SitesBLAST

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
42% identity, 93% coverage: 4:146/153 of query aligns to 8:151/157 of Q0QLF3

query
sites
Q0QLF3

L

L

T

N

I

L

N

N

G

G

E

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Y

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F

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N

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C

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M

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A

C42 (= C38) binding
C47 (= C43) binding
C50 (= C46) binding
C62 (= C58) binding
C101 (= C96) binding
C104 (= C99) binding
C136 (= C131) binding
C138 (= C133) binding

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
40% identity, 96% coverage: 3:149/153 of query aligns to 6:154/157 of 5y6qA

query
sites
5y6qA

T

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N

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x
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x
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C

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C

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D

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G

-

A

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N

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A
x
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M

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G

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Y

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E

binding flavin-adenine dinucleotide: G44 (≠ S41), Q45 (= Q42)
binding fe2/s2 (inorganic) cluster: K39 (≠ F36), G40 (= G37), C41 (= C38), D42 (≠ G39), G44 (≠ S41), C46 (= C43), G47 (= G44), C49 (= C46), C61 (= C58), F99 (≠ A94), Q100 (= Q95), C101 (= C96), G102 (= G97), C104 (= C99), C136 (= C131), R137 (= R132), C138 (= C133)
binding pterin cytosine dinucleotide: Q100 (= Q95), C101 (= C96), C138 (= C133)

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
43% identity, 95% coverage: 4:149/153 of query aligns to 8:155/166 of P19921

query
sites
P19921

L

L

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T

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C42 (= C38) binding
C47 (= C43) binding
C50 (= C46) binding
C62 (= C58) binding
C102 (= C96) binding
C105 (= C99) binding
C137 (= C131) binding
C139 (= C133) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
43% identity, 95% coverage: 4:149/153 of query aligns to 6:153/161 of 1n5wA

query
sites
1n5wA

L

L

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T

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N

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G

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binding flavin-adenine dinucleotide: T42 (≠ M40), S43 (= S41), H44 (≠ Q42)
binding fe2/s2 (inorganic) cluster: I38 (≠ F36), G39 (= G37), C40 (= C38), S43 (= S41), H44 (≠ Q42), C45 (= C43), G46 (= G44), C48 (= C46), K58 (≠ R56), C60 (= C58), L98 (≠ A94), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C135 (= C131), R136 (= R132), C137 (= C133)
binding pterin cytosine dinucleotide: Q99 (= Q95), C137 (= C133)

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
41% identity, 96% coverage: 3:149/153 of query aligns to 64:226/229 of P77165

query
sites
P77165

T

T

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N

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A

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A

L

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L

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L

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E

C99 (= C38) binding
C104 (= C43) binding
G105 (= G44) binding
C107 (= C46) binding
C119 (= C58) binding
C158 (= C96) binding
C161 (= C99) binding
C208 (= C131) binding
C210 (= C133) binding

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
41% identity, 96% coverage: 3:149/153 of query aligns to 13:175/175 of 5g5gA

query
sites
5g5gA

T

T

L

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N

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K

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x
K

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C
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G
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C
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C

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A

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C

T

T

V

V

H

L

L

V

N

N

G

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C

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L

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A

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G

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Q

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C

N

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A

S

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A

A

L

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L

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D

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G

-

I

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P

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H

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D

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L

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E

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T

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T

-

A

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E

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M

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G

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A

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Y

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A

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L

A

A

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D

A

A

S

A

G

G

K

E

binding flavin-adenine dinucleotide: G51 (≠ S41), Q52 (= Q42)
binding fe2/s2 (inorganic) cluster: K46 (≠ F36), G47 (= G37), C48 (= C38), D49 (≠ G39), G51 (≠ S41), Q52 (= Q42), C53 (= C43), G54 (= G44), C56 (= C46), N66 (≠ R56), C68 (= C58), Q106 (= Q95), C107 (= C96), G108 (= G97), C110 (= C99), C157 (= C131), C159 (= C133)
binding pterin cytosine dinucleotide: Q106 (= Q95), C159 (= C133)

1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
36% identity, 97% coverage: 1:149/153 of query aligns to 3:152/155 of 1ffvA

query
sites
1ffvA

M

I

A

I

T

T

L

V

T

N

I

V

N

N

G

G

E

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R

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Y

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E

E

L

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D

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D

P

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L

L

L

L

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E

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N

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x
I

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G

C
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C

G

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M
x
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S

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x
H

C
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C

G
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G

A

A

C
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C

T

T

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V

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D

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D

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G

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x
K

S

S

C
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C

V

T

T

H

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L

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A

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A

C

A

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G

G

S

E

E

I

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T

T

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E

E

A

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M

L

A

A

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N

D

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G

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K

A

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Q

Q

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G

A
x
L

Q
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Q

C
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C

G
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G

Y

F

C
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C

Q

T

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P

G

G

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M

I

L

M

M

N

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A

A

T

Y

A

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L

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P

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N

P

P

E

T

T

E

G

A

E

E

I

I

V

R

D

M

A

G

M

M

A

T

G

G

N

N

L

L

C
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C

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R

C
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C

G

T

T

G

Y

Y

N

Q

R

N

I

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L

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A

K

A

A

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A

A

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K

K

binding flavin-adenine dinucleotide: T42 (≠ M40), S43 (= S41), H44 (≠ Q42)
binding fe2/s2 (inorganic) cluster: I38 (≠ F36), G39 (= G37), C40 (= C38), S43 (= S41), H44 (≠ Q42), C45 (= C43), G46 (= G44), C48 (= C46), K58 (≠ R56), C60 (= C58), L97 (≠ A94), Q98 (= Q95), C99 (= C96), G100 (= G97), C102 (= C99), C134 (= C131), R135 (= R132), C136 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q95), C136 (= C133)

1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
36% identity, 96% coverage: 3:149/153 of query aligns to 6:153/156 of 1ffuD

query
sites
1ffuD

T

T

L

V

T

N

I

V

N

N

G

G

E

K

R

A

Y

Q

E

E

L

K

D

A

V

V

P

E

D

P

N

R

M

T

P

L

L

L

L

I

W

H

V

F

I

L

R

R

D

E

V

E

V

L

G

N

L

L

K

T

G

G

T

A

K

H

F
x
I

G
|
G

C
|
C

G

E

M

T

S
|
S

Q
x
H

C
|
C

G
|
G

A

A

C
|
C

T

T

V

V

H

D

L

I

N

D

G

G

T

R

A

S

I

V

R
x
K

S

S

C
|
C

V

T

T

H

-

L

P

A

V

V

S

Q

A

C

A

D

S

G

G

S

E

E

I

V

T

L

T

T

I

V

E

E

A

G

M

L

A

A

D

N

D

K

P

G

V

V

G

L

S

H

K

A

V

V

Q

Q

Q

E

A

G

W

F

L

Y

D

K

L

E

G

H

V

G

A

L

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

T

G

P

G

G

Q

M

I

L

M

M

N

R

A

A

T

Y

A

R

L

F

L

L

K

Q

R

E

T

N

P

P

N

N

P

P

E

T

T

E

G

A

E

E

I

I

V

R

D

M

A

G

M

M

A

T

G

G

N

N

L

L

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

Q

R

N

I

I

L

V

A

K

A

A

I

V

E

Q

R

Y

A

A

S

A

G

R

K

K

binding flavin-adenine dinucleotide: S44 (= S41), H45 (≠ Q42)
binding fe2/s2 (inorganic) cluster: I39 (≠ F36), G40 (= G37), C41 (= C38), S44 (= S41), H45 (≠ Q42), C46 (= C43), G47 (= G44), C49 (= C46), K59 (≠ R56), C61 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C135 (= C131), R136 (= R132), C137 (= C133)

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
38% identity, 91% coverage: 5:143/153 of query aligns to 9:148/162 of 1t3qA

query
sites
1t3qA

T

T

I

I

N

N

G

G

E

K

R

P

Y

R

E

V

L

F

D

Y

V

V

P

E

D

P

N

R

M

M

P

H

L

L

L

A

W

D

V

A

I

L

R

R

D

E

V

V

G

G

L

L

K

T

G

G

T

T

K

K

F
x
I

G
|
G

C
|
C

G
x
E

M
x
Q

S
x
G

Q
x
V

C
|
C

G
|
G

A
x
S

C
|
C

T

T

V

I

H

L

L

I

N

D

G

G

T

A

A

P

I

M

R
|
R

S

S

C
|
C

V

L

T

T

P

L

V

A

S

V

A

Q

A

A

S

E

G

G

-

C

E

S

I

I

T

E

T

T

I

V

E

E

A

G

M

L

A

S

D

Q

D

G

P

E

V

K

G

L

S

N

K

A

V

L

Q

Q

Q

D

A

S

W

F

L

R

D

R

L

H

G

H

V

A

A
x
L

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

T

G

A

G

G

Q

M

I

L

M

A

N

T

A

A

T

R

A

S

L

I

L

L

K

A

R

E

T

N

P

P

N

A

P

P

E

S

T

R

G

D

E

E

I

V

V

R

D

E

A

V

M

M

A

S

G

G

N

N

L

L

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

E

R

T

I

I

L

I

A

D

A

A

I

I

binding flavin-adenine dinucleotide: Q44 (≠ M40), G45 (≠ S41), V46 (≠ Q42)
binding fe2/s2 (inorganic) cluster: I40 (≠ F36), G41 (= G37), C42 (= C38), E43 (≠ G39), G45 (≠ S41), C47 (= C43), G48 (= G44), S49 (≠ A45), C50 (= C46), R60 (= R56), C62 (= C58), L99 (≠ A94), Q100 (= Q95), C101 (= C96), G102 (= G97), C104 (= C99), C136 (= C131), R137 (= R132), C138 (= C133)
binding pterin cytosine dinucleotide: Q100 (= Q95), C138 (= C133)

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
37% identity, 95% coverage: 3:147/153 of query aligns to 5:153/906 of 1dgjA

query
sites
1dgjA

T

T

L

L

T

I

I

V

N

N

G

G

E

M

R

A

Y

R

E

R

L

L

D

L

V

V

P

S

D

P

N

N

M

D

P

L

L

L

L

V

W

D

V

V

I

L

R

R

D

S

V

Q

V

L

G

Q

L

L

K

T

G

S

T

V

K

K

F
x
V

G
|
G

C
|
C

G
|
G

M

K

S
x
G

Q
|
Q

C
|
C

G
|
G

A
|
A

C
|
C

T

T

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

I

T

I

P

K

V

M

S

S

-

R

-

V

A

A

A

E

S

N

G

A

E

S

I

V

T

T

I

L

E

E

A

G

M

I

A

G

D

A

D

P

P

D

V

C

G

L

S

H

K

P

V

L

Q

Q

Q

H

A

A

W

W

L

I

D

Q

L

H

G

G

V

A

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

T

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

A

L

L

K

D

R

E

T

N

P

V

N

A

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

-

Q

-

K

A

H

G

H

N

N

L

I

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), G41 (= G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), A47 (= A45), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding pterin cytosine dinucleotide: Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 533, 534, 535, 655, 698, 869
binding pterin cytosine dinucleotide: 421, 422, 423, 424, 535, 652, 655, 656, 657, 658, 662, 697, 698, 700, 701, 702, 703, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 4usaA

query
sites
4usaA

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 501, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 4us9A

query
sites
4us9A

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 256, 257, 258, 752, 753, 755
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 4us8A

query
sites
4us8A

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding benzaldehyde: 255, 255, 394, 394, 425, 425, 425, 425, 494, 497, 497, 497, 501, 501, 531, 531, 535, 535, 626, 626, 626, 627, 694, 696, 697, 697, 869
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 4c7yA

query
sites
4c7yA

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 3fc4A

query
sites
3fc4A

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 3fahA

query
sites
3fahA

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 425, 531, 535, 622, 683, 696, 697, 869, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
37% identity, 94% coverage: 4:147/153 of query aligns to 6:153/907 of 1sijA

query
sites
1sijA

L

I

T

T

I

V

N

N

G

G

E

I

R

E

Y

Q

E

N

L

L

D

F

V

V

P

D

D

A

N

E

M

A

P

L

L

L

L

S

W

D

V

V

I

L

R

R

D

Q

V

Q

V

L

G

G

L

L

K

T

G

G

T

V

K

K

F
x
V

G
|
G

C
|
C

G
x
E

M

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

T

S

V

V

H

I

L

L

N

D

G

G

T

K

A

V

I

V

R
|
R

S

A

C
|
C

V

V

T

T

P

K

V

M

S

K

-

R

-

V

A

A

A

D

S

G

G

A

E

Q

I

I

T

T

I

I

E

E

A

G

M

V

A

G

D

Q

D

P

P

E

V

N

G

L

S

H

K

P

V

L

Q

Q

Q

K

A

A

W

W

L

V

D

L

L

H

G

G

V

G

A

A

Q
|
Q

C
|
C

G
|
G

Y

F

C
|
C

Q

S

G

P

G

G

Q

F

I

I

M

V

N

S

A

A

T

K

A

G

L

L

K

D

R

T

T

N

P

A

N

D

P

P

E

S

T

R

G

E

E

D

I

V

V

R

D

D

A

W

M

F

A

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R
|
R

C
|
C

G

T

T

G

Y

Y

N

K

R

P

I

L

L

V

A

D

A

A

I

V

E

M

R

D

A

A

S

A

binding fe2/s2 (inorganic) cluster: V38 (≠ F36), G39 (= G37), C40 (= C38), E41 (≠ G39), G43 (≠ S41), Q44 (= Q42), C45 (= C43), G46 (= G44), C48 (= C46), R58 (= R56), C60 (= C58), Q99 (= Q95), C100 (= C96), G101 (= G97), C103 (= C99), C137 (= C131), R138 (= R132), C139 (= C133)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q95), C139 (= C133)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding arsenite: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>GFF1600 HP15_1561 (2Fe-2S)-binding domain protein
MATLTINGERYELDVPDNMPLLWVIRDVVGLKGTKFGCGMSQCGACTVHLNGTAIRSCVT
PVSAASGEITTIEAMADDPVGSKVQQAWLDLGVAQCGYCQGGQIMNATALLKRTPNPETG
EIVDAMAGNLCRCGTYNRILAAIERASGKEGEA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory