SitesBLAST
Comparing GFF2309 FitnessBrowser__psRCH2:GFF2309 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
35% identity, 97% coverage: 6:260/262 of query aligns to 1:253/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), S14 (≠ G19), G15 (= G20), I16 (= I21), G35 (vs. gap), F36 (vs. gap), L60 (= L66), N86 (= N92), G88 (= G94), I89 (≠ V95), A137 (= A144), Y151 (= Y158), K155 (= K162), P181 (= P188), G182 (= G189), V184 (≠ I191), T186 (= T193)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
34% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 2ztlA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162), L200 (≠ M203)
- binding (3s)-3-hydroxybutanoic acid: Q94 (≠ E96), S142 (= S145), H144 (≠ W147), K152 (≠ F155), Y155 (= Y158), Q196 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), G15 (= G20), I16 (= I21), F36 (≠ R41), L64 (= L66), N90 (= N92), A91 (= A93), G92 (= G94), L113 (≠ N118), Y155 (= Y158), K159 (= K162), P185 (= P188), W187 (= W190), V188 (≠ I191), T190 (= T193), V193 (≠ A196)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
34% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 1wmbA
Sites not aligning to the query:
3uf0A Crystal structure of a putative NAD(p) dependent gluconate 5- dehydrogenase from beutenbergia cavernae(efi target efi-502044) with bound NADP (low occupancy)
35% identity, 97% coverage: 5:258/262 of query aligns to 3:245/249 of 3uf0A
- active site: G18 (= G20), S141 (= S145), V151 (≠ F155), Y154 (= Y158), K158 (= K162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G14 (= G16), S17 (≠ G19), G18 (= G20), I19 (= I21), R39 (= R41), D63 (= D65), L64 (= L66), N89 (= N92), G91 (= G94), I92 (≠ V95), I139 (≠ Q143), A140 (= A144), S141 (= S145), Y154 (= Y158), K158 (= K162), P184 (= P188), G185 (= G189), V187 (≠ I191), T189 (= T193), N191 (vs. gap), T192 (≠ D194)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
34% identity, 96% coverage: 8:258/262 of query aligns to 3:251/255 of 2q2qD
- active site: G15 (= G20), S138 (= S145), Y151 (= Y158), K155 (= K162), R196 (≠ M203)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), S14 (≠ G19), G15 (= G20), I16 (= I21), F36 (≠ L39), D59 (= D65), L60 (= L66), N86 (= N92), G88 (= G94), L109 (≠ N118), I136 (≠ Q143), S138 (= S145), Y151 (= Y158), K155 (= K162), P181 (= P188), G182 (= G189), W183 (= W190), V184 (≠ I191), T186 (= T193), L188 (≠ A195), V189 (≠ A196)
8dt1C Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
33% identity, 98% coverage: 6:262/262 of query aligns to 1:259/259 of 8dt1C
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), S14 (≠ G19), G15 (= G20), I16 (= I21), D35 (= D40), L36 (≠ R41), M60 (≠ L64), V62 (≠ L66), N88 (= N92), A89 (= A93), M139 (≠ Q143), Y154 (= Y158), K158 (= K162), P184 (= P188), G185 (= G189), F186 (≠ W190), V187 (≠ I191), T189 (= T193)
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
33% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 5b4tA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162), I200 (≠ M203)
- binding (3R)-3-hydroxybutanoic acid: Q94 (≠ E96), S142 (= S145), H144 (≠ W147), K152 (≠ F155), Y155 (= Y158), W187 (= W190), Q196 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), G15 (= G20), I16 (= I21), F36 (≠ L39), D63 (= D65), L64 (= L66), N90 (= N92), G92 (= G94), L113 (≠ N118), I140 (≠ Q143), Y155 (= Y158), K159 (= K162), P185 (= P188), G186 (= G189), W187 (= W190), V188 (≠ I191), T190 (= T193), L192 (≠ A195), V193 (≠ A196)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
33% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 3w8dA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162), I200 (≠ M203)
- binding methylmalonic acid: Q94 (≠ E96), S142 (= S145), H144 (≠ W147), K152 (≠ F155), Y155 (= Y158), W187 (= W190), Q196 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), S14 (≠ G19), G15 (= G20), I16 (= I21), F36 (≠ L39), A62 (vs. gap), D63 (= D65), L64 (= L66), N90 (= N92), A91 (= A93), G92 (= G94), L113 (≠ N118), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), G186 (= G189), W187 (= W190), V188 (≠ I191), T190 (= T193), L192 (≠ A195), V193 (≠ A196)
Sites not aligning to the query:
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
33% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 3vdrA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162), I200 (≠ M203)
- binding (3R)-3-hydroxybutanoic acid: Q94 (≠ E96), H144 (≠ W147), K152 (≠ F155), Y155 (= Y158), W187 (= W190), Q196 (≠ S199)
- binding acetoacetic acid: Q94 (≠ E96), H144 (≠ W147), K152 (≠ F155), Y155 (= Y158), W187 (= W190), Q196 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), I16 (= I21), F36 (≠ L39), D63 (= D65), L64 (= L66), N90 (= N92), A91 (= A93), G92 (= G94), L113 (≠ N118), K159 (= K162), G186 (= G189), V188 (≠ I191), T190 (= T193), L192 (≠ A195), V193 (≠ A196)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G16), T13 (≠ A18), I16 (= I21), F36 (≠ L39), D63 (= D65), L64 (= L66), N90 (= N92), A91 (= A93), G92 (= G94), L113 (≠ N118), S142 (= S145), Y155 (= Y158), K159 (= K162), G186 (= G189), V188 (≠ I191), T190 (= T193), L192 (≠ A195), V193 (≠ A196)
Sites not aligning to the query:
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
33% identity, 96% coverage: 8:258/262 of query aligns to 3:256/260 of 3vdqA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162), I200 (≠ M203)
- binding acetate ion: Q94 (≠ E96), H144 (≠ W147), K152 (≠ F155), W187 (= W190), L192 (≠ A195), Q196 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), S14 (≠ G19), I16 (= I21), F36 (≠ L39), D63 (= D65), L64 (= L66), N90 (= N92), A91 (= A93), G92 (= G94), L113 (≠ N118), I140 (≠ Q143), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), G186 (= G189), W187 (= W190), V188 (≠ I191), T190 (= T193), L192 (≠ A195), V193 (≠ A196)
Q5P5I4 (S)-1-Phenylethanol dehydrogenase; EC 1.1.1.311 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see 2 papers)
34% identity, 97% coverage: 10:262/262 of query aligns to 8:249/249 of Q5P5I4
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
2ewmB Crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1 (see paper)
34% identity, 97% coverage: 10:262/262 of query aligns to 6:247/247 of 2ewmB
- active site: G16 (= G20), S139 (= S145), Y149 (≠ F155), Y152 (= Y158), K156 (= K162)
- binding nicotinamide-adenine-dinucleotide: G12 (= G16), N15 (≠ G19), G16 (= G20), I17 (= I21), D36 (= D40), L37 (≠ R41), C59 (= C61), D60 (≠ T62), V61 (≠ A63), N87 (= N92), S139 (= S145), Y152 (= Y158), K156 (= K162), P182 (= P188), S183 (≠ G189), L184 (≠ W190), V185 (≠ I191), T189 (≠ A195)
8hi6A Crystal structure of the NADP+ and msa bound n terminal domain of bi- functional malonyl-coa reductase from roseiflexus castenholzii (see paper)
34% identity, 96% coverage: 8:258/262 of query aligns to 4:284/534 of 8hi6A
- binding 3-oxidanylidenepropanoic acid: T161 (≠ S145), Y168 (≠ V152), R171 (≠ F155), Y174 (= Y158), R211 (≠ A195), M215 (≠ S199)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), G15 (= G19), N16 (≠ G20), I17 (= I21), R37 (= R41), N38 (≠ D42), M65 (≠ L66), D66 (≠ G67), N100 (= N92), A101 (= A93), G102 (= G94), I138 (≠ S122), I159 (≠ Q143), T161 (≠ S145), Y174 (= Y158), K178 (= K162), P204 (= P188), G205 (= G189), I207 (= I191), R211 (≠ A195), I212 (≠ A196)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8 (see paper)
35% identity, 96% coverage: 7:258/262 of query aligns to 3:235/240 of 2d1yA
- active site: G16 (= G20), S135 (= S145), N145 (≠ F155), Y148 (= Y158), K152 (= K162)
- binding nicotinamide-adenine-dinucleotide: G12 (= G16), R15 (≠ G19), I17 (= I21), D36 (= D40), L37 (≠ R41), R38 (≠ D42), V55 (≠ L64), D56 (= D65), L57 (= L66), N83 (= N92), A84 (= A93), A85 (≠ G94), I86 (≠ V95), V133 (≠ Q143), S135 (= S145), Y148 (= Y158), K152 (= K162), P178 (= P188), G179 (= G189), I181 (= I191), T183 (= T193), A185 (= A195), V186 (≠ A196)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
32% identity, 96% coverage: 8:258/262 of query aligns to 3:232/236 of 1x1tA
- active site: G15 (= G20), N114 (= N119), S142 (= S145), Y155 (= Y158), K159 (= K162)
- binding cacodylate ion: S142 (= S145), H144 (≠ W147), Y155 (= Y158), W187 (= W190)
- binding nicotinamide-adenine-dinucleotide: G11 (= G16), T13 (≠ A18), S14 (≠ G19), G15 (= G20), I16 (= I21), G35 (≠ D40), F36 (≠ R41), D63 (= D65), L64 (= L66), N90 (= N92), G92 (= G94), L113 (≠ N118), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), W187 (= W190), V188 (≠ I191), T190 (≠ S199)
Sites not aligning to the query:
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
30% identity, 98% coverage: 6:262/262 of query aligns to 7:265/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G16), S20 (≠ G19), G21 (= G20), I22 (= I21), D41 (= D40), I42 (≠ R41), M66 (≠ L64), D67 (= D65), V68 (≠ L66), N94 (= N92), A95 (= A93), G96 (= G94), M145 (≠ Q143), S147 (= S145), Y160 (= Y158), K164 (= K162), P190 (= P188), F192 (≠ W190), V193 (≠ I191), T195 (= T193), L197 (≠ A195), V198 (≠ A196)
- binding 3-oxidanylidenepentanoic acid: Q98 (≠ E96), S147 (= S145), H149 (≠ W147), K157 (≠ F155), Y160 (= Y158), F192 (≠ W190), Q201 (≠ S199)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
30% identity, 98% coverage: 6:262/262 of query aligns to 7:265/265 of 6zzoC
- binding acetoacetic acid: Q98 (≠ E96), H149 (≠ W147), K157 (≠ F155), F192 (≠ W190), Q201 (≠ S199)
- binding nicotinamide-adenine-dinucleotide: G17 (= G16), S20 (≠ G19), G21 (= G20), I22 (= I21), D41 (= D40), I42 (≠ R41), M66 (≠ L64), D67 (= D65), V68 (≠ L66), N94 (= N92), A95 (= A93), G96 (= G94), M145 (≠ Q143), Y160 (= Y158), K164 (= K162), P190 (= P188), F192 (≠ W190), V193 (≠ I191), T195 (= T193), L197 (≠ A195), V198 (≠ A196)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
32% identity, 98% coverage: 5:261/262 of query aligns to 1:247/247 of 4jroC
- active site: G16 (= G20), S142 (= S145), Q152 (≠ F155), Y155 (= Y158), K159 (= K162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G16), S14 (≠ A18), R15 (≠ G19), G16 (= G20), I17 (= I21), N35 (≠ L39), Y36 (≠ D40), N37 (≠ R41), G38 (≠ D42), S39 (≠ A43), N63 (vs. gap), V64 (vs. gap), N90 (= N92), A91 (= A93), I93 (≠ V95), I113 (≠ N118), S142 (= S145), Y155 (= Y158), K159 (= K162), P185 (= P188), I188 (= I191), T190 (= T193)
5t5qC Crystal structure of short-chain dehydrogenase/reductase sdr:glucose/ribitol dehydrogenase from brucella melitensis
30% identity, 98% coverage: 5:261/262 of query aligns to 3:244/245 of 5t5qC
- active site: G18 (= G20), S140 (= S145), N150 (≠ F155), Y153 (= Y158), K157 (= K162)
- binding nicotinamide-adenine-dinucleotide: N16 (≠ A18), G17 (= G19), G18 (= G20), I19 (= I21), D38 (= D40), L39 (≠ R41), D63 (= D65), A64 (≠ L66), S90 (≠ N92), I113 (≠ N118), Y153 (= Y158), K157 (= K162), P182 (= P188), I185 (= I191), T187 (= T193), M189 (≠ A195)
6ci9D Rmm microcompartment-associated aminopropanol dehydrogenase NADP + aminoacetone holo-structure (see paper)
33% identity, 99% coverage: 2:261/262 of query aligns to 2:251/259 of 6ci9D
- active site: G20 (= G20), S145 (= S145), Y159 (= Y158)
- binding 1-aminopropan-2-one: F97 (≠ E96), S145 (= S145), T147 (≠ W147), W156 (≠ F155), Y159 (= Y158), G190 (= G189)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G16 (= G16), S18 (≠ A18), G20 (= G20), I21 (= I21), G40 (≠ D40), R41 (= R41), N42 (≠ D42), D66 (= D65), V67 (≠ L66), N93 (= N92), G95 (= G94), T143 (≠ Q143), S145 (= S145), Y159 (= Y158), K163 (= K162), P189 (= P188), N191 (≠ W190), I192 (= I191), T194 (= T193), G196 (≠ A195), L197 (≠ A204)
Query Sequence
>GFF2309 FitnessBrowser__psRCH2:GFF2309
MHKALDYSGRCVVITGAAGGIGRGLAQSFAAAGATLELLDRDADALARLADELAGDAPLR
CTALDLGDRQAVQRYADDLACRGLHADVLVNNAGVEYATPLDECSFEADQCWSTLLENNV
GSMQRLTRALLPRLRAGASVINQASIWGLKGVPGFSAYVASKHAVVGLTRSLAWELGPRR
IRVNAVCPGWIATDAAMRSLQVMADANGRSDSAELATILSNQAIPELLTPADLGGTFLFL
GSPLAAALTGQALSVSHGEVMH
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory