SitesBLAST
Comparing GFF1715 FitnessBrowser__Phaeo:GFF1715 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
42% identity, 100% coverage: 3:464/464 of query aligns to 1:471/473 of 5u8wA
- active site: P13 (= P15), L44 (≠ M39), C48 (= C43), C53 (= C48), S56 (≠ T51), G82 (≠ N76), V83 (≠ I77), V190 (≠ A183), E194 (= E187), S330 (= S322), F448 (= F441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G12 (= G14), P13 (= P15), G14 (= G16), E33 (= E35), K34 (≠ R36), G46 (= G41), T47 (≠ I42), C48 (= C43), G52 (= G47), C53 (= C48), K57 (= K52), H120 (≠ E114), G121 (≠ A115), A149 (= A142), S150 (≠ T143), G151 (= G144), S170 (≠ Y163), G317 (= G309), D318 (= D310), M324 (≠ W316), L325 (= L317), A326 (= A318), H327 (= H319), Y357 (= Y350), H450 (= H443), P451 (= P444)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (= I179), G189 (= G182), V190 (≠ A183), I191 (= I184), E194 (= E187), E210 (= E203), A211 (≠ V204), L212 (≠ M205), A275 (= A268), V276 (= V269), G277 (= G270), R278 (≠ I271), M324 (≠ W316), L325 (= L317), V355 (≠ C348), Y357 (= Y350)
Sites not aligning to the query:
P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
42% identity, 100% coverage: 3:464/464 of query aligns to 2:472/478 of P14218
- 34:49 (vs. 35:43, 25% identical) binding
- C49 (= C43) modified: Disulfide link with 54, Redox-active
- C54 (= C48) modified: Disulfide link with 49, Redox-active
- K58 (= K52) binding
- G122 (≠ A115) binding
- D319 (= D310) binding
- A327 (= A318) binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
42% identity, 99% coverage: 4:464/464 of query aligns to 1:470/472 of 5u8vA
- active site: P12 (= P15), L43 (≠ M39), C47 (= C43), C52 (= C48), S55 (≠ T51), G81 (≠ N76), V82 (≠ I77), V189 (≠ A183), E193 (= E187), S329 (= S322), F447 (= F441), H449 (= H443), E454 (= E448)
- binding flavin-adenine dinucleotide: I8 (= I11), G11 (= G14), P12 (= P15), G13 (= G16), E32 (= E35), G45 (= G41), T46 (≠ I42), C47 (= C43), G51 (= G47), C52 (= C48), K56 (= K52), H119 (≠ E114), G120 (≠ A115), A148 (= A142), S149 (≠ T143), G150 (= G144), S169 (≠ Y163), I190 (= I184), R277 (≠ I271), G316 (= G309), D317 (= D310), M323 (≠ W316), L324 (= L317), A325 (= A318), H326 (= H319), H449 (= H443), P450 (= P444)
- binding nicotinamide-adenine-dinucleotide: I185 (= I179), G186 (= G180), G188 (= G182), V189 (≠ A183), I190 (= I184), L208 (≠ V202), E209 (= E203), A210 (≠ V204), V243 (= V237), V275 (= V269), G276 (= G270)
Sites not aligning to the query:
5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
42% identity, 100% coverage: 3:464/464 of query aligns to 4:474/477 of 5u8uD
- active site: P16 (= P15), L47 (≠ M39), C51 (= C43), C56 (= C48), S59 (≠ T51), G85 (≠ N76), V86 (≠ I77), V193 (≠ A183), E197 (= E187), S333 (= S322), F451 (= F441), H453 (= H443), E458 (= E448)
- binding flavin-adenine dinucleotide: I12 (= I11), G15 (= G14), P16 (= P15), G17 (= G16), E36 (= E35), K37 (≠ R36), G49 (= G41), T50 (≠ I42), C51 (= C43), G55 (= G47), C56 (= C48), K60 (= K52), H123 (≠ E114), G124 (≠ A115), A152 (= A142), S153 (≠ T143), G154 (= G144), I194 (= I184), R281 (≠ I271), G320 (= G309), D321 (= D310), M327 (≠ W316), L328 (= L317), A329 (= A318), H330 (= H319), H453 (= H443), P454 (= P444)
Sites not aligning to the query:
3ii4A Structure of mycobacterial lipoamide dehydrogenase bound to a triazaspirodimethoxybenzoyl inhibitor (see paper)
42% identity, 96% coverage: 6:452/464 of query aligns to 3:451/463 of 3ii4A
- active site: W36 (≠ M39), C40 (= C43), C45 (= C48), S48 (≠ T51), A180 (= A183), E184 (= E187), H440 (≠ F441), H442 (= H443), E447 (= E448)
- binding N-[2-(2,4-dichlorophenyl)ethyl]-2-{8-[(2,4-dimethoxyphenyl)carbonyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl}acetamide: R146 (= R148), A180 (= A183), I181 (= I184), E184 (= E187), N208 (≠ V211), E209 (= E212), F268 (≠ I271), R287 (= R289), G311 (= G313), Q314 (≠ W316), L315 (= L317), R346 (≠ E343), A347 (≠ S344)
- binding flavin-adenine dinucleotide: L8 (≠ I11), G9 (= G12), G11 (= G14), P12 (= P15), G13 (= G16), V31 (= V34), E32 (= E35), P33 (≠ R36), Y35 (≠ H38), G38 (= G41), V39 (≠ I42), C40 (= C43), G44 (= G47), C45 (= C48), K49 (= K52), Y111 (≠ E114), G112 (≠ A115), A140 (= A142), T141 (= T143), G142 (= G144), Y160 (= Y163), I181 (= I184), Y275 (≠ L278), G307 (= G309), D308 (= D310), Q314 (≠ W316), L315 (= L317), A316 (= A318)
8u0qA Co-crystal structure of optimized analog tdi-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series (see paper)
42% identity, 96% coverage: 6:452/464 of query aligns to 4:452/464 of 8u0qA
- binding flavin-adenine dinucleotide: L9 (≠ I11), G10 (= G12), G12 (= G14), P13 (= P15), G14 (= G16), V32 (= V34), E33 (= E35), P34 (≠ R36), Y36 (≠ H38), G39 (= G41), V40 (≠ I42), C41 (= C43), G45 (= G47), C46 (= C48), K50 (= K52), Y112 (≠ E114), G113 (≠ A115), A141 (= A142), T142 (= T143), G143 (= G144), Y161 (= Y163), I182 (= I184), Y276 (≠ L278), G308 (= G309), D309 (= D310), Q315 (≠ W316), L316 (= L317), A317 (= A318), H318 (= H319)
- binding N-(3-acetamidophenyl)-N~2~-[3-(difluoromethyl)-5-methylbenzene-1-sulfonyl]-N~2~-methylglycinamide: Y16 (= Y18), R93 (≠ L95), G96 (= G98), F99 (≠ H101), E321 (≠ S322), A381 (≠ G381), A383 (≠ G383), H443 (= H443), E448 (= E448)
Sites not aligning to the query:
8ct4A Cryo-em structure of mtb lpd bound to inhibitor complex with 2-((2- cyano-n,5-dimethyl-1h-indole)-7-sulfonamido)-n-(4-(oxetan-3-yl)-3,4- dihydro-2h-benzo[b] [1,4]oxazin-7-yl)acetamide
42% identity, 96% coverage: 6:452/464 of query aligns to 4:452/464 of 8ct4A
- binding flavin-adenine dinucleotide: L9 (≠ I11), G10 (= G12), G12 (= G14), P13 (= P15), E33 (= E35), P34 (≠ R36), Y36 (≠ H38), G39 (= G41), V40 (≠ I42), C41 (= C43), G45 (= G47), C46 (= C48), K50 (= K52), Y112 (≠ E114), G113 (≠ A115), T142 (= T143), G143 (= G144), Y161 (= Y163), I182 (= I184), Y276 (≠ L278), D309 (= D310), Q315 (≠ W316), L316 (= L317), A317 (= A318)
- binding N~2~-(2-cyano-5-methyl-1H-indole-7-sulfonyl)-N~2~-methyl-N-[4-(oxetan-3-yl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl]glycinamide: Y16 (= Y18), R93 (≠ L95), F99 (≠ H101), E321 (≠ S322), F377 (= F377), A381 (≠ G381), A383 (≠ G383), H443 (= H443), E448 (= E448), A449 (≠ M449), E452 (= E452)
Sites not aligning to the query:
P9WHH9 Dihydrolipoyl dehydrogenase; LPD; Component of peroxynitrite reductase/peroxidase complex; Component of PNR/P; Dihydrolipoamide dehydrogenase; E3 component of alpha-ketoacid dehydrogenase complexes; EC 1.8.1.4 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
42% identity, 96% coverage: 6:452/464 of query aligns to 4:452/464 of P9WHH9
- D5 (= D7) mutation to A: Reduces lipoamide dehydrogenase activity by 95%.
- 33:41 (vs. 35:43, 44% identical) binding
- C41 (= C43) modified: Disulfide link with 46, Redox-active
- N43 (= N45) mutation to A: Reduces lipoamide dehydrogenase activity by 89%.
- C46 (= C48) modified: Disulfide link with 41, Redox-active
- K50 (= K52) binding
- R93 (≠ L95) mutation to A: Reduces lipoamide dehydrogenase activity by 94%.; mutation to E: Reduces lipoamide dehydrogenase activity by 96%.
- K103 (= K105) mutation to E: Reduces lipoamide dehydrogenase activity by 82%.
- D309 (= D310) binding
- A317 (= A318) binding
- H386 (≠ I386) mutation to K: Reduces lipoamide dehydrogenase activity by 91%.
Sites not aligning to the query:
- 464 F→A: Reduces lipoamide dehydrogenase activity by 95%.
7kmyA Structure of mtb lpd bound to 010705 (see paper)
42% identity, 96% coverage: 6:452/464 of query aligns to 5:453/465 of 7kmyA
- active site: W38 (≠ M39), C42 (= C43), C47 (= C48), S50 (≠ T51), A182 (= A183), E186 (= E187), H442 (≠ F441), H444 (= H443), E449 (= E448)
- binding flavin-adenine dinucleotide: L10 (≠ I11), G11 (= G12), G13 (= G14), P14 (= P15), V33 (= V34), E34 (= E35), P35 (≠ R36), Y37 (≠ H38), G40 (= G41), V41 (≠ I42), C42 (= C43), G46 (= G47), C47 (= C48), K51 (= K52), Y113 (≠ E114), G114 (≠ A115), A142 (= A142), T143 (= T143), G144 (= G144), Y162 (= Y163), I183 (= I184), Y277 (≠ L278), G309 (= G309), D310 (= D310), Q316 (≠ W316), L317 (= L317), A318 (= A318)
- binding N~2~-methyl-N~2~-[(5-methyl-1H-indazol-7-yl)sulfonyl]-N-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)glycinamide: Y17 (= Y18), R94 (≠ L95), G97 (= G98), F100 (≠ H101), E322 (≠ S322), A382 (≠ G381), H444 (= H443), E449 (= E448)
Sites not aligning to the query:
4m52A Structure of mtb lpd bound to sl827 (see paper)
42% identity, 96% coverage: 6:452/464 of query aligns to 5:453/465 of 4m52A
- active site: W38 (≠ M39), C42 (= C43), C47 (= C48), S50 (≠ T51), A182 (= A183), E186 (= E187), H442 (≠ F441), H444 (= H443), E449 (= E448)
- binding flavin-adenine dinucleotide: L10 (≠ I11), G11 (= G12), G13 (= G14), P14 (= P15), V33 (= V34), E34 (= E35), P35 (≠ R36), Y37 (≠ H38), V41 (≠ I42), C42 (= C43), G46 (= G47), C47 (= C48), K51 (= K52), Y113 (≠ E114), G114 (≠ A115), A142 (= A142), T143 (= T143), Y162 (= Y163), I183 (= I184), F270 (≠ I271), Y277 (≠ L278), G309 (= G309), D310 (= D310), Q316 (≠ W316), L317 (= L317), A318 (= A318)
- binding N~2~-[(2-amino-5-bromopyridin-3-yl)sulfonyl]-N-(4-methoxyphenyl)-N~2~-methylglycinamide: P14 (= P15), Y17 (= Y18), R94 (≠ L95), F100 (≠ H101), E322 (≠ S322), A382 (≠ G381), H444 (= H443)
Sites not aligning to the query:
P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
41% identity, 100% coverage: 3:464/464 of query aligns to 2:472/477 of P18925
- 34:49 (vs. 35:43, 25% identical) binding
- C49 (= C43) modified: Disulfide link with 54, Redox-active
- C54 (= C48) modified: Disulfide link with 49, Redox-active
- K58 (= K52) binding
- D319 (= D310) binding
- A327 (= A318) binding
3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
41% identity, 100% coverage: 3:464/464 of query aligns to 1:471/472 of 3ladA
- active site: L44 (≠ M39), C48 (= C43), C53 (= C48), S56 (≠ T51), V190 (≠ A183), E194 (= E187), F448 (= F441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G12 (= G14), P13 (= P15), E33 (= E35), K34 (≠ R36), G46 (= G41), T47 (≠ I42), C48 (= C43), G52 (= G47), C53 (= C48), H120 (≠ E114), G121 (≠ A115), A149 (= A142), S150 (≠ T143), G151 (= G144), I191 (= I184), R278 (≠ I271), D318 (= D310), L325 (= L317), A326 (= A318)
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
42% identity, 99% coverage: 6:464/464 of query aligns to 7:470/470 of 6uziC
- active site: C45 (= C43), C50 (= C48), S53 (≠ T51), V187 (≠ A183), E191 (= E187), H448 (= H443), E453 (= E448)
- binding flavin-adenine dinucleotide: I12 (= I11), G13 (= G12), G15 (= G14), P16 (= P15), G17 (= G16), E36 (= E35), K37 (≠ R36), G43 (= G41), T44 (≠ I42), C45 (= C43), G49 (= G47), C50 (= C48), S53 (≠ T51), K54 (= K52), V117 (≠ E114), G118 (≠ A115), T147 (= T143), G148 (= G144), I188 (= I184), R276 (≠ I271), D316 (= D310), M322 (≠ W316), L323 (= L317), A324 (= A318)
- binding zinc ion: H448 (= H443), E453 (= E448)
3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
41% identity, 99% coverage: 6:463/464 of query aligns to 1:465/465 of 3urhB
- active site: Y35 (≠ M39), C39 (= C43), C44 (= C48), S47 (≠ T51), V183 (≠ A183), E187 (= E187), H443 (≠ F441), H445 (= H443), E450 (= E448)
- binding flavin-adenine dinucleotide: I6 (= I11), G7 (= G12), G9 (= G14), P10 (= P15), G11 (= G16), E30 (= E35), K31 (vs. gap), G37 (= G41), T38 (≠ I42), C39 (= C43), G43 (= G47), C44 (= C48), K48 (= K52), T111 (≠ E114), G112 (≠ A115), A140 (= A142), T141 (= T143), G142 (= G144), I184 (= I184), R273 (≠ I271), G312 (= G309), D313 (= D310), M319 (≠ W316), L320 (= L317), A321 (= A318), H322 (= H319)
6bz0A 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from acinetobacter baumannii in complex with fad.
40% identity, 99% coverage: 6:463/464 of query aligns to 2:467/469 of 6bz0A
- active site: C45 (= C43), C50 (= C48), S53 (≠ T51), V187 (≠ A183), E191 (= E187), H447 (= H443), E452 (= E448)
- binding flavin-adenine dinucleotide: I7 (= I11), G10 (= G14), P11 (= P15), G12 (= G16), E31 (≠ V34), K32 (≠ E35), R33 (= R36), G43 (= G41), T44 (≠ I42), C45 (= C43), G49 (= G47), C50 (= C48), K54 (= K52), T117 (≠ E114), G118 (≠ A115), S147 (≠ T143), G148 (= G144), S167 (≠ Y163), I188 (= I184), R275 (≠ I271), Y278 (≠ N274), D315 (= D310), M321 (≠ W316), L322 (= L317), A323 (= A318), A326 (= A321), Y354 (= Y350)
1dxlA Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
40% identity, 100% coverage: 3:464/464 of query aligns to 1:467/467 of 1dxlA
- active site: L38 (≠ M39), C42 (= C43), C47 (= C48), S50 (≠ T51), Y184 (≠ A183), E188 (= E187), H444 (≠ F441), H446 (= H443), E451 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), P13 (= P15), G14 (= G16), E33 (≠ V34), K34 (≠ E35), R35 (= R36), G40 (= G41), T41 (≠ I42), C42 (= C43), G46 (= G47), C47 (= C48), K51 (= K52), Y114 (≠ E114), G115 (≠ A115), T144 (= T143), G145 (= G144), Y184 (≠ A183), I185 (= I184), R274 (≠ I271), D314 (= D310), M320 (≠ W316), L321 (= L317), A322 (= A318), H323 (= H319)
P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
40% identity, 99% coverage: 7:464/464 of query aligns to 39:501/501 of P31023
- 67:76 (vs. 34:43, 40% identical) binding
- C76 (= C43) modified: Disulfide link with 81, Redox-active
- C81 (= C48) modified: Disulfide link with 76, Redox-active
- G149 (≠ A115) binding
- D348 (= D310) binding
- MLAH 354:357 (≠ WLAH 316:319) binding
Sites not aligning to the query:
- 1:31 modified: transit peptide, Mitochondrion
6aonA 1.72 angstrom resolution crystal structure of 2-oxoglutarate dehydrogenase complex subunit dihydrolipoamide dehydrogenase from bordetella pertussis in complex with fad
39% identity, 99% coverage: 4:464/464 of query aligns to 1:473/473 of 6aonA
- active site: P43 (vs. gap), C47 (= C43), C52 (= C48), S55 (≠ T51), V191 (≠ A183), E195 (= E187), H450 (≠ F441), H452 (= H443), E457 (= E448)
- binding calcium ion: A218 (≠ P210), A220 (≠ E212), Q222 (≠ A214)
- binding flavin-adenine dinucleotide: I8 (= I11), G11 (= G14), P12 (= P15), G13 (= G16), D32 (≠ E35), A33 (≠ R36), W34 (≠ E37), G45 (= G41), T46 (≠ I42), C47 (= C43), G51 (= G47), C52 (= C48), K56 (= K52), K119 (≠ E114), G120 (≠ A115), T151 (= T143), G152 (= G144), N171 (≠ Y163), I192 (= I184), R280 (≠ I271), Y283 (≠ N274), G319 (= G309), D320 (= D310), M326 (≠ W316), L327 (= L317), A328 (= A318), H329 (= H319)
6awaA 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from pseudomonas putida in complex with fad and adenosine-5'-monophosphate.
40% identity, 99% coverage: 4:464/464 of query aligns to 3:472/475 of 6awaA
- active site: L45 (≠ M39), C49 (= C43), C54 (= C48), S57 (≠ T51), V191 (≠ A183), E195 (= E187), F449 (= F441), H451 (= H443), E456 (= E448)
- binding adenosine monophosphate: I187 (= I179), E211 (= E203), A212 (≠ V204), L213 (≠ M205), V245 (= V237), V277 (= V269)
- binding flavin-adenine dinucleotide: I10 (= I11), G13 (= G14), P14 (= P15), G15 (= G16), E34 (= E35), K35 (≠ R36), T48 (≠ I42), C49 (= C43), G53 (= G47), C54 (= C48), K58 (= K52), H121 (≠ E114), G122 (≠ A115), S151 (≠ T143), G152 (= G144), I192 (= I184), R279 (≠ I271), G318 (= G309), D319 (= D310), M325 (≠ W316), L326 (= L317), A327 (= A318), Y358 (= Y350)
Sites not aligning to the query:
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
38% identity, 100% coverage: 1:464/464 of query aligns to 6:467/470 of P11959
- 39:47 (vs. 35:43, 44% identical) binding
- K56 (= K52) binding
- D314 (= D310) binding
- A322 (= A318) binding
Query Sequence
>GFF1715 FitnessBrowser__Phaeo:GFF1715
MAAETYDVIVIGAGPGGYVAAIRAAQLGLKTCIVEREHMGGICLNWGCIPTKALLRSSEV
FHLMERAKDFGLKADNIGYDLDAVVKRSRGVAKQLSSGIGHLMKKNKIAVVMGEATLPAK
GKVSVKTEKGTQELAAKNIVLATGARARELPGLEADGDLVWTYKHALDPVRMPKKLLVIG
SGAIGIEFASFYNTLGADTTVVEVMDRVLPVEDAEISAFAKKAFVKQGMKIMEKAMVKQL
DRGKGKVTAHIEVGGKVEKQEFDTVISAVGIVGNVEGLGLDGLGVKVDRTHVVTDEYCRT
GVDGLYAIGDIAGAPWLAHKASHEGVMVAELIAGKHAHAVKPESIAGCTYCQPQVASVGY
TEAKAKELGYDIKVGRFPFIGNGKAIALGEAEGMVKTIFDAKTGELLGAHMVGAEVTEMI
QGYVVGRQLETTEEDLMNTVFPHPTLSEMMHESVLDAFDRVIHM
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory