Comparing GFF254 FitnessBrowser__WCS417:GFF254 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P29218 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Homo sapiens (Human) (see 5 papers)
27% identity, 85% coverage: 15:251/278 of query aligns to 13:248/277 of P29218
6giuA Human impase with l-690330 (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 11:246/275 of 6giuA
6zk0AAA human impase with ebselen (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 10:245/274 of 6zk0AAA
4as4A Structure of human inositol monophosphatase 1 (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 11:246/274 of 4as4A
1imdA Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 9:244/266 of 1imdA
2hhmA Structure of inositol monophosphatase, the putative target of lithium therapy (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 9:244/272 of 2hhmA
1imbA Structural analysis of inositol monophosphatase complexes with substrates (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 9:244/272 of 1imbA
1awbA Human myo-inositol monophosphatase in complex with d-inositol-1- phosphate and calcium
27% identity, 85% coverage: 15:251/278 of query aligns to 9:244/272 of 1awbA
2bjiA High resolution structure of myo-inositol monophosphatase, the target of lithium therapy (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 11:246/274 of 2bjiA
P20456 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Bos taurus (Bovine) (see paper)
27% identity, 85% coverage: 15:251/278 of query aligns to 13:248/277 of P20456
4as5A Structure of mouse inositol monophosphatase 1 (see paper)
27% identity, 85% coverage: 17:251/278 of query aligns to 13:246/274 of 4as5A
O55023 Inositol monophosphatase 1; IMP 1; IMPase 1; D-galactose 1-phosphate phosphatase; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; EC 3.1.3.25; EC 3.1.3.94 from Mus musculus (Mouse) (see paper)
26% identity, 85% coverage: 17:251/278 of query aligns to 15:248/277 of O55023
Q6NPM8 Bifunctional phosphatase IMPL2, chloroplastic; Histidinol-phosphatase; Histidinol-phosphate phosphatase; HPP; Inositol-phosphate phosphatase; L-galactose 1-phosphate phosphatase; Protein HISTIDINE BIOSYNTHESIS 7; Protein MYO-INOSITOL MONOPHOSPHATASE-LIKE 2; EC 3.1.3.15; EC 3.1.3.25; EC 3.1.3.93 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 85% coverage: 17:253/278 of query aligns to 93:319/346 of Q6NPM8
O14732 Inositol monophosphatase 2; IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2; EC 3.1.3.25 from Homo sapiens (Human) (see 2 papers)
29% identity, 85% coverage: 15:250/278 of query aligns to 24:258/288 of O14732
P95189 Histidinol-phosphatase; HolPase; Histidinol-phosphate phosphatase; EC 3.1.3.15 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
30% identity, 86% coverage: 6:243/278 of query aligns to 1:233/260 of P95189
5zonA Histidinol phosphate phosphatase from mycobacterium tuberculosis (see paper)
31% identity, 85% coverage: 8:243/278 of query aligns to 1:231/256 of 5zonA
5yhtA Crystal structure of a phosphatase from mycobacterium tuberculosis in complex with its substrate (see paper)
31% identity, 82% coverage: 15:243/278 of query aligns to 7:230/255 of 5yhtA
1qgxA X-ray structure of yeast hal2p (see paper)
27% identity, 74% coverage: 30:236/278 of query aligns to 30:306/354 of 1qgxA
1ka1A The papase hal2p complexed with calcium and magnesium ions and reaction substrate: pap (see paper)
27% identity, 74% coverage: 30:236/278 of query aligns to 30:306/354 of 1ka1A
1k9zA The papase hal2p complexed with zinc ions
27% identity, 74% coverage: 30:236/278 of query aligns to 30:306/354 of 1k9zA
Sites not aligning to the query:
>GFF254 FitnessBrowser__WCS417:GFF254
MSELFLGHPFIAPVIELARQAGEVILPFWRADVAVTSKADDSPVTAADLAAHHLILAGLT
ALDPSIPVLSEEDADIDQNVRAGWQRWWLVDPLDGTKEFISGSEEFTVNIALIEQGRVVF
GVVSMPTNGRCYFGGAGLGAWRSDVNEAPKQIQVREAPAAGESFTVVASRRHTSPEQERL
LDGLSEGLGALKLANIGSSLKFCLLAEGSADCYPRLAPTSQWDTAAAQGVLEGAGGEVLE
LSGEPFSYPARASLLNPFFLALPAKAAWRERLLTLARS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory