SitesBLAST

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
30% identity, 90% coverage: 4:234/258 of query aligns to 5:226/353 of Q97UY8

query
sites
Q97UY8

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S142 (= S151) mutation to A: Decrease in ATPase activity. Can form dimers.
G144 (= G153) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
E166 (= E175) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
30% identity, 84% coverage: 3:219/258 of query aligns to 1:206/241 of 4u00A

query
sites
4u00A

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binding adenosine-5'-diphosphate: F12 (≠ Y14), L15 (≠ V17), V17 (≠ A19), S37 (≠ N39), G38 (= G40), S39 (≠ A41), G40 (= G42), K41 (= K43), S42 (= S44), T43 (≠ S45)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
27% identity, 81% coverage: 12:219/258 of query aligns to 9:206/240 of 4ymuJ

query
sites
4ymuJ

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binding adenosine-5'-triphosphate: F11 (≠ Y14), L14 (≠ V17), V16 (≠ A19), S36 (≠ N39), G37 (= G40), S38 (≠ A41), G39 (= G42), K40 (= K43), S41 (= S44), T42 (≠ S45), E51 (≠ V54), E162 (= E175), H194 (= H207)
binding magnesium ion: S41 (= S44), E162 (= E175)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
25% identity, 84% coverage: 4:221/258 of query aligns to 4:222/254 of 1g6hA

query
sites
1g6hA

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binding adenosine-5'-diphosphate: F14 (≠ Y14), F17 (≠ V17), N39 (= N39), G40 (= G40), S41 (≠ A41), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 84% coverage: 4:221/258 of query aligns to 4:222/253 of 1g9xB

query
sites
1g9xB

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binding adenosine-5'-diphosphate: F14 (≠ Y14), F17 (≠ V17), N39 (= N39), G40 (= G40), S41 (≠ A41), G42 (= G42), K43 (= K43), S44 (= S44), T45 (≠ S45)
binding magnesium ion: S44 (= S44), E176 (= E175)

3c4jA Abc protein artp in complex with atp-gamma-s
27% identity, 90% coverage: 10:241/258 of query aligns to 9:236/242 of 3c4jA

query
sites
3c4jA

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Q

T

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

-

G

-

W

-

R

-

G

P

S

M

V

K

L

V

R

R

Q

K

L

W

D

P

R

R

A

E

R

K

M

A

E

E

Q

A

I

K

A

A

R

M

D

E

K

L

L

L

N

D

E

K

L

V

G

G

L

L

A

K

T

-

I

-

Q

D

N

K

I

A

N
x
H

Q

A

A
x
Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E
|
E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

Q

K

D

Q

V

L

K

A

S

N

R

E

G

G

I

M

P

T

I

M

I

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

V

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

Q

Q

H

H

S

E

M

R

S

T

D

K

A

A

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), P37 (≠ D38), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45), H133 (≠ N144), Y135 (≠ A146), E164 (= E175)

3c41J Abc protein artp in complex with amp-pnp/mg2+
27% identity, 90% coverage: 10:241/258 of query aligns to 9:236/242 of 3c41J

query
sites
3c41J

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

D

H

L

I

M

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D
x
P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K
x
R

A

C

V

L

S

N

G

L

A

L

V

E

V

D

P

F

D

D

A

E

G

G

E

E

V

I

W

I

L

I

E

D

G

G

R

I

R

N

V

L

Q

K

F

A

H

K

-

D

T

T

P

N

I

L

D

N

A

K

R

V

K

R

E

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

T

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

-

G

-

W

-

R

-

G

P

S

M

V

K

L

V

R

R

Q

K

L

W

D

P

R

R

A

E

R

K

M

A

E

E

Q

A

I

K

A

A

R

M

D

E

K

L

L

L

N

D

E

K

L

V

G

G

L

L

A

K

T

-

I

-

Q

D

N

K

I

A

N
x
H

Q

A

A
x
Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D
|
D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

Q

K

D

Q

V

L

K

A

S

N

R

E

G

G

I

M

P

T

I

M

I

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

V

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

Q

Q

H

H

S

E

M

R

S

T

D

K

A

A

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y14), V18 (≠ A19), P37 (≠ D38), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45), R47 (≠ K48), H133 (≠ N144), Y135 (≠ A146)
binding magnesium ion: S43 (= S44), D163 (= D174)

2olkA Abc protein artp in complex with adp-beta-s
27% identity, 90% coverage: 10:241/258 of query aligns to 9:236/242 of 2olkA

query
sites
2olkA

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V
x
L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

D

H

L

I

M

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

V

D

P

F

D

D

A

E

G

G

E

E

V

I

W

I

L

I

E

D

G

G

R

I

R

N

V

L

Q

K

F

A

H

K

-

D

T

T

P

N

I

L

D

N

A

K

R

V

K

R

E

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

T

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

-

G

-

W

-

R

-

G

P

S

M

V

K

L

V

R

R

Q

K

L

W

D

P

R

R

A

E

R

K

M

A

E

E

Q

A

I

K

A

A

R

M

D

E

K

L

L

L

N

D

E

K

L

V

G

G

L

L

A

K

T

-

I

-

Q

D

N

K

I

A

N

H

Q

A

A

Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

Q

K

D

Q

V

L

K

A

S

N

R

E

G

G

I

M

P

T

I

M

I

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

V

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

Q

Q

H

H

S

E

M

R

S

T

D

K

A

A

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y14), L16 (≠ V17), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45)

2oljA Abc protein artp in complex with adp/mg2+
27% identity, 90% coverage: 10:241/258 of query aligns to 9:236/242 of 2oljA

query
sites
2oljA

L

L

V

K

K

K

R

S

Y
x
F

G

G

R

S

V

L

T

E

A
x
V

L

L

D

K

H

G

C

I

D

N

F

V

D

H

L

I

M

R

P

E

G

G

E

E

I

V

L

V

A

V

V

V

I

I

G

G

D

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

L

F

I

L

K

R

A

C

V

L

S

N

G

L

A

L

V

E

V

D

P

F

D

D

A

E

G

G

E

E

V

I

W

I

L

I

E

D

G

G

R

I

R

N

V

L

Q

K

F

A

H

K

-

D

T

T

P

N

I

L

D

N

A

K

R

V

K

R

E

E

G

E

I

V

E

G

T

M

V

V

Y

F

Q

Q

T

R

L

F

A

N

M

L

S

F

P

P

A

H

L

M

S

T

I

V

A

L

D

N

N

N

M

I

F

T

M

L

G

A

R

-

E

-

L

-

R

-

K

-

P

-

G

-

W

-

R

-

G

P

S

M

V

K

L

V

R

R

Q

K

L

W

D

P

R

R

A

E

R

K

M

A

E

E

Q

A

I

K

A

A

R

M

D

E

K

L

L

L

N

D

E

K

L

V

G

G

L

L

A

K

T

-

I

-

Q

D

N

K

I

A

N
x
H

Q

A

A
x
Y

V

P

E

D

T

S

L

L

S

S

G

G

Q

Q

R

A

Q

Q

G

R

V

V

A

A

V

I

A

A

R

R

A

A

A

L

A

A

F

M

G

E

S

P

K

K

V

I

I

M

I

L

L

F

D

D

E

E

P

P

T

T

A

S

A

A

L

L

G

D

V

P

K

E

E

M

S

V

R

G

R

E

V

V

L

L

E

S

L

V

I

M

Q

K

D

Q

V

L

K

A

S

N

R

E

G

G

I

M

P

T

I

M

I

V

L

V

I

V

S

T

H

H

N

E

M

M

P

G

H

F

V

A

F

R

E

E

V

V

A

G

D

D

R

R

I

V

-

L

-

F

-

M

-

D

-

G

H

Y

V

I

H

I

R

E

L

E

G

G

K

K

R

P

L

E

C

D

V

L

I

F

D

D

P

R

K

P

Q

Q

H

H

S

E

M

R

S

T

D

K

A

A

binding adenosine-5'-diphosphate: F13 (≠ Y14), V18 (≠ A19), S38 (≠ N39), G39 (= G40), S40 (≠ A41), G41 (= G42), K42 (= K43), S43 (= S44), T44 (≠ S45), H133 (≠ N144), Y135 (≠ A146)

3d31A Modbc from methanosarcina acetivorans (see paper)
29% identity, 87% coverage: 11:235/258 of query aligns to 7:214/348 of 3d31A

query
sites
3d31A

V

L

K

S

R

R

Y

K

G

W

R

K

V

N

T

F

A

S

L

L

D

D

H

N

C

L

D

S

F

L

D

K

L

V

M

E

P

S

G

G

E

E

I

Y

L

F

A

V

V

I

I

L

G

G

D

P

N

T

G

G

A

A

G

G

K

K

S

T

S

L

L

F

I

L

K

E

A

L

V

I

S

A

G

G

A

F

V

H

V

V

P

P

D

D

A

S

G

G

E

R

V

I

W

L

L

L

E

D

G

G

R

K

R

D

V

V

Q

-

F

-

H

-

T

T

P

D

I

L

D

S

A

P

R

E

K

K

E

H

G

D

I

I

E

A

T

F

V

V

Y

Y

Q

Q

T

N

L

Y

A

S

M

L

S

F

P

P

A

H

L

M

S

N

I

V

A

K

D

K

N

N

M

L

F

E

M

F

G

G

R

M

E

R

L

M

R

K

K

K

P

I

G

K

W

-

R

-

G

-

S

-

V

-

L

-

R

-

Q

-

L

-

D

D

R

P

A

K

R

R

M

V

E

L

Q

D

I

T

A

A

R

R

D

D

-

L

K

K

L

I

N

E

E

H

L

L

G

-

L

-

A

-

T

-

I

-

Q

-

N

-

I

L

N

D

Q

R

A

N

V

P

E

L

T

T

L

L

S

S

G

G

Q

E

R

Q

Q

Q

G

R

V

V

A

A

V

L

A

A

R

R

A

A

A

L

A

V

F

T

G

N

S

P

K

K

V

I

I

L

L

L

D

D

E

E

P

P

T

L

A

S

A

A

L

L

G

D

V

P

K

R

E

T

S

Q

R

E

R

N

V

A

L

R

E

E

L

M

I

L

Q

S

D

V

V

L

-

H

K

K

S

K

R

N

G

K

I

L

P

T

I

V

I

L

L

H

I

I

S

T

H

H

N

D

M

Q

P

T

H

E

V

A

F

R

E

I

V

M

A

A

D

D

R

R

I

I

H

A

V

V

H

V

R

M

L

D

G

G

K

K

R

L

L

I

C

Q

V

V

I

G

D

K

P

P

K

E

Q

E

Sites not aligning to the query:

binding tungstate(vi)ion: 286, 287, 288, 319, 320, 323, 340, 341, 342

O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 35 papers)
32% identity, 86% coverage: 8:230/258 of query aligns to 902:1112/2261 of O95477

query
sites
O95477

R

Q

G

N

L

L

V

V

K

K

R

V

Y

Y

-

R

-

D

G

G

R

M

V

K

T

V

A

A

L

V

D
|
D

H

G

C

L

D

A

F

L

D

N

L

F

M

Y

P

E

G

G

E

Q

I

I

L
x
T

A

S

V

F

I

L

G

G

D

H

N
|
N

G

G

A

A

G

G

K
|
K

S

T

L

T

I

M

K

S

A

I

V

L

S

T

G

G

A

L

V

F

V

P

P

P

D

T

A

S

G

G

E

T

V

A

W

Y

L

I

E

L

G

G

R

K

R

-

V

-

Q

-

F

-

H

-

T

-

P

-

I

-

D

D

A

I

R

R

K

S

E

E

G

-

I

M

E

S

T

T

V

I

Y

R

Q

Q

T

N

L

L

A

G

M

V

S

C

P

P

A

Q

L

H

S

N

I

V

A

L

D

F

N

D

M

M

F

L

M

T

G

V

R

E

E

E

L

-

R

-

K

-

P

H

G

I

W

W

R

F

G

Y

S

A

V

R

L

L

R

K

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-

E

-

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-

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-

V

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A

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M

M

E

E

Q

Q

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M

A

A

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-

L

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N

-

E

-

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x
S

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M

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D917 (= D21) to Y: in a colorectal cancer sample; somatic mutation
T929 (≠ L33) to I: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane
N935 (= N39) to S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs28937313
K939 (= K43) mutation to M: Inhibits ATPase activity; when associated with M-1952. Decreases translocase activity; when associated with M-1952. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-1952.
S1042 (≠ A159) modified: Phosphoserine; by PKA
P1065 (≠ V182) natural variant: P -> S
M1091 (= M209) to T: in FHA1; loss of localization to plasma membrane; decreased cholesterol efflux; decreased phospholipid efflux
C1110 (≠ L228) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1111.
C1111 (= C229) modified: S-palmitoyl cysteine; mutation to S: Decreased palmitoylation; when associated with S-3, S-23 and S-1110.

Sites not aligning to the query:

3 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased cholesterol efflux. Decreased phospholipid efflux. Decreased palmitoylation; when associated with S-23, S-1110 and S-1111.
23 modified: S-palmitoyl cysteine; C→S: Mild decrease of palmitoylation. Loss of localization to plasma membrane. Decreased palmitoylation; when associated with S-3, S-1110 and S-1111.
74 I→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.; I→K: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-371.
75 modified: Disulfide link with 309
85 P → L: in FHA1; Alabama; dbSNP:rs145183203
98 modified: carbohydrate, N-linked (GlcNAc...) asparagine
100 S→C: Highly decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
210 E → D: in a colorectal cancer sample; somatic mutation
219 R → K: associated with a decreased severity of CAD; dbSNP:rs2230806
230 R → C: in dbSNP:rs9282541
244 modified: carbohydrate, N-linked (GlcNAc...) asparagine
248 P → A: in dbSNP:rs142625938
255 A → T: in TGD; deficient cellular cholesterol efflux; dbSNP:rs758100110
304 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-308.
308 V→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane; when associated with C-304.
309 modified: Disulfide link with 75
364 S → C: in dbSNP:rs775035559
371 I→C: No effect on phospholipid and cholesterol efflux or localization to cell membrane. 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-74 or C-375.; I→E: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-74.
375 L→C: 85-90% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with C-371.
399 V → A: in dbSNP:rs9282543
401 K → Q: in dbSNP:rs138487227
496 R → W: associated with increased plasma HDL cholesterol; dbSNP:rs147675550
568 K→A: 60-65% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane.
573 Y→F: No effect on phospholipid and cholesterol efflux and on localization to cell membrane.
581 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-584 and K-585.
583 F→K: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with E-590.
584 E→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-585.
585 D→K: 80-85% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-581 and K-584.
590 W → S: in TGD; moderately decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; dbSNP:rs137854496; W→E: 90-95% reduction in phospholipid and cholesterol efflux but no effect on localization to cell membrane; when associated with K-583.
593 F→L: Moderately decreased protein abundance. Highly decreased ATPase activity. Highly decreased phospholipid translocase activity.
638 R → Q: associated with reduced plasma HDL cholesterol; dbSNP:rs374190304
771 V → M: associated with HDL cholesterol; dbSNP:rs2066718
774 T → P: in dbSNP:rs35819696; natural variant: T -> S
776 K → N: may be associated with increased risk of ischemic heart disease; dbSNP:rs138880920
815 E → G: associated with reduced plasma HDL cholesterol; dbSNP:rs145582736
825 V → I: associated with higher plasma cholesterol; dbSNP:rs2066715
883 I → M: associated with higher plasma cholesterol; dbSNP:rs2066714
1172 E → D: associated with premature coronary heart disease; dbSNP:rs33918808
1181 S → F: associated with reduced plasma HDL cholesterol; dbSNP:rs76881554
1216 G → V: in dbSNP:rs562403512
1341 R → T: associated with reduced plasma HDL cholesterol; dbSNP:rs147743782
1376 S → G: in dbSNP:rs145689805
1379 L → F: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1407 A → T: in a colorectal cancer sample; somatic mutation; dbSNP:rs189206655
1463 modified: Disulfide link with 1477
1477 modified: Disulfide link with 1463; C → R: in TGD; loss of interaction with APOE; unable to generate APOE-containing high density lipoproteins; moderately decreased protein abundance; moderately decreased ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs137854494
1512 T→M: Moderately decreased protein abundance. Does not affect ATPase activity. Moderately decreased phospholipid translocase activity.
1555 I → T: in dbSNP:rs1997618
1587 K → R: associated with HDL cholesterol; dbSNP:rs2230808
1611 N → D: probable disease-associated variant; associated with atherosclerosis; deficient cellular cholesterol efflux
1615 R → Q: associated with reduced plasma HDL cholesterol; dbSNP:rs1251839800
1648 L → P: in dbSNP:rs1883024
1670 A → T: associated with reduced plasma HDL cholesterol; dbSNP:rs1203589782
1680 R → Q: associated with increased plasma HDL cholesterol; dbSNP:rs150125857
1704 V → D: in TGD; the mutant protein is retained in the endoplasmic reticulum while the wild-type protein is located at the plasma membrane
1731 S → C: in dbSNP:rs760507032
1897 R → W: in FHA1; uncertain pathological significance; dbSNP:rs760768125
1925 R → Q: in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane; dbSNP:rs142688906
1952 K→M: Inhibits ATPase activity; when associated with M-939. Decreases translocase activity; when associated with M-939. Does not affect protein subcellular localization in plasma membrane and endosome; when associated with M-939.
2054 modified: Phosphoserine; by PKA
2081 R → W: in TGD; highly decreased protein abundance; highly decreased ATPase activity; highly decreased phospholipid translocase activity; loss protein subcellular localization to the plasma membrane; dbSNP:rs137854501
2109 A → T: in a colorectal cancer sample; somatic mutation
2150 P → L: in FHA1; moderately decreased protein abundance; does not affect ATPase activity; moderately decreased phospholipid translocase activity; dbSNP:rs369098049
2163 F → S: could be associated with reduced plasma HDL cholesterol
2168 L → P: in dbSNP:rs2853577
2243 D → E: in dbSNP:rs34879708
2244 V → I: could be associated with reduced plasma HDL cholesterol; dbSNP:rs144588452

2d62A Crystal structure of multiple sugar binding transport atp- binding protein
29% identity, 83% coverage: 12:226/258 of query aligns to 14:220/375 of 2d62A

query
sites
2d62A

K

K

R

R

Y

F

G

G

R

D

V

V

T

T

A

A

L

V

D

K

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L

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x
P

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x
S

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G

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x
C

G
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G

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K

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x
T

L

T

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-

A

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-

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D

N

N

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M

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N

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binding pyrophosphate 2-: P40 (≠ D38), S41 (≠ N39), G42 (= G40), C43 (≠ A41), G44 (= G42), K45 (= K43), T46 (≠ S44), T47 (≠ S45)

7tbwA The structure of atp-bound abca1
31% identity, 86% coverage: 8:230/258 of query aligns to 757:967/1928 of 7tbwA

query
sites
7tbwA

R

Q

G

N

L

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K

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Y

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x
D

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Q

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H

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binding adenosine-5'-triphosphate: Y763 (= Y14), D765 (vs. gap), K768 (≠ V17), A770 (= A19), H789 (≠ D38), N790 (= N39), G791 (= G40), G793 (= G42), K794 (= K43), T795 (≠ S44), T796 (≠ S45), Q835 (≠ A93), K880 (≠ N142), Q887 (≠ T149), S889 (= S151), G891 (= G153), Q913 (≠ E175), H944 (= H207)
binding magnesium ion: Q835 (≠ A93), D912 (= D174), Q913 (≠ E175)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 1630, 1633, 1657, 1658, 1660, 1661, 1662, 1663, 1702, 1753, 1755, 1756, 1757, 1779, 1783, 1811
binding cholesterol: 213, 218, 219, 352, 360, 367
binding magnesium ion: 1662, 1702, 1779

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
27% identity, 91% coverage: 1:235/258 of query aligns to 1:222/285 of 4yerA

query
sites
4yerA

M

M

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G

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K

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T

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N

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S

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K

K

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Y

M

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K

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P

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E

binding adenosine-5'-diphosphate: F14 (≠ Y14), F17 (≠ V17), A19 (= A19), P38 (≠ D38), N39 (= N39), G40 (= G40), A41 (= A41), G42 (= G42), K43 (= K43), T44 (≠ S44), T45 (≠ S45), T135 (= T149), F136 (≠ L150), S137 (= S151)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
25% identity, 88% coverage: 1:226/258 of query aligns to 14:225/378 of P69874

query
sites
P69874

M

L

E

S

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P

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F

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C

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