Comparing GFF1139 FitnessBrowser__Marino:GFF1139 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
Q01468 2-hydroxymuconate tautomerase; 4-oxalocrotonate tautomerase; 4-OT; EC 5.3.2.6 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
71% identity, 100% coverage: 1:63/63 of query aligns to 1:63/63 of Q01468
5tigA Crystal structure of 4-oxalocrotonate tautomerase inactivated by brhpd (see paper)
71% identity, 98% coverage: 2:63/63 of query aligns to 1:62/62 of 5tigA
1bjpA Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2- oxo-3-pentynoate at 2.4 angstroms resolution (see paper)
71% identity, 98% coverage: 2:63/63 of query aligns to 1:62/62 of 1bjpA
6bgnA Crystal structure of 4-oxalocrotonate tautomerase after incubation with 5-fluoro-2-hydroxy-2,4-pentadienoate (see paper)
75% identity, 90% coverage: 2:58/63 of query aligns to 1:57/59 of 6bgnA
6ghwC Substituting the prolines of 4-oxalocrotonate tautomerase with non- canonical analogue (2s)-3,4-dehydroproline (see paper)
75% identity, 90% coverage: 2:58/63 of query aligns to 1:57/57 of 6ghwC
5cloM Crystal structure of a 4-oxalocrotonate tautomerase mutant in complex with nitrostyrene at 2.3 angstrom (see paper)
72% identity, 90% coverage: 2:58/63 of query aligns to 1:57/57 of 5cloM
P70994 2-hydroxymuconate tautomerase; (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase; 4-oxalocrotonate tautomerase; 4-OT; EC 5.3.2.6 from Bacillus subtilis (strain 168) (see paper)
43% identity, 89% coverage: 1:56/63 of query aligns to 1:56/62 of P70994
2opaA Ywhb binary complex with 2-fluoro-p-hydroxycinnamate
42% identity, 87% coverage: 2:56/63 of query aligns to 1:55/61 of 2opaA
Sites not aligning to the query:
>GFF1139 FitnessBrowser__Marino:GFF1139
MPVAQINILEGRSDEQKEMLIREVTDAISRSLGAPVESIRIIITEMPKQHFGIGGQSAKM
LGR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory