Q

Q

S

S

T

T

-

S

N

D

P

P

N

V

A

N

D

E

N

H

L

I

L

M

E

E

L

L

C

L

L

I

M

M

I

V

D

D

A

A

A

L

K

K

R

R

A

A

S

S

A

A

Y

K

K

T

V

I

C

N

A

I

V

V

V

I

P

P

Y

Y

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

K

D

S

R

R

P

E

R

-

V

-

S

P

I

I

A

T

A

A

K

K

L

L

I

F

A

A

N

N

M

L

I

L

M

E

S

T

A

A

G

G

A

A

D

T

R

R

I

V

M

I

T

A

C

L

D

D

L

L

H

H

A

A

G

P

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

I

D

D

H

H

L

L

N

M

G

G

S

V

A

P

I

I

F

L

V

G

P

E

Y

Y

L

F

K

E

S

G

L

K

D

N

L

L

G

E

D

D

N

-

L

I

I

V

F

I

A

V

S

S

P

P

D

D

V

H

G

G

V

V

S

T

R

R

A

A

R

R

A

K

Y

L

A

A

K

D

H

R

F

L

E

K

V

A

D

P

M

I

V

A

V

I

C

I

D

D

K

K

H

R

R

-

K

-

R

-

A

-

N

-

E

-

V

-

A

-

S

-

M

M

Q

N

V

I

I

V

G

G

D

N

V

I

E

E

G

G

K

K

D

T

V

A

V

I

L

L

V

I

D

D

L

I

V

I

D

D

T

T

A

A

G

G

T

T

M

I

C

T

K

L

A

A

E

N

I

A

L

L

L

V

D

E

K

N

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

C

A

C

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

E

N

R

I

I

E

N

N

N

S

S

K

T

L

I

S

K

E

E

L

L

V

V

I

V

T

T

D

N

T

S

I

I

-

K

-

L

P

P

I

E

K

E

K

K

E

K

S

I

S

E

K

R

I

F

K

K

V

Q

L

L

T

S

V

V

A

G

E

P

L

L

F

L

A

A

K

E

A

A

I

I

H

I

A

R

V

V

T

H

G

E

N

Q

D

Q

S

S

I

V

S

S

A

Y

L

L

F

F

binding methyl phosphonic acid adenosine ester: R96 (= R95), Q97 (= Q96), R99 (= R98)

P60891 Ribose-phosphate pyrophosphokinase 1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I; EC 2.7.6.1 from Homo sapiens (Human) (see 5 papers)
44% identity, 100% coverage: 1:308/309 of query aligns to 1:313/318 of P60891

query
sites
P60891

M
|
M

P

P

E

N

V

I

K

K

L

I

F

F

A

S

G

G

T

S

N

S

T

H

K

Q

K

D

L

L

A
x
S

D

Q

S

K

I

I

A

A

G

D

N

R

Y

L

G

G

Q

L

D

E

L

L

G

G

A

K

M

V

T

V

L

T

S

K

M

K

F

F

S

S

D

N

G

Q

E

E

M

T

S

C

P

V

S

E

F

I

D

G

E

E

S

S

V

V

R

R

G

G

C

E

H
x
D

V

V

F

Y

L

I

I

V

Q

Q

S

S

-

G

T

C

N

G

P

E

N

I

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

I

D

N

A

A

A

C

K

K

R

I

A

A

S

S

A

A

Y

S

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

C

Y

F

G

P

Y

Y

A

A

R

R

Q

Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

S

P

I

I

A

S

A

A

K

K

L

L

I

V

A

A

N
|
N

M

M

I

L

M

S

S

V

A

A

G

G

A

A

D

D

R

H

I

I

M

I

T

T

C

M

D

D

L
|
L

H

H

A

A

G
x
S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L
x
V

D

D

H
x
N

L

L

N
x
Y

G

A

S

E

A

P

I

A

F

V

V

L

P

K

Y

W

L

I

K

R

-

E

S

N

L

I

D

S

L

E

G

W

D

R

N

N

L

C

I

T

F

I

A

V

S

S

P

P

D

D

V

A

G

G

V

A

S

K

R

R

A

V

R

T

A

S

Y

I

A

A

K
x
D

H

R

F

L

E

N

V

V

D

D

M

F

V
x
A

V

L

C

I

D
x
H

K

K

H

E

R

R

K

K

R

K

A

A

N

N

E

E

V

V

A
x
D

S

R

M

M

Q

V

V

L

I

V

G

G

D

D

V

V

E

K

G

D

K

R

D

V

V

A

V

I

L

L

V
|
V

D

D

L

M

V

A

D

D

T

T

A

C

G

G

T

T

M

I

C

C

K
x
H

A

A

E

D

I

K

L

L

D

S

K

A

G

G

A

A

N

T

S

R

V

V

R

Y

A

A

I

I

A

L

T

T

H

H

G

G

V

I

L

F

S

S

G

G

K

P

A

A

Y

I

E

S

N

R

I

I

E

N

N

N

S

A

K

C

L

F

S

E

E

A

L

V

V

V

I

V

T

T

D

N

T

T

I

I

P

P

I

Q

K

E

-

D

-

K

-

M

K

K

E

H

S

C

S

S

K

K

I

I

K

Q

V

V

L

I

T

D

V

I

A

S

E

M

L

I

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

T

T

H

G

N

N

G

D

E

S

S

I

V

S

S

A

Y

L

L

F

F

M1 (= M1) modified: Initiator methionine, Removed
S16 (≠ A16) to P: found in patients with phosphoribosyl pyrophosphate synthetase I deficiency; likely pathogenic; dbSNP:rs869025594
D52 (≠ H52) to H: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852542
N114 (= N113) to S: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852540
L129 (= L128) to I: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852543
S132 (≠ G131) mutation to A: Reduces catalytic activity.; mutation to F: No effect on catalytic activity.
V142 (≠ L141) to L: found in a patient with an intermediate phenotype between ARTS and PRPS1 superactivity; likely pathogenic; normal PRPP synthetase activity in fibroblasts; loss of activity in erythrocytes; dbSNP:rs398122855
N144 (≠ H143) mutation to H: No effect on catalytic activity.
Y146 (≠ N145) mutation to F: No effect on catalytic activity.; mutation to M: Reduces catalytic activity.
D183 (≠ K181) to H: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852541
A190 (≠ V188) to V: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852544
H193 (≠ D191) to Q: in PRPS1 superactivity; no effect on Km; resistant to inhibition by ADP and GDP; dbSNP:rs137852545
D203 (≠ A201) to H: in a breast cancer sample; somatic mutation
V219 (= V217) to G: in a breast cancer sample; somatic mutation
H231 (≠ K229) to D: in a colorectal cancer sample; somatic mutation

8dbkB Human prps1 with phosphate, atp, and r5p; hexamer with resolved catalytic loops (see paper)
44% identity, 99% coverage: 2:308/309 of query aligns to 1:312/316 of 8dbkB

query
sites
8dbkB

P

P

E

N

V

I

K

K

L

I

F

F

A

S

G

G

T

S

N

S

T

H

K

Q

K

D

L

L

A

S

D

Q

S

K

I

I

A

A

G

D

N

R

Y

L

G

G

Q

L

D

E

L

L

G

G

A

K

M

V

T

V

L

T

S

K

M

K

F
|
F

S

S

D
x
N

G

Q

E
|
E

M

T

S

C

P

V

S

E

F

I

D

G

E

E

S
|
S

V

V

R
|
R

G

G

C

E

H

D

V

V

F

Y

L

I

I

V

Q

Q

S

S

-

G

T

C

N

G

P

E

N

I

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

I

D

N

A

A

A

C

K

K

R

I

A

A

S

S

A

A

Y

S

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

C

Y

F

G

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

S

P

I

I

A

S

A

A

K

K

L

L

I

V

A

A

N

N

M

M

I

L

M

S

S

V

A

A

G

G

A

A

D

D

R

H

I

I

M

I

T

T

C

M

D

D

L

L

H
|
H

A

A

G

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

V

D

D

H

N

L

L

N

Y

G

A

S

E

A

P

I

A

F

V

V

L

P

K

Y

W

L

I

K

R

-

E

S

N

L

I

D

S

L

E

G

W

D

R

N

N

L

C

I

T

F

I

A

V

S

S

P

P

D
|
D

V

A

G
|
G

G

G

V

A

S

K

R

R

A

V

R

T

A

S

Y

I

A

A

K

D

H

R

F

L

E

N

V

V

D

D

M

F

V

A

V

L

C

I

D

H

K
|
K

H

E

R
|
R

K

K

R

K

A

A

N
|
N

E

E

V

V

A

D

S

R

M

M

Q

V

V

L

I

V

G

G

D

D

V

V

E

K

G

D

K

R

D

V

V

A

V

I

L

L

V

V

D
|
D

L

M

V

A

D
|
D

T
|
T

A
x
C

G
|
G

T
|
T

M

I

C

C

K

H

A

A

E

D

I

K

L

L

D

S

K

A

G

G

A

A

N

T

S

R

V

V

R

Y

A

A

I

I

A

L

T

T

H

H

G

G

V

I

L

F

S

S

G

G

K

P

A

A

Y

I

E

S

N

R

I

I

E

N

N

N

S

A

K

C

L

F

S

E

E

A

L

V

V

V

I

V

T

T

D

N

T

T

I

I

P

P

I

Q

K

E

-

D

-

K

-

M

K

K

E

H

S

C

S

S

K

K

I

I

K

Q

V

V

L

I

T

D

V

I

A

S

E

M

L

I

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

T

T

H

G

N

N

G

D

E

S

S

I

V

S

S

A

Y

L

L

F

F

binding adenosine monophosphate: R95 (= R95), Q96 (= Q96), N199 (= N198)
binding adenosine-5'-triphosphate: F34 (= F35), N36 (≠ D37), E38 (= E39)
binding phosphate ion: S46 (= S47), R48 (= R49)
binding 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose: H129 (= H129), D170 (= D169), G172 (= G171), K193 (= K192), R195 (= R194), D219 (= D218), D220 (= D219), D223 (= D222), T224 (= T223), C225 (≠ A224), G226 (= G225), T227 (= T226)

8dbeA Human prps1 with adp; hexamer (see paper)
44% identity, 99% coverage: 2:308/309 of query aligns to 1:312/316 of 8dbeA

query
sites
8dbeA

P

P

E

N

V

I

K

K

L

I

F

F

A

S

G

G

T

S

N

S

T

H

K

Q

K

D

L

L

A

S

D

Q

S

K

I

I

A

A

G

D

N

R

Y

L

G

G

Q

L

D

E

L

L

G

G

A

K

M

V

T

V

L

T

S

K

M

K

F
|
F

S

S

D
x
N

G

Q

E
|
E

M

T

S

C

P

V

S

E

F

I

D

G

E

E

S

S

V

V

R

R

G

G

C

E

H

D

V

V

F

Y

L

I

I

V

Q

Q

S

S

-

G

T

C

N

G

P

E

N

I

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

I

D

N

A

A

A

C

K

K

R

I

A

A

S

S

A

A

Y

S

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

C

Y

F

G

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
x
K

K
|
K

D
|
D

R

K

P
x
S

R
|
R

V

A

S

P

I

I

A

S

A

A

K

K

L

L

I

V

A

A

N

N

M

M

I

L

M

S

S

V

A

A

G

G

A

A

D

D

R

H

I

I

M

I

T

T

C

M

D

D

L

L

H
|
H

A

A

G

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

V

D
|
D

H

N

L

L

N
x
Y

G

A

S

E

A

P

I

A

F

V

V

L

P

K

Y

W

L

I

K

R

-

E

S

N

L

I

D

S

L

E

G

W

D

R

N

N

L

C

I

T

F

I

A

V

S

S

P

P

D
|
D

V

A

G

G

V

A

S

K

R

R

A

V

R

T

A

S

Y

I

A

A

K

D

H

R

F

L

E

N

V

V

D

D

M

F

V

A

V

L

C

I

D

H

K

K

H

E

R

R

K

K

R

K

A

A

N

N

E

E

V

V

A

D

S

R

M

M

Q

V

V

L

I

V

G

G

D

D

V

V

E

K

G

D

K

R

D

V

V

A

V

I

L

L

V

V

D
|
D

L

M

V

A

D
|
D

T
|
T

A

C

G
|
G

T
|
T

M

I

C

C

K

H

A

A

E

D

I

K

L

L

D

S

K

A

G

G

A

A

N

T

S

R

V

V

R

Y

A

A

I

I

A

L

T

T

H

H

G

G

V

I

L

F

S

S

G

G

K

P

A

A

Y

I

E

S

N

R

I

I

E

N

N

N

S

A

K

C

L

F

S

E

E

A

L

V

V

V

I

V

T

T

D

N

T

T

I

I

P

P

I

Q

K

E

-

D

-

K

-

M

K

K

E

H

S

C

S

S

K

K

I

I

K

Q

V

V

L

I

T

D

V

I

A

S

E

M

L

I

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

T

T

H

G

N

N

G

D

E

S
|
S

I
x
V

S
|
S

A

Y

L

L

F
|
F

binding adenosine-5'-diphosphate: F34 (= F35), N36 (≠ D37), E38 (= E39), R95 (= R95), Q96 (= Q96), K98 (≠ R98), K99 (= K99), D100 (= D100), S102 (≠ P102), R103 (= R103), H129 (= H129), D142 (= D142), Y145 (≠ N145), S307 (= S303), V308 (≠ I304), S309 (= S305), F312 (= F308)
binding 5-O-phosphono-alpha-D-ribofuranose: H129 (= H129), D170 (= D169), D219 (= D218), D220 (= D219), D223 (= D222), T224 (= T223), G226 (= G225), T227 (= T226)

5t3oA Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus (see paper)
43% identity, 98% coverage: 6:308/309 of query aligns to 4:306/307 of 5t3oA

query
sites
5t3oA

L

I

F

F

A

S

G

G

T

Q

N

S

T

N

K

R

K

P

L

L

A

A

D

Q

S

A

I

I

A

A

G

E

N

A

Y

L

G

G

Q

L

D

P

L

L

G

G

A

K

M

S

T

T

L

T

S

L

M

R

F

F

S

A

D

N

G

D

E

N

M

L

S

F

P

V

S

R

F

Y

D

E

E

E

S
|
S

V

L

R
|
R

G

E

C

G

H

D

V

V

F

F

L

I

I

V

Q

Q

S

S

-

F

T

V

N

P

P

P

N

V

A

Q

D

D

N

H

L

L

L

M

E

E

L

L

C

L

L

M

M

M

I

V

D

D

A

A

K

K

R

G

A

A

S

S

A

A

Y

A

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

S

Y

Y

A

A

R
|
R

Q
x
S

D

D

R

K

K

K

D
|
D

R

A

P

P

R

R

V

I

S

S

I

I

A

T

A

A

K

R

L

L

I

I

A

A

N

D

M

L

I

L

M

Q

S

T

A

A

G

G

A

A

D

D

R

R

I

V

M

L

T

T

C

M

D

T

L

L

H
|
H

A

S

G

P

Q

Q

I

V

Q

H

G

G

F

F

D

K

I

I

P

P

L

V

D

D

H

H

L

L

N

S

G

A

S

E

A

P

I

V

F

I

V

A

P

N

Y

Y

L

F

K

A

S

T

-

R

L

V

D

D

L

L

G

-

D

E

N

N

L

A

I

V

F

V

A

V

S

A

P

P

D

D

V

A

G

G

G

D

V

L

S

K

R

R

A

A

R

S

A

A

Y

L

A

A

K

R

H

R

F

L

E

G

V

L

D

P

M

L

V

A

V

F

C

I

D

D

K

K

H

E

R
|
R

K

V

R

S

A

D

N

T

E

E

V

V

A

R

S

V

M

R

Q

M

V

L

I

V

G

G

D

E

V

V

E

E

G

G

K

K

D

T

V

A

V

L

L

I

V

V

D

D

L

E

V

I

D

S

T

T

A

A

G

G

T

S

M

L

C

V

K

E

A

A

A

V

E

E

I

A

L

L

L

M

D

Q

K

A

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

A

A

A

T

T

H

H

G

G

V

V

L

Y

S

V

G

G

K

P

A

A

Y

L

E

D

N

R

I

I

E

A

N

K

S

S

K

P

L

V

S

K

E

E

L

V

V

A

I

A

T

T

D

D

T

T

I

C

P

P

I

-

K

P

K

K

E

E

S

G

S

P

K

K

I

L

K

R

V

T

L

L

T

T

V

V

A

A

E

P

L

L

F

F

A

A

K

E

A

A

I

I

H

W

A

R

V

I

T

H

G

R

N

G

D

E

S

S

I

V

S

S

A

S

L

L

F

F

binding adenosine-5'-diphosphate: R94 (= R95), S95 (≠ Q96), D99 (= D100), H128 (= H129), R193 (= R194)
binding sulfate ion: S45 (= S47), R47 (= R49)

7pn0A Crystal structure of the phosphorybosylpyrophosphate synthetase ii from thermus thermophilus at r32 space group
43% identity, 98% coverage: 6:308/309 of query aligns to 5:307/312 of 7pn0A

query
sites
7pn0A

L

I

F

F

A

S

G

G

T

Q

N

S

T

N

K

R

K

P

L

L

A

A

D

Q

S

A

I

I

A

A

G

E

N

A

Y

L

G

G

Q

L

D

P

L

L

G

G

A

K

M

S

T

T

L

T

S

L

M

R

F

F

S

A

D

N

G

D

E

N

M

L

S

F

P

V

S

R

F

Y

D

E

E

E

S

S

V

L

R

R

G

E

C

G

H

D

V

V

F

F

L

I

I

V

Q

Q

S

S

-

F

T

V

N

P

P

P

N

V

A

Q

D

D

N

H

L

L

L

M

E

E

L

L

C

L

L

M

M

M

I

V

D

D

A

A

K

K

R

G

A

A

S

S

A

A

Y

A

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

Y

Y

F

G

S

Y

Y

A

A

R
|
R

Q
x
S

D

D

R

K

K

K

D

D

R

A

P

P

R

R

V

I

S

S

I

I

A

T

A

A

K

R

L

L

I

I

A

A

N

D

M

L

I

L

M

Q

S

T

A

A

G

G

A

A

D

D

R

R

I

V

M

L

T

T

C

M

D

T

L

L

H
|
H

A

S

G

P

Q

Q

I

V

Q

H

G

G

F

F

D

K

I

I

P

P

L

V

D

D

H

H

L

L

N

S

G

A

S

E

A

P

I

V

F

I

V

A

P

N

Y

Y

L

F

K

A

S

T

-

R

L

V

D

D

L

L

G

-

D

E

N

N

L

A

I

V

F

V

A

V

S

A

P

P

D

D

V

A

G

G

G

D

V

L

S

K

R

R

A

A

R

S

A

A

Y

L

A

A

K

R

H

R

F

L

E

G

V

L

D

P

M

L

V

A

V

F

C

I

D

D

K

K

H

E

R

R

K

V

R

S

A

D

N

T

E

E

V

V

A

R

S

V

M

R

Q

M

V

L

I

V

G

G

D

E

V

V

E

E

G

G

K

K

D

T

V

A

V

L

L

I

V

V

D

D

L

E

V

I

D

S

T

T

A

A

G

G

T

S

M

L

C

V

K

E

A

A

A

V

E

E

I

A

L

L

L

M

D

Q

K

A

G

G

A

A

N

K

S

E

V

V

R

Y

A

A

I

A

A

A

T

T

H

H

G

G

V

V

L

Y

S

V

G

G

K

P

A

A

Y

L

E

D

N

R

I

I

E

A

N

K

S

S

K

P

L

V

S

K

E

E

L

V

V

A

I

A

T

T

D

D

T

T

I

C

P

P

I

-

K

P

K

K

E

E

S

G

S

P

K

K

I

L

K

R

V

T

L

L

T

T

V

V

A

A

E

P

L

L

F

F

A

A

K

E

A

A

I

I

H

W

A

R

V

I

T

H

G

R

N

G

D

E

S

S

I

V

S

S

A

S

L

L

F

F

binding adenosine-5'-diphosphate: R95 (= R95), S96 (≠ Q96), H129 (= H129)

6nfeB Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
45% identity, 95% coverage: 6:298/309 of query aligns to 5:297/299 of 6nfeB

query
sites
6nfeB

L

I

F

F

A

T

G

G

T

N

N

A

T

N

K

P

K

E

L

L

A

A

D

L

S

K

I

I

A

S

G

S

N

H

Y

L

G

Q

Q

I

D

P

L

I

G

G

A

K

M

A

T

T

L

V

S

G

M

T

F
|
F

S

S

D
|
D

G

G

E
|
E

M

T

S

M

P

V

S

E

F

I

D

L

E

E

S

N

V

V

R

R

G

G

C

K

H

D

V

V

F

F

L

V

I

L

Q

Q

S

S

T

T

-

C

N

A

P

P

N

A

A

N

D

N

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

A

D

D

A

A

A

L

K

R

R

R

A

S

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R

R

K

R

D

V

R

R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

M

I

M

M

A

S

S

A

V

G

G

A

I

D

C

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H
|
H

A

A

G

D

Q

Q

I

I

Q

Q

G

G

F

F

D

Y

I

M

P

P

L

V

D

D

H

N

L

V

N

Y

G

S

S

T

A

P

I

V

F

L

V

L

P

E

Y

D

L

I

K

T

S

K

L

Q

D

K

L

L

G

-

D

N

N

N

L

I

I

M

F

I

A

V

S

S

P

P

D

D

V

V

G

G

V

V

S

V

R

R

A

A

R

R

A

A

Y

V

A

A

K

K

H

R

F

L

-

N

E

D

V

A

D

E

M

L

V

S

V

I

C

I

D

D

K

K

H

R

R

R

K

S

R

E

A

V

N

-

E

-

V

-

A

-

S

-

M

M

Q

H

V

I

I

I

G

G

D

E

V

P

E

A

G

N

K

K

D

N

V

C

V

I

L

I

V

V

D
|
D

L
x
I

V

V

D
|
D

T
|
T

A
|
A

G

G

T
|
T

M

L

C

C

K

T

A

A

E

H

I

E

L

L

L

K

D

K

K

N

G

G

A

A

N

K

S

S

V

V

R

R

A

A

I

Y

A

I

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

N

N

N

I

I

E

K

N

H

S

S

K

G

L

L

S

D

E

E

L

V

V

V

I

V

T

T

D

D

T

T

I

I

P

P

I

L

K

S

K

A

E

E

S

A

S

Q

-

N

-

C

-

E

K

K

I

I

K

R

V

V

L

V

T

S

V

L

A

A

E

D

L

M

F

L

A

A

K

Q

A

A

I

I

H

K

A

R

V

V

binding adenosine-5'-diphosphate: F34 (= F35), D36 (= D37), E38 (= E39), R95 (= R95), Q96 (= Q96), H130 (= H129)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H129), D214 (= D218), D215 (= D219), I216 (≠ L220), D218 (= D222), T219 (= T223), A220 (= A224), T222 (= T226)

6nfeA Crystal structure of ribose-phosphate pyrophosphokinase from legionella pneumophila with bound amp, adp, and ribose-5-phosphate
45% identity, 95% coverage: 6:298/309 of query aligns to 5:296/298 of 6nfeA

query
sites
6nfeA

L

I

F

F

A

T

G

G

T

N

N

A

T

N

K

P

K

E

L

L

A

A

D

L

S

K

I

I

A

S

G

S

N

H

Y

L

G

Q

Q

I

D

P

L

I

G

G

A

K

M

A

T

T

L

V

S

G

M

T

F
|
F

S

S

D
|
D

G

G

E
|
E

M

T

S

M

P

V

S

E

F

I

D

L

E

E

S

N

V

V

R

R

G

G

C

K

H

D

V

V

F

F

L

V

I

L

Q

Q

S

S

T

T

-

C

N

A

P

P

N

A

A

N

D

N

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

A

D

D

A

A

A

L

K

R

R

R

A

S

S

S

A

A

Y

G

K

R

V

I

C

T

A

A

V

V

P

P

Y

Y

Y

F

G

G

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
|
R

K

R

D
x
V

R

R

P

S

-

A

R

R

V

V

S

P

I

I

A

T

A

A

K

K

L

V

I

V

A

A

N

D

M

M

I

M

M

A

S

S

A

V

G

G

A

I

D

C

R

R

I

V

M

L

T

T

C

V

D

D

L

L

H
|
H

A

A

G

D

Q

Q

I

I

Q

Q

G

G

F

F

D

Y

I

M

P

P

L

V

D

D

H

N

L

V

N
x
Y

G

S

S

T

A

P

I

V

F

L

V

L

P

E

Y

D

L

I

K

T

S

K

L

Q

D

K

L

L

G

-

D

N

N

N

L

I

I

M

F

I

A

V

S

S

P

P

D

D

V

V

G

G

V

V

S

V

R
|
R

A

A

R

R

A
|
A

Y

V

A

A

K
|
K

H

R

F

L

-

N

E

D

V

A

D

E

M

L

V

S

V

I

C

I

D

D

K

K

H

R

R

R

K

E

R

-

A

-

N

-

E

-

V

-

A

-

S

V

M

M

Q

H

V

I

I

I

G

G

D

E

V

P

E

A

G

N

K

K

D

N

V

C

V

I

L

I

V

V

D
|
D

L
x
I

V

V

D
|
D

T
|
T

A
|
A

G

G

T
|
T

M

L

C

C

K

T

A

A

E

H

I

E

L

L

L

K

D

K

K

N

G

G

A

A

N

K

S

S

V

V

R

R

A

A

I

Y

A

I

T

T

H

H

G

P

V

V

L

L

S

S

G

G

K

P

A

A

Y

V

E

N

N

N

I

I

E

K

N

H

S

S

K

G

L

L

S

D

E

E

L

V

V

V

I

V

T

T

D

D

T

T

I

I

P

P

I

L

K

S

K

A

E

E

S

A

S

Q

-

N

-

C

-

E

K

K

I

I

K

R

V

V

L

V

T

S

V

L

A

A

E

D

L

M

F

L

A

A

K

Q

A

A

I

I

H

K

A

R

V

V

binding adenosine-5'-diphosphate: F34 (= F35), D36 (= D37), E38 (= E39), R95 (= R95), Q96 (= Q96), H130 (= H129)
binding adenosine monophosphate: R98 (= R98), V100 (≠ D100), Y146 (≠ N145), R175 (= R175), A178 (= A178), K181 (= K181)
binding 5-O-phosphono-alpha-D-ribofuranose: H130 (= H129), D213 (= D218), D214 (= D219), I215 (≠ L220), D217 (= D222), T218 (= T223), A219 (= A224), T221 (= T226)

O94413 Ribose-phosphate pyrophosphokinase 2; Phosphoribosyl pyrophosphate synthase 2; EC 2.7.6.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
41% identity, 99% coverage: 4:308/309 of query aligns to 6:316/321 of O94413

query
sites
O94413

V

I

K

K

L

I

F

F

A

A

G

G

T

N

N

S

T

H

K

P

K

E

L

L

A

A

D

E

S

K

I

V

A

A

G

R

N

R

Y

I

G

G

Q

L

D

S

L

L

G

G

A

K

M

V

T

A

L

V

S

V

M

Q

F

Y

S

S

D

N

G

R

E

E

M

T

S

S

P

V

S

T

F

I

D

G

E

E

S

S

V

V

R

R

G

D

C

E

H

D

V

V

F

F

L

I

I

L

Q

Q

S

T

-

G

T

C

N

G

P

S

N

I

A

N

D

D

N

H

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

I

D

N

A

A

A

C

K

R

R

S

A

A

S

S

A

A

Y

R

K

R

V

I

C

T

A

A

V

I

P

P

Y

C

Y

F

G

P

Y

Y

A

A

R

R

Q

Q

D

D

R

K

K

K

D

D

R

K

P

S

R

R

V

A

S

P

I

I

A

T

A

A

K

R

L

L

I

V

A

A

N

N

M

M

I

L

M

Q

S

T

A

A

G

G

A

C

D

N

R

H

I

I

M

I

T

T

C

M

D

D

L

L

H

H

A

A

G

S

Q

Q

I

I

Q

Q

G

G

F

F

D

N

I

V

P

P

L

V

D

D

H

N

L

L

N

Y

G

A

S

E

A

P

I

S

F

V

V

L

P

R

Y

Y

L

I

K

R

-

E

S

N

L

I

D

D

L

T

G

T

D

V

N

N

-

P

L

T

I

V

F

I

A

V

S
|
S

P

P

D

D

V

A

G

G

V

A

S

K

R

R

A

A

R

T

A

A

Y

L

A

A

K

D

H

R

F

L

E

D

V

L

D

D

M

F

V

A

V

L

C

I

D

H

K

K

H

E

R

R

K

Q

R

K

A

A

N

N

E

E

V

V

A

S

S

R

M

M

Q

V

V

L

I

V

G

G

D

D

V

V

E

R

G

D

K

K

D

L

V

A

V

I

L

L

V

V

D

D

L

M

V

A

D

D

T

T

A

C

G

G

T

T

M

L

C

G

K

L

A

A

E

K

I

T

L

L

L

K

D

D

K

N

G

G

A

A

N

K

S

A

V

V

R

Y

A

A

I

I

A

V

T

T

H

H

G

G

V

I

L

L

S

S

G

G

K

K

A

A

Y

I

E

K

N

V

I

I

E

N

N

E

S

S

K

A

L

L

S

E

E

K

L

V

V

I

I

V

T

T

D

N

T

T

I

I

P

P

-

H

-

D

I

K

K

R

K

S

E

L

S

C

S

S

K

K

I

I

K

E

V

T

L

I

T

D

V

I

A

S

E

G

L

V

F

L

A

A

K

E

A

C

I

I

H

R

A

R

V

I

T

H

G

H

N

G

D

E

S

S

I

V

S

S

A

V

L

L

F

F

S172 (= S167) modified: Phosphoserine

2hcrA Crystal structure of human phosphoribosyl pyrophosphate synthetase 1 in complex with amp(atp), cadmium and sulfate ion (see paper)
43% identity, 99% coverage: 4:308/309 of query aligns to 2:305/305 of 2hcrA

query
sites
2hcrA

V

I

K

K

L

I

F

F

A

S

G

G

T

S

N

S

T

H

K

Q

K

D

L

L

A

S

D

Q

S

K

I

I

A

A

G

D

N

R

Y

L

G

G

Q

L

D

E

L

L

G

G

A

K

M

V

T

V

L

T

S

K

M

K

F

F

S

S

D

N

G

Q

E

E

M

T

S

C

P

V

S

E

F

I

D

G

E

E

S

S

V

V

R

R

G

G

C

E

H

D

V

V

F

Y

L

I

I

V

Q

Q

S

S

-

G

T

C

N

G

P

E

N

I

A

N

D

D

N

N

L

L

L

M

E

E

L

L

C

L

L

I

M

M

I

I

D

N

A

A

A

C

K

K

R

I

A

A

S

S

A

A

Y

S

K

R

V

V

C

T

A

A

V

V

V

I

P

P

Y

C

Y

F

G

P

Y

Y

A

A

R
|
R

Q
|
Q

D

D

R
x
K

K

K

D

D

R

K

P

S

R

R

V

A

S

P

I

I

A

S

A

A

K

K

L

L

I

V

A

A

N

N

M

M

I

L

M

S

S

V

A

A

G

G

A

A

D

D

R

H

I

I

M

I

T

T

C

M

D

D

L

L

H
|
H

A

A

G

S

Q

Q

I

I

Q

Q

G

G

F

F

D

D

I

I

P

P

L

V

D

D

H

N

L

L

N

Y

G

A

S

E

A

P

I

A

F

V

V

L

P

K

Y

W

L

I

K

R

-

E

S

N

L

I

D

S

L

E

G

W

D

R

N

N

L

C

I

T

F

I

A

V

S

S

P

P

D

D

V

A

G

G

V

A

S

K

R

R

A

V

R

T

A

S

Y

I

A

A

K

D

H

R

F

L

E

N

V

V

D

D

M

F

V

A

V

L

C

I

D

H

K

K

H

E

R

R

K

D

R

R

A

-

N

-

E

-

V

-

A

-

S

-

M

M

Q

V

V

L

I

V

G

G

D

D

V

V

E

K

G

D

K

R

D

V

V

A

V

I

L

L

V

V

D

D

L

M

V

A

D

D

T

T

A

C

G

G

T

T

M

I

C

C

K

H

A

A

E

D

I

K

L

L

D

S

K

A

G

G

A

A

N

T

S

R

V

V

R

Y

A

A

I

I

A

L

T

T

H

H

G

G

V

I

L

F

S

S

G

G

K

P

A

A

Y

I

E

S

N

R

I

I

E

N

N

N

S

A

K

C

L

F

S

E

E

A

L

V

V

V

I

V

T

T

D

N

T

T

I

I

P

P

I

Q

K

E

-

D

-

K

-

M

K

K

E

H

S

C

S

S

K

K

I

I

K

Q

V

V

L

I

T

D

V

I

A

S

E

M

L

I

F

L

A

A

K

E

A

A

I

I

H

R

A

R

V

T

T

H

G

N

N

G

D

E

S

S

I

V

S

S

A

Y

L

L

F

F

binding adenosine monophosphate: R94 (= R95), Q95 (= Q96), K97 (≠ R98), H128 (= H129)

Query Sequence

>Echvi_4597 Echvi_4597 ribose-phosphate pyrophosphokinase
MPEVKLFAGTNTKKLADSIAGNYGQDLGAMTLSMFSDGEMSPSFDESVRGCHVFLIQSTN
PNADNLLELCLMIDAAKRASAYKVCAVVPYYGYARQDRKDRPRVSIAAKLIANMIMSAGA
DRIMTCDLHAGQIQGFFDIPLDHLNGSAIFVPYLKSLDLGDNLIFASPDVGGVSRARAYA
KHFEVDMVVCDKHRKRANEVASMQVIGDVEGKDVVLVDDLVDTAGTMCKAAEILLDKGAN
SVRAIATHGVLSGKAYENIENSKLSELVITDTIPIKKESSKIKVLTVAELFAKAIHAVTG
NDSISALFI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory