Comparing GFF1490 PS417_07580 3-ketoacyl-CoA thiolase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2d3tC Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form v (see paper)
94% identity, 100% coverage: 2:391/391 of query aligns to 1:390/390 of 2d3tC
P45359 Acetyl-CoA acetyltransferase; Acetoacetyl-CoA thiolase; CaTHL; EC 2.3.1.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see paper)
42% identity, 98% coverage: 6:390/391 of query aligns to 2:391/392 of P45359
8opuC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
40% identity, 96% coverage: 15:391/391 of query aligns to 11:399/399 of 8opuC
8oqlC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
40% identity, 96% coverage: 15:391/391 of query aligns to 11:397/397 of 8oqlC
Sites not aligning to the query:
8oqoC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
40% identity, 96% coverage: 15:391/391 of query aligns to 11:398/398 of 8oqoC
8oqmD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-10
40% identity, 96% coverage: 15:391/391 of query aligns to 12:399/399 of 8oqmD
8opyD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-b-dnq
40% identity, 96% coverage: 15:391/391 of query aligns to 12:401/401 of 8opyD
4xl4A Crystal structure of thiolase from clostridium acetobutylicum in complex with coa (see paper)
42% identity, 98% coverage: 6:390/391 of query aligns to 2:391/392 of 4xl4A
8pf8C Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
40% identity, 96% coverage: 15:391/391 of query aligns to 11:402/402 of 8pf8C
8oqsC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
40% identity, 96% coverage: 15:391/391 of query aligns to 11:402/402 of 8oqsC
8oqpC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
40% identity, 96% coverage: 15:391/391 of query aligns to 11:402/402 of 8oqpC
Sites not aligning to the query:
4b3iC Crystal structure of mycobacterium tuberculosis fatty acid beta-oxidation complex with coenzymea bound at the hydratase active sites (see paper)
40% identity, 96% coverage: 15:391/391 of query aligns to 11:402/402 of 4b3iC
7o4tD Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme with coenzyme a bound at the hydratase, thiolase active sites and possible additional binding site (coa(ech/had)) (see paper)
40% identity, 96% coverage: 15:391/391 of query aligns to 12:403/403 of 7o4tD
O53871 Putative acyltransferase Rv0859; EC 2.3.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
40% identity, 96% coverage: 15:391/391 of query aligns to 12:403/403 of O53871
8opxC Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with trehalose (fragment-b-tre)
40% identity, 96% coverage: 15:391/391 of query aligns to 11:398/398 of 8opxC
2vu2A Biosynthetic thiolase from z. Ramigera. Complex with s-pantetheine-11- pivalate. (see paper)
43% identity, 98% coverage: 8:391/391 of query aligns to 2:389/389 of 2vu2A
1dm3A Acetylated biosynthetic thiolase from zoogloea ramigera in complex with acetyl-coa (see paper)
43% identity, 98% coverage: 8:391/391 of query aligns to 2:389/389 of 1dm3A
1dlvA Biosynthetic thiolase from zoogloea ramigera in complex with coa (see paper)
43% identity, 98% coverage: 8:391/391 of query aligns to 2:389/389 of 1dlvA
1ou6A Biosynthetic thiolase from zoogloea ramigera in complex with acetyl-o- pantetheine-11-pivalate
43% identity, 98% coverage: 8:391/391 of query aligns to 5:392/392 of 1ou6A
6pccA Crystal structure of beta-ketoadipyl-coa thiolase mutant (h356a) in complex hexanoyl coenzyme a (see paper)
41% identity, 98% coverage: 7:391/391 of query aligns to 6:403/403 of 6pccA
>GFF1490 PS417_07580 3-ketoacyl-CoA thiolase
MSLNPRDVVIVDFGRTPMGRSKGGMHRNTRAEDMSAHLISKVLERNTKVDPNEVEDVIWG
CVNQTLEQGWNIARMASLMTQIPHTAAGQTVSRLCGSSMSALHTAAQAIMTGNGDVFVVG
GVEHMGHVSMMHGVDPNPHMSLYAAKASGMMGLTAEMLGKMHGITREAQDAFGLRSHQLA
HKATLEGKFKDEIIPMNGYDENGFLKLCDYDETIRPDTTLESLAALKPAFNPKGGTVTAG
TSSQITDGASCMIVMSAQRAQDLGIQPLAVIRSMAVAGVDPAIMGYGPVPATQKALKRAG
LTINDIDFFELNEAFAAQALPVLKDLKVLDKMNEKVNLHGGAIALGHPFGCSGARISGTL
LNVMKQNGGNLGVATMCIGLGQGISTVFERV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory