SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF210 FitnessBrowser__Marino:GFF210 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6nqhA

query
sites
6nqhA

M

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active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding magnesium ion: D237 (= D236), D239 (= D238), D241 (= D240)
binding 1-O-phosphono-alpha-D-xylopyranose: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), R242 (= R241), R280 (= R279), S301 (≠ T300), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)

6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6np8A

query
sites
6np8A

M

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A

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G

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A

A

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H

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M

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N

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A

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A

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active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding calcium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)
binding 6-O-phosphono-alpha-D-mannopyranose: Y9 (= Y9), R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)

6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6nolA

query
sites
6nolA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

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Y

D

D

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G

G

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R

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V

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D

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E

A

A

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A

A

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D

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I

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Y

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D

A

G

G

I

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M

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H

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A

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A

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L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding 1-O-phosphono-alpha-D-mannopyranose: R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)
binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

6nnpA Xanthomonas citri dephospho-pgm in complex with glucose-6-phosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6nnpA

query
sites
6nnpA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y
|
Y

D

D

L

I

R
|
R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H
|
H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K
|
K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R
|
R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R
|
R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S
|
S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding 6-O-phosphono-alpha-D-glucopyranose: Y9 (= Y9), R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)
binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

6nn2A Xanthomonas citri pgm apo-phospho (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6nn2A

query
sites
6nn2A

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y

Y

D

D

L

I

R
|
R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H
|
H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K
|
K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R
|
R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R

R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G

G

H

H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E

E

M

M

S

S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R

R

M

S

S

S

N

N

T

T

E

E

P

P

V

L

R

R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding calcium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

6n1eA Crystal structure of x. Citri phosphoglucomutase in complex with 1- methyl-glucose 6-phosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6n1eA

query
sites
6n1eA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y

Y

D

D

L

I

R

R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H

H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K

K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R

R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R

R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S

S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)
binding 1-deoxy-7-O-phosphono-alpha-D-gluco-hept-2-ulopyranose: G302 (= G301), H303 (= H302), E320 (= E319), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)

6mnvA Crystal structure of x. Citri phosphoglucomutase in complex with ch2fg1p (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6mnvA

query
sites
6mnvA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y
|
Y

D

D

L

I

R

R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H

H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K

K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R

R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R
|
R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S
|
S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

binding 1-deoxy-1-fluoro-2-O-phosphono-alpha-D-gluco-hept-2-ulopyranose: Y9 (= Y9), R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)
binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

6mlhA Crystal structure of x. Citri phosphoglucomutase in complex with glucopyranosyl-1-methyl-phosphonic acid (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6mlhA

query
sites
6mlhA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y

Y

D

D

L

I

R
|
R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H
|
H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K
|
K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R
|
R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R
|
R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S
|
S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding (1S)-1,5-anhydro-1-(phosphonomethyl)-D-glucitol: R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)
binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

6mlfA Crystal structure of x. Citri phosphoglucomutase in complex with 6- fluoro glucose 1-phosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 6mlfA

query
sites
6mlfA

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y

Y

D

D

L

I

R
|
R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H
|
H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K
|
K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R
|
R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R
|
R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S
|
S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A

A

R

R

I

M

E

Q

A

K

Y

F

P

P

A

C

S

S

G

G

E

E

I

I

N

N

R

F

T

K

I

V

D

A

D

D

P

A

P

K

K

A

V

S

I

V

A

A

A

R

I

V

E

M

A

E

K

H

Y

Y

S

A

V

S

G

L

A

S

K

P

S

E

V

L

S

D

H

Y

V

T

D

D

G

G

V

I

S

S

I

A

E

D

F

F

D

G

D

Q

W

W

R

R

F

F

N

N

L

L

R
|
R

M

S

S
|
S

N
|
N

T
|
T

E

E

P

P

V

L

R
|
R

L

L

N

N

V

V

E

E

S

T

R

R

A

G

D

D

I

A

P

A

L

L

M

L

E

E

E

T

K

R

T

T

E

Q

E

E

L

I

active site: R12 (= R12), S97 (= S97), H98 (= H98), K107 (= K107), D237 (= D236), D239 (= D238), D241 (= D240), R242 (= R241), H324 (= H323)
binding 6-deoxy-6-fluoro-1-O-phosphono-alpha-D-glucopyranose: R280 (= R279), G302 (= G301), H303 (= H302), E320 (= E319), S322 (= S321), H324 (= H323), R414 (= R413), S416 (= S415), N417 (= N416), T418 (= T417), R423 (= R422)
binding magnesium ion: S97 (= S97), D237 (= D236), D239 (= D238), D241 (= D240)

5kl0A Crystal structure of phosphoglucomutase from xanthomonas citri citri complexed with glucose-1,6-biphosphate (see paper)
58% identity, 98% coverage: 1:441/452 of query aligns to 1:442/448 of 5kl0A

query
sites
5kl0A

M

M

D

T

L

L

S

P

C

A

F

F

K

K

A

A

Y
|
Y

D

D

L

I

R
|
R

G

G

R

R

V

V

P

P

D

D

Q

E

L

L

N

N

P

E

V

D

L

L

A

A

E

R

K

R

I

I

G

G

R

V

A

A

Y

L

V

A

E

A

I

Q

T

L

G

D

A

Q

K

G

K

P

V

V

I

V

V

L

G

G

Y

H

D

D

I

V

R

R

L

L

S

A

S

S

P

P

D

A

I

L

A

Q

E

E

A

A

L

L

S

S

S

A

G

G

L

L

M

R

A

A

A

S

G

G

A

R

D

D

V

V

F

I

D

D

I

I

G

G

L

L

C

C

G

G

T

T

E

E

Q

E

V

V

Y

Y

F

F

A

Q

T

T

S

D

H

Y

Y

L

K

K

M

A

D

A

G

G

I

V

M

M

V

V

T

T

A

A

S
|
S

H
|
H

N

N

P

P

K

M

D

D

H

Y

N

N

G

G

M

M

K
|
K

M

L

V

V

G

R

P

E

E

Q

S

A

R

R

P

P

I

I

S

S

D

D

N

T

G

G

L

L

N

F

E

A

I

I

R

R

D

D

R

T

V

V

L

A

-

A

-

D

-

T

-

A

-

P

-

G

E

E

P

P

F

-

G

-

D

T

A

A

P

S

Q

E

Q

Q

G

S

R

R

Y

T

E

D

P

K

L

-

E

-

V

-

M

-

S

T

A

A

Y

Y

V

L

D

E

H

H

L

L

G

S

Y

Y

I

V

D

D

A

R

G

S

S

T

L

L

S

K

P

P

L

L

T

K

I

L

V

V

C

V

N

N

A

A

G

G

N

N

G

G

A

A

G

G

L

L

V

I

I

V

D

D

E

L

L

L

E

A

Q

P

H

H

L

L

P

P

F

F

E

E

F

F

V

V

K

R

V

V

H

F

H

H

Q

E

P

P

D

D

G

G

H

N

F

F

P

P

N

N

G

G

V

I

P

P

N

N

P

P

I

L

L

L

P

P

E

E

N

N

R

R

A

D

A

A

T

T

A

A

D

K

A

A

V

V

I

K

A

D

E

N

G

G

A

A

A

D

M

F

G

G

I

I

A

A

W

W

D
|
D

G

G

D
|
D

Y

F

D
|
D

R
|
R

C

C

F

F

D

D

E

H

N

T

G

G

R

R

F

F

I

I

E

E

G

G

Y

Y

I

L

V

V

G

G

L

L

A

A

D

Q

Q

A

F

I

L

L

R

A

K

K

T

Q

G

P

G

G

K

K

V

V

I

V

H

H

D

D

P

P

R
|
R

L

L

T

T

W

W

N

N

T

T

M

V

D

E

L

Q

V

V

K

E

A

E

A

A

G

G

E

I

A

P

I

V

E

L

S

C

K

K

T

S

G
|
G

H
|
H

A

A

F

F

I

I

K

K

Q

E

R

K

M

M

R

R

D

S

E

E

D

N

A

A

V

V

Y

Y

G

G

E
|
E

M

M

S
|
S

A

A

H
|
H

H

H

Y

Y

F

F

R

R

D

E

F

F

A

A

Y

Y

C

A

D

D

S

S

G

G

M

M

I

I

P

P

W

W

L

L

V

I

A

A

E

E

R

L

L

V

C

S

Q

Q

S

S

G

G

Q

R

T

S

L

L

S

A

S

D

L

L

I

V

D

E

A
&nb