SitesBLAST
Comparing GFF1617 FitnessBrowser__WCS417:GFF1617 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ahkA Crystal structure of acetohydroxy acid synthase pf5 from pseudomonas protegens
71% identity, 99% coverage: 1:565/571 of query aligns to 1:555/555 of 5ahkA
- active site: L22 (= L22), G24 (= G24), G25 (= G25), M26 (= M26), I27 (= I27), E48 (= E48), T73 (= T73), K110 (≠ E110), R111 (= R111), F118 (= F118), Q119 (= Q119), M168 (= M168), A253 (= A263), Q280 (= Q290), V384 (= V394), G410 (= G420), M412 (= M422), D436 (= D446), N463 (= N473), S465 (= S475), L466 (= L476), M468 (= M478), V469 (= V479), F472 (= F482), D535 (= D545)
- binding flavin-adenine dinucleotide: R158 (= R158), G208 (= G218), G209 (= G219), G210 (= G220), S234 (= S244), L235 (= L245), M250 (= M260), L251 (= L261), Y254 (= Y264), G273 (= G283), S274 (= S284), R275 (= R285), D277 (= D287), R279 (= R289), Q280 (= Q290), D298 (= D308), L299 (= L309), Q303 (= Q313), E317 (= E327), L318 (= L328), M389 (= M399), G407 (= G417)
- binding magnesium ion: D436 (= D446), N463 (= N473), S465 (= S475)
- binding thiamine diphosphate: I23 (= I23), E48 (= E48), P76 (= P76), V384 (= V394), G385 (= G395), N386 (= N396), N387 (= N397), G410 (= G420), M412 (= M422), D436 (= D446), G437 (= G447), G438 (= G448), N463 (= N473), S465 (= S475), L466 (= L476), G467 (= G477), M468 (= M478), V469 (= V479)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
32% identity, 97% coverage: 2:556/571 of query aligns to 95:651/667 of P09342
- C161 (≠ A70) modified: Disulfide link with 307
- P194 (≠ N103) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A221) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
32% identity, 97% coverage: 2:556/571 of query aligns to 92:648/664 of P09114
- P191 (≠ N103) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ F482) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6lpiB Crystal structure of ahas holo-enzyme (see paper)
34% identity, 92% coverage: 24:548/571 of query aligns to 29:523/539 of 6lpiB
- active site: G29 (= G24), G30 (= G25), S31 (≠ M26), I32 (= I27), E53 (= E48), C76 (≠ T73), F115 (= F118), Q116 (= Q119), E117 (= E120), K165 (≠ M168), M256 (≠ A263), A283 (≠ Q290), V375 (= V394), G401 (= G420), M403 (= M422), D428 (= D446), N455 (= N473), A457 (≠ S475), L458 (= L476), L460 (≠ M478), V461 (= V479), Q464 (≠ F482)
- binding flavin-adenine dinucleotide: R155 (= R158), G212 (= G218), G213 (= G219), G214 (= G220), T236 (≠ S244), L237 (= L245), M238 (≠ K246), L254 (= L261), M256 (≠ A263), H257 (≠ Y264), G276 (= G283), A277 (≠ S284), R278 (= R285), D280 (= D287), R282 (= R289), A283 (≠ Q290), D300 (= D308), I301 (≠ L309), D319 (≠ E327), V320 (≠ L328), M380 (= M399), G398 (= G417)
- binding magnesium ion: D428 (= D446), N455 (= N473)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ T73), P79 (= P76), G376 (= G395), Q377 (≠ N396), H378 (≠ N397), G401 (= G420), M403 (= M422), G427 (= G445), D428 (= D446), G429 (= G447), S430 (≠ G448), M433 (≠ L451), N455 (= N473), A457 (≠ S475), L458 (= L476), G459 (= G477), L460 (≠ M478), V461 (= V479)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ A263), R292 (= R289), W489 (≠ F482), S568 (≠ F555)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), G452 (= G445), D453 (= D446), G454 (= G447), S455 (≠ G448), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), M263 (= M260), L264 (= L261), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), R288 (= R285), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417)
- binding magnesium ion: A37 (≠ M26), T82 (= T73), S83 (= S74), Q122 (= Q119), Y381 (≠ V374), D453 (= D446), M458 (≠ L451), Q461 (= Q454), N480 (= N473), H482 (≠ S475), K533 (≠ H520)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/585 of 5k2oA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ A263), R292 (= R289), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), G286 (= G283), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), Q404 (= Q398), M405 (= M399), G423 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), M428 (= M422), D453 (= D446), G454 (= G447), S455 (≠ G448), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
31% identity, 99% coverage: 2:565/571 of query aligns to 98:663/670 of P17597
- A122 (≠ M26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ T28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E48) binding
- S186 (= S92) binding
- P197 (≠ N103) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (= R111) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q119) binding
- K220 (= K132) binding
- R246 (= R158) binding ; binding
- K256 (≠ M168) binding
- G308 (= G219) binding
- TL 331:332 (≠ SL 244:245) binding
- C340 (≠ A253) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ LGAY 261:264) binding
- GVRFD 371:375 (≠ GSRLD 283:287) binding
- DR 376:377 (≠ VR 288:289) binding
- DI 395:396 (≠ DL 308:309) binding
- DV 414:415 (≠ EL 327:328) binding
- QH 487:488 (≠ NN 396:397) binding
- GG 508:509 (= GG 417:418) binding
- GAM 511:513 (≠ GTM 420:422) binding
- D538 (= D446) binding
- DGS 538:540 (≠ DGG 446:448) binding
- N565 (= N473) binding
- NQHLGM 565:570 (≠ NHSLGM 473:478) binding
- H567 (≠ S475) binding
- W574 (≠ F482) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ F555) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/583 of 5k3sA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R289), M485 (= M478), W489 (≠ F482), G569 (= G556)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), M266 (≠ A263), G286 (= G283), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), D453 (= D446), G454 (= G447), S455 (≠ G448), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), G452 (= G445), D453 (= D446), G454 (= G447), S455 (≠ G448), M458 (≠ L451), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), R292 (= R289), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417)
- binding magnesium ion: F370 (≠ Y365), D453 (= D446), M458 (≠ L451), Q461 (= Q454), N480 (= N473), H482 (≠ S475), K533 (≠ H520)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ A263), R292 (= R289), M485 (= M478), W489 (≠ F482), S568 (≠ F555)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 5wj1A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), M263 (= M260), L264 (= L261), G286 (= G283), R288 (= R285), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ A263), D291 (≠ V288), R292 (= R289), M485 (= M478), W489 (≠ F482), S568 (≠ F555)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), M428 (= M422), D453 (= D446), G454 (= G447), S455 (≠ G448), M458 (≠ L451), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 5k6tA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Y264), R292 (= R289), M485 (= M478), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), G286 (= G283), R288 (= R285), D290 (= D287), R292 (= R289), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), Q404 (= Q398), M405 (= M399), G423 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), G452 (= G445), G454 (= G447), S455 (≠ G448), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 5k6rA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R289), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), M266 (≠ A263), G286 (= G283), R288 (= R285), R292 (= R289), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), G328 (≠ M326), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), D453 (= D446), G454 (= G447), S455 (≠ G448), M458 (≠ L451), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1z8nA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K132), R161 (= R158), Y191 (≠ C187), R194 (≠ Q190), D291 (≠ V288), R292 (= R289), D312 (≠ M310), W489 (≠ F482), G569 (= G556)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), G265 (= G262), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), R292 (= R289), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473)
- binding thiamine diphosphate: V400 (= V394), G401 (= G395), Q402 (≠ N396), H403 (≠ N397), G426 (= G420), M428 (= M422), G452 (= G445), G454 (= G447), S455 (≠ G448), N480 (= N473), H482 (≠ S475), L483 (= L476), G484 (= G477), M485 (= M478), V486 (= V479)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1yi1A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ V288), R292 (= R289), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), M263 (= M260), L264 (= L261), G265 (= G262), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1yi0A
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ V288), R292 (= R289), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), G265 (= G262), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), R292 (= R289), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), G328 (≠ M326), D329 (≠ E327), V330 (≠ L328), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1yhzA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ V288), R292 (= R289), M485 (= M478), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), Q404 (= Q398), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1yhyA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ V288), R292 (= R289), V486 (= V479), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G222 (= G218), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), G265 (= G262), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), Q404 (= Q398), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 13:578/582 of 1ybhA
- active site: Y33 (≠ L22), G35 (= G24), G36 (= G25), A37 (≠ M26), S38 (≠ I27), E59 (= E48), T82 (= T73), F121 (= F118), Q122 (= Q119), E123 (= E120), K171 (≠ M168), M266 (≠ A263), V293 (≠ Q290), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D446), N480 (= N473), H482 (≠ S475), L483 (= L476), M485 (= M478), V486 (= V479), W489 (≠ F482), H558 (≠ D545)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ A263), D291 (≠ V288), R292 (= R289), M485 (= M478), W489 (≠ F482), S568 (≠ F555)
- binding flavin-adenine dinucleotide: R161 (= R158), G223 (= G219), G224 (= G220), T246 (≠ S244), L247 (= L245), M248 (≠ K246), L264 (= L261), M266 (≠ A263), H267 (≠ Y264), G286 (= G283), V287 (≠ S284), R288 (= R285), D290 (= D287), V293 (≠ Q290), D310 (= D308), I311 (≠ L309), D329 (≠ E327), V330 (≠ L328), Q404 (= Q398), M405 (= M399), G423 (= G417), G424 (= G418)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ S475)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 12:577/582 of 3ea4A
- active site: Y32 (≠ L22), G34 (= G24), G35 (= G25), A36 (≠ M26), S37 (≠ I27), E58 (= E48), T81 (= T73), F120 (= F118), Q121 (= Q119), E122 (= E120), K170 (≠ M168), M265 (≠ A263), V292 (≠ Q290), V399 (= V394), G425 (= G420), M427 (= M422), D452 (= D446), N479 (= N473), H481 (≠ S475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (≠ F482), H557 (≠ D545)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ V288), R291 (= R289), W488 (≠ F482), S567 (≠ F555)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R158), G221 (= G218), G222 (= G219), G223 (= G220), T245 (≠ S244), L246 (= L245), M247 (≠ K246), L263 (= L261), G264 (= G262), M265 (≠ A263), H266 (≠ Y264), G285 (= G283), R287 (= R285), D289 (= D287), R291 (= R289), D309 (= D308), I310 (≠ L309), G327 (≠ M326), D328 (≠ E327), V329 (≠ L328), M404 (= M399), G422 (= G417)
- binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ S475)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V394), G400 (= G395), Q401 (≠ N396), H402 (≠ N397), M427 (= M422), G451 (= G445), D452 (= D446), G453 (= G447), S454 (≠ G448), N479 (= N473), H481 (≠ S475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
31% identity, 99% coverage: 2:565/571 of query aligns to 12:577/582 of 3e9yA
- active site: Y32 (≠ L22), G34 (= G24), G35 (= G25), A36 (≠ M26), S37 (≠ I27), E58 (= E48), T81 (= T73), F120 (= F118), Q121 (= Q119), E122 (= E120), K170 (≠ M168), M265 (≠ A263), V292 (≠ Q290), V399 (= V394), G425 (= G420), M427 (= M422), D452 (= D446), N479 (= N473), H481 (≠ S475), L482 (= L476), M484 (= M478), V485 (= V479), W488 (≠ F482), H557 (≠ D545)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (≠ V288), R291 (= R289), W488 (≠ F482), S567 (≠ F555)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R158), G221 (= G218), G222 (= G219), G223 (= G220), T245 (≠ S244), L246 (= L245), M247 (≠ K246), L263 (= L261), G285 (= G283), R287 (= R285), D289 (= D287), R291 (= R289), D309 (= D308), I310 (≠ L309), G327 (≠ M326), D328 (≠ E327), V329 (≠ L328), M404 (= M399), G422 (= G417)
- binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ S475)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V394), G400 (= G395), Q401 (≠ N396), H402 (≠ N397), M427 (= M422), G451 (= G445), G453 (= G447), S454 (≠ G448), N479 (= N473), H481 (≠ S475), L482 (= L476), G483 (= G477), M484 (= M478), V485 (= V479)
Query Sequence
>GFF1617 FitnessBrowser__WCS417:GFF1617
MKASDAVALVLAQNKVLYGYELIGGMITHLVDSINQLGKTKLVSVHHEQGAAFAASAVSR
ATHHEVLGVALGTSGPGATNLITGIADCWLDSHPCLFLTGQVNTYELKGERNIRQQGFQE
LDSVALVSSITKYAYQVRHVDELLPCLQKAIDLAREGRPGPVLLDIPMDIQRTDIDDAAV
SAFLLPCAQQIAAPLQAADLETISNALACARNPLILLGGGAVNTPNFAHWLNQLETSGIP
YVASLKGAEKIPASANYLGMLGAYGTRAANHAVQNCDFLLVLGSRLDVRQTGAKPEDFAR
KAKVFQIDLMEGQLNNRVKAHASYVMELNTFFADFPLCEVQENAAWNAWAADLRADFDQS
FVDEYTDWSVSPFVICSTLGALTKGHGVDFVADVGNNQMWAAHTLRLSPGQSMHHSGGLG
TMGFAIPAAIGACNAGNKPVIVITGDGGAQLNIQELDIIARDQLPVLIIVLNNHSLGMVR
GFQEMYFEGRNSSTYWNGYTSQFKAIGEAYGISSTVVSTHEEFAAQVGMFIESPRPALIE
LMMPDARECRPRLEFGRSIDQQLPEKTRTAR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory