SitesBLAST – Find functional sites

 

SitesBLAST

Comparing GFF2748 FitnessBrowser__Phaeo:GFF2748 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

2e2oA Crystal structure of sulfolobus tokodaii hexokinase in complex with glucose (see paper)
28% identity, 60% coverage: 79:257/300 of query aligns to 68:249/299 of 2e2oA

query
sites
2e2oA
A
 
A
G
|
G
L
 
L
A
x
D
G
 
S
V
 
K
I
 
F
D
 
D
G
 
W
E
 
E
S
 
N
A
 
F
A
 
T
R
 
P
V
 
L
A
 
A
E
 
S
A
 
L
L
 
I
P
 
A
Q
 
P
A
 
K
H
 
V
V
 
I
R
 
I
V
 
Q
E
x
H
D
|
D
D
 
G
R
 
V
M
 
I
P
 
A
A
 
L
V
 
F
V
 
A
G
 
E
A
 
T
L
 
L
G
 
G
E
 
E
D
 
P
T
 
G
A
 
V
S
 
V
L
 
V
I
 
I
G
 
A
V
 
-
G
 
G
T
 
T
G
|
G
S
|
S
F
x
V
L
 
V
G
 
E
R
 
G
Q
 
Y
V
 
N
A
 
G
G
 
K
Q
 
E
V
 
F
T
 
L
L
 
R
I
 
V
G
 
G
G
|
G
H
 
R
G
 
G
T
 
W
V
 
L
L
 
L
G
 
S
D
|
D
E
 
D
A
 
G
S
 
S
G
 
A
G
 
Y
W
 
W
L
 
V
G
 
G
R
 
R
R
 
K
A
 
A
L
 
L
Q
 
R
L
 
K
T
 
V
L
 
L
Q
 
K
A
 
M
A
 
M
E
 
D
G
 
G
I
 
L
E
 
E
P
 
N
M
 
K
T
 
T
P
 
I
L
 
L
L
 
Y
R
 
N
S
 
K
C
 
V
L
 
L
R
 
K
D
 
T
F
 
I
S
 
N
-
 
V
N
 
K
E
 
D
T
 
L
A
 
D
K
 
E
I
 
L
V
 
V
R
 
M
F
 
W
A
 
S
Q
 
Y
T
 
T
A
 
S
-
 
S
-
 
C
R
 
Q
P
 
I
V
 
D
A
 
L
F
 
V
G
 
A
A
 
S
Y
 
I
A
 
A
P
 
K
R
 
A
V
 
V
A
 
D
K
 
E
A
 
A
A
 
A
V
 
N
E
 
E
G
 
G
D
 
D
A
 
T
A
 
V
G
 
A
R
 
M
R
 
D
L
 
I
M
 
L
A
 
K
E
 
Q
G
 
G
A
 
A
E
 
E
Y
 
L
L
 
L
C
 
A
N
 
S
G
 
Q
L
 
A
Q
 
V
A
 
Y
L
 
L
G
 
A
R
 
R
R
 
K
P
 
I
-
 
G
E
 
T
E
 
N
P
 
K
V
 
V
Y
 
Y
H
 
L
I
 
K
G
 
G
G
 
G
V
 
M

2e2qA Crystal structure of sulfolobus tokodaii hexokinase in complex with xylose, mg2+, and adp (see paper)
28% identity, 60% coverage: 79:257/300 of query aligns to 68:249/297 of 2e2qA

query
sites
2e2qA
A
 
A
G
 
G
L
 
L
A
x
D
G
 
S
V
 
K
I
 
F
D
 
D
G
 
W
E
 
E
S
 
N
A
 
F
A
 
T
R
 
P
V
 
L
A
 
A
E
 
S
A
 
L
L
 
I
P
 
A
Q
 
P
A
 
K
H
 
V
V
 
I
R
 
I
V
 
Q
E
x
H
D
|
D
D
 
G
R
 
V
M
 
I
P
 
A
A
 
L
V
 
F
V
 
A
G
 
E
A
 
T
L
 
L
G
 
G
E
 
E
D
 
P
T
 
G
A
 
V
S
 
V
L
 
V
I
 
I
G
 
A
V
 
-
G
|
G
T
|
T
G
|
G
S
|
S
F
 
V
L
 
V
G
 
E
R
 
G
Q
 
Y
V
 
N
A
 
G
G
 
K
Q
 
E
V
 
F
T
 
L
L
 
R
I
 
V
G
 
G
G
|
G
H
 
R
G
 
G
T
 
W
V
 
L
L
 
L
G
 
S
D
|
D
E
 
D
A
 
G
S
 
S
G
 
A
G
 
Y
W
 
W
L
 
V
G
 
G
R
 
R
R
 
K
A
 
A
L
 
L
Q
 
R
L
 
K
T
 
V
L
 
L
Q
 
K
A
 
M
A
 
M
E
 
D
G
 
G
I
 
L
E
 
E
P
 
N
M
 
K
T
 
T
P
 
I
L
 
L
L
 
Y
R
 
N
S
 
K
C
 
V
L
 
L
R
 
K
D
 
T
F
 
I
S
 
N
-
 
V
N
 
K
E
 
D
T
 
L
A
 
D
K
 
E
I
 
L
V
 
V
R
 
M
F
 
W
A
 
S
Q
 
Y
T
 
T
A
 
S
-
 
S
-
 
C
R
 
Q
P
 
I
V
 
D
A
 
L
F
 
V
G
x
A
A
x
S
Y
 
I
A
|
A
P
x
K
R
 
A
V
 
V
A
x
D
K
 
E
A
 
A
A
 
A
V
 
N
E
 
E
G
 
G
D
 
D
A
 
T
A
 
V
G
 
A
R
 
M
R
 
D
L
 
I
M
 
L
A
 
K
E
 
Q
G
 
G
A
 
A
E
 
E
Y
 
L
L
 
L
C
 
A
N
 
S
G
 
Q
L
 
A
Q
 
V
A
 
Y
L
 
L
G
 
A
R
 
R
R
 
K
P
 
I
-
 
G
E
 
T
E
 
N
P
 
K
V
 
V
Y
 
Y
H
 
L
I
 
K
G
|
G
G
|
G
V
 
M

Sites not aligning to the query:

2e2pA Crystal structure of sulfolobus tokodaii hexokinase in complex with adp (see paper)
28% identity, 60% coverage: 79:257/300 of query aligns to 68:249/298 of 2e2pA

query
sites
2e2pA
A
 
A
G
 
G
L
 
L
A
 
D
G
 
S
V
 
K
I
 
F
D
 
D
G
 
W
E
 
E
S
 
N
A
 
F
A
 
T
R
 
P
V
 
L
A
 
A
E
 
S
A
 
L
L
 
I
P
 
A
Q
 
P
A
 
K
H
 
V
V
 
I
R
 
I
V
 
Q
E
 
H
D
 
D
D
 
G
R
 
V
M
 
I
P
 
A
A
 
L
V
 
F
V
 
A
G
 
E
A
 
T
L
 
L
G
 
G
E
 
E
D
 
P
T
 
G
A
 
V
S
 
V
L
 
V
I
 
I
G
 
A
V
 
-
G
|
G
T
|
T
G
 
G
S
 
S
F
 
V
L
 
V
G
 
E
R
 
G
Q
 
Y
V
 
N
A
 
G
G
 
K
Q
 
E
V
 
F
T
 
L
L
 
R
I
 
V
G
 
G
G
 
G
H
 
R
G
 
G
T
 
W
V
 
L
L
 
L
G
 
S
D
 
D
E
 
D
A
 
G
S
 
S
G
 
A
G
 
Y
W
 
W
L
 
V
G
 
G
R
 
R
R
 
K
A
 
A
L
 
L
Q
 
R
L
 
K
T
 
V
L
 
L
Q
 
K
A
 
M
A
 
M
E
 
D
G
 
G
I
 
L
E
 
E
P
 
N
M
 
K
T
 
T
P
 
I
L
 
L
L
 
Y
R
 
N
S
 
K
C
 
V
L
 
L
R
 
K
D
 
T
F
 
I
S
 
N
-
 
V
N
 
K
E
 
D
T
 
L
A
 
D
K
 
E
I
 
L
V
 
V
R
 
M
F
 
W
A
 
S
Q
 
Y
T
 
T
A
 
S
-
 
S
-
 
C
R
 
Q
P
 
I
V
 
D
A
 
L
F
 
V
G
x
A
A
 
S
Y
 
I
A
|
A
P
x
K
R
 
A
V
 
V
A
x
D
K
 
E
A
 
A
A
 
A
V
 
N
E
 
E
G
 
G
D
 
D
A
 
T
A
 
V
G
 
A
R
 
M
R
 
D
L
 
I
M
 
L
A
 
K
E
 
Q
G
 
G
A
 
A
E
 
E
Y
 
L
L
 
L
C
 
A
N
 
S
G
 
Q
L
 
A
Q
 
V
A
 
Y
L
 
L
G
 
A
R
 
R
R
 
K
P
 
I
-
 
G
E
 
T
E
 
N
P
 
K
V
 
V
Y
 
Y
H
 
L
I
 
K
G
 
G
G
|
G
V
 
M

Sites not aligning to the query:

Query Sequence

>GFF2748 FitnessBrowser__Phaeo:GFF2748
MTDSRFPYLIAVDGGGTSCRFALLKSGATPPQQLVVTGGSANVYTAPDQAVETLSAGLAD
LQRQSGLTDEVFHQIPVYAGLAGVIDGESAARVAEALPQAHVRVEDDRMPAVVGALGEDT
ASLIGVGTGSFLGRQVAGQVTLIGGHGTVLGDEASGGWLGRRALQLTLQAAEGIEPMTPL
LRSCLRDFSNETAKIVRFAQTARPVAFGAYAPRVAKAAVEGDAAGRRLMAEGAEYLCNGL
QALGRRPEEPVYHIGGVAAQYAAYLPADVADYLRGAEGSPLDGALELARRFAREIAQEVV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory