Comparing GFF1177 FitnessBrowser__Marino:GFF1177 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4mttA Ni- and zn-bound gloa2 at low resolution (see paper)
37% identity, 87% coverage: 1:122/140 of query aligns to 7:127/128 of 4mttA
Sites not aligning to the query:
P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see paper)
32% identity, 89% coverage: 1:124/140 of query aligns to 7:129/135 of P0AC81
Sites not aligning to the query:
1fa6A Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli (see paper)
32% identity, 88% coverage: 1:123/140 of query aligns to 7:128/128 of 1fa6A
Sites not aligning to the query:
1fa5A Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli (see paper)
32% identity, 88% coverage: 1:123/140 of query aligns to 7:128/128 of 1fa5A
Sites not aligning to the query:
2c21A Specificity of the trypanothione-dependednt leishmania major glyoxalase i: structure and biochemical comparison with the human enzyme (see paper)
32% identity, 99% coverage: 1:139/140 of query aligns to 8:138/139 of 2c21A
Sites not aligning to the query:
6bnnA Crystal structure of v278e-glyoxalase i mutant from zea mays in space group p4(1)2(1)2 (see paper)
32% identity, 91% coverage: 1:127/140 of query aligns to 21:146/282 of 6bnnA
Sites not aligning to the query:
5d7zA Crystal structure of glyoxalase i from zea mays (see paper)
32% identity, 91% coverage: 1:127/140 of query aligns to 15:140/281 of 5d7zA
Sites not aligning to the query:
Q04760 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Homo sapiens (Human) (see 12 papers)
34% identity, 85% coverage: 1:119/140 of query aligns to 36:175/184 of Q04760
Sites not aligning to the query:
7wt0A Human glyoxalase i (with c-ter his tag) in complex with tlsc702 (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 35:174/185 of 7wt0A
Sites not aligning to the query:
3w0tA Human glyoxalase i with an n-hydroxypyridone derivative inhibitor
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/176 of 3w0tA
Sites not aligning to the query:
3vw9A Human glyoxalase i with an n-hydroxypyridone inhibitor (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/176 of 3vw9A
Sites not aligning to the query:
1qipA Human glyoxalase i complexed with s-p- nitrobenzyloxycarbonylglutathione (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/176 of 1qipA
Sites not aligning to the query:
1qinA Human glyoxalase i complexed with s-(n-hydroxy-n-p- iodophenylcarbamoyl) glutathione (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/176 of 1qinA
Sites not aligning to the query:
1froA Human glyoxalase i with benzyl-glutathione inhibitor (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/176 of 1froA
Sites not aligning to the query:
3w0uA Human glyoxalase i with an n-hydroxypyridone inhibitor
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/175 of 3w0uA
Sites not aligning to the query:
7wszA Human glyoxalase i (with c-ter his tag) in glycerol-bound form (see paper)
34% identity, 85% coverage: 1:119/140 of query aligns to 28:167/183 of 7wszA
Sites not aligning to the query:
1bh5A Human glyoxalase i q33e, e172q double mutant (see paper)
33% identity, 85% coverage: 1:119/140 of query aligns to 29:168/177 of 1bh5A
Sites not aligning to the query:
P50107 Glyoxalase I; Glx I; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase; EC 4.4.1.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
31% identity, 84% coverage: 2:119/140 of query aligns to 28:165/326 of P50107
Sites not aligning to the query:
2za0A Crystal structure of mouse glyoxalase i complexed with methyl-gerfelin (see paper)
31% identity, 85% coverage: 1:119/140 of query aligns to 33:172/180 of 2za0A
Sites not aligning to the query:
Q9CPU0 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Mus musculus (Mouse) (see paper)
31% identity, 85% coverage: 1:119/140 of query aligns to 36:175/184 of Q9CPU0
Sites not aligning to the query:
>GFF1177 FitnessBrowser__Marino:GFF1177
MIRVSNLDETLHFFCDLLGMVEISRKSSDKGRFTLVFLAAPDDEARAREDRAPMIELTYN
WDPEEYTGGRNFGHLAYRVDDIYALCEHLKANGVTINRPPRDGHMAFIRTPDNISIELLQ
KGDALPPKEPWASMENTGTW
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory