SitesBLAST
Comparing GFF1987 FitnessBrowser__Phaeo:GFF1987 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 8:569/591 of 5wkcA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R222 (≠ Q224), M258 (= M260), V285 (≠ I287), V401 (= V396), L426 (= L421), G427 (= G422), M429 (= M424), D454 (≠ E449), N481 (= N476), E483 (≠ R478), Q484 (≠ L479), M486 (= M481), V487 (= V482), W490 (= W485), L512 (= L508), G517 (= G513), L518 (≠ A514), K551 (= K547)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V396), G402 (= G397), Q403 (= Q398), H404 (= H399), G427 (= G422), M429 (= M424), G453 (= G448), D454 (≠ E449), A455 (= A450), S456 (= S451), M459 (= M454), N481 (= N476), E483 (≠ R478), Q484 (≠ L479), G485 (= G480), M486 (= M481), V487 (= V482)
- binding ethaneperoxoic acid: G32 (= G29), Q118 (= Q115)
- binding flavin-adenine dinucleotide: R157 (= R154), G211 (= G212), A212 (≠ G213), G213 (= G214), N216 (= N217), T238 (= T240), L239 (= L241), Q240 (≠ M242), L256 (= L258), M258 (= M260), G278 (= G280), A279 (= A281), R280 (= R282), R284 (= R286), V285 (≠ I287), E311 (≠ D304), V312 (≠ I305), N316 (≠ S309), D330 (= D323), A331 (vs. gap), M406 (= M401), G424 (= G419)
- binding magnesium ion: D454 (≠ E449), N481 (= N476), E483 (≠ R478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G29), A33 (= A30), V107 (= V104), F117 (= F114), K167 (= K164), M258 (= M260), R284 (= R286), M486 (= M481), W490 (= W485)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P27), E55 (= E52)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
45% identity, 97% coverage: 5:572/583 of query aligns to 14:584/599 of 6denA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K230 (≠ Q224), M266 (= M260), V293 (≠ I287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (≠ E449), N489 (= N476), E491 (≠ R478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (= L508), N525 (≠ G513), V526 (≠ A514)
- binding flavin-adenine dinucleotide: R163 (= R154), G219 (= G212), A220 (≠ G213), G221 (= G214), N224 (= N217), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ I287), E319 (≠ D304), I320 (= I305), N324 (≠ S309), D338 (= D323), V339 (≠ I324), M414 (= M401), G432 (= G419)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W485)
- binding magnesium ion: D462 (≠ E449), N489 (= N476), E491 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (≠ E449), A463 (= A450), S464 (= S451), N489 (= N476), E491 (≠ R478), Q492 (≠ L479), G493 (= G480), M494 (= M481), V495 (= V482)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R227 (≠ Q224), M263 (= M260), V290 (≠ I287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (≠ E449), N486 (= N476), E488 (≠ R478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (= L508), G522 (= G513), L523 (≠ A514), K556 (= K547)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G29), V107 (= V104), P108 (= P105), F117 (= F114), K167 (= K164), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G212), A217 (≠ G213), G218 (= G214), N221 (= N217), T243 (= T240), L244 (= L241), Q245 (≠ M242), L261 (= L258), M263 (= M260), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (≠ I287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (= D323), A336 (vs. gap), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (≠ E449), N486 (= N476), E488 (≠ R478)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R226 (≠ Q224), M262 (= M260), V289 (≠ I287), V405 (= V396), L430 (= L421), G431 (= G422), M433 (= M424), D458 (≠ E449), N485 (= N476), E487 (≠ R478), Q488 (≠ L479), M490 (= M481), V491 (= V482), W494 (= W485), L516 (= L508), G521 (= G513), L522 (≠ A514), K555 (= K547)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V104), P108 (= P105), D287 (= D285), R288 (= R286), M490 (= M481), W494 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R154), G215 (= G212), A216 (≠ G213), G217 (= G214), N220 (= N217), T242 (= T240), L243 (= L241), Q244 (≠ M242), M259 (= M257), L260 (= L258), M262 (= M260), H263 (= H261), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (≠ I287), E315 (≠ D304), V316 (≠ I305), N320 (≠ S309), G333 (= G322), D334 (= D323), A335 (vs. gap), Q409 (= Q400), M410 (= M401), G428 (= G419), G429 (= G420)
- binding magnesium ion: D458 (≠ E449), N485 (= N476), E487 (≠ R478)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R227 (≠ Q224), M263 (= M260), V290 (≠ I287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (≠ E449), N486 (= N476), E488 (≠ R478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (= L508), G522 (= G513), L523 (≠ A514), K556 (= K547)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G29), A33 (= A30), V107 (= V104), P108 (= P105), F117 (= F114), K167 (= K164), M263 (= M260), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G212), A217 (≠ G213), G218 (= G214), N221 (= N217), T243 (= T240), L244 (= L241), Q245 (≠ M242), M260 (= M257), L261 (= L258), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (≠ I287), E316 (≠ D304), V317 (≠ I305), N321 (≠ S309), G334 (= G322), D335 (= D323), A336 (vs. gap), Q410 (= Q400), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (≠ E449), N486 (= N476), E488 (≠ R478)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E52), P81 (= P78), Q118 (= Q115), G432 (= G422), M434 (= M424), M464 (= M454)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y26), G32 (= G28), G33 (= G29), A34 (= A30), I35 (≠ V31), E56 (= E52), T79 (= T75), F118 (= F114), Q119 (= Q115), E120 (= E116), K168 (= K164), R228 (≠ Q224), M264 (= M260), V291 (≠ I287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), G523 (= G513), L524 (≠ A514), K557 (= K547)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G29), V108 (= V104), P109 (= P105), F118 (= F114), K168 (= K164), M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), V493 (= V482), W496 (= W485)
- binding flavin-adenine dinucleotide: R158 (= R154), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), M264 (= M260), H265 (= H261), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ I287), E317 (≠ D304), V318 (≠ I305), N322 (≠ S309), G335 (= G322), D336 (= D323), A337 (vs. gap), Q411 (= Q400), M412 (= M401), G430 (= G419), G431 (= G420)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ R478)
- binding propyl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), G491 (= G480), M492 (= M481)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G422), M435 (= M424), M465 (= M454)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
45% identity, 96% coverage: 5:565/583 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y26), G33 (= G28), G34 (= G29), A35 (= A30), I36 (≠ V31), E57 (= E52), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (= K164), R230 (≠ Q224), M266 (= M260), V293 (≠ I287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (≠ E449), N489 (= N476), E491 (≠ R478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (= L508), G525 (= G513), L526 (≠ A514), K559 (= K547)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (≠ E449), A463 (= A450), S464 (= S451), M467 (= M454), N489 (= N476), E491 (≠ R478), Q492 (≠ L479), G493 (= G480), V495 (= V482)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G29), A35 (= A30), V109 (= V104), P110 (= P105), F119 (= F114), K169 (= K164), M266 (= M260), D291 (= D285), R292 (= R286), V495 (= V482), W498 (= W485)
- binding flavin-adenine dinucleotide: R159 (= R154), G219 (= G212), A220 (≠ G213), G221 (= G214), N224 (= N217), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (= L258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (≠ I287), E319 (≠ D304), V320 (≠ I305), N324 (≠ S309), G337 (= G322), D338 (= D323), A339 (vs. gap), M414 (= M401), G432 (= G419), G433 (= G420)
- binding magnesium ion: D462 (≠ E449), N489 (= N476), E491 (≠ R478)
- binding thiamine diphosphate: Y31 (= Y26), E57 (= E52), P83 (= P78)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
45% identity, 97% coverage: 5:572/583 of query aligns to 10:578/593 of 6deoA
- active site: Y31 (= Y26), G33 (= G28), G34 (= G29), A35 (= A30), I36 (≠ V31), E57 (= E52), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (= E116), K169 (= K164), K224 (≠ Q224), M260 (= M260), V287 (≠ I287), V403 (= V396), L428 (= L421), G429 (= G422), M431 (= M424), D456 (≠ E449), N483 (= N476), E485 (≠ R478), Q486 (≠ L479), M488 (= M481), V489 (= V482), W492 (= W485), L514 (= L508), N519 (≠ G513), V520 (≠ A514)
- binding flavin-adenine dinucleotide: R159 (= R154), G213 (= G212), A214 (≠ G213), G215 (= G214), N218 (= N217), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (= L258), G280 (= G280), A281 (= A281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (≠ I287), E313 (≠ D304), I314 (= I305), N318 (≠ S309), D332 (= D323), V333 (≠ I324), M408 (= M401), G426 (= G419)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M481), W492 (= W485)
- binding magnesium ion: D456 (≠ E449), N483 (= N476), E485 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V396), G404 (= G397), Q405 (= Q398), H406 (= H399), G429 (= G422), M431 (= M424), G455 (= G448), D456 (≠ E449), A457 (= A450), S458 (= S451), M461 (= M454), N483 (= N476), E485 (≠ R478), Q486 (≠ L479), G487 (= G480), M488 (= M481), V489 (= V482)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 97% coverage: 5:572/583 of query aligns to 12:582/597 of 6demA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ Q224), M264 (= M260), V291 (≠ I287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), N523 (≠ G513), V524 (≠ A514)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), W496 (= W485), A567 (≠ S557)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ I287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (= D323), V337 (≠ I324), M412 (= M401), G430 (= G419)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
44% identity, 97% coverage: 5:572/583 of query aligns to 12:582/597 of 6delA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K228 (≠ Q224), M264 (= M260), V291 (≠ I287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), N523 (≠ G513), V524 (≠ A514)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R154), G217 (= G212), A218 (≠ G213), G219 (= G214), N222 (= N217), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (= L258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (≠ I287), E317 (≠ D304), I318 (= I305), N322 (≠ S309), D336 (= D323), V337 (≠ I324), M412 (= M401), G430 (= G419)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ R478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 7:560/582 of 1t9dB
- active site: Y28 (= Y26), G30 (= G28), G31 (= G29), A32 (= A30), I33 (≠ V31), E54 (= E52), T77 (= T75), F116 (= F114), Q117 (= Q115), E118 (= E116), K166 (= K164), R213 (≠ Q224), M249 (= M260), V276 (≠ I287), V392 (= V396), L417 (= L421), G418 (= G422), M420 (= M424), D445 (≠ E449), N472 (= N476), E474 (≠ R478), Q475 (≠ L479), M477 (= M481), V478 (= V482), W481 (= W485), L503 (= L508), G508 (= G513), L509 (≠ A514), K542 (= K547)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G29), A32 (= A30), V106 (= V104), P107 (= P105), F116 (= F114), K166 (= K164), M249 (= M260), D274 (= D285), R275 (= R286), W481 (= W485)
- binding flavin-adenine dinucleotide: R156 (= R154), G202 (= G212), A203 (≠ G213), G204 (= G214), N207 (= N217), T229 (= T240), L230 (= L241), Q231 (≠ M242), L247 (= L258), M249 (= M260), H250 (= H261), G269 (= G280), A270 (= A281), R271 (= R282), D273 (= D284), R275 (= R286), V276 (≠ I287), E302 (≠ D304), V303 (≠ I305), N307 (≠ S309), G320 (= G322), D321 (= D323), A322 (vs. gap), Q396 (= Q400), M397 (= M401), G415 (= G419), G416 (= G420)
- binding magnesium ion: D445 (≠ E449), N472 (= N476), E474 (≠ R478)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E52), P80 (= P78), G418 (= G422), M420 (= M424), M450 (= M454)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 96% coverage: 5:565/583 of query aligns to 8:561/583 of 1t9bA
- active site: Y29 (= Y26), G31 (= G28), G32 (= G29), A33 (= A30), I34 (≠ V31), E55 (= E52), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (= E116), K167 (= K164), R214 (≠ Q224), M250 (= M260), V277 (≠ I287), V393 (= V396), L418 (= L421), G419 (= G422), M421 (= M424), D446 (≠ E449), N473 (= N476), E475 (≠ R478), Q476 (≠ L479), M478 (= M481), V479 (= V482), W482 (= W485), L504 (= L508), G509 (= G513), L510 (≠ A514), K543 (= K547)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V104), P108 (= P105), F117 (= F114), D275 (= D285), R276 (= R286), M478 (= M481), W482 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R154), G203 (= G212), A204 (≠ G213), G205 (= G214), N208 (= N217), T230 (= T240), L231 (= L241), Q232 (≠ M242), M247 (= M257), L248 (= L258), M250 (= M260), H251 (= H261), G270 (= G280), A271 (= A281), R272 (= R282), D274 (= D284), R276 (= R286), V277 (≠ I287), E303 (≠ D304), V304 (≠ I305), N308 (≠ S309), D322 (= D323), A323 (vs. gap), Q397 (= Q400), M398 (= M401), G416 (= G419), G417 (= G420)
- binding magnesium ion: D446 (≠ E449), N473 (= N476), E475 (≠ R478)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 97% coverage: 5:572/583 of query aligns to 14:586/601 of 6deqA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K232 (≠ Q224), M268 (= M260), V295 (≠ I287), V411 (= V396), L436 (= L421), G437 (= G422), M439 (= M424), D464 (≠ E449), N491 (= N476), E493 (≠ R478), Q494 (≠ L479), M496 (= M481), V497 (= V482), W500 (= W485), L522 (= L508), N527 (≠ G513), V528 (≠ A514)
- binding flavin-adenine dinucleotide: R163 (= R154), G221 (= G212), A222 (≠ G213), G223 (= G214), N226 (= N217), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (= L258), G288 (= G280), A289 (= A281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (≠ I287), E321 (≠ D304), I322 (= I305), D340 (= D323), V341 (≠ I324), M416 (= M401), G434 (= G419)
- binding magnesium ion: D464 (≠ E449), N491 (= N476), E493 (≠ R478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M481), V497 (= V482), W500 (= W485), A571 (≠ S557)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V396), G412 (= G397), Q413 (= Q398), H414 (= H399), M439 (= M424), G463 (= G448), D464 (≠ E449), A465 (= A450), S466 (= S451), N491 (= N476), E493 (≠ R478), Q494 (≠ L479), G495 (= G480), M496 (= M481), V497 (= V482)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
45% identity, 97% coverage: 5:572/583 of query aligns to 14:585/600 of 6derA
- active site: Y35 (= Y26), G37 (= G28), G38 (= G29), A39 (= A30), I40 (≠ V31), E61 (= E52), T84 (= T75), F123 (= F114), Q124 (= Q115), E125 (= E116), K173 (= K164), K231 (≠ Q224), M267 (= M260), V294 (≠ I287), V410 (= V396), L435 (= L421), G436 (= G422), M438 (= M424), D463 (≠ E449), N490 (= N476), E492 (≠ R478), Q493 (≠ L479), M495 (= M481), V496 (= V482), W499 (= W485), L521 (= L508), N526 (≠ G513), V527 (≠ A514)
- binding flavin-adenine dinucleotide: R163 (= R154), G220 (= G212), A221 (≠ G213), G222 (= G214), N225 (= N217), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (= L258), H268 (= H261), G287 (= G280), A288 (= A281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (≠ I287), E320 (≠ D304), I321 (= I305), N325 (≠ S309), G338 (= G322), D339 (= D323), V340 (≠ I324), Q414 (= Q400), M415 (= M401), G433 (= G419)
- binding Metosulam: R293 (= R286), M495 (= M481), W499 (= W485), A570 (≠ S557)
- binding magnesium ion: D463 (≠ E449), N490 (= N476), E492 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (≠ E449), A464 (= A450), S465 (= S451), N490 (= N476), E492 (≠ R478), Q493 (≠ L479), G494 (= G480), M495 (= M481), V496 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (≠ E449), A464 (= A450), S465 (= S451), M468 (= M454), N490 (= N476), E492 (≠ R478), Q493 (≠ L479), G494 (= G480), V496 (= V482)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
45% identity, 97% coverage: 5:572/583 of query aligns to 12:583/598 of 6desA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K229 (≠ Q224), M265 (= M260), V292 (≠ I287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (≠ E449), N488 (= N476), E490 (≠ R478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (= L508), N524 (≠ G513), V525 (≠ A514)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R154), G218 (= G212), A219 (≠ G213), G220 (= G214), N223 (= N217), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ I287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (= D323), V338 (≠ I324), Q412 (= Q400), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (≠ E449), N488 (= N476), E490 (≠ R478)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), N488 (= N476), E490 (≠ R478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
45% identity, 97% coverage: 5:572/583 of query aligns to 12:583/598 of 6depA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), K229 (≠ Q224), M265 (= M260), V292 (≠ I287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (≠ E449), N488 (= N476), E490 (≠ R478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (= L508), N524 (≠ G513), V525 (≠ A514)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M481), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R154), G218 (= G212), A219 (≠ G213), G220 (= G214), N223 (= N217), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (= L258), G264 (= G259), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (≠ I287), E318 (≠ D304), I319 (= I305), N323 (≠ S309), D337 (= D323), V338 (≠ I324), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (≠ E449), N488 (= N476), E490 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ R478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ R478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
45% identity, 96% coverage: 5:565/583 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), I38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M274 (= M260), V301 (≠ I287), V417 (= V396), G443 (= G422), M445 (= M424), D470 (≠ E449), N497 (= N476), E499 (≠ R478), Q500 (≠ L479), M502 (= M481), V503 (= V482), W506 (= W485)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G29), V111 (= V104), P112 (= P105), F121 (= F114), K171 (= K164), D299 (= D285), R300 (= R286), M502 (= M481), W506 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R154), A228 (≠ G213), G229 (= G214), N232 (= N217), T254 (= T240), L255 (= L241), Q256 (≠ M242), L272 (= L258), M274 (= M260), G294 (= G280), R296 (= R282), D298 (= D284), R300 (= R286), V301 (≠ I287), E327 (≠ D304), V328 (≠ I305), N332 (≠ S309), D346 (= D323), A347 (vs. gap), M422 (= M401), G440 (= G419), G441 (= G420)
- binding magnesium ion: D470 (≠ E449), N497 (= N476)
- binding thiamine diphosphate: E59 (= E52), P85 (= P78), V417 (= V396), G418 (= G397), Q419 (= Q398), H420 (= H399), G443 (= G422), M445 (= M424), A471 (= A450), S472 (= S451), N497 (= N476), E499 (≠ R478), Q500 (≠ L479), G501 (= G480), M502 (= M481), V503 (= V482)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
45% identity, 96% coverage: 5:565/583 of query aligns to 92:665/687 of P07342
- R241 (= R154) binding
- 355:376 (vs. 261:282, 50% identical) binding
- 407:426 (vs. 304:323, 40% identical) binding
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
45% identity, 96% coverage: 7:565/583 of query aligns to 99:661/670 of P17597
- A122 (= A30) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L32) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E52) binding
- S186 (= S94) binding
- P197 (= P105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ F107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (= K164) binding
- G308 (= G213) binding
- TL 331:332 (= TL 240:241) binding
- C340 (≠ A249) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 258:261) binding
- GVRFD 371:375 (≠ GARFD 280:284) binding
- DR 376:377 (= DR 285:286) binding
- DI 395:396 (= DI 304:305) binding
- DV 414:415 (≠ DI 323:324) binding
- QH 487:488 (= QH 398:399) binding
- GG 508:509 (= GG 419:420) binding
- GAM 511:513 (≠ GTM 422:424) binding
- D538 (≠ E449) binding
- DGS 538:540 (≠ EAS 449:451) binding
- N565 (= N476) binding
- NQHLGM 565:570 (≠ NERLGM 476:481) binding
- H567 (≠ R478) binding
- W574 (= W485) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S557) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
45% identity, 96% coverage: 7:565/583 of query aligns to 14:576/583 of 5k3sA
- active site: Y33 (= Y26), G35 (= G28), G36 (= G29), A37 (= A30), S38 (≠ V31), E59 (= E52), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (= E116), K171 (= K164), M266 (= M260), V293 (≠ I287), V400 (= V396), G426 (= G422), M428 (= M424), D453 (≠ E449), N480 (= N476), H482 (≠ R478), L483 (= L479), M485 (= M481), V486 (= V482), W489 (= W485), H558 (≠ K547)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R286), M485 (= M481), W489 (= W485), G569 (= G558)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G212), G223 (= G213), G224 (= G214), T246 (= T240), L247 (= L241), M248 (= M242), L264 (= L258), M266 (= M260), G286 (= G280), R288 (= R282), D290 (= D284), V293 (≠ I287), D310 (= D304), I311 (= I305), D329 (= D323), V330 (≠ I324), M405 (= M401), G423 (= G419)
- binding magnesium ion: D453 (≠ E449), N480 (= N476), H482 (≠ R478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (= H399), G426 (= G422), M428 (= M424), D453 (≠ E449), G454 (≠ A450), S455 (= S451), N480 (= N476), H482 (≠ R478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)
Query Sequence
>GFF1987 FitnessBrowser__Phaeo:GFF1987
MKREMTGAKMVVQALKDQGVDTVFGYPGGAVLPIYDEIFLQNDIRHILVRHEQGAVHAAE
GYARSTGKPGVVLVTSGPGATNAVTGLTDALLDSIPLVVLTGQVPTFMIGSDAFQEADTV
GITRPCTKHNWLVKDTEKLAGTLHEAFHVATAGRPGPVLIDIPKDVQFATGTYQDPKPAA
SHYQPPVKGDLEAITELVAAMETAKRPVFYTGGGVINSGPGASQLLRELVAATGIPVTST
LMGLGAYPASGKNWLGMLGMHGLYEANMAMHDCDLMINIGARFDDRITGRLDAFSPNSTK
AHIDIDPSSINKVIRVDIPIVGDIGHVLEDVLKVWKSRGRKVDSAAIAKWQEQITEWRDI
RCLAYTASESTIKPQYALERLEALTKDRNRYITTEVGQHQMWAAQYLGFEDPNRWMTSGG
LGTMGYGTPASLGVQVAHPDALVINVAGEASWLMNMQEMGTAVQYRLPVKQFILNNERLG
MVRQWQELLHGERYSHSWSEALPDFVKLAEAFGAKGIICKDPKDLDDAIMEMLDYDGPVI
FDCLVEKHENCFPMIPSGKAHNEMLLGEADTQGVIQAGGAVLV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory