SitesBLAST
Comparing GFF2053 FitnessBrowser__Phaeo:GFF2053 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
33% identity, 100% coverage: 1:261/262 of query aligns to 1:272/274 of 4zohB
- active site: Y256 (= Y245)
- binding flavin-adenine dinucleotide: R28 (≠ Q25), P29 (≠ A26), A31 (≠ G28), G32 (= G29), G33 (= G30), H34 (≠ Q31), S35 (≠ T32), L36 (= L33), H77 (= H74), I95 (= I95), G96 (= G96), V100 (= V100), T105 (= T105), G108 (= G108), S109 (= S109), S111 (≠ A111), A117 (= A117), D118 (≠ C118), L160 (≠ I156), V161 (≠ I157), D185 (≠ R179), F186 (= F180)
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
33% identity, 98% coverage: 4:261/262 of query aligns to 6:282/287 of 1n5wC
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
33% identity, 98% coverage: 4:261/262 of query aligns to 6:282/288 of P19920
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
31% identity, 99% coverage: 3:261/262 of query aligns to 5:282/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (≠ Q25), L30 (≠ A26), A32 (≠ G28), G33 (= G29), G34 (= G30), H35 (≠ Q31), S36 (≠ T32), L37 (= L33), I54 (≠ L50), I101 (= I95), A102 (≠ G96), G110 (= G104), T111 (= T105), G114 (= G108), D115 (≠ S109), A117 (= A111), N123 (≠ A117), D124 (≠ C118), L161 (= L151), V166 (≠ I156), M167 (≠ I157), W193 (≠ F180)
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
29% identity, 98% coverage: 4:261/262 of query aligns to 6:279/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (≠ A26), A31 (≠ G28), G32 (= G29), G33 (= G30), Q34 (= Q31), S35 (≠ T32), L36 (= L33), V100 (≠ I95), A101 (≠ G96), V105 (= V100), T110 (= T105), G113 (= G108), S114 (= S109), A116 (= A111), A122 (= A117), E123 (≠ C118), L166 (≠ I157), Y190 (≠ F180)
7dqxE Crystal structure of xanthine dehydrogenase family protein
27% identity, 98% coverage: 4:261/262 of query aligns to 6:283/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (≠ Q25), I30 (≠ A26), I31 (≠ L27), G33 (= G29), G34 (= G30), Q35 (= Q31), S36 (≠ T32), L37 (= L33), H78 (= H74), I101 (= I95), A102 (≠ G96), I106 (≠ V100), G110 (= G104), T111 (= T105), G113 (= G107), G114 (= G108), S115 (= S109), A117 (= A111), A123 (= A117), E124 (≠ C118), I167 (= I157), Y193 (≠ F180)
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
27% identity, 81% coverage: 1:211/262 of query aligns to 1:217/296 of Q0QLF4
- 29:36 (vs. 26:33, 38% identical) binding
- G101 (= G96) binding
- TIGGN 110:114 (≠ TIGGS 105:109) binding
- D123 (≠ C118) binding
- R160 (≠ T148) binding
- M169 (≠ I157) binding
- K187 (≠ Q175) binding
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
27% identity, 81% coverage: 1:211/262 of query aligns to 1:217/292 of 3hrdG
- binding flavin-adenine dinucleotide: I29 (≠ A26), A31 (≠ G28), G32 (= G29), G33 (= G30), T34 (≠ Q31), D35 (≠ T32), F77 (≠ H74), V100 (≠ I95), G101 (= G96), I105 (≠ V100), T110 (= T105), G113 (= G108), N114 (≠ S109), S116 (≠ A111), T117 (≠ N112), G122 (≠ A117), D123 (≠ C118), I168 (= I156), M169 (≠ I157)
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
30% identity, 77% coverage: 1:202/262 of query aligns to 4:260/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (≠ A26), G31 (= G28), A32 (≠ G29), G33 (= G30), T34 (≠ Q31), D35 (≠ T32), L36 (= L33), L53 (= L50), V101 (≠ I95), A102 (≠ G96), A110 (≠ G104), T111 (= T105), G114 (= G108), N115 (≠ S109), C117 (≠ A111), Q118 (≠ N112), D162 (vs. gap), L207 (≠ I157), V231 (≠ S178), D232 (≠ R179), F233 (= F180)
- binding iron/sulfur cluster: C122 (vs. gap), F124 (vs. gap), C138 (vs. gap), C146 (vs. gap), H147 (vs. gap), V148 (vs. gap), C155 (= C118), Y156 (= Y119), A157 (vs. gap)
O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see paper)
30% identity, 77% coverage: 1:202/262 of query aligns to 4:260/324 of O33820
- 29:36 (vs. 26:33, 50% identical) binding
- T111 (= T105) binding
- N115 (≠ S109) binding
- Q118 (≠ N112) binding
- D162 (vs. gap) binding
- K224 (= K172) binding
2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
27% identity, 80% coverage: 50:258/262 of query aligns to 213:435/450 of 2w54A
- binding flavin-adenine dinucleotide: L213 (= L50), F258 (≠ I95), A259 (≠ G96), A267 (≠ G104), T268 (= T105), G271 (= G108), N272 (≠ S109), A274 (= A111), N275 (= N112), G280 (≠ A117), D281 (≠ C118), R318 (≠ L151), V324 (≠ I157), Q347 (vs. gap)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42, 189, 191, 192, 193, 194, 195, 196, 199
- binding fe2/s2 (inorganic) cluster: 38, 39, 40, 42, 44, 45, 47, 63, 103, 104, 106, 134, 135, 136
- binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: 102, 136
1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
27% identity, 80% coverage: 50:258/262 of query aligns to 213:435/450 of 1jroA
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42, 43, 189, 191, 192, 193, 194, 195, 196
- binding fe2/s2 (inorganic) cluster: 37, 38, 39, 40, 42, 44, 45, 47, 63, 103, 106, 134, 136
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
25% identity, 66% coverage: 1:172/262 of query aligns to 1:232/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ A26), A28 (≠ G28), G29 (= G29), G30 (= G30), T31 (≠ Q31), T32 (= T32), Q33 (≠ L33), A97 (≠ I95), A98 (≠ G96), I102 (≠ V100), A106 (≠ G104), T107 (= T105), G110 (= G108), N111 (≠ S109), R113 (≠ A111), Q114 (≠ N112), G164 (vs. gap), D165 (vs. gap), I213 (= I156), I214 (= I157), K232 (= K172)
- binding iron/sulfur cluster: C118 (vs. gap), Y121 (vs. gap), C130 (= C118), N131 (vs. gap), C139 (vs. gap), A141 (vs. gap), C158 (vs. gap), I159 (vs. gap), A160 (vs. gap)
Sites not aligning to the query:
Query Sequence
>GFF2053 FitnessBrowser__Phaeo:GFF2053
MYEFEFEKPSTIADAVKALGEEDAQALGGGQTLIPTLKQRLAMPSTLVSLSGIEEMKGVC
PDGDGLAIGGATTHGEVEAATADSYPALSALAGQIGDPAVRNRGTIGGSLANNDPSACYP
AAALASGATIVTNTREIAADDYFQGLFTTALEEGEIITNIRLPVPQSAHYEKFVQPASRF
ALVGVFVARFAEGVRVAVTGASEEGVFRWSAAEAALSANFSPDAIDGLTVDPDGMIGDLH
GTKAYRAHLVGVITKRAVAAAG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory