Comparing GFF2220 FitnessBrowser__Marino:GFF2220 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
6ovtA Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
28% identity, 83% coverage: 69:572/610 of query aligns to 36:532/562 of 6ovtA
P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
28% identity, 83% coverage: 69:572/610 of query aligns to 49:545/575 of P9WKJ5
8hs0A The mutant structure of dhad v178w
30% identity, 78% coverage: 90:564/610 of query aligns to 68:527/570 of 8hs0A
Sites not aligning to the query:
Q1JUQ1 L-arabonate dehydratase; L-arabinonate dehydratase; EC 4.2.1.25 from Azospirillum brasilense (see paper)
31% identity, 85% coverage: 57:572/610 of query aligns to 30:532/583 of Q1JUQ1
Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
29% identity, 79% coverage: 90:572/610 of query aligns to 106:577/608 of Q9LIR4
Sites not aligning to the query:
B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
31% identity, 73% coverage: 129:572/610 of query aligns to 98:534/579 of B5ZZ34
Sites not aligning to the query:
5j85A Ser480ala mutant of l-arabinonate dehydratase (see paper)
30% identity, 73% coverage: 129:572/610 of query aligns to 95:531/576 of 5j85A
Sites not aligning to the query:
8ej0A Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mg
31% identity, 75% coverage: 113:570/610 of query aligns to 76:521/568 of 8ej0A
Sites not aligning to the query:
8epzA Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mn
31% identity, 75% coverage: 113:570/610 of query aligns to 77:522/569 of 8epzA
Sites not aligning to the query:
Q9A9Z2 D-xylonate dehydratase; XyDHT; Gluconate dehydratase; EC 4.2.1.82; EC 4.2.1.39 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see 2 papers)
28% identity, 70% coverage: 149:572/610 of query aligns to 123:548/595 of Q9A9Z2
Sites not aligning to the query:
5oynA Crystal structure of d-xylonate dehydratase in holo-form (see paper)
28% identity, 70% coverage: 149:572/610 of query aligns to 117:542/589 of 5oynA
Sites not aligning to the query:
7m3kA Crystal structure of galactonate dehydratase from brucella melitensis biovar abortus 2308
26% identity, 75% coverage: 149:607/610 of query aligns to 112:573/587 of 7m3kA
Sites not aligning to the query:
>GFF2220 FitnessBrowser__Marino:GFF2220
MEPTMHPTVDKVTQRIIERSHPTRQDYLNRMNALKAQSPHRSSLSCGNLAHGFAACNQGD
KDTLKFMNKANVAMVTAYNDMLSAHQPYEKFPDIIREAARGMGSVAQVAGGTPAMCDGVT
QGQPGMELSLFSRDTIAMSTAVALSHNMFDATLLLGICDKIVPGLLIGSLSFGYLPTILL
PAGPMPSGLPNKEKQRIRQLYAEGKVGKEELLEAESKSYHSPGTCTFYGTANSNQLLVEV
MGLHMPGSAFVNPNTPLRDELTRAATEQVIRLSKPHGGELGLGDMVDEKSIVNALVALLV
TGGSTNHTIHWIAIARAAGIIIDWNDYAELSSVVPSMTRIYPNGQEDVNAFHEAGGTPFL
IRELLSGGYVHNDVNTVVGYGLERYTEMPELSDEQLVWKPAPEKSLRPDVLSPVAEPFAP
DGGLRVLDGNLGRGVIKVSAVAPEHRKVEAPAVVFNDQNELKAAFEAGDLDRDCIVIVRF
QGPKSNGMPELHKLTPYLGVLQDRGFKVGLVTDGRMSGASGKVPAAIHVYPEALDGGPLA
KVKNGDMVCLDAESGVLAIRLDDQEFAGRESEKADLTGYHHGYGRELFGWMRRAASNPEE
GASFFWNHEA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory