Comparing GFF1211 FitnessBrowser__WCS417:GFF1211 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
65% identity, 95% coverage: 21:383/383 of query aligns to 16:376/377 of 7t1qA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
57% identity, 98% coverage: 10:383/383 of query aligns to 5:376/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
57% identity, 97% coverage: 10:382/383 of query aligns to 5:375/375 of 4pqaA
7lgpB Dape enzyme from shigella flexneri
59% identity, 98% coverage: 9:383/383 of query aligns to 6:377/377 of 7lgpB
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
57% identity, 97% coverage: 11:382/383 of query aligns to 10:379/380 of 5vo3A
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
57% identity, 97% coverage: 11:382/383 of query aligns to 6:375/377 of P44514
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
61% identity, 47% coverage: 8:187/383 of query aligns to 3:180/265 of 4op4B
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
58% identity, 46% coverage: 11:187/383 of query aligns to 8:182/258 of 4h2kA
Sites not aligning to the query:
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
25% identity, 93% coverage: 17:372/383 of query aligns to 28:408/426 of 3pfoA
7uoiA Crystallographic structure of dape from enterococcus faecium
26% identity, 96% coverage: 16:383/383 of query aligns to 16:383/383 of 7uoiA
7rsfA Acetylornithine deacetylase from escherichia coli
31% identity, 56% coverage: 7:222/383 of query aligns to 2:213/380 of 7rsfA
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
22% identity, 82% coverage: 68:381/383 of query aligns to 75:398/408 of Q03154
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
23% identity, 81% coverage: 73:381/383 of query aligns to 80:397/407 of P37111
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
35% identity, 21% coverage: 64:142/383 of query aligns to 82:159/458 of 2pokA
Sites not aligning to the query:
5xoyA Crystal structure of lysk from thermus thermophilus in complex with lysine (see paper)
32% identity, 36% coverage: 35:172/383 of query aligns to 31:145/341 of 5xoyA
Sites not aligning to the query:
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
30% identity, 32% coverage: 68:188/383 of query aligns to 127:246/507 of Q96KN2
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
30% identity, 35% coverage: 72:205/383 of query aligns to 124:262/503 of Q8C165
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
32% identity, 27% coverage: 68:170/383 of query aligns to 96:197/471 of 3dljA
Sites not aligning to the query:
1q7lA Zn-binding domain of the t347g mutant of human aminoacylase-i (see paper)
34% identity, 22% coverage: 73:155/383 of query aligns to 74:155/192 of 1q7lA
Sites not aligning to the query:
4mmoA The crystal structure of a m20 family metallo-carboxypeptidase sso-cp2 from sulfolobus solfataricus
30% identity, 34% coverage: 11:142/383 of query aligns to 5:138/437 of 4mmoA
Sites not aligning to the query:
>GFF1211 FitnessBrowser__WCS417:GFF1211
MTAHADLSPTLQLAIDLIRRPSVTPIDADCQKLMMQRLGDAGFALEPMRIEDVDNFWATH
GKHDGPVLCFAGHTDVVPTGPVQAWQNDPFDALIDENGMLCGRGAADMKGSLAAMLVAAE
RFVTDYPDHKGSVAFLITSDEEGPAHHGTKAVIERLAARKERLDWCIVGEPSSTTLVGDV
VKNGRRGSLGATLTVRGIQGHVAYPHLAKNPIHLAAPALAELAAEHWDDGNAFFPPTSFQ
ISNLNSGTGATNVIPGDLKAVFNFRFSTESTVEGLQQRVAEILDKHGLDWHVEWALSGLP
FLTEPGALLDAVSASIKAITGRETQASTSGGTSDGRFIATLGTQVVELGPVNATIHQVNE
RILASDLDVLTEIYYQTLIKLLA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory