SitesBLAST
Comparing GFF2287 FitnessBrowser__Phaeo:GFF2287 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
52% identity, 98% coverage: 8:459/459 of query aligns to 9:466/474 of P0A9P0
- K220 (≠ T214) modified: N6-acetyllysine
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
52% identity, 98% coverage: 8:459/459 of query aligns to 8:465/471 of 4jdrA
- active site: P15 (= P15), L40 (= L40), C44 (= C44), C49 (= C49), S52 (= S52), E77 (≠ N77), P78 (≠ V78), I184 (= I179), E188 (= E183), V324 (≠ T318), H442 (= H436), H444 (= H438), E449 (= E443)
- binding flavin-adenine dinucleotide: G12 (= G12), G14 (= G14), P15 (= P15), A16 (≠ G16), E35 (≠ D35), R36 (≠ P36), Y37 (≠ R37), V43 (= V43), C44 (= C44), G48 (= G48), C49 (= C49), K53 (= K53), L115 (≠ S115), G116 (≠ A116), A144 (≠ V140), G145 (= G141), I185 (= I180), G311 (= G305), D312 (= D306), M318 (= M312), L319 (= L313), A320 (= A314), H321 (= H315)
Sites not aligning to the query:
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
42% identity, 98% coverage: 7:455/459 of query aligns to 11:463/470 of P11959
- 39:47 (vs. 35:44, 50% identical) binding
- K56 (= K53) binding
- D314 (= D306) binding
- A322 (= A314) binding
1bhyA Low temperature middle resolution structure of p64k from masc data (see paper)
47% identity, 96% coverage: 18:459/459 of query aligns to 19:477/482 of 1bhyA
- active site: L41 (= L40), C45 (= C44), C50 (= C49), S53 (= S52), I195 (= I179), E199 (= E183), H454 (= H436), H456 (= H438), E461 (= E443)
- binding flavin-adenine dinucleotide: E36 (≠ D35), R37 (≠ P36), Y38 (≠ R37), G43 (= G42), V44 (= V43), C45 (= C44), G49 (= G48), C50 (= C49), K54 (= K53), D116 (≠ S115), G117 (≠ A116), Y135 (≠ W131), A156 (≠ V140), G157 (= G141), D324 (= D306), L331 (= L313), A332 (= A314)
Sites not aligning to the query:
1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
42% identity, 97% coverage: 7:453/459 of query aligns to 5:455/455 of 1ebdA
- active site: P13 (= P15), L37 (= L40), C41 (= C44), C46 (= C49), S49 (= S52), N74 (= N77), V75 (= V78), Y180 (≠ I179), E184 (= E183), S320 (≠ T318), H438 (= H436), H440 (= H438), E445 (= E443)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), P13 (= P15), V32 (= V34), E33 (≠ D35), K34 (≠ R37), G39 (= G42), V40 (= V43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), E112 (≠ S115), A113 (= A116), T141 (≠ V140), G142 (= G141), Y180 (≠ I179), I181 (= I180), R268 (= R266), D308 (= D306), A314 (≠ M312), L315 (= L313), A316 (= A314)
2eq6A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8
46% identity, 97% coverage: 7:450/459 of query aligns to 5:449/460 of 2eq6A
- active site: V37 (≠ L40), C41 (= C44), C46 (= C49), T49 (≠ S52), A176 (≠ I179), E180 (= E183), H435 (= H436), H437 (= H438), E442 (= E443)
- binding flavin-adenine dinucleotide: I9 (≠ L11), G10 (= G12), G12 (= G14), P13 (= P15), G14 (= G16), E33 (≠ D35), A34 (≠ P36), G39 (= G42), V40 (= V43), C41 (= C44), G45 (= G48), C46 (= C49), K50 (= K53), F111 (≠ S115), A112 (= A116), A135 (= A139), T136 (≠ V140), G137 (= G141), S155 (= S159), R269 (≠ N269), D306 (= D306), L312 (≠ M312), L313 (= L313), A314 (= A314), H315 (= H315), Y344 (= Y345)
Sites not aligning to the query:
2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
42% identity, 97% coverage: 7:449/459 of query aligns to 3:445/452 of 2eq7A
- active site: P11 (= P15), L36 (= L40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ N77), V73 (= V78), V177 (≠ I179), E181 (= E183), S314 (≠ T318), H432 (= H436), H434 (= H438), E439 (= E443)
- binding flavin-adenine dinucleotide: G10 (= G14), P11 (= P15), G12 (= G16), E31 (≠ D35), K32 (≠ P36), G38 (= G42), T39 (≠ V43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ S115), A111 (= A116), T137 (≠ V140), G138 (= G141), S157 (= S159), I178 (= I180), R262 (= R266), Y265 (≠ N269), D302 (= D306), M308 (= M312), L309 (= L313), A310 (= A314), H311 (= H315), Y341 (= Y345)
- binding nicotinamide-adenine-dinucleotide: W146 (= W150), G174 (= G176), G176 (= G178), V177 (≠ I179), I178 (= I180), E197 (= E199), Y198 (≠ F200), V231 (= V233), V260 (= V264), G261 (= G265), R262 (= R266), M308 (= M312), L309 (= L313), V339 (= V343)
2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
42% identity, 97% coverage: 7:449/459 of query aligns to 3:445/455 of 2yquB
- active site: P11 (= P15), L36 (= L40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ N77), V73 (= V78), V177 (≠ I179), E181 (= E183), S314 (≠ T318), H432 (= H436), H434 (= H438), E439 (= E443)
- binding carbonate ion: A310 (= A314), S314 (≠ T318), S423 (≠ T427), D426 (= D430)
- binding flavin-adenine dinucleotide: G8 (= G12), G10 (= G14), P11 (= P15), G12 (= G16), E31 (≠ D35), K32 (≠ P36), G38 (= G42), T39 (≠ V43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ S115), A111 (= A116), T137 (≠ V140), G138 (= G141), I178 (= I180), Y265 (≠ N269), G301 (= G305), D302 (= D306), M308 (= M312), L309 (= L313), A310 (= A314), H311 (= H315)
2yquA Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
42% identity, 97% coverage: 7:449/459 of query aligns to 3:445/455 of 2yquA
- active site: P11 (= P15), L36 (= L40), C40 (= C44), C45 (= C49), S48 (= S52), G72 (≠ N77), V73 (= V78), V177 (≠ I179), E181 (= E183), S314 (≠ T318), H432 (= H436), H434 (= H438), E439 (= E443)
- binding flavin-adenine dinucleotide: G8 (= G12), G10 (= G14), P11 (= P15), G12 (= G16), E31 (≠ D35), K32 (≠ P36), G38 (= G42), T39 (≠ V43), C40 (= C44), R42 (≠ N46), G44 (= G48), C45 (= C49), K49 (= K53), T110 (≠ S115), A111 (= A116), T137 (≠ V140), G138 (= G141), S157 (= S159), I178 (= I180), Y265 (≠ N269), G301 (= G305), D302 (= D306), M308 (= M312), L309 (= L313), A310 (= A314)
3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
39% identity, 98% coverage: 7:456/459 of query aligns to 2:460/465 of 3urhB
- active site: Y35 (≠ L40), C39 (= C44), C44 (= C49), S47 (= S52), V183 (≠ I179), E187 (= E183), H443 (= H436), H445 (= H438), E450 (= E443)
- binding flavin-adenine dinucleotide: I6 (≠ L11), G7 (= G12), G9 (= G14), P10 (= P15), G11 (= G16), E30 (≠ D35), K31 (≠ P36), G37 (= G42), T38 (≠ V43), C39 (= C44), G43 (= G48), C44 (= C49), K48 (= K53), T111 (≠ S115), G112 (≠ A116), A140 (= A139), T141 (≠ V140), G142 (= G141), I184 (= I180), R273 (= R266), G312 (= G305), D313 (= D306), M319 (= M312), L320 (= L313), A321 (= A314), H322 (= H315)
P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
40% identity, 97% coverage: 7:449/459 of query aligns to 6:462/478 of P14218
- 34:49 (vs. 35:44, 25% identical) binding
- C49 (= C44) modified: Disulfide link with 54, Redox-active
- C54 (= C49) modified: Disulfide link with 49, Redox-active
- K58 (= K53) binding
- G122 (≠ A116) binding
- D319 (= D306) binding
- A327 (= A314) binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
40% identity, 97% coverage: 7:449/459 of query aligns to 8:464/477 of 5u8uD
- active site: P16 (= P15), L47 (= L40), C51 (= C44), C56 (= C49), S59 (= S52), G85 (≠ N77), V86 (= V78), V193 (≠ I179), E197 (= E183), S333 (≠ T318), F451 (≠ H436), H453 (= H438), E458 (= E443)
- binding flavin-adenine dinucleotide: I12 (≠ L11), G15 (= G14), P16 (= P15), G17 (= G16), E36 (≠ D35), K37 (≠ P36), G49 (= G42), T50 (≠ V43), C51 (= C44), G55 (= G48), C56 (= C49), K60 (= K53), H123 (≠ S115), G124 (≠ A116), A152 (= A139), S153 (≠ V140), G154 (= G141), I194 (= I180), R281 (= R266), G320 (= G305), D321 (= D306), M327 (= M312), L328 (= L313), A329 (= A314), H330 (= H315), H453 (= H438), P454 (= P439)
Sites not aligning to the query:
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
40% identity, 97% coverage: 7:449/459 of query aligns to 4:460/472 of 5u8vA
- active site: P12 (= P15), L43 (= L40), C47 (= C44), C52 (= C49), S55 (= S52), G81 (≠ N77), V82 (= V78), V189 (≠ I179), E193 (= E183), S329 (≠ T318), F447 (≠ H436), H449 (= H438), E454 (= E443)
- binding flavin-adenine dinucleotide: I8 (≠ L11), G11 (= G14), P12 (= P15), G13 (= G16), E32 (≠ D35), G45 (= G42), T46 (≠ V43), C47 (= C44), G51 (= G48), C52 (= C49), K56 (= K53), H119 (≠ S115), G120 (≠ A116), A148 (= A139), S149 (≠ V140), G150 (= G141), S169 (= S159), I190 (= I180), R277 (= R266), G316 (= G305), D317 (= D306), M323 (= M312), L324 (= L313), A325 (= A314), H326 (= H315), H449 (= H438), P450 (= P439)
- binding nicotinamide-adenine-dinucleotide: I185 (≠ V175), G186 (= G176), G188 (= G178), V189 (≠ I179), I190 (= I180), L208 (≠ I198), E209 (= E199), A210 (≠ F200), V243 (= V233), V275 (= V264), G276 (= G265)
Sites not aligning to the query:
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
40% identity, 97% coverage: 7:449/459 of query aligns to 5:461/473 of 5u8wA
- active site: P13 (= P15), L44 (= L40), C48 (= C44), C53 (= C49), S56 (= S52), G82 (≠ N77), V83 (= V78), V190 (≠ I179), E194 (= E183), S330 (≠ T318), F448 (≠ H436), H450 (= H438), E455 (= E443)
- binding flavin-adenine dinucleotide: I9 (≠ L11), G12 (= G14), P13 (= P15), G14 (= G16), E33 (≠ D35), K34 (≠ P36), G46 (= G42), T47 (≠ V43), C48 (= C44), G52 (= G48), C53 (= C49), K57 (= K53), H120 (≠ S115), G121 (≠ A116), A149 (= A139), S150 (≠ V140), G151 (= G141), S170 (= S159), G317 (= G305), D318 (= D306), M324 (= M312), L325 (= L313), A326 (= A314), H327 (= H315), Y357 (= Y345), H450 (= H438), P451 (= P439)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ V175), G189 (= G178), V190 (≠ I179), I191 (= I180), E194 (= E183), E210 (= E199), A211 (≠ F200), L212 (≠ M201), A275 (= A263), V276 (= V264), G277 (= G265), R278 (= R266), M324 (= M312), L325 (= L313), V355 (= V343), Y357 (= Y345)
Sites not aligning to the query:
P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
40% identity, 97% coverage: 7:449/459 of query aligns to 39:491/501 of P31023
- 67:76 (vs. 35:44, 50% identical) binding
- C76 (= C44) modified: Disulfide link with 81, Redox-active
- C81 (= C49) modified: Disulfide link with 76, Redox-active
- G149 (≠ A116) binding
- D348 (= D306) binding
- MLAH 354:357 (= MLAH 312:315) binding
Sites not aligning to the query:
- 1:31 modified: transit peptide, Mitochondrion
1dxlA Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
40% identity, 97% coverage: 7:449/459 of query aligns to 5:457/467 of 1dxlA
- active site: L38 (= L40), C42 (= C44), C47 (= C49), S50 (= S52), Y184 (≠ I179), E188 (= E183), H444 (= H436), H446 (= H438), E451 (= E443)
- binding flavin-adenine dinucleotide: I9 (≠ L11), P13 (= P15), G14 (= G16), E33 (≠ D35), K34 (≠ P36), R35 (= R37), G40 (= G42), T41 (≠ V43), C42 (= C44), G46 (= G48), C47 (= C49), K51 (= K53), Y114 (≠ S115), G115 (≠ A116), T144 (≠ V140), G145 (= G141), Y184 (≠ I179), I185 (= I180), R274 (= R266), D314 (= D306), M320 (= M312), L321 (= L313), A322 (= A314), H323 (= H315)
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
37% identity, 98% coverage: 4:454/459 of query aligns to 5:464/470 of 6uziC
- active site: C45 (= C44), C50 (= C49), S53 (= S52), V187 (≠ I179), E191 (= E183), H448 (= H438), E453 (= E443)
- binding flavin-adenine dinucleotide: I12 (≠ L11), G13 (= G12), G15 (= G14), P16 (= P15), G17 (= G16), E36 (≠ D35), K37 (≠ P36), G43 (= G42), T44 (≠ V43), C45 (= C44), G49 (= G48), C50 (= C49), S53 (= S52), K54 (= K53), V117 (≠ S115), G118 (≠ A116), T147 (≠ V140), G148 (= G141), I188 (= I180), R276 (= R266), D316 (= D306), M322 (= M312), L323 (= L313), A324 (= A314)
- binding zinc ion: H448 (= H438), E453 (= E443)
6bz0A 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from acinetobacter baumannii in complex with fad.
39% identity, 97% coverage: 7:449/459 of query aligns to 3:458/469 of 6bz0A
- active site: C45 (= C44), C50 (= C49), S53 (= S52), V187 (≠ I179), E191 (= E183), H447 (= H438), E452 (= E443)
- binding flavin-adenine dinucleotide: I7 (≠ L11), G10 (= G14), P11 (= P15), G12 (= G16), E31 (≠ D35), K32 (≠ P36), R33 (= R37), G43 (= G42), T44 (≠ V43), C45 (= C44), G49 (= G48), C50 (= C49), K54 (= K53), T117 (≠ S115), G118 (≠ A116), S147 (≠ V140), G148 (= G141), S167 (= S159), I188 (= I180), R275 (= R266), Y278 (≠ N269), D315 (= D306), M321 (= M312), L322 (= L313), A323 (= A314), A326 (= A317), Y354 (= Y345)
P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
40% identity, 97% coverage: 7:449/459 of query aligns to 6:462/477 of P18925
- 34:49 (vs. 35:44, 25% identical) binding
- C49 (= C44) modified: Disulfide link with 54, Redox-active
- C54 (= C49) modified: Disulfide link with 49, Redox-active
- K58 (= K53) binding
- D319 (= D306) binding
- A327 (= A314) binding
3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
40% identity, 97% coverage: 7:449/459 of query aligns to 5:461/472 of 3ladA
- active site: L44 (= L40), C48 (= C44), C53 (= C49), S56 (= S52), V190 (≠ I179), E194 (= E183), F448 (≠ H436), H450 (= H438), E455 (= E443)
- binding flavin-adenine dinucleotide: I9 (≠ L11), G10 (= G12), G12 (= G14), P13 (= P15), E33 (≠ D35), K34 (≠ P36), G46 (= G42), T47 (≠ V43), C48 (= C44), G52 (= G48), C53 (= C49), H120 (≠ S115), G121 (≠ A116), A149 (= A139), S150 (≠ V140), G151 (= G141), I191 (= I180), R278 (= R266), D318 (= D306), L325 (= L313), A326 (= A314)
Query Sequence
>GFF2287 FitnessBrowser__Phaeo:GFF2287
MSDNHADLIVLGAGPGGYACAFRAADLGRSVIIVDPRATLGGVCLNVGCIPSKALLHAAE
MIRETRHGGGWGILTGNVSVDLNKLRAKKDSIVEQLTTGLVGLAKRRKVQTIRGSAQFTS
DKSLEIDGESWTFDQAVIAVGSAPVRLPGWPEDDRIWDSTDALELREIPKRLSIVGGGII
GLEMATVYAALGSKVTVIEFMDQIAPGADADAVTILRAALETEDVTIHTGTKVTEVKASK
TALTLTCEGGFEGTIKADAAIQAVGRRSNGSLVDPAAAGVEADDRGIIPVDASCRTNVAT
VFAIGDVTGNPMLAHRATHQGHVAAEVASGHATALDTDLIPSVAYTAPELAWAGLTQAKA
TERGIPHRVANFPWAASGRNLSSGGGEGLTKLVYCPDSHRLLGATIVGRNAGELLAECVL
AMEMGATLEDMSLAVHAHPTLSETVGFAAERALGTLTDL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory