SitesBLAST
Comparing GFF2392 FitnessBrowser__psRCH2:GFF2392 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
71% identity, 97% coverage: 7:378/383 of query aligns to 7:378/378 of 4n5fA
- active site: L126 (= L126), T127 (= T127), G243 (= G243), E364 (= E364), R376 (= R376)
- binding dihydroflavine-adenine dinucleotide: L126 (= L126), T127 (= T127), G132 (= G132), S133 (= S133), F157 (= F157), T159 (≠ S159), T210 (= T210), Y363 (= Y363), T366 (≠ S366), E368 (= E368), M372 (≠ L372)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
71% identity, 97% coverage: 7:378/383 of query aligns to 5:376/376 of 4m9aB
- active site: L124 (= L126), T125 (= T127), G241 (= G243), E362 (= E364), R374 (= R376)
- binding dihydroflavine-adenine dinucleotide: F122 (= F124), T125 (= T127), G130 (= G132), S131 (= S133), F155 (= F157), T157 (≠ S159), T208 (= T210), Y361 (= Y363), T364 (≠ S366), E366 (= E368), M370 (≠ L372)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
51% identity, 97% coverage: 8:378/383 of query aligns to 4:372/374 of 5lnxD
- active site: L122 (= L126), T123 (= T127), G239 (= G243), E358 (= E364), K370 (≠ R376)
- binding flavin-adenine dinucleotide: L122 (= L126), T123 (= T127), G128 (= G132), S129 (= S133), F153 (= F157), T155 (≠ S159), R265 (= R269), Q267 (= Q271), F268 (= F272), I272 (= I276), N275 (≠ H279), I278 (= I282), Q331 (= Q337), I332 (= I338), G335 (= G341), Y357 (= Y363), T360 (≠ S366), E362 (= E368)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
50% identity, 98% coverage: 2:378/383 of query aligns to 3:379/384 of 1jqiA
- active site: G377 (≠ R376)
- binding acetoacetyl-coenzyme a: L95 (≠ V94), F125 (= F124), S134 (= S133), F234 (≠ L233), M238 (≠ L237), Q239 (≠ S238), L241 (= L240), D242 (≠ E241), R245 (= R244), Y364 (= Y363), E365 (= E364), G366 (= G365)
- binding flavin-adenine dinucleotide: F125 (= F124), L127 (= L126), S128 (≠ T127), G133 (= G132), S134 (= S133), W158 (≠ F157), T160 (≠ S159), R270 (= R269), F273 (= F272), L280 (≠ H279), Q338 (= Q337), I339 (= I338), G342 (= G341), I360 (= I359), T367 (≠ S366), E369 (= E368), I370 (= I369)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
50% identity, 98% coverage: 2:378/383 of query aligns to 30:406/412 of P15651
- 152:161 (vs. 124:133, 70% identical) binding FAD
- S161 (= S133) binding substrate
- WIT 185:187 (≠ FCS 157:159) binding FAD
- DMGR 269:272 (≠ EGGR 241:244) binding substrate
- R297 (= R269) binding FAD
- QILGG 365:369 (≠ QIHGG 337:341) binding FAD
- E392 (= E364) active site, Proton acceptor
- TSE 394:396 (≠ SSE 366:368) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
50% identity, 98% coverage: 2:378/383 of query aligns to 3:379/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ Y342), T347 (≠ E346), E348 (≠ D347)
- binding flavin-adenine dinucleotide: F125 (= F124), L127 (= L126), S128 (≠ T127), G133 (= G132), S134 (= S133), W158 (≠ F157), T160 (≠ S159), R270 (= R269), F273 (= F272), L280 (≠ H279), V282 (≠ S281), Q338 (= Q337), I339 (= I338), G342 (= G341), I360 (= I359), Y364 (= Y363), T367 (≠ S366), E369 (= E368), I370 (= I369), L373 (= L372)
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
50% identity, 98% coverage: 4:378/383 of query aligns to 2:376/381 of 8sgsA
- binding coenzyme a: S131 (= S133), A133 (= A135), N177 (≠ K179), F231 (≠ L233), M235 (≠ L237), L238 (= L240), I312 (≠ L314), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (= F124), L124 (= L126), S125 (≠ T127), G130 (= G132), S131 (= S133), W155 (≠ F157), T157 (≠ S159), R267 (= R269), F270 (= F272), L274 (≠ I276), L277 (≠ H279), Q335 (= Q337), I336 (= I338), G338 (= G340), G339 (= G341), I357 (= I359), I360 (= I362), Y361 (= Y363), T364 (≠ S366), E366 (= E368)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
50% identity, 98% coverage: 2:378/383 of query aligns to 6:382/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (= F124), L130 (= L126), S131 (≠ T127), G136 (= G132), S137 (= S133), W161 (≠ F157), T163 (≠ S159), T214 (= T210), R273 (= R269), F276 (= F272), L280 (≠ I276), L283 (≠ H279), V285 (≠ S281), Q341 (= Q337), I342 (= I338), G345 (= G341), I363 (= I359), Y367 (= Y363), T370 (≠ S366), E372 (= E368), L376 (= L372)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
50% identity, 98% coverage: 2:378/383 of query aligns to 30:406/412 of P16219
- G90 (= G62) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E76) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 124:133, 70% identical) binding in other chain
- R171 (≠ E143) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FCS 157:159) binding in other chain
- A192 (≠ S164) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G181) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R269) binding FAD
- Q308 (= Q280) binding in other chain
- R325 (= R297) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (= S325) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QIHGG 337:341) binding FAD
- R380 (= R352) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ SSE 366:368) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
46% identity, 98% coverage: 3:378/383 of query aligns to 2:377/380 of 4l1fA
- active site: L125 (= L126), T126 (= T127), G242 (= G243), E363 (= E364), R375 (= R376)
- binding coenzyme a persulfide: T132 (≠ S133), H179 (≠ K180), F232 (≠ L233), M236 (≠ L237), E237 (≠ S238), L239 (= L240), D240 (≠ E241), R243 (= R244), Y362 (= Y363), E363 (= E364), G364 (= G365), R375 (= R376)
- binding flavin-adenine dinucleotide: F123 (= F124), L125 (= L126), T126 (= T127), G131 (= G132), T132 (≠ S133), F156 (= F157), I157 (≠ C158), T158 (≠ S159), R268 (= R269), Q270 (= Q271), F271 (= F272), I275 (= I276), F278 (≠ H279), L281 (≠ I282), Q336 (= Q337), I337 (= I338), G340 (= G341), I358 (= I359), Y362 (= Y363), T365 (≠ S366), Q367 (≠ E368)
- binding 1,3-propandiol: L5 (= L6), Q10 (≠ R11)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
47% identity, 97% coverage: 7:378/383 of query aligns to 5:376/378 of 5ol2F
- active site: L124 (= L126), T125 (= T127), G241 (= G243), G374 (≠ R376)
- binding calcium ion: E29 (≠ A31), E33 (≠ A35), R35 (≠ W37)
- binding coenzyme a persulfide: L238 (= L240), R242 (= R244), E362 (= E364), G363 (= G365)
- binding flavin-adenine dinucleotide: F122 (= F124), L124 (= L126), T125 (= T127), P127 (= P129), T131 (≠ S133), F155 (= F157), I156 (≠ C158), T157 (≠ S159), E198 (= E200), R267 (= R269), F270 (= F272), L274 (≠ I276), F277 (≠ H279), Q335 (= Q337), L336 (≠ I338), G338 (= G340), G339 (= G341), Y361 (= Y363), T364 (≠ S366), E366 (= E368)
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
49% identity, 97% coverage: 6:378/383 of query aligns to 1:366/371 of 2vigB