SitesBLAST

K46 (= K54) mutation K->G,I,Q,R: 25% to 50% stimulation of K(+) uptake by TrkH.; mutation Missing: Almost no stimulation of K(+) uptake by TrkH.
G162 (= G158) mutation to A: 80% stimulation of K(+) uptake by TrkH.
Q165 (= Q161) mutation to L: 60% stimulation of K(+) uptake by TrkH.
D183 (= D179) mutation to E: About 60% stimulation of K(+) uptake by TrkH.; mutation D->K,N: 15% to 20% stimulation of K(+) uptake by TrkH.

Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
36% identity, 85% coverage: 28:300/323 of query aligns to 21:299/326 of Q8RDH4

query
sites
Q8RDH4

V

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R

K

A

A

V

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N

D

G

G

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S

L

L

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x
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G
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G

K
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A

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L

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L

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-

G

-

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G

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K

ASGKST 44:49 (≠ GSGKST 51:56) binding
N61 (vs. gap) binding
Q97 (= Q99) binding
C285 (= C286) binding
C291 (= C292) binding
C298 (= C299) binding

Sites not aligning to the query:

316 binding

4fwiB Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
36% identity, 85% coverage: 28:300/323 of query aligns to 20:288/310 of 4fwiB

query
sites
4fwiB

V
x
I

R

K

A

A

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G

G

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L

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G

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A

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N

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x
L

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N

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K

binding adenosine-5'-triphosphate: I20 (≠ V28), S42 (= S50), A43 (≠ G51), S44 (= S52), G45 (= G53), K46 (= K54), S47 (= S55), T48 (= T56), N60 (vs. gap), Q96 (= Q99), E179 (= E180), L267 (≠ P279)
binding magnesium ion: S47 (= S55), Q96 (= Q99), D178 (= D179)
binding iron/sulfur cluster: H247 (= H248), P248 (= P249), C274 (= C286), H277 (= H289), C280 (= C292), Y282 (≠ H294), A283 (= A295), C287 (= C299)

Sites not aligning to the query:

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
38% identity, 79% coverage: 18:272/323 of query aligns to 8:262/343 of P30750

query
sites
P30750

T

T

G

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G

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Y

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G

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K

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T

L

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C

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T

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E

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P

L

F

40:46 (vs. 50:56, 86% identical) binding
E166 (= E180) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
38% identity, 79% coverage: 18:272/323 of query aligns to 9:263/344 of 6cvlD

query
sites
6cvlD

T

T

G

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F
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F

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H

L
x
Q

N

G

K

T

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R

W

T

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x
I

R

Q

A

A

V

L

N

N

G

N

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V

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S

L

L

S

H

L

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A

P

A

A

G

G

E

Q

T

I

L

Y

G

G

L

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V

I

G

G

E

A

S
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S

G
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G

S
x
A

G
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G

K
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K

S
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S

T
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T

L

L

G

I

R

R

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C

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H

L

L

L

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E

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Y

F

A

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A

L

L

L

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S

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R

H

T

T

V

I

F

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G

E

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T

N

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A

A

E

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L

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R

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K

N

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E

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K

D

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R

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V

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T

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E

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L

L

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E

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P

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S
x
N

L
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L

S
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S

G
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G

Q
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Q

C

K

Q

Q

R

R

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V

G

A

I

I

A

A

R

R

A

A

L

L

A

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E

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C

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K

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C

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F

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K

H

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P

Y

L

T

A

A

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A

K

L

F

I

I

Q

Q

A

S

-

T

-

L

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H

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L

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D

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E

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D

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L

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E

E

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P

L

F

binding phosphothiophosphoric acid-adenylate ester: F12 (= F21), Q14 (≠ L23), I19 (≠ V28), S41 (= S50), G42 (= G51), A43 (≠ S52), G44 (= G53), K45 (= K54), S46 (= S55), T47 (= T56), N141 (≠ S154), L142 (= L155), S143 (= S156), G144 (= G157), G145 (= G158), Q146 (= Q159), H200 (= H213)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
38% identity, 79% coverage: 18:272/323 of query aligns to 9:263/344 of 3tuzC

query
sites
3tuzC

T

T

G

K

L

V

F
|
F

G

H

L
x
Q

N

G

K

T

Q

R

W

T

V

I

R

Q

A
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A

V

L

N

N

G

N

V

V

S

S

L

L

S

H

L

V

A

P

A

A

G

G

E

Q

T

I

L

Y

G

G

L

V

V

I

G

G

E

A

S

S

G
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G

S
x
A

G
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G

K
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K

S
|
S

T
|
T

L

L

G

I

R

R

A

C

I

V

L

N

H

L

L

L

N

E

P

R

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E

G

G

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V

L

L

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D

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G

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M

L

A

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T

G

L

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I

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K

L

A

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I

A

G

M

M

I

I

F

F

Q

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D

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Y

F

A

N

A

L

L

L

N

S

P

S

R

R

H

T

T

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I

F

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G

E

-

T

N

I

V

A

A

E

L

V

P

L

L

R

E

V

L

Q

D

R

-

K

N

V

T

A

P

P

K

E

D

R

E

I

V

S

K

D

R

R

R

V

V

N

T

E

E

L

L

D

S

L

L

V

V

G

G

L

L

R

G

P

D

E

K

L

H

A

D

S

S

R

Y

K

-

P

P

G

S

S

N

L

L

S

S

G

G

Q

Q

C

K

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

S

E

N

P

P

R

K

L

V

I

L

A

C

D

D

E

Q

C

A

V

T

A

S

A

A

L

L

D

D

V

P

S

A

I

T

Q

T

G

R

Q

S

I

I

I

L

N

E

L

L

L

K

E

D

L

I

Q

N

Q

R

R

R

M

L

H

G

L

L

A

T

I

I

L

L

F

L

I

I

A

T

H

H

D

E

L

M

A

D

I

V

V

V

R

K

R

R

L

I

C

C

D

D

R

C

V

V

A

A

V

V

M

I

Y

S

L

N

G

G

K

E

I

L

V

I

E

E

E

Q

G

D

P

T

V

V

E

S

S

E

V

V

F

F

T

S

A

H

P

P

R

K

H

T

P

P

Y

L

T

A

A

Q

A

K

L

F

I

I

Q

Q

A

S

-

T

-

L

-

H

-

L

-

D

I

I

P

P

E

E

I

-

D

D

P

Y

H

Q

R

E

P

R

L

L

P

Q

T

A

E

E

P

P

L

F

binding adenosine-5'-diphosphate: F12 (= F21), Q14 (≠ L23), A21 (= A30), G42 (= G51), A43 (≠ S52), G44 (= G53), K45 (= K54), S46 (= S55), T47 (= T56)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 312, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
38% identity, 79% coverage: 18:272/323 of query aligns to 9:263/344 of 3tuiC

query
sites
3tuiC

T

T

G

K

L

V

F
|
F

G

H

L
x
Q

N

G

K

T

Q

R

W

T

V

I

R

Q

A

A

V

L

N

N

G

N

V

V

S

S

L

L

S

H

L

V

A

P

A

A

G

G

E

Q

T

I

L

Y

G

G

L

V

V

I

G

G

E

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

I

R

R

A

C

I

V

L

N

H

L

L

L

N

E

P

R

I

P

S

T

A

E

G

G

Q

S

V

V

L

L

F

V

D

D

G

G

I

Q

D

E

M

L

A

T

H

T

G

L

S

S

A

E

I

S

D

E

I

L

T

T

R

K

L

A

R

R

H

R

E

Q

T

I

A

G

M

M

I

I

F

F

Q

Q

D

H

P

-

Y

F

A

N

A

L

L

L

N

S

P

S

R

R

H

T

T

V

I

F

G

G

E

-

T

N

I

V

A

A

E

L

V

P

L

L

R

E

V

L

Q

D

R

-

K

N

V

T

A

P

P

K

E

D

R

E

I

V

S

K

D

R

R

R

V

V

N

T

E

E

L

L

D

S

L

L

V

V

G

G

L

L

R

G

P

D

E

K

L

H

A

D

S

S

R

Y

K

-

P

P

G

S

S

N

L

L

S

S

G

G

Q

Q

C

K

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

S

E

N

P

P

R

K

L

V

I

L

A

C

D

D

E

Q

C

A

V

T

A

S

A

A

L

L

D

D

V

P

S

A

I

T

Q

T

G

R

Q

S

I

I

I

L

N

E

L

L

L

K

E

D

L

I

Q

N

Q

R

R

R

M

L

H

G

L

L

A

T

I

I

L

L

F

L

I

I

A

T

H

H

D

E

L

M

A

D

I

V

V

V

R

K

R

R

L

I

C

C

D

D

R

C

V

V

A

A

V

V

M

I

Y

S

L

N

G

G

K

E

I

L

V

I

E

E

E

Q

G

D

P

T

V

V

E

S

S

E

V

V

F

F

T

S

A

H

P

P

R

K

H

T

P

P

Y

L

T

A

A

Q

A

K

L

F

I

I

Q

Q

A

S

-

T

-

L

-

H

-

L

-

D

I

I

P

P

E

E

I

-

D

D

P

Y

H

Q

R

E

P

R

L

L

P

Q

T

A

E

E

P

P

L

F

binding adenosine-5'-diphosphate: F12 (= F21), Q14 (≠ L23), S41 (= S50), G42 (= G51), A43 (≠ S52), G44 (= G53), K45 (= K54), S46 (= S55), T47 (= T56)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
36% identity, 71% coverage: 31:258/323 of query aligns to 18:239/241 of 4u00A

query
sites
4u00A

V

L

N

K

G

G

V

I

S

H

L

L

S

E

L

V

A

A

A

P

G

G

E

E

T

K

L

L

G

V

L

I

V

I

G

G

E

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

I

R

R

A

T

I

I

L

N

H

R

L

L

N

E

P

D

I

F

S

Q

A

E

G

G

Q

E

V

V

L

V

F

V

D

D

G

G

I

L

D

S

M

V

A

K

H

D

G

D

S

R

A

A

I

L

D

-

I

-

T

R

R

E

L

I

R

R

H

R

E

E

T

V

A

G

M

M

I

V

F

F

Q

Q

D

Q

P

-

Y

-

A

F

A

N

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

L

E

E

T

N

I

V

A

T

E

L

V

A

L

P

R

M

V

R

Q

V

R

R

K

R

V

W

A

P

P

R

E

E

R

K

I

A

S

E

D

K

R

K

V

A

N

L

E

E

L

L

D

E

L

R

V

V

G

G

L

I

R

L

P

D

E

Q

L

-

A

A

S

R

R

K

K

Y

P

P

G

A

S

Q

L

L

S

S

G

G

Q

Q

C

Q

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

E

E

P

P

R

K

L

I

I

M

I

L

A

F

D

D

E

E

C

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

G

G

Q

E

I

V

I

L

N

D

L

V

L

M

L

R

E

D

L

L

Q

A

Q

Q

R

-

M

G

H

G

L

M

A

T

I

M

L

V

F

V

I

V

A

T

H

H

D

E

L

M

A

G

I

F

V

A

R

R

R

E

L

V

C

A

D

D

R

R

V

V

A

V

V

F

M

M

Y

D

L

G

G

G

K

Q

I

I

V

V

E

E

G

G

P

R

V

P

E

E

S

E

V

I

F

F

T

T

A

R

P

P

R

K

H

E

P

E

Y

R

T

T

A

R

A

S

L

F

I

L

Q

Q

A

R

I

V

binding adenosine-5'-diphosphate: S37 (= S50), G38 (= G51), S39 (= S52), G40 (= G53), K41 (= K54), S42 (= S55), T43 (= T56)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 15, 17

3c4jA Abc protein artp in complex with atp-gamma-s
34% identity, 72% coverage: 28:258/323 of query aligns to 16:241/242 of 3c4jA

query
sites
3c4jA

V

L

R

E

A
x
V

V

L

N

K

G

G

V

I

S

N

L

V

S

H

L

I

A

R

A

E

G

G

E

E

T

V

L

V

G

V

L

V

V

I

G

G

E
x
P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

A

C

I

L

L

N

H

L

L

L

N

E

P

D

I

F

S

D

A

E

G

G

Q

E

V

I

L

I

F

I

D

D

G

G

I

I

D

N

M

L

A

-

H

K

G

A

S

K

A

D

I

T

D

N

I

L

T

N

R

K

L

V

R

R

H

E

E

E

T

V

A

G

M

M

I

V

F

F

Q

Q

D

-

P

-

Y

R

A

F

A

N

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

L

E

N

T

N

I

I

A

T

E

L

V

A

L

P

R

M

V

K

Q

V

R

R

K

K

V

W

A

P

P

R

E

E

R

K

I

A

S

E

D

A

R

K

V

A

N

M

E

E

L

L

D

D

L

K

V

V

G

G

L

L

R

K

P

D

E

K

L

-

A

A

S
x
H

R

A

K
x
Y

P

P

G

D

S

S

L

L

S

S

G

G

Q

Q

C

A

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

E

E

P

P

R

K

L

I

I

M

I

L

A

F

D

D

E
|
E

C

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

G

G

Q

E

I

V

I

L

N

S

L

V

L

M

L

K

E

Q

L

L

Q

A

Q

N

R

E

M

-

H

G

L

M

A

T

I

M

L

V

F

V

I

V

A

T

H

H

D

E

L

M

A

G

I

F

V

A

R

R

R

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

M

M

Y

D

L

G

G

G

K

Y

I

I

V

I

E

E

G

G

P

K

V

P

E

E

S

D

V

L

F

F

T

D

A

R

P

P

R

Q

H

H

P

E

Y

R

T

T

A

K

A

A

L

F

I

L

Q

S

A

K

I

V

binding phosphothiophosphoric acid-adenylate ester: V18 (≠ A30), P37 (≠ E49), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), S43 (= S55), T44 (= T56), H133 (≠ S149), Y135 (≠ K151), E164 (= E180)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 13

3c41J Abc protein artp in complex with amp-pnp/mg2+
34% identity, 72% coverage: 28:258/323 of query aligns to 16:241/242 of 3c41J

query
sites
3c41J

V

L

R

E

A
x
V

V

L

N

K

G

G

V

I

S

N

L

V

S

H

L

I

A

R

A

E

G

G

E

E

T

V

L

V

G

V

L

V

V

I

G

G

E
x
P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R
|
R

A

C

I

L

L

N

H

L

L

L

N

E

P

D

I

F

S

D

A

E

G

G

Q

E

V

I

L

I

F

I

D

D

G

G

I

I

D

N

M

L

A

-

H

K

G

A

S

K

A

D

I

T

D

N

I

L

T

N

R

K

L

V

R

R

H

E

E

E

T

V

A

G

M

M

I

V

F

F

Q

Q

D

-

P

-

Y

R

A

F

A

N

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

L

E

N

T

N

I

I

A

T

E

L

V

A

L

P

R

M

V

K

Q

V

R

R

K

K

V

W

A

P

P

R

E

E

R

K

I

A

S

E

D

A

R

K

V

A

N

M

E

E

L

L

D

D

L

K

V

V

G

G

L

L

R

K

P

D

E

K

L

-

A

A

S
x
H

R

A

K
x
Y

P

P

G

D

S

S

L

L

S

S

G

G

Q

Q

C

A

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

E

E

P

P

R

K

L

I

I

M

I

L

A

F

D
|
D

E

E

C

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

G

G

Q

E

I

V

I

L

N

S

L

V

L

M

L

K

E

Q

L

L

Q

A

Q

N

R

E

M

-

H

G

L

M

A

T

I

M

L

V

F

V

I

V

A

T

H

H

D

E

L

M

A

G

I

F

V

A

R

R

R

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

M

M

Y

D

L

G

G

G

K

Y

I

I

V

I

E

E

G

G

P

K

V

P

E

E

S

D

V

L

F

F

T

D

A

R

P

P

R

Q

H

H

P

E

Y

R

T

T

A

K

A

A

L

F

I

L

Q

S

A

K

I

V

binding phosphoaminophosphonic acid-adenylate ester: V18 (≠ A30), P37 (≠ E49), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), S43 (= S55), T44 (= T56), R47 (= R59), H133 (≠ S149), Y135 (≠ K151)
binding magnesium ion: S43 (= S55), D163 (= D179)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 13

2olkA Abc protein artp in complex with adp-beta-s
34% identity, 72% coverage: 28:258/323 of query aligns to 16:241/242 of 2olkA

query
sites
2olkA

V
x
L

R

E

A
x
V

V

L

N

K

G

G

V

I

S

N

L

V

S

H

L

I

A

R

A

E

G

G

E

E

T

V

L

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

A

C

I

L

L

N

H

L

L

L

N

E

P

D

I

F

S

D

A

E

G

G

Q

E

V

I

L

I

F

I

D

D

G

G

I

I

D

N

M

L

A

-

H

K

G

A

S

K

A

D

I

T

D

N

I

L

T

N

R

K

L

V

R

R

H

E

E

E

T

V

A

G

M

M

I

V

F

F

Q

Q

D

-

P

-

Y

R

A

F

A

N

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

L

E

N

T

N

I

I

A

T

E

L

V

A

L

P

R

M

V

K

Q

V

R

R

K

K

V

W

A

P

P

R

E

E

R

K

I

A

S

E

D

A

R

K

V

A

N

M

E

E

L

L

D

D

L

K

V

V

G

G

L

L

R

K

P

D

E

K

L

-

A

A

S

H

R

A

K

Y

P

P

G

D

S

S

L

L

S

S

G

G

Q

Q

C

A

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

E

E

P

P

R

K

L

I

I

M

I

L

A

F

D

D

E

E

C

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

G

G

Q

E

I

V

I

L

N

S

L

V

L

M

L

K

E

Q

L

L

Q

A

Q

N

R

E

M

-

H

G

L

M

A

T

I

M

L

V

F

V

I

V

A

T

H

H

D

E

L

M

A

G

I

F

V

A

R

R

R

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

M

M

Y

D

L

G

G

G

K

Y

I

I

V

I

E

E

G

G

P

K

V

P

E

E

S

D

V

L

F

F

T

D

A

R

P

P

R

Q

H

H

P

E

Y

R

T

T

A

K

A

A

L

F

I

L

Q

S

A

K

I

V

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: L16 (≠ V28), V18 (≠ A30), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), S43 (= S55), T44 (= T56)

Sites not aligning to the query:

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: 13

2oljA Abc protein artp in complex with adp/mg2+
34% identity, 72% coverage: 28:258/323 of query aligns to 16:241/242 of 2oljA

query
sites
2oljA

V

L

R

E

A
x
V

V

L

N

K

G

G

V

I

S

N

L

V

S

H

L

I

A

R

A

E

G

G

E

E

T

V

L

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

A

C

I

L

L

N

H

L

L

L

N

E

P

D

I

F

S

D

A

E

G

G

Q

E

V

I

L

I

F

I

D

D

G

G

I

I

D

N

M

L

A

-

H

K

G

A

S

K

A

D

I

T

D

N

I

L

T

N

R

K

L

V

R

R

H

E

E

E

T

V

A

G

M

M

I

V

F

F

Q

Q

D

-

P

-

Y

R

A

F

A

N

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

L

E

N

T

N

I

I

A

T

E

L

V

A

L

P

R

M

V

K

Q

V

R

R

K

K

V

W

A

P

P

R

E

E

R

K

I

A

S

E

D

A

R

K

V

A

N

M

E

E

L

L

D

D

L

K

V

V

G

G

L

L

R

K

P

D

E

K

L

-

A

A

S
x
H

R

A

K
x
Y

P

P

G

D

S

S

L

L

S

S

G

G

Q

Q

C

A

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

E

E

P

P

R

K

L

I

I

M

I

L

A

F

D

D

E

E

C

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

G

G

Q

E

I

V

I

L

N

S

L

V

L

M

L

K

E

Q

L

L

Q

A

Q

N

R

E

M

-

H

G

L

M

A

T

I

M

L

V

F

V

I

V

A

T

H

H

D

E

L

M

A

G

I

F

V

A

R

R

R

E

L

V

C

G

D

D

R

R

V

V

A

L

V

F

M

M

Y

D

L

G

G

G

K

Y

I

I

V

I

E

E

G

G

P

K

V

P

E

E

S

D

V

L

F

F

T

D

A

R

P

P

R

Q

H

H

P

E

Y

R

T

T

A

K

A

A

L

F

I

L

Q

S

A

K

I

V

binding adenosine-5'-diphosphate: V18 (≠ A30), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), S43 (= S55), T44 (= T56), H133 (≠ S149), Y135 (≠ K151)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 13

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
36% identity, 70% coverage: 34:258/323 of query aligns to 36:251/378 of P69874

query
sites
P69874

V

L

S

D

L

L

S

T

L

I

A

N

G

G

E

E

T
x
F

L

L

G

T

L

L

V

L

G

G

E

P

S

S

G

G

S
x
C

G

G

K

K

S

T

T

T

L

V

G
x
L

R

R

A

L

I

I

L

A

H

G

L

L

N

E

P

T

I

V

S

D

A

S

G

G

Q

R

V

I

L

M

F
x
L

D

D

G

N

I

E

D

D

M

I

A

T

H

H

G

V

S

P

A

A

I

E

D

N

I

-

T

-

R

-

L

-

R

-

H

R

E

Y

T

V

A

N

M

T

I

V

F

F

Q

Q

D

S

P

-

Y

-

A

Y

A

A

L

L

N

F

P

P

R

H

H

M

T

T

I

V

G

F

E

E

T

N

I

V

A

A

E

F

V

G

L

L

R

R

V

M

Q

Q

R

K

K

T

V

P

A

A

P

A

E

E

R

-

I

I

S

T

D

P

R

R

V

V

N

M

E

E

L

A

L

L

D

R

L

M

V
|
V

G

Q

L

L

R

E

P

T

E

-

L

F

A

A

S

Q

R

R

K

K

P

P

G

H

S

Q

L

L

S

S

G

G

Q

Q

C

Q

Q

Q

R

R

V

V

G

A

I

I

A

A

R

R

A

A

L

V

A

V

V

N

E

K

P

P

R

R

L

L

I

L

A

L

D
|
D

E

E

C

S

V

L

A

S

A

A

L

L

D

D

V

Y

S

K

I

L

Q

R

G

K

Q

Q

I

M

I

Q

N

N

L

E

L

L

L

K

E

A

L

L

Q

Q

Q

R

R

K

M

L

H

G

L

I

A

T

I

F

L

V

F

F

I

V

A

T

H

H

D

D

L

Q

A

E

I

E

V

A

R

L

R

T

L

M

C

S

D

D

R

R

V

I

A

V

V

V

M

M

Y

R

L

D

G

G

K

R

I

I

V

E

E

Q

E

D

G

G

P

T

V

P

E

R

S

E

V

I

F

Y

T

E

A

E

P

P

R

K

H

N

P

L

Y

F

T

V

A

A

A

G

L

F

I

I

Q

G

A

E

I

I

F45 (≠ T43) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ S52) mutation to T: Loss of ATPase activity and transport.
L60 (≠ G58) mutation to F: Lower ATPase activity and transport efficiency.
L76 (≠ F74) mutation to P: Lower ATPase activity and transport efficiency.
V135 (= V141) mutation to M: Loss of ATPase activity and transport.
D172 (= D179) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

26 C→A: Lower ATPase activity and transport efficiency.
27 F→L: Lower ATPase activity and transport efficiency.
276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

7ahhC Opua inhibited inward-facing, sbd docked (see paper)
36% identity, 72% coverage: 30:260/323 of query aligns to 41:268/382 of 7ahhC

query
sites
7ahhC

A
x
G

V

V

N

Y

G

D

V

T

S

N

L

F

S

E

L

I

A

N

A

E

G

G

E

E

T

I

L

F

G

V

L

I

V

M

G

G

E

L

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

L

R

R

A

L

I

L

L

N

H

R

L

L

N

I

P

E

I

P

S

T

A

S

G

G

Q

K

V

I

L

F

F

I

D

D

G

N

I

Q

D

D

M

V

A

A

H

T

G

L

S

N

A

K

I

E

D

D

I

L

T

L

R

Q

L

V

R

R

H

R

E

K

T

T

-

M

A

S

M

M

I

V

F

F

Q

Q

D

N

P

-

Y

-

A

F

A

G

L

L

N

F

P

P

R

H

H

R

T

T

I

I

G

L

E

E

T

N

I

T

A

E

E

Y

V

G

L

L

R

E

V

V

Q

Q

R

N

K

-

V

V

A

P

P

K

E

E

R

E

I

R

S

R

D

K

R

R

V

A

N

E

E

K

L

A

L

L

D

D

L

N

V

A

G

N

L

L

R

-

P

L

E

D

L

F

A

K

S

D

R

Q

K

Y

P

P

G

K

S

Q

L

L

S

S

G

G

Q

M

C

Q

Q

Q

R

R

V

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

V

N

E

D

P

P

R

E

L

I

I

L

A

M

D
|
D

E
|
E

C

A

V

F

A

S

A

A

L

L

D

D

V

P

S

L

I

I

Q

R

G

R

Q

E

I

M

I

Q

N

D

L

E

L

L

E

E

L

L

Q

Q

Q

A

R

K

M

F

H

Q

L

K

A

T

I

I

L

I

F

F

I

V

A

S

H

H

D

D

L

L

A

N

I

E

V

A

R

L

R

R

L

I

C

G

D

D

R

R

V

I

A

A

V

I

M

M

Y

K

L

D

G

G

K

K

I

I

V

M

E

Q

E

I

G

G

P

T

V

G

E

E

S

E

V

I

F

L

T

T

A

N

P

P

R

A

H

N

P

D

Y

Y

T

V

A

K

A

T

L

F

I

V

Q

E

A

D

I

T

P

A

E

E

binding phosphoaminophosphonic acid-adenylate ester: G41 (≠ A30), S61 (= S50), G62 (= G51), S63 (= S52), G64 (= G53), K65 (= K54), S66 (= S55), T67 (= T56), D187 (= D179), E188 (= E180)

Sites not aligning to the query:

7aheC Opua inhibited inward facing (see paper)
36% identity, 72% coverage: 30:260/323 of query aligns to 41:268/382 of 7aheC

query
sites
7aheC

A

G

V

V

N

Y

G

D

V

T

S

N

L

F

S

E

L

I

A

N

A

E

G

G

E

E

T

I

L

F

G

V

L

I

V

M

G

G

E

L

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

G

L

R

R

A

L

I

L

L

N

H

R

L

L

N

I

P

E

I

P

S

T

A

S

G

G

Q

K

V

I

L

F

F

I

D

D

G

N

I

Q

D

D

M

V

A

A

H

T

G

L

S

N

A

K

I

E

D

D

I

L

T

L

R

Q

L

V

R

R

H

R

E

K

T

T

-

M

A

S

M

M

I

V

F

F

Q

Q

D

N

P

-

Y

-

A

F

A

G

L

L

N

F

P

P

R

H

H

R

T

T

I

I

G

L

E

E

T

N

I

T

A

E

E

Y

V

G

L

L

R

E

V

V

Q

Q

R

N

K

-

V

V

A

P

P

K

E

E

R

E

I

R

S

R

D

K

R

R

V

A

N

E

E

K

L

A

L

L

D

D

L

N

V

A

G

N

L

L

R

-

P

L

E

D

L

F

A

K

S

D

R

Q

K

Y

P

P

G

K

S

Q

L

L

S

S

G

G

Q

M

C

Q

Q

Q

R

R

V

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

V

N

E

D

P

P

R

E

L

I

I

L

A

M

D

D

E

E

C

A

V

F

A

S

A

A

L

L

D

D

V

P

S

L

I

I

Q

R

G

R

Q

E

I

M

I

Q

N

D

L

E

L

L

E

E

L

L

Q

Q

Q

A

R

K

M

F

H

Q

L

K

A

T

I

I

L

I

F

F

I

V

A

S

H

H

D

D

L

L

A

N

I

E

V

A

R

L

R

R

L

I

C

G

D

D

R

R

V

I

A

A

V

I

M

M

Y

K

L

D

G

G

K

K

I

I

V

M

E

Q

E

I

G

G

P

T

V

G

E

E

S

E

V

I

F

L

T

T

A

N

P

P

R

A

H

N

P

D

Y

Y

T

V

A

K

A

T

L

F

I

V

Q

E

A

D

I

T

P

A

E

E

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 275, 295, 296, 297, 298, 357, 372

7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp (see paper)
35% identity, 71% coverage: 29:258/323 of query aligns to 17:247/250 of 7z18I

query
sites
7z18I

R
x
K

A
x
G

V

F

N

S

G

D

V

V

S

S

L

F

S

D

L

L

A

W

A

P

G

G

E

E

T

V

L

L

G

G

L

I

V

V

G

G

E

E

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

G

L

R

K

A

S

I

I

-

S

L

A

H

R

L

L

N

T

P

P

I

-

S

Q

A

Q

G

G

Q

E

V

I

L

H

F

Y

D

E

G

N

I

R

D

S

M

L

A

Y

H

A

G

M

S

S

A

E

I

A

D

D

I

R

T

R

R

R

L

L

-

L

R

R

H

T

E

E

T

W

A

G

M

V

I

V

F

H

Q
|
Q

D

H

P

P

Y

L

A

D

A

G

L

L

N

R

P

R

R

Q

H

V

T

S

I

A

G

G

E

G

T

N

I

I

A

G

E

E

V

R

L

L

R

M

V

A

Q

T

R

G

K

A

V

R

A

H

P

Y

E

G

R

D

I

I

S

R

D

A

R

T

V

A

N

Q

E

K

L

W

L

L

D

E

L

E

V

V

G

E

L

I

R

P

P

A

E

N

L
x
R

A

I

S

D

R

D

K

L

P

P

G

T

S
x
T

L
x
F

S
|
S

G
|
G

Q
x
M

C

Q

Q

Q

R

R

V

L

G

Q

I

I

A

A

R

R

A

N

L

L

A

V

V

T

E

H

P

P

R

K

L

L

I

V

I

F

A

M

D

D

E

E

C

P

V

T

A

G

L

L

D

D

V

V

S

S

I

V

Q

Q

G

A

Q

R

I

L

N

D

L

L

L

R

E

G

L

L

Q

V

R

E

M

L

H

N

L

L

A

A

I

V

L

V

F

I

I

V

A

T

H
|
H

D

D

L

L

A

G

I

V

V

A

R

R

R

L

L

L

C

A

D

D

R

R

V

L

A

L

V

V

M

M

Y

K

L

Q

G

G

K

Q

I

V

V

V

E

E

E

S

G

G

P

L

V

T

E

D

S

R

V

V

F

L

T

D

A

D

P

P

R

H

H

H

P

P

Y

Y

T

T

A

Q

A

L

L

L

I

V

Q

S

A

S

I

V

binding adenosine-5'-triphosphate: K17 (≠ R29), G18 (≠ A30), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), T43 (≠ S55), T44 (= T56), Q88 (= Q99), R136 (≠ L147), T143 (≠ S154), F144 (≠ L155), S145 (= S156), G146 (= G157), G147 (= G158), M148 (≠ Q159), H202 (= H213)
binding magnesium ion: T43 (≠ S55), Q88 (= Q99)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

7z15I E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
35% identity, 71% coverage: 29:258/323 of query aligns to 17:247/253 of 7z15I

query
sites
7z15I

R
x
K

A
x
G

V

F

N

S

G

D

V

V

S

S

L

F

S

D

L

L

A

W

A

P

G

G

E

E

T

V

L

L

G

G

L

I

V

V

G

G

E
|
E

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

G

L

R

K

A

S

I

I

-

S

L

A

H

R

L

L

N

T

P

P

I

-

S

Q

A

Q

G

G

Q

E

V

I

L

H

F

Y

D

E

G

N

I

R

D

S

M

L

A

Y

H

A

G

M

S

S

A

E

I

A

D

D

I

R

T

R

R

R

L

L

-

L

R

R

H

T

E

E

T

W

A

G

M

V

I

V

F

H

Q
|
Q

D

H

P

P

Y

L

A

D

A

G

L

L

N

R

P

R

R

Q

H

V

T

S

I

A

G

G

E

G

T

N

I

I

A

G

E

E

V

R

L

L

R

M

V

A

Q

T

R

G

K

A

V

R

A

H

P

Y

E

G

R

D

I

I

S

R

D

A

R

T

V

A

N

Q

E

K

L

W

L

L

D

E

L

E

V

V

G

E

L

I

R

P

P

A

E

N

L
x
R

A

I

S

D

R

D

K

L

P

P

G

T

S
x
T

L

F

S
|
S

G

G

Q
x
M

C

Q

Q

Q

R

R

V

L

G

Q

I

I

A

A

R

R

A

N

L

L

A

V

V

T

E

H

P

P

R

K

L

L

I

V

I

F

A

M

D
|
D

E

E

C

P

V

T

A

G

L

L

D

D

V

V

S

S

I

V

Q

Q

G

A

Q

R

I

L

N

D

L

L

L

R

E

G

L

L

Q

V

R

E

M

L

H

N

L

L

A

A

I

V

L

V

F

I

I

V

A

T

H

H

D

D

L

L

A

G

I

V

V

A

R

R

R

L

L

L

C

A

D

D

R

R

V

L

A

L

V

V

M

M

Y

K

L

Q

G

G

K

Q

I

V

V

V

E

E

E

S

G

G

P

L

V

T

E

D

S

R

V

V

F

L

T

D

A

D

P

P

R

H

H

H

P

P

Y

Y

T

T

A

Q

A

L

L

L

I

V

Q

S

A

S

I

V

binding adenosine-5'-diphosphate: K17 (≠ R29), G18 (≠ A30), E37 (= E49), S38 (= S50), G39 (= G51), S40 (= S52), G41 (= G53), K42 (= K54), T43 (≠ S55), T44 (= T56), R136 (≠ L147), T143 (≠ S154), S145 (= S156), M148 (≠ Q159)
binding magnesium ion: T43 (≠ S55), Q88 (= Q99), D168 (= D179)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 13

7ahdC Opua (e190q) occluded (see paper)
36% identity, 68% coverage: 30:250/323 of query aligns to 41:258/260 of 7ahdC

query
sites
7ahdC

A

G

V

V

N

Y

G

D

V

T

S

N

L

F

S

E

L

I

A

N

A

E

G

G

E

E

T

I

L

F

G

V

L

I

V

M

G

G

E

L

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

L

R

R

A

L

I

L

L

N

H

R

L

L

N

I

P

E

I

P

S

T

A

S

G

G

Q

K

V

I

L

F

F

I

D

D

G

N

I

Q

D

D

M

V

A

A

H

T

G

L

S

N

A

K

I

E

D

D

I

L

T

L

R

Q

L

V

R

R

H

R

E

K

T

T

-

M

A

S

M

M

I

V

F

F

Q
|
Q

D

N

P

-

Y

-

A

F

A

G

L

L

N

F

P

P

R

H

H

R

T

T

I

I

G

L

E

E

T

N

I

T

A

E

E

Y

V

G

L

L

R

E

V

V

Q

Q

R

-

K

N

V

V

A

P

P

K

E

E

R

E

I

R

S

R

D

K

R

R

V

A

N

E

E

K

L

A

L

L

D

D

L

N

V

A

G

N

L

L

R

-

P

L

E

D

L

F

A

K

S

D

R

Q

K

Y

P

P

G
x
K

S
x
Q

L

L

S
|
S

G

G