SitesBLAST
Comparing GFF1133 FitnessBrowser__Marino:GFF1133 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
61% identity, 98% coverage: 10:493/493 of query aligns to 2:483/483 of 4npiA
- active site: N152 (= N162), K175 (= K185), E251 (= E261), C285 (= C295), E387 (= E397), E464 (= E474)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R113), L157 (= L167), W160 (= W170), E251 (= E261), C285 (= C295), Y445 (≠ F455), R447 (= R457), F453 (= F463)
- binding nicotinamide-adenine-dinucleotide: I148 (= I158), S149 (= S159), P150 (= P160), W151 (= W161), K175 (= K185), E178 (= E188), G208 (= G218), G213 (= G223), E214 (≠ A224), F227 (= F237), G229 (= G239), E230 (= E240), T233 (= T243), G253 (= G263), C285 (= C295), K335 (= K345), E387 (= E397), F389 (= F399)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
61% identity, 98% coverage: 10:493/493 of query aligns to 2:483/483 of 4i2rA
- active site: N152 (= N162), K175 (= K185), E251 (= E261), C285 (= C295), E387 (= E397), E464 (= E474)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R113), L157 (= L167), C285 (= C295), Y445 (≠ F455), R447 (= R457), F453 (= F463)
- binding nicotinamide-adenine-dinucleotide: I148 (= I158), S149 (= S159), W151 (= W161), N152 (= N162), K175 (= K185), E178 (= E188), G208 (= G218), F227 (= F237), T228 (= T238), G229 (= G239), E230 (= E240), T233 (= T243), E251 (= E261), L252 (= L262), G253 (= G263), C285 (= C295), E387 (= E397), F389 (= F399)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
61% identity, 98% coverage: 10:493/493 of query aligns to 2:483/483 of 4i25A
- active site: N152 (= N162), K175 (= K185), E251 (= E261), C285 (= C295), E387 (= E397), E464 (= E474)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R113), L157 (= L167), C285 (= C295), Y445 (≠ F455), R447 (= R457), F453 (= F463)
- binding nicotinamide-adenine-dinucleotide: I148 (= I158), S149 (= S159), P150 (= P160), W151 (= W161), N152 (= N162), K175 (= K185), E178 (= E188), G208 (= G218), G213 (= G223), F227 (= F237), T228 (= T238), G229 (= G239), E230 (= E240), T233 (= T243), E251 (= E261), L252 (= L262), C285 (= C295), E387 (= E397), F389 (= F399)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
61% identity, 98% coverage: 10:493/493 of query aligns to 2:483/483 of 5kllA
- active site: D152 (≠ N162), K175 (= K185), E251 (= E261), C285 (= C295), E387 (= E397), E464 (= E474)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R113), D152 (≠ N162), L157 (= L167), W160 (= W170), C285 (= C295), Y445 (≠ F455), R447 (= R457), F453 (= F463)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
61% identity, 98% coverage: 10:493/493 of query aligns to 3:484/484 of 5kj5B
- active site: D153 (≠ N162), K176 (= K185), E252 (= E261), C286 (= C295), E388 (= E397), E465 (= E474)
- binding nicotinamide-adenine-dinucleotide: I149 (= I158), S150 (= S159), P151 (= P160), W152 (= W161), D153 (≠ N162), L158 (= L167), K176 (= K185), G209 (= G218), K210 (≠ G219), G214 (= G223), F228 (= F237), T229 (= T238), G230 (= G239), E231 (= E240), T234 (= T243), E252 (= E261), L253 (= L262), C286 (= C295), E388 (= E397), F390 (= F399), F454 (= F463)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
61% identity, 98% coverage: 9:493/493 of query aligns to 1:483/483 of 4ou2A
- active site: N152 (= N162), K175 (= K185), A251 (≠ E261), C285 (= C295), E387 (= E397), E464 (= E474)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R113), L157 (= L167), C285 (= C295), Y445 (≠ F455), R447 (= R457), F453 (= F463)
- binding nicotinamide-adenine-dinucleotide: I148 (= I158), S149 (= S159), P150 (= P160), W151 (= W161), N152 (= N162), K175 (= K185), G208 (= G218), G213 (= G223), E214 (≠ A224), F227 (= F237), T228 (= T238), G229 (= G239), E230 (= E240), T233 (= T243), A251 (≠ E261), L252 (= L262), G253 (= G263), C285 (= C295), E387 (= E397), F389 (= F399)
4u3wA X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from burkholderia cenocepacia
56% identity, 98% coverage: 11:493/493 of query aligns to 4:484/485 of 4u3wA
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
43% identity, 99% coverage: 4:492/493 of query aligns to 3:486/487 of Q9H2A2
- R109 (= R113) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N162) mutation to A: Complete loss of activity.
- R451 (= R457) mutation to A: Complete loss of activity.
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 100% coverage: 1:493/493 of query aligns to 5:490/491 of 5gtlA
- active site: N165 (= N162), K188 (= K185), E263 (= E261), C297 (= C295), E394 (= E397), E471 (= E474)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I158), P163 (= P160), K188 (= K185), A190 (≠ S187), E191 (= E188), Q192 (≠ E189), G221 (= G218), G225 (= G223), G241 (= G239), S242 (≠ E240), T245 (= T243), L264 (= L262), C297 (= C295), E394 (= E397), F396 (= F399)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 100% coverage: 1:493/493 of query aligns to 5:490/491 of 5gtkA
- active site: N165 (= N162), K188 (= K185), E263 (= E261), C297 (= C295), E394 (= E397), E471 (= E474)
- binding nicotinamide-adenine-dinucleotide: I161 (= I158), I162 (≠ S159), P163 (= P160), W164 (= W161), K188 (= K185), E191 (= E188), G221 (= G218), G225 (= G223), A226 (= A224), F239 (= F237), G241 (= G239), S242 (≠ E240), T245 (= T243), Y248 (≠ V246), L264 (= L262), C297 (= C295), Q344 (≠ H342), R347 (≠ K345), E394 (= E397), F396 (= F399)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8vqwC
- binding coenzyme a: I147 (= I158), W150 (= W161), K174 (= K185), S176 (= S187), E177 (= E188), G207 (= G218), G211 (= G223), F225 (= F237), G227 (= G239), G228 (≠ E240), S231 (≠ T243), H331 (= H342), F387 (= F399)
8vj3A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (fad bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8vj3A
8uzoA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (adp bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8uzoA
8uznA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (amp bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8uznA
- binding adenosine monophosphate: I147 (= I158), G148 (≠ S159), K174 (= K185), S176 (= S187), E177 (= E188), G207 (= G218), G211 (= G223), F225 (= F237), G228 (≠ E240), S231 (≠ T243), K234 (≠ V246)
8uzmA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADPH bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8uzmA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G148 (≠ S159), W150 (= W161), K174 (= K185), S176 (= S187), E177 (= E188), G207 (= G218), G211 (= G223), F225 (= F237), T226 (= T238), G227 (= G239), G228 (≠ E240), S231 (≠ T243), E250 (= E261), G252 (= G263), C284 (= C295), E385 (= E397), F387 (= F399)
8uzkA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADP+ bound)
40% identity, 99% coverage: 8:493/493 of query aligns to 2:481/488 of 8uzkA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I147 (= I158), G148 (≠ S159), W150 (= W161), N151 (= N162), K174 (= K185), S176 (= S187), E177 (= E188), G207 (= G218), G211 (= G223), F225 (= F237), G227 (= G239), G228 (≠ E240), S231 (≠ T243), E250 (= E261), F387 (= F399)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
40% identity, 99% coverage: 8:493/493 of query aligns to 11:490/497 of 8skfA
- binding calcium ion: T33 (≠ N30), I34 (≠ V31), D100 (= D98), V187 (≠ E189)
- binding nicotinamide-adenine-dinucleotide: I156 (= I158), G157 (≠ S159), A158 (≠ P160), W159 (= W161), K183 (= K185), E186 (= E188), G216 (= G218), G220 (= G223), T235 (= T238), G236 (= G239), G237 (≠ E240), S240 (≠ T243), K243 (≠ V246), E259 (= E261), C293 (= C295), F396 (= F399)
Query Sequence
>GFF1133 FitnessBrowser__Marino:GFF1133
MKPGKAAMKEIKHHINGQYVSSCSSRLFDNVNPANGKIISKVHEAGREEVDAAVKAARAA
LRGPWGKMTLDERTSILHKVADGINARFDEFLEGECLDTGKPKSMASHIDIPRGAANFKV
FADMIKNVPTESFEMPTPDGTGALNYAVRRPKGVIGVISPWNLPLLLMTWKVGPALACGN
TVVVKPSEETPTTTTLLGEVMKEAGVPDGVFNVVHGFGGDSAGAFLTEHPQVDGITFTGE
IGTGEVIMKAAAKGIRDISLELGGKNAGVVFADCDIDKAIEGTMRSAFANCGQVCLGTER
VYVERSIFDEFVGRLKEAAEGMKIGPPDDAEADMGPLVSLNHREKVLSYYQKAVDDGATV
VTGGGVPEMPEALAGGAWVQPTIWTGLPEDSAVITDEIFGPCCHIRPFDTEEEAIELANS
LPYGLASAIWSENITRAHRVAGQIEAGIIWVNSWFLRDLRTPFGGSKQSGIGREGGVHSL
EFYTEMKNICVKL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory