SitesBLAST
Comparing GFF1038 FitnessBrowser__Marino:GFF1038 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
44% identity, 97% coverage: 1:551/566 of query aligns to 6:539/539 of 6lpiB
- active site: I27 (≠ Y22), G29 (= G24), G30 (= G25), S31 (≠ C26), I32 (= I27), E53 (= E48), C76 (≠ T71), F115 (= F110), Q116 (= Q111), E117 (= E112), K165 (= K160), M256 (= M249), A283 (= A276), V375 (= V382), G401 (= G408), M403 (= M410), D428 (= D435), N455 (= N462), A457 (≠ C464), L458 (= L465), L460 (≠ M467), V461 (= V468), Q464 (= Q471)
- binding flavin-adenine dinucleotide: R155 (= R150), G212 (= G203), G213 (= G204), G214 (= G205), T236 (= T229), L237 (= L230), M238 (≠ K231), L254 (= L247), M256 (= M249), H257 (= H250), G276 (= G269), A277 (= A270), R278 (= R271), D280 (= D273), R282 (= R275), A283 (= A276), D300 (= D293), I301 (≠ A294), D319 (= D312), V320 (≠ L313), M380 (= M387), G398 (= G405)
- binding magnesium ion: D428 (= D435), N455 (= N462)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ T71), P79 (= P74), G376 (= G383), Q377 (= Q384), H378 (= H385), G401 (= G408), M403 (= M410), G427 (= G434), D428 (= D435), G429 (= G436), S430 (= S437), M433 (= M440), N455 (= N462), A457 (≠ C464), L458 (= L465), G459 (= G466), L460 (≠ M467), V461 (= V468)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 12:577/582 of 3ea4A
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (≠ C26), S37 (≠ I27), E58 (= E48), T81 (= T71), F120 (= F110), Q121 (= Q111), E122 (= E112), K170 (= K160), M265 (= M249), V292 (≠ A276), V399 (= V382), G425 (= G408), M427 (= M410), D452 (= D435), N479 (= N462), H481 (≠ C464), L482 (= L465), M484 (= M467), V485 (= V468), W488 (≠ Q471), H557 (≠ R533)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D274), R291 (= R275), W488 (≠ Q471), S567 (≠ P543)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R150), G221 (= G203), G222 (= G204), G223 (= G205), T245 (= T229), L246 (= L230), M247 (≠ K231), L263 (= L247), G264 (= G248), M265 (= M249), H266 (= H250), G285 (= G269), R287 (= R271), D289 (= D273), R291 (= R275), D309 (= D293), I310 (≠ A294), G327 (= G311), D328 (= D312), V329 (vs. gap), M404 (= M387), G422 (= G405)
- binding magnesium ion: D452 (= D435), N479 (= N462), H481 (≠ C464)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V382), G400 (= G383), Q401 (= Q384), H402 (= H385), M427 (= M410), G451 (= G434), D452 (= D435), G453 (= G436), S454 (= S437), N479 (= N462), H481 (≠ C464), L482 (= L465), G483 (= G466), M484 (= M467), V485 (= V468)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 12:577/582 of 3e9yA
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (≠ C26), S37 (≠ I27), E58 (= E48), T81 (= T71), F120 (= F110), Q121 (= Q111), E122 (= E112), K170 (= K160), M265 (= M249), V292 (≠ A276), V399 (= V382), G425 (= G408), M427 (= M410), D452 (= D435), N479 (= N462), H481 (≠ C464), L482 (= L465), M484 (= M467), V485 (= V468), W488 (≠ Q471), H557 (≠ R533)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D274), R291 (= R275), W488 (≠ Q471), S567 (≠ P543)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R150), G221 (= G203), G222 (= G204), G223 (= G205), T245 (= T229), L246 (= L230), M247 (≠ K231), L263 (= L247), G285 (= G269), R287 (= R271), D289 (= D273), R291 (= R275), D309 (= D293), I310 (≠ A294), G327 (= G311), D328 (= D312), V329 (vs. gap), M404 (= M387), G422 (= G405)
- binding magnesium ion: D452 (= D435), N479 (= N462), H481 (≠ C464)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V382), G400 (= G383), Q401 (= Q384), H402 (= H385), M427 (= M410), G451 (= G434), G453 (= G436), S454 (= S437), N479 (= N462), H481 (≠ C464), L482 (= L465), G483 (= G466), M484 (= M467), V485 (= V468)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
43% identity, 98% coverage: 2:553/566 of query aligns to 98:663/670 of P17597
- A122 (≠ C26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (= M28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E48) binding
- S186 (= S90) binding
- P197 (= P101) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ G103) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q111) binding
- K220 (= K124) binding
- R246 (= R150) binding ; binding
- K256 (= K160) binding
- G308 (= G204) binding
- TL 331:332 (= TL 229:230) binding
- C340 (≠ K238) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 247:250) binding
- GVRFD 371:375 (≠ GARLD 269:273) binding
- DR 376:377 (= DR 274:275) binding
- DI 395:396 (≠ DA 293:294) binding
- DV 414:415 (≠ D- 312) binding
- QH 487:488 (= QH 384:385) binding
- GG 508:509 (= GG 405:406) binding
- GAM 511:513 (≠ GTM 408:410) binding
- D538 (= D435) binding
- DGS 538:540 (= DGS 435:437) binding
- N565 (= N462) binding
- NQHLGM 565:570 (≠ NQCLGM 462:467) binding
- H567 (≠ C464) binding
- W574 (≠ Q471) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P543) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), G452 (= G434), D453 (= D435), G454 (= G436), S455 (= S437), M458 (= M440), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), R292 (= R275), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405)
- binding magnesium ion: F370 (≠ A349), D453 (= D435), M458 (= M440), Q461 (= Q443), N480 (= N462), H482 (≠ C464), K533 (≠ T508)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M249), R292 (= R275), M485 (= M467), W489 (≠ Q471), S568 (≠ P543)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 5wj1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), M263 (= M246), L264 (= L247), G286 (= G269), R288 (= R271), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M249), D291 (= D274), R292 (= R275), M485 (= M467), W489 (≠ Q471), S568 (≠ P543)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), M428 (= M410), D453 (= D435), G454 (= G436), S455 (= S437), M458 (= M440), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 5k6tA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H250), R292 (= R275), M485 (= M467), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), G286 (= G269), R288 (= R271), D290 (= D273), R292 (= R275), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), Q404 (= Q386), M405 (= M387), G423 (= G405)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), G452 (= G434), G454 (= G436), S455 (= S437), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 5k6rA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R275), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), M266 (= M249), G286 (= G269), R288 (= R271), R292 (= R275), V293 (≠ A276), D310 (= D293), I311 (≠ A294), G328 (= G311), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), D453 (= D435), G454 (= G436), S455 (= S437), M458 (= M440), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1z8nA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K124), R161 (= R150), Y191 (vs. gap), R194 (vs. gap), D291 (= D274), R292 (= R275), D312 (= D295), W489 (≠ Q471), G569 (= G544)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), G265 (= G248), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), R292 (= R275), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462)
- binding thiamine diphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), G452 (= G434), G454 (= G436), S455 (= S437), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1yi1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D274), R292 (= R275), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), M263 (= M246), L264 (= L247), G265 (= G248), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1yi0A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D274), R292 (= R275), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), G265 (= G248), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), R292 (= R275), V293 (≠ A276), D310 (= D293), I311 (≠ A294), G328 (= G311), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1yhzA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D274), R292 (= R275), M485 (= M467), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), Q404 (= Q386), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1yhyA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D274), R292 (= R275), V486 (= V468), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), G265 (= G248), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), Q404 (= Q386), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 1ybhA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M249), D291 (= D274), R292 (= R275), M485 (= M467), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), M266 (= M249), H267 (= H250), G286 (= G269), V287 (≠ A270), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), Q404 (= Q386), M405 (= M387), G423 (= G405), G424 (= G406)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/583 of 5k3sA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R275), M485 (= M467), W489 (≠ Q471), G569 (= G544)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), M266 (= M249), G286 (= G269), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), D453 (= D435), G454 (= G436), S455 (= S437), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 13:578/585 of 5k2oA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (≠ C26), S38 (≠ I27), E59 (= E48), T82 (= T71), F121 (= F110), Q122 (= Q111), E123 (= E112), K171 (= K160), M266 (= M249), V293 (≠ A276), V400 (= V382), G426 (= G408), M428 (= M410), D453 (= D435), N480 (= N462), H482 (≠ C464), L483 (= L465), M485 (= M467), V486 (= V468), W489 (≠ Q471), H558 (≠ R533)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M249), R292 (= R275), W489 (≠ Q471), S568 (≠ P543)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), L264 (= L247), G286 (= G269), R288 (= R271), D290 (= D273), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), Q404 (= Q386), M405 (= M387), G423 (= G405)
- binding magnesium ion: D453 (= D435), N480 (= N462), H482 (≠ C464)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), M428 (= M410), D453 (= D435), G454 (= G436), S455 (= S437), N480 (= N462), H482 (≠ C464), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
42% identity, 98% coverage: 2:553/566 of query aligns to 95:660/667 of P09342
- C161 (= C68) modified: Disulfide link with 307
- P194 (= P101) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ I206) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
43% identity, 98% coverage: 2:553/566 of query aligns to 92:657/664 of P09114
- P191 (= P101) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ Q471) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
42% identity, 98% coverage: 2:553/566 of query aligns to 13:578/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M249), R292 (= R275), W489 (≠ Q471), S568 (≠ P543)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V382), G401 (= G383), Q402 (= Q384), H403 (= H385), G426 (= G408), M428 (= M410), G452 (= G434), D453 (= D435), G454 (= G436), S455 (= S437), L483 (= L465), G484 (= G466), M485 (= M467), V486 (= V468)
- binding flavin-adenine dinucleotide: R161 (= R150), G222 (= G203), G223 (= G204), G224 (= G205), T246 (= T229), L247 (= L230), M248 (≠ K231), M263 (= M246), L264 (= L247), M266 (= M249), H267 (= H250), G286 (= G269), R288 (= R271), V293 (≠ A276), D310 (= D293), I311 (≠ A294), D329 (= D312), V330 (vs. gap), M405 (= M387), G423 (= G405)
- binding magnesium ion: A37 (≠ C26), T82 (= T71), S83 (= S72), Q122 (= Q111), Y381 (≠ T360), D453 (= D435), M458 (= M440), Q461 (= Q443), N480 (= N462), H482 (≠ C464), K533 (≠ T508)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
40% identity, 98% coverage: 1:552/566 of query aligns to 8:570/591 of 5wkcA
- active site: Y29 (= Y22), G31 (= G24), G32 (= G25), A33 (≠ C26), I34 (= I27), E55 (= E48), T78 (= T71), F117 (= F110), Q118 (= Q111), E119 (= E112), K167 (= K160), R222 (≠ E213), M258 (= M249), V285 (≠ A276), V401 (= V382), L426 (= L407), G427 (= G408), M429 (= M410), D454 (= D435), N481 (= N462), E483 (≠ C464), Q484 (≠ L465), M486 (= M467), V487 (= V468), W490 (≠ Q471), L512 (≠ M494), G517 (≠ D499), L518 (≠ I500), K551 (≠ R533)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V382), G402 (= G383), Q403 (= Q384), H404 (= H385), G427 (= G408), M429 (= M410), G453 (= G434), D454 (= D435), A455 (≠ G436), S456 (= S437), M459 (= M440), N481 (= N462), E483 (≠ C464), Q484 (≠ L465), G485 (= G466), M486 (= M467), V487 (= V468)
- binding ethaneperoxoic acid: G32 (= G25), Q118 (= Q111)
- binding flavin-adenine dinucleotide: R157 (= R150), G211 (= G203), A212 (≠ G204), G213 (= G205), N216 (≠ G209), T238 (= T229), L239 (= L230), Q240 (≠ K231), L256 (= L247), M258 (= M249), G278 (= G269), A279 (= A270), R280 (= R271), R284 (= R275), V285 (≠ A276), E311 (≠ D293), V312 (≠ A294), N316 (≠ E298), D330 (= D312), A331 (≠ L313), M406 (= M387), G424 (= G405)
- binding magnesium ion: D454 (= D435), N481 (= N462), E483 (≠ C464)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G25), A33 (≠ C26), V107 (= V100), F117 (= F110), K167 (= K160), M258 (= M249), R284 (= R275), M486 (= M467), W490 (≠ Q471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P23), E55 (= E48)
Query Sequence
>GFF1038 FitnessBrowser__Marino:GFF1038
MNGAQHILEAFHRHNISTVFGYPGGCIMPLYDALVDDVGVEHVLCRHEQGCALAADGYAR
ASGKLGVCIATSGPGATNLITGVANAHRDSIPMLVITGQVPSGLIGTDAFQETDVLGMTL
GIVKHSYLINDADSLPIIMEEAIELAQSGRPGPVWIDIPKDLLLSDVADAPFPQAQPYEP
ASPDLKEALAMLRAARKPLLYSGGGISLGHAEENFRAFAESSALPAVVTLKGIGNPGKHN
PYNLGMLGMHGSRAANKAVDECDLLLVIGARLDDRATGKLDGFAPNARMIHIDADAAEIN
KLRDADLAIRGDLNHILKSLAGELHADPLAISEWQKQCRSWYTTGGFHAADNEEPLAPIT
GPAFIRQLSRIAPDDTVIACDVGQHQMWVAQHYDFDHPRHHLTSGGLGTMGFGLPAAIGA
QFADRNSTVINVTGDGSFMMNAQELATIRRYNLPVKLIVMDNQCLGMVRQQQELFYNNRE
SQINLDDNPDFVAMARAFDIPALYIERTDQIRRGIETILAYNGPMLLHVAISREENVWPI
VKPGASNTDMIDETARTAKTSKEQVA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory