SitesBLAST

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
28% identity, 93% coverage: 3:214/229 of query aligns to 4:219/285 of 4yerA

query
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4yerA

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binding adenosine-5'-diphosphate: F14 (≠ Y13), F17 (≠ S16), N39 (= N38), G40 (= G39), G42 (= G41), K43 (= K42), T44 (≠ S43), T45 (= T44), T135 (≠ S130), F136 (≠ L131), S137 (= S132)

Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
29% identity, 92% coverage: 4:214/229 of query aligns to 481:699/1624 of Q8IUA7

query
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Q8IUA7

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Sites not aligning to the query:

353 R → H: in dbSNP:rs1860447
949 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1306 K → T: in dbSNP:rs2302294

O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 35 papers)
29% identity, 97% coverage: 4:226/229 of query aligns to 899:1126/2261 of O95477

query
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O95477

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D917 (≠ F20) to Y: in a colorectal cancer sample; somatic mutation
T929 (≠ V32) to I: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane
N935 (= N38) to S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs28937313
K939 (= K42) mutation to M: Inhibits ATPase activity; when associated with M-1952. Decreases translocase activity; when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-1952.
S1042 (≠ A140) modified: Phosphoserine; by PKA
P1065 (= P163) natural variant: P -> S
M1091 (≠ L191) to T: in FHA1; loss of localization to plasma membrane; decreased cholesterol efflux; decreased phospholipid efflux
C1110 (≠ V210) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1111.
C1111 (≠ W211) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1110.

Sites not aligning to the query:

3 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation; when associated with S-23, S-1110 and S-1111.
23 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation; when associated with S-3, S-1110 and S-1111.
74 I→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.; I→K: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-371.
75 modified: Disulfide link with 309
85 P → L: in FHA1; Alabama; dbSNP:rs145183203
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S→C: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
210 E → D: in a colorectal cancer sample; somatic mutation
219 R → K: in dbSNP:rs2230806
230 R → C: in dbSNP:rs9282541
244 modified: carbohydrate, N-linked (GlcNAc...) asparagine
248 P → A: in dbSNP:rs142625938
255 A → T: in TGD; deficient cellular cholesterol efflux; dbSNP:rs758100110
304 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-308.
308 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-304.
309 modified: Disulfide link with 75
364 S → C: in dbSNP:rs775035559
371 I→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane. 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-74 or C-375.; I→E: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-74.
375 L→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.
399 V → A: in dbSNP:rs9282543
401 K → Q: in dbSNP:rs138487227
496 R → W: in dbSNP:rs147675550
568 K→A: 60-65% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane.
573 Y→F: No effect on phospholipid and cholesterol efflux and on localization to cell membrane.
581 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-584 and K-585.
583 F→K: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-590.
584 E→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-585.
585 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-584.
590 W → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs137854496; W→E: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-583.
593 F→L: Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
638 R → Q: in dbSNP:rs374190304
771 V → M: in dbSNP:rs2066718
774 T → P: in dbSNP:rs35819696; natural variant: T -> S
776 K → N: in dbSNP:rs138880920
815 E → G: in dbSNP:rs145582736
825 V → I: in dbSNP:rs2066715
883 I → M: in dbSNP:rs2066714
1172 E → D: in dbSNP:rs33918808
1181 S → F: in dbSNP:rs76881554
1216 G → V: in dbSNP:rs562403512
1341 R → T: in dbSNP:rs147743782
1376 S → G: in dbSNP:rs145689805
1379 L → F: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1407 A → T: in a colorectal cancer sample; somatic mutation; dbSNP:rs189206655
1463 modified: Disulfide link with 1477
1477 modified: Disulfide link with 1463; C → R: in TGD; loss of interaction with APOE; unable to generate APOE-containing high density lipoproteins; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs137854494
1512 T→M: Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
1555 I → T: in dbSNP:rs1997618
1587 K → R: in dbSNP:rs2230808
1611 N → D: in FHA1; deficient cellular cholesterol efflux
1615 R → Q: in dbSNP:rs1251839800
1648 L → P: in dbSNP:rs1883024
1670 A → T: in dbSNP:rs1203589782
1680 R → Q: in dbSNP:rs150125857
1704 V → D: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1731 S → C: in dbSNP:rs760507032
1897 R → W: in FHA1; uncertain significance; dbSNP:rs760768125
1925 R → Q: in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane; dbSNP:rs142688906
1952 K→M: Inhibits ATPase activity; when associated with M-939. Decreases translocase activity; when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-939.
2054 modified: Phosphoserine; by PKA
2081 R → W: in TGD; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs137854501
2109 A → T: in a colorectal cancer sample; somatic mutation
2150 P → L: in FHA1; moderately decreased protein abundance; does not affect ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs369098049
2163 natural variant: F -> S
2168 L → P: in dbSNP:rs2853577
2243 D → E: in dbSNP:rs34879708
2244 V → I: in dbSNP:rs144588452

7o12B Abc transporter nosdfy, amppnp-bound in gdn (see paper)
35% identity, 95% coverage: 4:221/229 of query aligns to 3:217/298 of 7o12B

query
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7o12B

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binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y13), V17 (≠ A18), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44), E80 (= E85)
binding magnesium ion: T42 (≠ S43), E80 (= E85)

P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see paper)
29% identity, 97% coverage: 4:226/229 of query aligns to 899:1126/2261 of P41233

query
sites
P41233

L

V

S

S

L

I

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Q

N

N

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A

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Y

-

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Y

Sites not aligning to the query:

489 modified: carbohydrate, N-linked (GlcNAc...) asparagine

7tbwA The structure of atp-bound abca1 (see paper)
29% identity, 97% coverage: 4:226/229 of query aligns to 754:981/1928 of 7tbwA

query
sites
7tbwA

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Y

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x
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x
T

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H

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Y

binding adenosine-5'-triphosphate: Y763 (= Y13), D765 (vs. gap), K768 (≠ S16), N790 (= N38), G791 (= G39), G793 (= G41), K794 (= K42), T795 (≠ S43), Q835 (≠ E85), Q887 (≠ S130), S889 (= S132), H944 (≠ K189)
binding magnesium ion: Q835 (≠ E85), D912 (= D155), Q913 (≠ E156)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 1630, 1633, 1657, 1658, 1660, 1661, 1662, 1663, 1702, 1753, 1755, 1756, 1757, 1779, 1783, 1811
binding cholesterol: 218, 219, 360, 367
binding magnesium ion: 1662, 1702

7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc (see paper)
34% identity, 95% coverage: 4:221/229 of query aligns to 3:217/298 of 7o17B

query
sites
7o17B

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M

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A

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I

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-

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E

binding adenosine-5'-triphosphate: Y12 (= Y13), V17 (≠ A18), N37 (= N38), G38 (= G39), A39 (≠ M40), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44), E80 (= E85), R123 (≠ Q126), T127 (≠ S130), S129 (= S132), K130 (≠ G133), G131 (= G134), M132 (≠ E135)
binding magnesium ion: K41 (= K42), T42 (≠ S43)

Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
29% identity, 89% coverage: 4:207/229 of query aligns to 478:689/1617 of Q8N139

query
sites
Q8N139

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N

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D

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G

G

Sites not aligning to the query:

282 V → I: in dbSNP:rs4968839
875 M → I: in dbSNP:rs7212506
940 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1322 N → S: in dbSNP:rs2302134

7roqA Alternative structure of human abca1
30% identity, 90% coverage: 21:226/229 of query aligns to 789:996/1831 of 7roqA

query
sites
7roqA

G

G

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A

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Y

E

E

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N

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Y

Y

Sites not aligning to the query:

binding cholesterol: 688, 1106, 1426, 1526, 1527

Query Sequence

>GFF1630 FitnessBrowser__Phaeo:GFF1630
MTLLSLKNVTASYGPSQALFGVELDIGEGEVVALMGRNGMGKSTTIKTICGMLPASEGTL
HFAGNDLRKLHSHKIARLGIGLVPEGRRCFAPLTVEENLRAAARPGPWDFAMVADLFPRL
AERRDQTASSLSGGEQQMLAIGRALMINPRLLILDEATEGLAPVVRQEIWAAIARLKRDS
GLSILVVDKTLRELAAVADRAVIVNKGATVWTGAMDALTPELKDRYLGV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory