SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF2758 FitnessBrowser__Marino:GFF2758 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P77455 Bifunctional protein PaaZ; EC 3.3.2.12; EC 1.2.1.91 from Escherichia coli (strain K12) (see paper)
55% identity, 99% coverage: 5:683/685 of query aligns to 1:675/681 of P77455

query
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P77455

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Q

E256 (= E259) mutation to Q: Catalyzes the formation of 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde instead of 3-oxo-5,6-dehydrosuberyl-CoA.

6jqoA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ccoa (see paper)
55% identity, 99% coverage: 8:683/685 of query aligns to 3:674/678 of 6jqoA

query
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6jqoA

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R

F

F

I

I

E

E

P

P

V

V

A

K

P

P

G

G

D

D

T

T

I

I

R

Q

A

V

R

R

L

L

T

T

C

C

K

K

R

R

K

K

I

T

D

L

Q

K

G

K

R

Q

T
x
R

S

S

P

A

D

E

G

E

H

K

P

P

Q

T

G

G

V

V

V

V

V

E

W

W

D

A

V

V

Q

E

V

V

H

F

N

N

Q

Q

N

H

D

Q

E

T

M

P

V

V

A

A

S

L

Y

Y

D

S

I

I

L

L

T

T

L

L

V

V

A

A

K

R

K

Q

active site: N157 (= N161), E255 (= E259), C294 (= C298), L483 (= L492)
binding crotonyl coenzyme a: K68 (= K72), V97 (≠ I101), F107 (= F111), T108 (≠ S112), S111 (= S115), F158 (= F162), W161 (= W165), S464 (= S473), P465 (= P474), L466 (= L475), R638 (≠ T647)
binding nadp nicotinamide-adenine-dinucleotide phosphate: R19 (≠ K23), I153 (= I157), N154 (≠ D158), A155 (= A159), F156 (≠ Y160), N157 (= N161), K180 (= K184), P181 (= P185), A182 (= A186), T183 (= T187), F229 (= F233), T230 (= T234), G231 (= G235), S232 (= S236), T235 (= T239), L239 (= L243), E255 (= E259), A256 (= A260), D257 (= D261), C294 (= C298), F396 (= F405), L422 (= L431), H471 (= H480)

6jqnA Structure of paaz, a bifunctional enzyme in complex with NADP+ and ocoa (see paper)
55% identity, 99% coverage: 8:683/685 of query aligns to 3:674/678 of 6jqnA

query
sites
6jqnA

L

L

K

A

S

S

F

F

I

L

A

S

G

G

Q

T

W

W

-

Q

V

S

G

G

E

R

K

G

P

R

A

S

K
x
R

A

L

L

I

P

H

S

H

A

A

V

I

N

S

G

G

E

E

I

A

V

L

A

W

H

E

T

V

H

T

D

S

D

E

T

G

L

L

D

D

F

M

K

A

N

A

A

A

V

R

E

Q

Y

F

G

A

R

I

K

E

V

K

G

G

G

A

K

P

N

A

L

L

M

R

A

A

M

M

D

T

F

F

Q

I

E

E

R

R

A

A

L

A

A

M

L

L

K

K

A

A

M

V

A

A

L

K

Y

H

L

L

Q

L

E

S

H

E

K

K

K

E

E

R

L

F

Y

Y

A

A

L

L

S

S

M

A

H

Q

T

T

G

G

S

A

T

T

K

R

G

A

D

D

N

S

G

W

I

V

D

D

I

I

D

E

G

G

G

G

F

I

G

G

T

T

L

L

F

F

S

T

Y

Y

A

A

S

S

M

L

G

G

R

S

R
|
R

E

E

L

L

P

P

S

D

G

D

N

T

V

L

V

W

H

P

E

E

G

D

P

E

V

L

T

I

P

P

L

L

G

S

K

K

N

E

N

G

H

G

F

F

A

A

G

A

T

R

H

H

I

L

L

L

V

T

P

S

R

K

G

S

G

G

V

V

A

A

V

V

H

H

I
|
I

D
x
N

A
|
A

Y
x
F

N
|
N

F

F

P

P

V

C

W

W

G

G

M

M

L

L

E

E

K

K

F

L

A

A

P

P

T

T

F

W

L

L

A

G

G

G

M

M

P

P

S

A

I

I

V

I

K
|
K

P
|
P

A
|
A

T
|
T

S

A

T

T

C

A

Y

Q

V

L

T

T

E

Q

L

A

A

M

V

V

R

K

L

S

M

I

Q

V

E

D

S

S

G

G

A

L

L

V

P

P

E

E

G

G

S

A

L

I

Q

S

L

L

I

I

I

C

G

G

S

S

T

A

G

G

D

D

L

L

F

L

D

D

H

H

L

L

E

D

E

S

Q

Q

D

D

V

V

V

V

T

T

F
|
F

T
|
T

G
|
G

S
|
S

A

A

A

A

T
|
T

A

G

R

Q

K

M

L
|
L

R

R

N

V

H

Q

P

P

N

N

I

I

I

V

N

A

R

K

S

S

I

I

P

P

F

F

N

T

A

M

E
|
E

A
|
A

D
|
D

S

S

L

L

N

N

S

C

A

C

I

V

L

L

A

G

P

E

D

D

V

V

T

T

P

P

E

D

H

Q

E

P

E

E

F

F

D

A

V

L

F

F

V

I

K

R

E

E

I

V

R

V

R

R

E

E

M

M

T

T

A

T

K

K

A

A

G

G

Q

Q

K

K

C
|
C

T

T

A

A

I

I

R

R

R

R

I

I

F

I

V

V

P

P

K

Q

D

A

Q

L

V

V

N

N

A

A

V

V

C

S

D

D

K

A

L

L

K

V

E

A

Q

R

L

L

S

Q

K

K

I

V

T

V

V

V

G

G

D

D

P

P

S

A

V

Q

E

E

G

G

V

V

R

K

M

M

G

G

A

A

L

L

A

V

S

N

I

A

D

E

Q

Q

L

R

E

A

D

D

V

V

K

Q

A

E

N

K

I

V

Q

N

E

I

L

L

L

L

K

A

T

A

-

G

S

C

E

E

L

I

V

R

V

L

G

G

G

G

E

Q

G

A

N

D

F

L

K

S

A

A

T

A

G

-

D

-

G

-

T

-

E

-

K

-

G

G

A

A

F

F

I

F

E

P

P

P

H

T

L

L

L

L

L

Y

C

C

R

P

N

Q

P

P

E

D

N

E

G

T

C

P

G

A

A

V

H

H

D

A

I

T

E
|
E

A

A

F
|
F

G

G

P

P

V

V

A

A

T

T

V

L

I

M

P

P

Y

A

E

Q

T

N

I

Q

D

R

D

H

A

A

V

L

E

Q

L

L

C

A

S

C

R

A

G

G

R

G

G

G

S

S

L

L

V

A

T

G

T

T

L

L

T

V

T

T

R

A

D

D

P

P

A

Q

I

I

A

A

G

R

R

Q

I

F

A

I

P

A

L

D

L

A

A

A

A

R

F

T

H

H

G

G

R

R

L

I

H

Q

L

I

L

L

D

N

A

E

E

E

A

S

A

A

K

K

E

E

S

S

T

T

G

G

H

H

G

G

S

S

P

P

L

L

P

P

M

Q

L

L

K

V

H
|
H

G

G

G

G

P

P

G

G

R

R

A

A

G

G

G

G

G

G

E

E

E

E

L
|
L

G

G

G

G

I

L

R

R

A

A

V

V

H

K

H

H

Y

Y

L

M

Q

Q

R

R

T

T

A

A

I

V

Q

Q

G

G

S

S

P

P

S

T

M

M

L

L

A

A

A

A

V

I

T

S

R

K

E

Q

Y

W

V

V

R

R

G

G

A

A

D

K

L

V

I

E

E

E

T

D

D

R

V

I

H

H

P

P

F
|
F

R

R

R

K

H

Y

F

F

E

E

D

E

L

L

Q

Q

I

P

N

G

E

D

S

S

L

L

L

L

T

T

H

P

R

R

R

R

T

T

V

M

T

T

E

E

A

A

D

D

I

I

V

V

N

N

F

F

G

A

C

C

L

L

S

S

G

G

D

D

H

H

F
|
F

Y

Y

M

A

H
|
H

F

M

D

D

E

K

I

I

A

A

A

A

R

A

D

E

S

S

Q

I

F
|
F

G

G

K

E

R

R

I
x
V

A
x
V

H

H

G
|
G

Y

Y

F

F

V

V

L

L

S

S

A

A

A

A

A

A

G

G

L

L

F

F

V
|
V

Y

D

P

A

G

G

E

V

G

G

P

P

V

V

L

I

A
|
A

N
|
N

Y
|
Y

G

G

L

L

D

E

T

S

L

L

R
|
R

F
|
F

I
|
I

E
|
E

P
|
P

V

V

A

K

P

P

G

G

D

D

T

T

I

I

R

Q

A

V

R

R

L

L

T

T

C

C

K

K

R

R

K

K

I

T

D

L

Q
x
K

G

K

R

Q

T

R

S

S

P

A

D

E

G

E

H

K

P

P

Q

T

G

G

V

V

V

V

V

E

W

W

D

A

V

V

Q

E

V

V

H

F

N

N

Q

Q

N

H

D

Q

E

T

M

P

V

V

A

A

S

L

Y

Y

D

S

I

I

L

L

T

T

L
|
L

V

V

A

A

K

R

K

Q

active site: N157 (= N161), E255 (= E259), C294 (= C298), L483 (= L492)
binding octanoyl-coenzyme a: R115 (= R119), F526 (= F535), F562 (= F571), H565 (= H574), F576 (= F585), V580 (≠ I589), V581 (≠ A590), G583 (= G592), V595 (= V604), A604 (= A613), N605 (= N614), Y606 (= Y615), R612 (= R621), F613 (= F622), I614 (= I623), E615 (= E624), P616 (= P625), K635 (≠ Q644), L670 (= L679)
binding nadp nicotinamide-adenine-dinucleotide phosphate: R19 (≠ K23), I153 (= I157), N154 (≠ D158), A155 (= A159), F156 (≠ Y160), N157 (= N161), K180 (= K184), P181 (= P185), A182 (= A186), T183 (= T187), F229 (= F233), T230 (= T234), G231 (= G235), S232 (= S236), T235 (= T239), L239 (= L243), E255 (= E259), A256 (= A260), D257 (= D261), C294 (= C298), E394 (= E403), F396 (= F405), H471 (= H480)

6jqmA Structure of paaz with NADPH (see paper)
55% identity, 99% coverage: 8:683/685 of query aligns to 3:674/678 of 6jqmA

query
sites
6jqmA

L

L

K

A

S

S

F

F

I

L

A

S

G

G

Q

T

W

W

-

Q

V

S

G

G

E

R

K

G

P

R

A

S

K
x
R

A

L

L

I

P

H

S

H

A

A

V

I

N

S

G

G

E

E

I

A

V

L

A

W

H

E

T

V

H

T

D

S

D

E

T

G

L

L

D

D

F

M

K

A

N

A

A

A

V

R

E

Q

Y

F

G

A

R

I

K

E

V

K

G

G

G

A

K

P

N

A

L

L

M

R

A

A

M

M

D

T

F

F

Q

I

E

E

R

R

A

A

L

A

A

M

L

L

K

K

A

A

M

V

A

A

L

K

Y

H

L

L

Q

L

E

S

H

E

K

K

K

E

E

R

L

F

Y

Y

A

A

L

L

S

S

M

A

H

Q

T

T

G

G

S

A

T

T

K

R

G

A

D

D

N

S

G

W

I

V

D

D

I

I

D

E

G

G

G

G

F

I

G

G

T

T

L

L

F

F

S

T

Y

Y

A

A

S

S

M

L

G

G

R

S

R

R

E

E

L

L

P

P

S

D

G

D

N

T

V

L

V

W

H

P

E

E

G

D

P

E

V

L

T

I

P

P

L

L

G

S

K

K

N

E

N

G

H

G

F

F

A

A

G

A

T

R

H

H

I

L

L

L

V

T

P

S

R

K

G

S

G

G

V

V

A

A

V

V

H

H

I
|
I

D
x
N

A
|
A

Y
x
F

N
|
N

F

F

P

P

V

C

W

W

G

G

M

M

L

L

E

E

K

K

F

L

A

A

P

P

T

T

F

W

L

L

A

G

G

G

M

M

P

P

S

A

I

I

V

I

K
|
K

P
|
P

A
|
A

T
|
T

S

A

T

T

C

A

Y

Q

V

L

T

T

E

Q

L

A

A

M

V

V

R

K

L

S

M

I

Q

V

E

D

S

S

G

G

A

L

L

V

P

P

E

E

G

G

S

A

L

I

Q

S

L

L

I

I

I

C

G

G

S

S

T

A

G

G

D

D

L

L

F

L

D

D

H

H

L

L

E

D

E

S

Q

Q

D

D

V

V

V

V

T

T

F
|
F

T

T

G
|
G

S
|
S

A

A

A

A

T
|
T

A

G

R

Q

K

M

L
|
L

R

R

N

V

H

Q

P

P

N

N

I

I

I

V

N

A

R

K

S

S

I

I

P

P

F

F

N

T

A

M

E
|
E

A
|
A

D
|
D

S

S

L

L

N

N

S

C

A

C

I

V

L

L

A

G

P

E

D

D

V

V

T

T

P

P

E

D

H

Q

E

P

E

E

F

F

D

A

V

L

F

F

V

I

K

R

E

E

I

V

R

V

R

R

E

E

M

M

T

T

A

T

K

K

A

A

G

G

Q

Q

K

K

C
|
C

T

T

A

A

I

I

R

R

R

R

I

I

F

I

V

V

P

P

K

Q

D

A

Q

L

V

V

N

N

A

A

V

V

C

S

D

D

K

A

L

L

K

V

E

A

Q

R

L

L

S

Q

K

K

I

V

T

V

V

V

G

G

D

D

P

P

S

A

V

Q

E

E

G

G

V

V

R

K

M

M

G

G

A

A

L

L

A

V

S

N

I

A

D

E

Q
|
Q

L

R

E

A

D

D

V

V

K

Q

A

E

N

K

I

V

Q

N

E

I

L

L

L

L

K

A

T

A

-

G

S

C

E

E

L

I

V

R

V

L

G

G

G

G

E

Q

G

A

N

D

F

L

K

S

A

A

T

A

G

-

D

-

G

-

T

-

E

-

K

-

G

G

A

A

F

F

I

F

E

P

P

P

H

T

L

L

L

L

L

Y

C

C

R

P

N

Q

P

P

E

D

N

E

G

T

C

P

G

A

A

V

H

H

D

A

I

T

E
|
E

A

A

F
|
F

G

G

P

P

V

V

A

A

T

T

V

L

I

M

P

P

Y

A

E

Q

T

N

I

Q

D

R

D

H

A

A

V

L

E

Q

L

L

C

A

S

C

R

A

G

G

R

G

G

G

S

S

L

L

V

A

T

G

T

T

L

L

T

V

T

T

R

A

D

D

P

P

A

Q

I

I

A

A

G

R

R

Q

I

F

A

I

P

A

L

D

L

A

A

A

A

R

F

T

H

H

G

G

R

R

L

I

H

Q

L

I

L

L

D

N

A

E

E

E

A

S

A

A

K

K

E

E

S

S

T

T

G

G

H

H

G

G

S

S

P

P

L

L

P

P

M

Q

L

L

K

V

H

H

G

G

G

G

P

P

G

G

R

R

A

A

G

G

G

G

G

G

E

E

E

E

L
|
L

G

G

G

G

I

L

R

R

A

A

V

V

H

K

H

H

Y

Y

L

M

Q

Q

R

R

T

T

A

A

I

V

Q

Q

G

G

S

S

P

P

S

T

M

M

L

L

A

A

A

A

V

I

T

S

R

K

E

Q

Y

W

V

V

R

R

G

G

A

A

D

K

L

V

I

E

E

E

T

D

D

R

V

I

H

H

P

P

F

F

R

R

R

K

H

Y

F

F

E

E

D

E

L

L

Q

Q

I

P

N

G

E

D

S

S

L

L

L

L

T

T

H

P

R

R

R

R

T

T

V

M

T

T

E

E

A

A

D

D

I

I

V

V

N

N

F

F

G

A

C

C

L

L

S

S

G

G

D

D

H

H

F

F

Y

Y

M

A

H

H

F

M

D

D

E

K

I

I

A

A

A

A

R

A

D

E

S

S

Q

I

F

F

G

G

K

E

R

R

I

V

A

V

H

H

G

G

Y

Y

F

F

V

V

L

L

S

S

A

A

A

A

A

A

G

G

L

L

F

F

V

V

Y

D

P

A

G

G

E

V

G

G

P

P

V

V

L

I

A

A

N

N

Y

Y

G

G

L

L

D

E

T

S

L

L

R

R

F

F

I

I

E

E

P

P

V

V

A

K

P

P

G

G

D

D

T

T

I

I

R

Q

A

V

R

R

L

L

T

T

C

C

K

K

R

R

K

K

I

T

D

L

Q

K

G

K

R

Q

T

R

S

S

P

A

D

E

G

E

H

K

P

P

Q

T

G

G

V

V

V

V

V

E

W

W

D

A

V

V

Q

E

V

V

H

F

N

N

Q

Q

N

H

D

Q

E

T

M

P

V

V

A

A

S

L

Y

Y

D

S

I

I

L

L

T

T

L

L

V

V

A

A

K

R

K

Q

active site: N157 (= N161), E255 (= E259), C294 (= C298), L483 (= L492)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: R19 (≠ K23), I153 (= I157), N154 (≠ D158), A155 (= A159), F156 (≠ Y160), N157 (= N161), K180 (= K184), P181 (= P185), A182 (= A186), T183 (= T187), F229 (= F233), G231 (= G235), S232 (= S236), T235 (= T239), L239 (= L243), A256 (= A260), D257 (= D261), C294 (= C298), Q341 (= Q345), E394 (= E403), F396 (= F405)

2vroA Crystal structure of aldehyde dehydrogenase from burkholderia xenovorans lb400 (see paper)
42% identity, 69% coverage: 7:480/685 of query aligns to 5:484/521 of 2vroA

query
sites
2vroA

V

L

L

L

K

K

S

N

F

H

I

V

A

A

G

G

Q

Q

W

W

V

I

-

A

G

G

E

T

K

G

P

A

A

G

K

I

A

T

L

L

P

T

S

D

A

P

V

V

N

T

G

G

E

V

I

A

V

L

A

V

H

R

T

V

H

S

D

S

D

E

T

G

L

L

D

D

F

L

K

A

N

R

A

A

V

F

E

S

Y

F

G

A

R

R

K

E

V

D

G

G

G

G

K

A

N

A

L

L

M

R

A

A

M

L

D

T

F

Y

Q

A

E

Q

R

R

A

A

L

A

A

R

L

L

K

A

A

D

M

I

A

V

L

K

Y

L

L

L

Q

Q

E

A

H

K

K

R

K

G

E

D

L

Y

Y

Y

A

A

L

I

S

A

M

T

-

A

H

N

T

S

G

G

S

T

T

T

K

R

G

N

D

D

N

S

G

A

I

V

D

D

I

I

D

D

G

G

G

G

F

I

G

F

T

T

L

L

F

S

S

Y

Y

Y

A

A

S

K

M

L

G

G

R

A

R

-

E

S

L

L

P

G

S

E

G

V

N

H

V

A

V

L

H

R

E

D

G

G

P

S

V

A

T

E

P

S

L

L

G

S

K

K

N

D

N

R

H

S

F

F

A

S

G

A

T

Q

H

H

I

V

L

L

V

S

P

P

R

T

G

R

G

G

V

V

A

A

V

L

H

F

I
|
I

D

N

A

A

Y
x
F

N
|
N

F

F

P

P

V

S

W

W

G

G

M

L

L

W

E

E

K

K

F

A

A

A

P

P

T

A

F

L

L

L

A

S

G

G

M

V

P

P

S

V

I

I

V

V

K
|
K

P

P

A

A

T

T

S

A

T

T

C

A

Y

W

V

L

T

T

E

Q

L

R

A

M

V

V

R

A

L

D

M

V

Q

V

E

D

S

A

G

G

A

I

L

L

P

P

E

P

G

G

S

A

L

L

Q

S

L

I

I

I

I

C

G
|
G

S
|
S

T
x
S

G

A

D

G

L

L

F
x
L

D

D

H

Q

L

I

E

R

E

S

Q

F

D

D

V

V

V

V

T

S

F

F

T

T

G

G

S
|
S

A

A

A

D

T
|
T

A

A

R

A

K

T

L
|
L

R

R

N

A

H

H

P

P

N

A

I

F

I

V

N

Q

R

R

S

G

I

A

P

R

F

L

N

N

A

V

E
|
E

A

A

D
|
D

S

S

L

L

N

N

S

S

A

A

I

I

L

L

A

C

P

A

D

D

V

A

T

T

P

P

E

D

H

T

E

P

E

A

F

F

D

D

V

L

F

F

V

I

K

K

E

E

I

V

R

V

R

R

E

E

M

M

T

T

A

V

K

K

A

S

G

G

Q

Q

K

K

C
|
C

T

T

A

A

I

I

R

R

R

R

I

A

F

F

V

V

P

P

K

E

D

A

Q

A

V

L

N

E

A

P

V

V

C

L

D

E

K

A

L

L

K

K

E

A

Q

K

L

L

S

A

K

K

I

I

T

T

V

V

G

G

D

N

P

P

S

R

V

N

E

D

G

A

V

V

R

R

M

M

G

G

A

S

L

L

A

V

S

S

I

R

D

E

Q

Q

L

Y

E

E

D
x
N

V

V

K

L

A

A

N

G

I

I

Q

A

E

A

L

L

L

R

K

E

T

E

S

A

E

V

L

L

V

A

V

Y

G

D

G

S

E

S

G

A

N

V

F

P

K

L

A

I

T

D

G

A

D

D

G

A

T

-

E

N

K

I

G

A

A

A

F

C

I

V

E

A

P

P

H

H

L

L

L

F

L

V

C

V

R

N

N

D

P

P

E

D

N

N

G

A

C

T

G

L

A

L

H

H

D

D

I

V

E
|
E

A

V

F
|
F

G

G

P

P

V

V

A

A

T

S

V

V

I

A

P

P

Y

Y

E

R

T

V

I

T

D

T

D

D

-

T

-

L

-

P

-

E

-

A

-

H

A

A

V

V

E

A

L

L

C

A

S

R

R

R

G

G

R

Q

G

G

S

S

L

L

V

V

T

A

T

S

L

I

T

Y

T

S

R

N

D

D

P

D

A

A

I

H

A

L

G

G

R

R

I

L

A

A

P

L

L

E

L

L

A

A

A

D

F

S

H

H

G

G

R

R

L

V

H

H

L

A

L

I

D

S

A

P

E

S

A

V

A

Q

K

H

E

S

S

Q

T

T

G

G

H

H

G

G

S

N

P

V

L

M

P

P

M

M

L

S

K

L

H

H

active site: N160 (= N161), K183 (= K184), E258 (= E259), C297 (= C298), E401 (= E403)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I156 (= I157), F159 (≠ Y160), K183 (= K184), G215 (= G216), S216 (= S217), S217 (≠ T218), L221 (≠ F222), S235 (= S236), T238 (= T239), L242 (= L243), D260 (= D261), N347 (≠ D348), F403 (= F405)

Sites not aligning to the query:

active site: 496

2y53A Crystal structure of e257q mutant of the box pathway encoded aldh from burkholderia xenovorans lb400 (see paper)
42% identity, 69% coverage: 7:480/685 of query aligns to 5:483/529 of 2y53A

query
sites
2y53A

V

L

L

L

K

K

S

N

F

H

I

V

A

A

G

G

Q

Q

W

W

V

I

-

A

G

G

E

T

K

G

P

A

A

G

K

I

A

T

L

L

P

T

S

D

A

P

V

V

N

T

G

G

E

V

I

A

V

L

A

V

H

R

T

V

H

S

D

S

D

E

T

G

L

L

D

D

F

L

K

A

N

R

A

A

V

F

E

S

Y

F

G

A

R

R

K

E

V

D

G

G

G

G

K

A

N

A

L

L

M

R

A

A

M

L

D

T

F

Y

Q

A

E

Q

R

R

A

A

L

A

A

R

L

L

K

A

A

D

M

I

A

V

L

K

Y

L

L

L

Q

Q

E

A

H

K

K

R

K

G

E

D

L

Y

Y

Y

A

A

L

I

S

A

M

T

-

A

H

N

T

S

G

G

S

T

T

T

K

R

G

N

D

D

N

S

G

A

I

V

D

D

I

I

D

D

G

G

G

G

F

I

G

F

T

T

L

L

F

S

S

Y

Y

Y

A

A

S

K

M

L

G

G

R

A

R

-

E

S

L

L

P

G

S

E

G

V

N

H

V

A

V

L

H

R

E

D

G

G

P

S

V

A

T

E

P

S

L

L

G

S

K

K

N

D

N

R

H

S

F

F

A

S

G

A

T

Q

H

H

I

V

L

L

V

S

P

P

R

T

G

R

G

G

V

V

A

A

V

L

H

F

I
|
I

D
x
N

A
|
A

Y
x
F

N
|
N

F

F

P

P

V

S

W

W

G

G

M

L

L

W

E

E

K

K

F

A

A

A

P

P

T

A

F

L

L

L

A

S

G

G

M

V

P

P

S

V

I

I

V

V

K
|
K

P

P

A
|
A

T
|
T

S

A

T

T

C

A

Y

W

V

L

T

T

E

Q

L

R

A

M

V

V

R

A

L

D

M

V

Q

V

E

D

S

A

G

G

A

I

L

L

P

P

E

P

G

G

S

A

L

L

Q

S

L

I

I

I

I

C

G

G

S

S

T
x
S

G

A

D

G

L

L

F

L

D

D

H

Q

L

I

E

R

E

S

Q

F

D

D

V

V

V

V

T

S

F
|
F

T
|
T

G
|
G

S
|
S

A
|
A

A

D

T
|
T

A

A

R

A

K

T

L

L

R

R

N

A

H

H

P

P

N

A

I

F

I

V

N

Q

R

R

S

G

I

A

P

R

F

L

N

N

A

V

E
x
Q

A
|
A

D
|
D

S

S

L

L

N

N

S

S

A

A

I

I

L

L

A

C

P

A

D

D

V

A

T

T

P

P

E

D

H

T

E

P

E

A

F

F

D

D

V

L

F

F

V

I

K

K

E

E

I

V

R

V

R

R

E

E

M

M

T

T

A

V

K

K

A

S

G

G

Q

Q

K

K

C
|
C

T

T

A

A

I

I

R

R

R

R

I

A

F

F

V

V

P

P

K

E

D

A

Q

A

V

L

N

E

A

P

V

V

C

L

D

E

K

A

L

L

K

K

E

A

Q

K

L

L

S

A

K

K

I

I

T

T

V

V

G

G

D

N

P

P

S

R

V

N

E

D

G

A

V

V

R

R

M

M

G

G

A

S

L

L

A

V

S

S

I

R

D

E

Q

Q

L

Y

E

E

D

N

V

V

K

L

A

A

N

G

I

I

Q

A

E

A

L

L

L

R

K

E

T

E

S

A

E

V

L

L

V

A

V

Y

G

D

G

S

E

S

G

A

N

V

F

P

K

L

A

I

T

D

G

A

D

D

G

A

T

-

E

N

K

I

G

A

A

A

F

C

I

V

E

A

P

P

H

H

L

L

L

F

L

V

C

V

R

N

N

D

P

P

E

D

N

N

G

A

C

T

G

L

A

L

H

H

D

D

I

V

E
|
E

A

V

F
|
F

G

G

P

P

V

V

A

A

T

S

V

V

I

A

P

P

Y

Y

E

R

T

V

I

T

D

T

D

D

-

L

-

P

-

E

-

A

-

H

A

A

V

V

E

A

L

L

C

A

S

R

R

R

G

G

R

Q

G

G

S

S

L

L

V

V

T

A

T

S

L

I

T

Y

T

S

R

N

D

D

P

D

A

A

I

H

A

L

G

G

R

R

I

L

A

A

P

L

L

E

L

L

A

A

A

D

F

S

H

H

G

G

R

R

L

V

H

H

L

A

L

I

D

S

A

P

E

S

A

V

A

Q

K

H

E

S

S

Q

T

T

G

G

H

H

G

G

S

N

P

V

L

M

P

P

M

M

L

S

K

L

H

H

active site: N160 (= N161), K183 (= K184), Q258 (≠ E259), C297 (= C298), E401 (= E403)
binding nadp nicotinamide-adenine-dinucleotide phosphate: I156 (= I157), N157 (≠ D158), A158 (= A159), F159 (≠ Y160), N160 (= N161), K183 (= K184), A185 (= A186), T186 (= T187), S217 (≠ T218), F232 (= F233), T233 (= T234), G234 (= G235), S235 (= S236), A236 (= A237), T238 (= T239), Q258 (≠ E259), A259 (= A260), D260 (= D261), C297 (= C298), E401 (= E403), F403 (= F405)

Sites not aligning to the query:

active site: 495

3ty7B Crystal structure of aldehyde dehydrogenase family protein from staphylococcus aureus
28% identity, 44% coverage: 152:452/685 of query aligns to 139:429/454 of 3ty7B

query
sites
3ty7B

G

G

V

V

A

S

V

G

H

L

I

I

D

T

A

P

Y

W

N
|
N

F

F

P

P

V

T

W

N

G

Q

M

T

L

S

E

L

K

K

F

L

A

A

P

A

T

A

F

F

L

A

A

A

G

G

M

S

P

P

S

V

I

V

V

L

K
|
K

P

P

A

S

T

E

S
x
E

T

T

C

P

Y

F

V

A

T

A

E

V

L

I

A

L

V

A

R

E

L

I

M

F

Q

D

E

K

S

V

G

G

A

-

L

V

P

P

E

K

G

G

S

V

L

F

Q

N

L

L

I

V

I

N

G

G

S

D

T

G

G

A

D

G

L

V

F

G

D

N

H

P

L

L

E

S

E

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Q

H

-

P

-

K

-

V

D

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V

M

V

M

T

S

F

F

T

T

G

G

S

S

A

G

A

P

T

T

A

G

R

S

K

K

L

I

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M

N

E

H

K

P

A

N

A

I

K

I

D

N

F

R

K

S

K

I

V

P

-

F

-

N

-

A

-

E

-

A

-

D

-

S

S

L

L

N
x
E

S

L

A

G

I

G

L

K

A

S

P

P

D

Y

V

I

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V

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L

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H

-

E

-

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D

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V

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K

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A

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A

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K

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A

M

T

T

T

A

G

K

K

-

V

-

V

-

N

-

N

A

T

G

G

Q

Q

K

V

C
|
C

T

T

A

A

I

G

R

T

R

R

I

V

F

L

V

V

P

P

K

N

D

K

Q

I

V

K

N

D

A

A

V

F

C

L

D

A

K

E

L

L

K

K

E

E

Q

Q

L

F

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S

K

Q

I

V

T

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V

V

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G

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N

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D

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M

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L

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A

I

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S

I

K

D

K

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Q

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F

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D

D

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V

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A

N

N

Y

I

I

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N

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-

G

L

I

L

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K

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L

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-

K

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-

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L

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K

K

G

G

A

Y

F

F

I

A

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P

P

H

T

L

I

L

F

L

I

C

-

R

-

N

N

P

V

E

D

N

N

G

Q

C

M

G

T

A

I

H

A

D

Q

I

E

E
|
E

A

I

F

F

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G

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P

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V

A

M

T

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V

V

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Y

Y

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N

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L

D

D

D

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A

A

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I

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Q

L

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A

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N

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K

G

Y

S

G

L

L

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A

T

G

T

Y

L

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T

I

T

G

R

K

D

D

P

K

A

E

I

T

A

L

G

H

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K

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A

A

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L

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L

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A

E

A

A

active site: N148 (= N161), K171 (= K184), E246 (≠ N264), C280 (= C298), E380 (= E403)
binding magnesium ion: E175 (≠ S188)

Sites not aligning to the query:

binding magnesium ion: 26

4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
27% identity, 73% coverage: 9:508/685 of query aligns to 7:479/489 of 4cazA

query
sites
4cazA

K

K

S

L

F

Y

I

I

A

G

G

G

Q

R

W

Y

V

V

G

E

E

A

K

S

P

S

A

G

K

A

A

T

L

F

P

E

S

T

A

I

-

N

-

P

V

A

N

N

G

G

E

E

I

V

V

L

A

A

H

K

T

V

H

Q

D

R

D

A

T

S

L

R

-

E

D

D

F

V

K

E

N

R

A

A

V

V

E

Q

Y

S

G

A

R

V

K

E

V

-

G

G

G

Q

K

K

N

V

L

W

M

A

A

A

M

M

D

T

F

A

Q

M

E

Q

R

R

A

S

L

R

A

I

L

L

K

R

A

R

M

A

A

V

L

D

Y

I

L

L

Q

R

E

E

H

R

K

N

K

D

E

E

L

L

Y

A

A

A

L

L

-

E

S

T

M

L

H

D

T

T

G

G

S

K

T

P

K

L

G

A

D

E

N

T

-

R

G

S

I

V

D

D

I

I

D

V

G

T

G

G

F

A

G

D

T

V

L

L

F

E

S

Y

Y

Y

A

A

S

G

M

L

G

-

R

-

R

-

E

-

L

V

P

P

S

A

G

-

N

-

V

-

V

-

H

I

E

E

G

G

P

E

V

Q

T

I

P

P

L

L

G

-

K

R

N

E

N

T

H

S

F

F

A

V

G

Y

T

T

H

R

I

-

L

R

V

E

P

P

R

L

G

G

G

V

V

V

A

A

V

-

H

G

I
|
I

D
x
G

A
|
A

Y
x
W

N
|
N

F

Y

P

P

V

V

W

Q

G

I

M

A

L

L

E

W

K

K

F

S

A

A

P

P

T

A

F

L

L

A

A

A

G

G

M

N

P

A

S

M

I

I

V

F

K
|
K

P
|
P

A
x
S

T
x
E

S

V

T

T

C

P

Y

L

V

T

T

A

E

L

L

K

A

L

V

A

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E

L

I

M

Y

Q

T

E

E

S

A

G

G

A

-

L

V

P

P

E

D

G

G

S

V

L

F

Q

N

L

V

I

L

I

T

G

G

S

S

T
x
G

G

R

D

E

L

V

F
x
G

D
x
Q

H

W

L

L

E

T

E

E

Q

H

-

P

-

L

-

I

D

E

V

K

V

I

T

S

F
|
F

T
|
T

G
|
G

S
x
G

A

T

A

S

T
|
T

A

G

R

K

K

K

L
x
V

R

M

N

A

H

S

P

A

N

S

I

S

I

S

N

S

R

L

S

K

I

-

P

E

F

V

N

T

A

M

E
|
E

A
x
L

D
x
G

S

G

L

K

N

S

S

P

A

L

I

I

L

I

A

F

P

P

D

D

V

A

T

D

P

L

E

D

H

R

E

A

E

A

F

-

D

D

V

I

F

A

V

V

K

M

E

A

I

-

R

-

R

-

E

-

M

N

T

F

A

F

K

S

A

S

G

G

Q

Q

K

V

C
|
C

T

T

A

N

I

G

R

T

R

R

I

V

F

F

V

I

P

H

K

R

D

S

Q

Q

V

Q

N

A

A

R

V

F

C

E

D

A

K

K

L

V

K

L

E

E

Q

R

L

V

S

Q

K

R

I

I

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R

V

L

G

G

D

D

P

P

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Q

V

D

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N

M

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G

G

A

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L

L

A

V

S

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I

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D

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Q

H

L

M

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D

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V

V

K

L

A

G

N

Y

I

I

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G

L

K

L

A

K

Q

T

K

S

A

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L

L

V

L

V

C

G

G

G

G

E

E

G

-

N

-

F

-

K

R

A

V

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G

D

D

G

G

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F

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G

K

K

G

G

A

A

F

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I

V

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A

P

P

H

T

L

V

L

F

L

T

-

D

C

C

R

R

N

D

P

D

E

M

N

T

G

I

C

V

G

R

A

E

H

-

D

-

I

-

E
|
E

A

I

F
|
F

G

G

P

P

V

V

A

M

T

S

V

I

I

L

P

V

Y

Y

E

D

T

D

I

E

D

D

D

E

A

A

V

I

E

R

L

R