SitesBLAST
Comparing GFF1551 FitnessBrowser__Phaeo:GFF1551 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
71% identity, 96% coverage: 18:405/406 of query aligns to 3:385/385 of 3gqtC
- active site: L135 (= L150), T136 (= T151), A250 (= A264), E365 (= E385), R377 (= R397)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W181), K210 (= K224), L213 (= L227), T218 (= T232), Y364 (= Y384)
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
71% identity, 95% coverage: 18:404/406 of query aligns to 4:380/380 of 3gncA
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
71% identity, 95% coverage: 18:404/406 of query aligns to 3:382/382 of 3eonC
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
69% identity, 95% coverage: 18:404/406 of query aligns to 3:377/377 of 3d6bC
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
65% identity, 96% coverage: 17:405/406 of query aligns to 1:388/390 of 2r0nA
- active site: L133 (= L150), T134 (= T151), A247 (= A264), E368 (= E385), R380 (= R397)
- binding flavin-adenine dinucleotide: F131 (= F148), L133 (= L150), T134 (= T151), G139 (= G156), S140 (= S157), W166 (= W181), I167 (= I182), T168 (≠ S183), Y367 (= Y384), T370 (= T387), D372 (= D389)
- binding 3-thiaglutaryl-CoA: R92 (= R109), S93 (= S110), V97 (= V114), P142 (= P159), G238 (≠ K255), F241 (= F258), L244 (= L261), N245 (= N262), P318 (= P335), Y367 (= Y384), E368 (= E385), I377 (= I394)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
65% identity, 96% coverage: 17:405/406 of query aligns to 1:388/390 of 1sirA
- active site: L133 (= L150), T134 (= T151), A247 (= A264), E368 (= E385), R380 (= R397)
- binding flavin-adenine dinucleotide: F131 (= F148), L133 (= L150), T134 (= T151), G139 (= G156), S140 (= S157), W166 (= W181), I167 (= I182), T168 (≠ S183), Y367 (= Y384), T370 (= T387)
- binding s-4-nitrobutyryl-coa: S93 (= S110), S140 (= S157), F241 (= F258), G242 (= G259), L244 (= L261), N245 (= N262), R248 (= R265), P318 (= P335), Y367 (= Y384), E368 (= E385), R380 (= R397)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
65% identity, 96% coverage: 17:405/406 of query aligns to 1:388/390 of 2r0mA
- active site: L133 (= L150), T134 (= T151), A247 (= A264), D368 (≠ E385), R380 (= R397)
- binding 4-nitrobutanoic acid: L101 (= L118), Y367 (= Y384), D368 (≠ E385)
- binding flavin-adenine dinucleotide: F131 (= F148), L133 (= L150), T134 (= T151), G139 (= G156), S140 (= S157), W166 (= W181), I167 (= I182), T168 (≠ S183), L210 (= L227), Y367 (= Y384), T370 (= T387)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
50% identity, 94% coverage: 26:405/406 of query aligns to 7:380/380 of 2ebaA
- active site: L131 (= L150), T132 (= T151), A239 (= A264), E360 (= E385), R372 (= R397)
- binding flavin-adenine dinucleotide: L131 (= L150), T132 (= T151), G136 (≠ A155), G137 (= G156), S138 (= S157), W161 (= W181), T163 (≠ S183), R265 (= R290), L272 (= L297), K275 (≠ T300), D333 (= D358), I334 (≠ M359), G337 (= G362), T355 (= T380), T358 (= T383), Y359 (= Y384), T362 (= T387)
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
48% identity, 95% coverage: 21:405/406 of query aligns to 5:386/387 of 3sf6A
- active site: L134 (= L150), T135 (= T151), A245 (= A264), E366 (= E385), Q378 (≠ R397)
- binding dihydroflavine-adenine dinucleotide: F132 (= F148), L134 (= L150), T135 (= T151), G140 (= G156), S141 (= S157), W165 (= W181), I166 (= I182), T167 (≠ S183), S361 (≠ T380), T364 (= T383), Y365 (= Y384), T368 (= T387), E370 (≠ D389), M371 (≠ V390)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
47% identity, 94% coverage: 23:405/406 of query aligns to 6:387/388 of 3swoA
- active site: L135 (= L150), T136 (= T151), A246 (= A264), E367 (= E385), K379 (≠ R397)
- binding dihydroflavine-adenine dinucleotide: F133 (= F148), L135 (= L150), T136 (= T151), G141 (= G156), S142 (= S157), W166 (= W181), I167 (= I182), T168 (≠ S183), R272 (= R290), V274 (≠ Q292), F275 (= F293), L279 (= L297), Y282 (≠ T300), T340 (≠ D358), L341 (≠ M359), G344 (= G362), I347 (= I365), T365 (= T383), Y366 (= Y384), T369 (= T387), E371 (≠ D389), M372 (≠ V390)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
34% identity, 95% coverage: 21:405/406 of query aligns to 46:428/436 of Q96329
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
34% identity, 95% coverage: 21:405/406 of query aligns to 30:412/416 of 2ix6A
- active site: L158 (= L150), T159 (= T151), S271 (≠ A264), E392 (= E385), R404 (= R397)
- binding flavin-adenine dinucleotide: T159 (= T151), G164 (= G156), S165 (= S157), W189 (= W181), N239 (≠ T232), R297 (= R290), F300 (= F293), L304 (= L297), F307 (≠ T300), N310 (≠ F303), E365 (≠ D358), L366 (≠ M359), G369 (= G362), I372 (= I365), Y391 (= Y384), T394 (= T387), D396 (= D389)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
34% identity, 95% coverage: 21:405/406 of query aligns to 30:412/415 of 2ix5A
- active site: L158 (= L150), T159 (= T151), S271 (≠ A264), E392 (= E385), R404 (= R397)
- binding acetoacetyl-coenzyme a: S165 (= S157), A167 (≠ P159), S168 (≠ A160), F261 (≠ L254), L268 (= L261), R272 (= R265), E392 (= E385), G393 (= G386), R404 (= R397)
- binding flavin-adenine dinucleotide: L158 (= L150), T159 (= T151), G164 (= G156), S165 (= S157), W189 (= W181), N239 (≠ T232), R297 (= R290), F300 (= F293), L304 (= L297), F307 (≠ T300), L309 (= L302), N310 (≠ F303), E365 (≠ D358), L366 (≠ M359), G368 (= G361), G369 (= G362), Y391 (= Y384), T394 (= T387), D396 (= D389), I397 (≠ V390)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
35% identity, 92% coverage: 26:398/406 of query aligns to 1:376/380 of 4l1fA
- active site: L125 (= L150), T126 (= T151), G242 (≠ A264), E363 (= E385), R375 (= R397)
- binding coenzyme a persulfide: T132 (≠ S157), H179 (vs. gap), F232 (≠ L254), M236 (≠ F258), E237 (≠ G259), L239 (= L261), D240 (≠ N262), R243 (= R265), Y362 (= Y384), E363 (= E385), G364 (= G386), R375 (= R397)
- binding flavin-adenine dinucleotide: F123 (= F148), L125 (= L150), T126 (= T151), G131 (= G156), T132 (≠ S157), F156 (≠ W181), I157 (= I182), T158 (≠ S183), R268 (= R290), Q270 (= Q292), F271 (= F293), I275 (≠ L297), F278 (≠ T300), L281 (≠ F303), Q336 (≠ D358), I337 (≠ M359), G340 (= G362), I358 (≠ T380), Y362 (= Y384), T365 (= T387), Q367 (≠ D389)
- binding 1,3-propandiol: L5 (= L30), Q10 (≠ R35)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
34% identity, 90% coverage: 32:397/406 of query aligns to 4:370/374 of 5lnxD
- active site: L122 (= L150), T123 (= T151), G239 (≠ A264), E358 (= E385), K370 (≠ R397)
- binding flavin-adenine dinucleotide: L122 (= L150), T123 (= T151), G128 (= G156), S129 (= S157), F153 (≠ W181), T155 (≠ S183), R265 (= R290), Q267 (= Q292), F268 (= F293), I272 (≠ L297), N275 (≠ T300), I278 (≠ F303), Q331 (≠ D358), I332 (≠ M359), G335 (= G362), Y357 (= Y384), T360 (= T387), E362 (≠ D389)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
34% identity, 92% coverage: 26:397/406 of query aligns to 2:376/378 of 4n5fA
- active site: L126 (= L150), T127 (= T151), G243 (≠ A264), E364 (= E385), R376 (= R397)
- binding dihydroflavine-adenine dinucleotide: L126 (= L150), T127 (= T151), G132 (= G156), S133 (= S157), F157 (≠ W181), T159 (≠ S183), T210 (= T232), Y363 (= Y384), T366 (= T387), E368 (≠ D389), M372 (≠ L393)
C3UVB0 Glutaryl-CoA dehydrogenase; GDH(Des); EC 1.3.99.32 from Desulfococcus multivorans (see paper)
33% identity, 93% coverage: 26:403/406 of query aligns to 1:385/389 of C3UVB0
- A80 (≠ E102) mutation to E: Loses the FAD cofactor and dehydrogenase activity.
- R87 (= R109) binding
- V88 (≠ S110) mutation to S: A residual dehydrogenase activity is observed.
- N91 (≠ S113) binding
- FGIT 126:129 (≠ FGLT 148:151) binding
- S135 (= S157) binding ; binding
- WIS 159:161 (= WIS 181:183) binding
- S181 (≠ K203) binding
- R271 (= R290) binding
- FQMN 281:284 (≠ TQLF 300:303) binding
- R340 (≠ D358) binding
- A344 (≠ G362) binding
- V366 (≠ Y384) mutation to Y: Loses the FAD cofactor but a residual dehydrogenase activity is observed.
- EGSAN 367:371 (≠ EGTHD 385:389) binding
- R385 (≠ Q403) binding
3mpjB Structure of the glutaryl-coenzyme a dehydrogenase (see paper)
33% identity, 93% coverage: 26:403/406 of query aligns to 1:385/393 of 3mpjB
- active site: I128 (≠ L150), T129 (= T151), T245 (≠ A264), E367 (= E385), L379 (≠ R397)
- binding flavin-adenine dinucleotide: F126 (= F148), I128 (≠ L150), T129 (= T151), G134 (= G156), S135 (= S157), W159 (= W181), I160 (= I182), S161 (= S183), V366 (≠ Y384), S369 (≠ T387), N371 (≠ D389), M375 (≠ L393)
- binding : H36 (≠ T62), F37 (≠ D63), Y39 (vs. gap), A164 (≠ P186), Q165 (≠ I187), D167 (= D189), N193 (≠ G212)
3mpiC Structure of the glutaryl-coenzyme a dehydrogenase glutaryl-coa complex (see paper)
33% identity, 93% coverage: 26:403/406 of query aligns to 1:385/395 of 3mpiC
- active site: I128 (≠ L150), T129 (= T151), T245 (≠ A264), E367 (= E385), L379 (≠ R397)
- binding flavin-adenine dinucleotide: I128 (≠ L150), T129 (= T151), G134 (= G156), S135 (= S157), W159 (= W181), I160 (= I182), S161 (= S183), M365 (≠ T383), V366 (≠ Y384), S369 (≠ T387), N371 (≠ D389), M375 (≠ L393)
- binding glutaryl-coenzyme A: R87 (= R109), F126 (= F148), S135 (= S157), V137 (≠ P159), S181 (≠ K203), F239 (= F258), R246 (= R265), N315 (≠ A334), V366 (≠ Y384), E367 (= E385), G368 (= G386), I376 (= I394), R385 (≠ Q403)
Sites not aligning to the query:
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
32% identity, 91% coverage: 28:395/406 of query aligns to 2:372/378 of 5ol2F
- active site: L124 (= L150), T125 (= T151), G241 (≠ A264)
- binding calcium ion: E29 (≠ N55), E33 (≠ N59), R35 (≠ E61)
- binding coenzyme a persulfide: L238 (= L261), R242 (= R265), E362 (= E385), G363 (= G386)
- binding flavin-adenine dinucleotide: F122 (= F148), L124 (= L150), T125 (= T151), P127 (= P153), T131 (≠ S157), F155 (≠ W181), I156 (= I182), T157 (≠ S183), E198 (≠ A222), R267 (= R290), F270 (= F293), L274 (= L297), F277 (≠ T300), Q335 (≠ D358), L336 (≠ M359), G338 (= G361), G339 (= G362), Y361 (= Y384), T364 (= T387), E366 (≠ D389)
Sites not aligning to the query:
Query Sequence
>GFF1551 FitnessBrowser__Phaeo:GFF1551
MTDRPALRAKDAPDLGQFNWDDPLRLDDQLSEDERMIAASARSYAQEKLQPRVLNAYENE
ETDPEIFREMGEMGLLGTTIPEQYGGLGAGYVSYGLVAREVERVDSGYRSMMSVQSSLVM
YPIYAYGSEEQRQKYLPKLSSGEWIGCFGLTEPDAGSDPAGMKTRAEKTDGGYRLTGSKM
WISNAPIADVFVVWAKSEAHGGKIRGFVLEKGMKGLSAPKIANKASLRASITGEIVMDGV
EVGDDALLPHVEGLKGPFGCLNRARYGISWGAMGAAEACWHAARQYGLDRKQFGRPLANT
QLFQLKLANMQTEITLGLQASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDMH
GGNGISLEFGVIRHMVNLETVNTYEGTHDVHALILGRAQTGLQAFF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory