SitesBLAST

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
48% identity, 96% coverage: 3:156/160 of query aligns to 2:156/166 of P19921

query
sites
P19921

S

A

K

K

I

A

H

H

V

I

S

E

A

L

T

T

I

I

N

N

G

G

D

H

A

P

V

V

D

E

Y

A

L

L

C

V

D

E

P

P

R

R

E

T

T

L

L

L

L

I

D

H

V

F

L

I

R

R

D

E

R

Q

L

Q

N

N

L

L

T

T

G

G

A

A

K

H

E

I

G

G

C
|
C

G

D

T

T

G

S

D

H

C
|
C

G

G

A

A

C
|
C

S

T

I

V

T

D

L

L

N

D

G

G

R

M

L

S

V

V

C

K

S

S

C
|
C

L

T

V

M

L

F

G

A

V

V

E

Q

A

A

E

N

G

G

Q

A

E

S

I

I

A

T

T

T

V

I

E

E

G

G

I

M

A

A

-

A

P

P

G

D

E

G

T

T

L

L

H

S

P

A

L

L

Q

Q

Q

E

K

G

F

F

I

R

D

M

H

M

A

H

A

G

L

L

Q

Q

C
|
C

G

G

I

Y

C
|
C

T

T

P

P

G

G

I

M

L

I

V

M

A

R

A

S

K

H

A

R

L

L

E

Q

K

E

N

N

P

P

D

S

P

P

T

T

E

E

T

A

E

E

V

I

R

R

Y

F

W

G

L

I

A

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

Q

K

N

I

I

I

V

R

K

A

A

V

I

M

Q

D

Y

A

A

E

K

M

I

C42 (= C43) binding
C47 (= C48) binding
C50 (= C51) binding
C62 (= C63) binding
C102 (= C102) binding
C105 (= C105) binding
C137 (= C137) binding
C139 (= C139) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
48% identity, 96% coverage: 4:156/160 of query aligns to 1:154/161 of 1n5wA

query
sites
1n5wA

K

K

I

A

H

H

V

I

S

E

A

L

T

T

I

I

N

N

G

G

D

H

A

P

V

V

D

E

Y

A

L

L

C

V

D

E

P

P

R

R

E

T

T

L

L

L

L

I

D

H

V

F

L

I

R

R

D

E

R

Q

L

Q

N

N

L

L

T

T

G

G

A

A

K

H

E
x
I

G
|
G

C
|
C

G

D

T

T

G
x
S

D
x
H

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

D

L

L

N

D

G

G

R

M

L

S

V

V

C

K

S

S

C
|
C

L

T

V

M

L

F

G

A

V

V

E

Q

A

A

E

N

G

G

Q

A

E

S

I

I

A

T

T

T

V

I

E

E

G

G

I

M

A

A

-

A

P

P

G

D

E

G

T

T

L

L

H

S

P

A

L

L

Q

Q

Q

E

K

G

F

F

I

R

D

M

H

M

A

H

A

G

L

L

Q

Q

C
|
C

G
|
G

I

Y

C
|
C

T

T

P

P

G

G

I

M

L

I

V

M

A

R

A

S

K

H

A

R

L

L

E

Q

K

E

N

N

P

P

D

S

P

P

T

T

E

E

T

A

E

E

V

I

R

R

Y

F

W

G

L

I

A

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

Q

K

N

I

I

I

V

R

K

A

A

V

I

M

Q

D

Y

A

A

E

K

M

I

binding flavin-adenine dinucleotide: S43 (≠ G46), H44 (≠ D47)
binding fe2/s2 (inorganic) cluster: I38 (≠ E41), G39 (= G42), C40 (= C43), S43 (≠ G46), C45 (= C48), G46 (= G49), C48 (= C51), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)

1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
48% identity, 96% coverage: 4:156/160 of query aligns to 1:154/158 of 1n5wD

query
sites
1n5wD

K

K

I

A

H

H

V

I

S

E

A

L

T

T

I

I

N

N

G

G

D

H

A

P

V

V

D

E

Y

A

L

L

C

V

D

E

P

P

R

R

E

T

T

L

L

L

L

I

D

H

V

F

L

I

R

R

D

E

R

Q

L

Q

N

N

L

L

T

T

G

G

A

A

K

H

E

I

G

G

C
|
C

G

D

T

T

G
x
S

D
x
H

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

D

L

L

N

D

G

G

R

M

L

S

V

V

C

K

S

S

C
|
C

L

T

V

M

L

F

G

A

V

V

E

Q

A

A

E

N

G

G

Q

A

E

S

I

I

A

T

T

T

V

I

E

E

G

G

I

M

A

A

-

A

P

P

G

D

E

G

T

T

L

L

H

S

P

A

L

L

Q

Q

Q

E

K

G

F

F

I

R

D

M

H

M

A

H

A

G

L

L

Q
|
Q

C
|
C

G
|
G

I

Y

C
|
C

T

T

P

P

G

G

I

M

L

I

V

M

A

R

A

S

K

H

A

R

L

L

E

Q

K

E

N

N

P

P

D

S

P

P

T

T

E

E

T

A

E

E

V

I

R

R

Y

F

W

G

L

I

A

G

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

Q

K

N

I

I

I

V

R

K

A

A

V

I

M

Q

D

Y

A

A

E

K

M

I

binding flavin-adenine dinucleotide: S43 (≠ G46), H44 (≠ D47)
binding fe2/s2 (inorganic) cluster: C40 (= C43), S43 (≠ G46), C45 (= C48), G46 (= G49), C48 (= C51), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)
binding pterin cytosine dinucleotide: Q99 (= Q101), C137 (= C139)

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
50% identity, 95% coverage: 2:153/160 of query aligns to 1:152/162 of 1t3qA

query
sites
1t3qA

S

S

S

Q

K

L

I

M

H

R

V

I

S

S

A

A

T

T

I

I

N

N

G

G

D

K

A

P

V

R

D

V

Y

F

L

Y

C

V

D

E

P

P

R

R

E

M

T

H

L

L

L

A

D

D

V

A

L

L

R

R

D

E

R

V

L

V

N

G

L

L

T

T

G

G

A

T

K

K

E
x
I

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

V

C
|
C

G
|
G

A

S

C
|
C

S

T

I

I

T

L

L

I

N

D

G

G

R

A

L

P

V

M

C
x
R

S

S

C
|
C

L

L

V

T

L

L

G

A

V

V

E

Q

A

A

E

E

G

G

Q

C

E

S

I

I

A

E

T

T

V

V

E

E

G

G

I

L

A

S

P

Q

G

G

E

E

T

K

L

L

H

N

P

A

L

L

Q

Q

Q

D

K

S

F

F

I

R

D

R

H

H

A

H

A

A

L

L

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

T

P

A

G

G

I

M

L

L

V

A

A

T

A

A

K

R

A

S

L

I

L

L

E

A

K

E

N

N

P

P

D

A

P

P

T

S

E

R

T

D

E

E

V

V

R

R

Y

E

W

V

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

E

K

T

I

I

R

D

A

A

V

I

M

T

D

D

A

P

A

A

binding fe2/s2 (inorganic) cluster: I40 (≠ E41), C42 (= C43), E43 (≠ G44), G45 (= G46), C47 (= C48), G48 (= G49), C50 (= C51), R60 (≠ C61), C62 (= C63), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
49% identity, 92% coverage: 11:157/160 of query aligns to 8:157/906 of 1dgjA

query
sites
1dgjA

I

V

N

N

G

G

D

M

A

A

V

R

D

R

Y

L

L

L

C

V

D

S

P

P

R

N

E

D

T

L

L

L

L

V

D

D

V

V

L

L

R

R

D

S

R

Q

L

L

N

Q

L

L

T

T

G

S

A

V

K

K

E
x
V

G
|
G

C
|
C

G
|
G

T

K

G
|
G

D
x
Q

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

I

V

I

-

K

L

M

G

S

V

R

E

V

A

A

E

E

G

N

Q

A

E

S

I

V

A

T

T

T

V

L

E

E

G

G

I

I

A

G

P

A

G

P

E

D

T

C

L

L

H

H

P

P

L

L

Q

Q

Q

H

K

A

F

W

I

I

D

Q

H

H

A

G

A

A

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

T

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

A

L

L

E

D

K

E

N

N

P

V

D

A

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

N

N

L

I

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

E

I

M

L

R

R

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), G39 (= G42), C40 (= C43), G41 (= G44), G43 (= G46), Q44 (≠ D47), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding pterin cytosine dinucleotide: Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 535, 698, 869
binding pterin cytosine dinucleotide: 423, 424, 535, 652, 655, 656, 657, 658, 697, 698, 700, 702, 703, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
46% identity, 96% coverage: 4:156/160 of query aligns to 2:155/157 of 5y6qA

query
sites
5y6qA

K

R

I

I

H

S

V

L

S

T

A

M

T

Q

I

V

N

N

G

G

D

Q

A

P

V

Y

D

P

Y

M

L

E

C

I

D

D

P

P

R

R

E

V

T

T

L

L

D

D

V

A

L

L

R

R

D

E

R

H

L

L

N

N

L

L

T

T

G

G

A

T

K

K

E

K

G
|
G

C
|
C

G
x
D

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

L

L

V

N

N

G

G

R

Q

L

R

V

V

C

L

S

S

C
|
C

L

L

V

T

L

L

G

A

V

A

E

Q

A

A

E

D

G

G

Q

A

E

E

I

V

A

T

T

S

V

I

E

E

G

G

I

L

-

Q

-

S

A

A

P

S

G

G

E

E

T

-

L

L

H

H

P

P

L

V

Q

Q

Q

R

K

C

F

F

I

V

D

E

H

N

A

D

A

A

L

F

Q
|
Q

C
|
C

G
|
G

I

Y

C
|
C

T

T

P

P

G

G

I

Q

L

I

V

M

A

S

A

A

K

V

A

A

L

C

L

I

E

K

K

E

N

G

P

H

D

A

P

G

T

S

E

D

T

D

E

E

V

I

R

R

Y

E

W

Y

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

D

P

K

H

I

I

R

D

A

A

V

I

M

K

D

Q

A

A

E

E

M

M

binding fe2/s2 (inorganic) cluster: G40 (= G42), C41 (= C43), D42 (≠ G44), G44 (= G46), C46 (= C48), G47 (= G49), C49 (= C51), C61 (= C63), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

3hrdD Crystal structure of nicotinate dehydrogenase (see paper)
48% identity, 92% coverage: 3:149/160 of query aligns to 2:148/160 of 3hrdD

query
sites
3hrdD

S

N

K

K

I

I

H

T

V

I

S

N

A

L

T

N

I

L

N

N

G

G

D

E

A

A

V

R

D

S

Y

I

L

V

C

T

D

E

P

P

R

N

E

K

T

R

L

L

D

D

V

L

L

L

R

R

D

E

R

D

L

F

N

G

L

L

T

T

G

S

A

V

K

K

E
|
E

G

G

C
|
C

G
x
S

T
x
E

G
|
G

D
x
E

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

I

L

F

N

N

G

G

R

D

L

P

V

V

C

T

S

T

C
|
C

L

C

V

M

L

L

G

A

V

G

E

Q

A

A

E

D

G

E

Q

S

E

T

I

I

A

I

T

T

V

L

E

E

G

G

I

V

A

A

P

E

G

D

E

G

T

K

L

P

H

S

P

L

L

L

Q

Q

K

C

F

F

I

L

D

E

H

A

A

G

A

A

L

V

Q
|
Q

C
|
C

G
|
G

I

Y

C
|
C

T

T

P

P

G

G

I

M

L

I

V

L

A

T

A

A

K

K

A

A

L

L

E

D

K

K

N

N

P

P

D

D

P

P

T

T

E

D

T

E

E

E

V

I

R

T

Y

V

W

A

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

I

K

K

I

I

I

H

R

A

A

A

V

V

binding flavin-adenine dinucleotide: E44 (≠ T45), G45 (= G46), E46 (≠ D47)
binding fe2/s2 (inorganic) cluster: E40 (= E41), C42 (= C43), S43 (≠ G44), G45 (= G46), C47 (= C48), G48 (= G49), C50 (= C51), C62 (= C63), Q100 (= Q101), C101 (= C102), G102 (= G103), C104 (= C105), C136 (= C137), C138 (= C139)
binding pterin cytosine dinucleotide: Q100 (= Q101), C138 (= C139)

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
48% identity, 92% coverage: 3:149/160 of query aligns to 2:148/157 of Q0QLF3

query
sites
Q0QLF3

S

N

K

K

I

I

H

T

V

I

S

N

A

L

T

N

I

L

N

N

G

G

D

E

A

A

V

R

D

S

Y

I

L

V

C

T

D

E

P

P

R

N

E

K

T

R

L

L

D

D

V

L

L

L

R

R

D

E

R

D

L

F

N

G

L

L

T

T

G

S

A

V

K

K

E

E

G

G

C
|
C

G

S

T

E

G

G

D

E

C
|
C

G

G

A

A

C
|
C

S

T

I

V

T

I

L

F

N

N

G

G

R

D

L

P

V

V

C

T

S

T

C
|
C

L

C

V

M

L

L

G

A

V

G

E

Q

A

A

E

D

G

E

Q

S

E

T

I

I

A

I

T

T

V

L

E

E

G

G

I

V

A

A

P

E

G

D

E

G

T

K

L

P

H

S

P

L

L

L

Q

Q

K

C

F

F

I

L

D

E

H

A

A

G

A

A

L

V

Q

Q

C
|
C

G

G

I

Y

C
|
C

T

T

P

P

G

G

I

M

L

I

V

L

A

T

A

A

K

K

A

A

L

L

E

D

K

K

N

N

P

P

D

D

P

P

T

T

E

D

T

E

E

E

V

I

R

T

Y

V

W

A

L

M

A

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

I

K

K

I

I

I

H

R

A

A

A

V

V

C42 (= C43) binding
C47 (= C48) binding
C50 (= C51) binding
C62 (= C63) binding
C101 (= C102) binding
C104 (= C105) binding
C136 (= C137) binding
C138 (= C139) binding

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 4usaA

query
sites
4usaA

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 531, 532, 535, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 4us9A

query
sites
4us9A

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 257, 258, 752
binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 4us8A

query
sites
4us8A

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 532, 535, 539
binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 4c7yA

query
sites
4c7yA

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E

V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 535, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 3fc4A

query
sites
3fc4A

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 3fahA

query
sites
3fahA

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 535, 622, 683, 696, 697, 869, 884, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of 1sijA

query
sites
1sijA

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E
x
V

G

G

C
|
C

G
x
E

T

Q

G
|
G

D

Q

C
|
C

G
|
G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C
x
R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

binding fe2/s2 (inorganic) cluster: V38 (≠ E41), C40 (= C43), E41 (≠ G44), G43 (= G46), C45 (= C48), G46 (= G49), C48 (= C51), R58 (≠ C61), C60 (= C63), Q99 (= Q101), C100 (= C102), G101 (= G103), C103 (= C105), C137 (= C137), C139 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C139 (= C139)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding arsenite: 535, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 698, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

Q46509 Aldehyde oxidoreductase; Molybdenum iron sulfur protein; EC 1.2.99.7 from Megalodesulfovibrio gigas (Desulfovibrio gigas) (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 7:154/907 of Q46509

query
sites
Q46509

T

T

I

V

N

N

G

G

D

I

A

E

V

Q

D

N

Y

L

L

F

C

V

D

D

P

A

R

E

E

A

T

L

L

L

L

S

D

D

V

V

L

L

R

R

D

Q

R

Q

L

L

N

G

L

L

T

T

G

G

A

V

K

K

E

V

G

G

C
|
C

G

E

T

Q

G

G

D

Q

C
|
C

G

G

A

A

C
|
C

S

S

I

V

T

I

L

L

N

D

G

G

R

K

L

V

V

V

C

R

S

A

C
|
C

L

V

V

T

-

K

L

M

G

K

V

R

E

V

A

A

E

D

G

G

Q

A

E

Q

I

I

A

T

T

T

V

I

E

E

G

G

I

V

A

G

P

Q

G

P

E

E

T

N

L

L

H

H

P

P

L

L

Q

Q

Q

K

K

A

F

W

I

V

D

L

H

H

A

G

L

A

Q

Q

C
|
C

G

G

I

F

C
|
C

T

S

P

P

G

G

I

F

L

I

V

V

A

S

A

A

K

K

A

G

L

L

E

D

K

T

N

N

P

A

D

D

P

P

T

S

E

R

T

E

E

D

V

V

R

R

Y

D

W

W

L

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

K

K

P

I

L

I

V

R

D

A

A

V

V

M

M

D

D

A

A

C40 (= C43) binding
C45 (= C48) binding
C48 (= C51) binding
C60 (= C63) binding
C100 (= C102) binding
C103 (= C105) binding
C137 (= C137) binding
C139 (= C139) binding

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
47% identity, 91% coverage: 10:154/160 of query aligns to 8:152/161 of 1sb3C

query
sites
1sb3C

T

T

I

L

N

N

G

G

D

R

A

A

V

R

D

E

Y

D

L

L

C

V

D

P

P

D

R

N

E

M

T

L

L

L

D

D

V

Y

L

L

R

R

D

E

R

T

L

V

N

G

L

L

T

T

G

G

A

T

K

K

E
x
Q

G

G

C
|
C

G

D

T

G

G
|
G

D

E

C
|
C

G
|
G

A

A

C
|
C

S

T

I

V

T

L

L

V

N

D

G

D

R

R

L

P

V

R

C

L

S

A

C
|
C

L

S

V

T

L

L

G

A

V

H

E

Q

A

V

E

A

G

G

Q

K

E

K

I

V

A

E

T

T

V

V

E

E

G

S

I

L

A

A

P

T

G

Q

E

G

T

T

L

L

H

S

P

K

L

L

Q

Q

Q

A

K

A

F

F

I

H

D

E

H

K

A

L

A

G

L

T

Q
|
Q

C
|
C

G
|
G

I

F

C
|
C

T

T

P

P

G

G

I

M

L

I

V

M

A

A

A

S

K

E

A

A

L

L

E

R

K

K

N

N

P

P

D

S

P

P

T

S

E

R

T

D

E

E

V

I

R

K

Y

A

W

A

L

L

A

A

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

D

V

K

K

I

I

R

K

A

S

V

V

M

E

D

T

A

A

binding fe2/s2 (inorganic) cluster: Q39 (≠ E41), C41 (= C43), G44 (= G46), C46 (= C48), G47 (= G49), C49 (= C51), C61 (= C63), C100 (= C102), G101 (= G103), C103 (= C105), C135 (= C137), C137 (= C139)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q101), C137 (= C139)

Query Sequence

>GFF1599 FitnessBrowser__Phaeo:GFF1599
MSSKIHVSATINGDAVDYLCDPRETLLDVLRDRLNLTGAKEGCGTGDCGACSITLNGRLV
CSCLVLGVEAEGQEIATVEGIAPGETLHPLQQKFIDHAALQCGICTPGILVAAKALLEKN
PDPTETEVRYWLAGNLCRCTGYDKIIRAVMDAAAEMREAS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory