Comparing GFF1244 FitnessBrowser__psRCH2:GFF1244 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
52% identity, 98% coverage: 7:549/556 of query aligns to 42:644/644 of P9WQB3
3figB Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
54% identity, 98% coverage: 7:549/556 of query aligns to 25:577/577 of 3figB
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
54% identity, 97% coverage: 7:547/556 of query aligns to 25:575/576 of 3hpzB
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
53% identity, 97% coverage: 7:547/556 of query aligns to 25:572/573 of 3hq1A
1sr9A Crystal structure of leua from mycobacterium tuberculosis (see paper)
53% identity, 97% coverage: 7:547/556 of query aligns to 25:572/573 of 1sr9A
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
53% identity, 97% coverage: 7:547/556 of query aligns to 25:574/575 of 3hpsA
4ov4A Isopropylmalate synthase binding with ketoisovalerate (see paper)
28% identity, 65% coverage: 40:402/556 of query aligns to 11:347/379 of 4ov4A
4ov9A Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
28% identity, 65% coverage: 40:402/556 of query aligns to 11:349/380 of 4ov9A
Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
26% identity, 93% coverage: 28:546/556 of query aligns to 2:501/517 of Q9JZG1
Sites not aligning to the query:
Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 65% coverage: 36:394/556 of query aligns to 88:438/503 of Q9FN52
6e1jA Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
26% identity, 68% coverage: 19:394/556 of query aligns to 8:371/409 of 6e1jA
Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 60% coverage: 38:370/556 of query aligns to 90:412/506 of Q9FG67
3rmjB Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
28% identity, 54% coverage: 30:329/556 of query aligns to 1:288/308 of 3rmjB
6ktqA Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
23% identity, 63% coverage: 36:388/556 of query aligns to 25:346/399 of 6ktqA
O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
27% identity, 47% coverage: 36:294/556 of query aligns to 7:243/376 of O87198
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate (see paper)
26% identity, 47% coverage: 36:294/556 of query aligns to 7:237/314 of 2zyfA
3a9iA Crystal structure of homocitrate synthase from thermus thermophilus complexed with lys (see paper)
26% identity, 47% coverage: 36:294/556 of query aligns to 6:236/347 of 3a9iA
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate (see paper)
26% identity, 47% coverage: 36:294/556 of query aligns to 7:235/312 of 2ztjA
3ivtB Homocitrate synthase lys4 bound to 2-og (see paper)
23% identity, 61% coverage: 36:372/556 of query aligns to 33:338/400 of 3ivtB
Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
23% identity, 61% coverage: 36:372/556 of query aligns to 38:343/418 of Q9Y823
Sites not aligning to the query:
>GFF1244 FitnessBrowser__psRCH2:GFF1244
MTMLKNPSKKYRAFPAIDIPDRTWPSKTITQAPIWLSSDLRDGNQSLIEPMDAAKKMRFF
KTLVQVGIKEIEVGFPSASQTDFDFVRELIEGGHIPDDVTIQVLTQAREDLITRTFESLK
GAKQAIVHYYNATAPSFRRIVFNQDKAGVVNIAVNAAQIIKRLAAQNPETAWRFEYSPEI
FSSTEPEFAVEVCNAVIEVFQPTPEQKLILNLPATVEAATPNIYADQIEWFCRHVDRRDS
VLVSLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGIDPQ
LDFSDIDAVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFSQQDPDSIWEVP
YLPIDPADIGRSYEAVIRVNSQSGKGGITFLLEQEYGISLPRRMQIEFSQVVQKETDRLG
LEMSAKQIYALLEAEYLQATAPYTLKGHRLQEENGTSAVDVEVAADGEVVHWRGIGKGPL
EALVAALPVKLEIMDYHEHSIGAGSNAKAAAYIEVRLDGERPLHGIGIDENITTASIRAL
FSAMNRALREAQDKAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory