SitesBLAST – Find functional sites

 

SitesBLAST

Comparing GFF2245 HP15_2195 amino acid ABC transporter, permease protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
34% identity, 31% coverage: 260:382/395 of query aligns to 85:210/215 of 4ymtC

query
sites
4ymtC
I
 
I
P
 
P
E
 
A
L
 
F
A
 
T
A
 
A
L
 
G
W
 
V
I
 
S
A
 
A
L
 
L
S
 
A
L
 
I
Y
x
N
T
x
S
A
 
S
S
 
A
F
x
Y
I
 
V
A
 
A
E
 
E
I
 
I
V
 
I
R
 
R
S
 
A
G
 
G
I
 
I
L
 
Q
S
 
A
V
 
V
S
 
D
K
 
P
G
 
G
Q
 
Q
T
 
N
E
 
E
A
 
A
S
 
A
K
 
R
A
 
S
L
 
L
G
 
G
L
 
M
P
 
T
N
 
H
G
 
A
L
 
M
T
 
A
L
 
M
R
 
R
L
 
Y
V
 
V
V
 
I
I
 
I
P
 
P
Q
 
Q
A
 
A
M
 
I
R
 
K
V
 
N
I
 
I
I
 
L
P
 
P
P
 
A
L
 
L
T
 
G
S
 
N
Q
x
E
Y
 
F
L
 
I
N
 
V
L
x
M
V
 
L
K
|
K
N
x
E
S
 
S
S
 
A
L
 
I
A
 
V
T
 
S
A
 
V
I
 
I
G
 
G
Y
 
F
P
 
A
D
 
D
L
 
L
V
 
T
-
 
R
-
 
Q
-
 
A
A
 
D
V
 
I
F
 
I
M
 
Q
G
 
S
T
 
V
T
 
T
L
 
Y
N
 
R
Q
 
Y
T
 
F
G
 
E
Q
 
P
A
 
Y
V
 
I
E
 
I
V
 
I
V
 
A
A
 
A
I
 
I
T
 
Y
M
 
F
A
 
V
V
 
M
Y
 
T
L
 
L
T
 
T
I
 
F
S
 
S
L
 
K
L
 
L
I
 
L
S
 
S
L
 
L
F
 
F

Sites not aligning to the query:

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
34% identity, 31% coverage: 260:382/395 of query aligns to 85:210/214 of 4ymwC

query
sites
4ymwC
I
 
I
P
 
P
E
 
A
L
 
F
A
 
T
A
 
A
L
 
G
W
 
V
I
 
S
A
 
A
L
 
L
S
 
A
L
 
I
Y
x
N
T
 
S
A
 
S
S
 
A
F
x
Y
I
 
V
A
 
A
E
 
E
I
 
I
V
 
I
R
 
R
S
 
A
G
 
G
I
 
I
L
 
Q
S
 
A
V
 
V
S
 
D
K
 
P
G
 
G
Q
 
Q
T
 
N
E
 
E
A
 
A
S
 
A
K
 
R
A
 
S
L
 
L
G
 
G
L
 
M
P
 
T
N
 
H
G
 
A
L
 
M
T
 
A
L
 
M
R
 
R
L
 
Y
V
 
V
V
 
I
I
 
I
P
 
P
Q
 
Q
A
 
A
M
 
I
R
 
K
V
 
N
I
 
I
I
 
L
P
 
P
P
 
A
L
 
L
T
 
G
S
 
N
Q
x
E
Y
 
F
L
 
I
N
 
V
L
x
M
V
 
L
K
 
K
N
x
E
S
 
S
S
 
A
L
 
I
A
 
V
T
 
S
A
 
V
I
 
I
G
 
G
Y
 
F
P
 
A
D
 
D
L
 
L
V
 
T
-
 
R
-
 
Q
-
 
A
A
 
D
V
 
I
F
 
I
M
 
Q
G
 
S
T
 
V
T
 
T
L
 
Y
N
 
R
Q
 
Y
T
 
F
G
 
E
Q
 
P
A
 
Y
V
 
I
E
 
I
V
 
I
V
 
A
A
 
A
I
 
I
T
 
Y
M
 
F
A
 
V
V
 
M
Y
 
T
L
 
L
T
 
T
I
 
F
S
 
S
L
 
K
L
 
L
I
 
L
S
 
S
L
 
L
F
 
F

Sites not aligning to the query:

Query Sequence

>GFF2245 HP15_2195 amino acid ABC transporter, permease protein
MKKQTIDTRPAGPKPWYDPRVRSLFFQAVAIALVFWGGWILVDNTLSNMESRGISTGFGF
LGETAGFGIIMNLVPYDATMSYGRTFWVGLTNTLLVSAMGVVAATILGFIIGVARLSSNW
LVAKMALVYIEVIRNIPLLLQIFFWYFAVLSNLPSPRQSVDVGGALFLNNRGLYLPDPVT
QEGFGIVWGGILLAIAAVVGIRIWAKKRQLATGQIFPTFKVGVAILVLVPIISYLVAGRP
LEWDLPALRGFNFGGGITIIPELAALWIALSLYTASFIAEIVRSGILSVSKGQTEASKAL
GLPNGLTLRLVVIPQAMRVIIPPLTSQYLNLVKNSSLATAIGYPDLVAVFMGTTLNQTGQ
AVEVVAITMAVYLTISLLISLFMNIYNRAVAIKER

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory